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Q9JJV5

- CCG3_MOUSE

UniProt

Q9JJV5 - CCG3_MOUSE

Protein

Voltage-dependent calcium channel gamma-3 subunit

Gene

Cacng3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.By similarity

    GO - Molecular functioni

    1. calcium channel activity Source: UniProtKB-KW
    2. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-3 subunit
    Alternative name(s):
    Neuronal voltage-gated calcium channel gamma-3 subunit
    Transmembrane AMPAR regulatory protein gamma-3
    Short name:
    TARP gamma-3
    Gene namesi
    Name:Cacng3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1859165. Cacng3.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Voltage-dependent calcium channel gamma-3 subunitPRO_0000164676Add
    BLAST

    Proteomic databases

    PaxDbiQ9JJV5.
    PRIDEiQ9JJV5.

    PTM databases

    PhosphoSiteiQ9JJV5.

    Expressioni

    Gene expression databases

    BgeeiQ9JJV5.
    GenevestigatoriQ9JJV5.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000081664.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG48125.
    GeneTreeiENSGT00550000074547.
    HOGENOMiHOG000233440.
    HOVERGENiHBG003682.
    InParanoidiA6H6R5.
    KOiK04868.
    OMAiKHNVILS.
    OrthoDBiEOG7TQV1Q.
    TreeFamiTF327980.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.

    Sequencei

    Sequence statusi: Complete.

    Q9JJV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET    50
    SRKNEEVMTH SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA 100
    VRASSVFPIL SVTLLFFGGL CVAASEFHRS RHSVILSAGI FFVSAGLSNI 150
    IGIIVYISAN AGDPGQRDSK KSYSYGWSFY FGAFSFIIAE IVGVVAVHIY 200
    IEKHQQLRAR SHSELLKKST FARLPPYRYR FRRRSSSRST EPRSRDLSPI 250
    SKGFHTIPST DISMFTLSRD PSKLTMGTLL NSDRDHAFLQ FHNSTPKEFK 300
    ESLHNNPANR RTTPV 315
    Length:315
    Mass (Da):35,516
    Last modified:July 27, 2011 - v2
    Checksum:iFB4EA036C494B6AD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611S → F in CAB86385. (PubMed:10734232)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272044 mRNA. Translation: CAB86385.1.
    CH466531 Genomic DNA. Translation: EDL17281.1.
    BC138673 mRNA. Translation: AAI38674.1.
    BC145971 mRNA. Translation: AAI45972.1.
    CCDSiCCDS21816.1.
    RefSeqiNP_062303.2. NM_019430.2.
    UniGeneiMm.444212.

    Genome annotation databases

    EnsembliENSMUST00000084615; ENSMUSP00000081664; ENSMUSG00000066189.
    GeneIDi54376.
    KEGGimmu:54376.
    UCSCiuc009jov.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272044 mRNA. Translation: CAB86385.1 .
    CH466531 Genomic DNA. Translation: EDL17281.1 .
    BC138673 mRNA. Translation: AAI38674.1 .
    BC145971 mRNA. Translation: AAI45972.1 .
    CCDSi CCDS21816.1.
    RefSeqi NP_062303.2. NM_019430.2.
    UniGenei Mm.444212.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000081664.

    PTM databases

    PhosphoSitei Q9JJV5.

    Proteomic databases

    PaxDbi Q9JJV5.
    PRIDEi Q9JJV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084615 ; ENSMUSP00000081664 ; ENSMUSG00000066189 .
    GeneIDi 54376.
    KEGGi mmu:54376.
    UCSCi uc009jov.3. mouse.

    Organism-specific databases

    CTDi 10368.
    MGIi MGI:1859165. Cacng3.

    Phylogenomic databases

    eggNOGi NOG48125.
    GeneTreei ENSGT00550000074547.
    HOGENOMi HOG000233440.
    HOVERGENi HBG003682.
    InParanoidi A6H6R5.
    KOi K04868.
    OMAi KHNVILS.
    OrthoDBi EOG7TQV1Q.
    TreeFami TF327980.

    Miscellaneous databases

    NextBioi 311188.
    PROi Q9JJV5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JJV5.
    Genevestigatori Q9JJV5.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCCG3_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJV5
    Secondary accession number(s): A6H6R5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3