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Protein

Voltage-dependent calcium channel gamma-3 subunit

Gene

Cacng3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-3 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-3 subunit
Transmembrane AMPAR regulatory protein gamma-3
Short name:
TARP gamma-3
Gene namesi
Name:Cacng3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1859165. Cacng3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Voltage-dependent calcium channel gamma-3 subunitPRO_0000164676Add
BLAST

Proteomic databases

PaxDbiQ9JJV5.
PRIDEiQ9JJV5.

PTM databases

PhosphoSiteiQ9JJV5.

Expressioni

Gene expression databases

BgeeiQ9JJV5.
ExpressionAtlasiQ9JJV5. baseline and differential.
GenevestigatoriQ9JJV5.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081664.

Structurei

3D structure databases

ProteinModelPortaliQ9JJV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG48125.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ9JJV5.
KOiK04868.
OMAiKHNVILS.
OrthoDBiEOG7TQV1Q.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.

Sequencei

Sequence statusi: Complete.

Q9JJV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET
60 70 80 90 100
SRKNEEVMTH SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA
110 120 130 140 150
VRASSVFPIL SVTLLFFGGL CVAASEFHRS RHSVILSAGI FFVSAGLSNI
160 170 180 190 200
IGIIVYISAN AGDPGQRDSK KSYSYGWSFY FGAFSFIIAE IVGVVAVHIY
210 220 230 240 250
IEKHQQLRAR SHSELLKKST FARLPPYRYR FRRRSSSRST EPRSRDLSPI
260 270 280 290 300
SKGFHTIPST DISMFTLSRD PSKLTMGTLL NSDRDHAFLQ FHNSTPKEFK
310
ESLHNNPANR RTTPV
Length:315
Mass (Da):35,516
Last modified:July 27, 2011 - v2
Checksum:iFB4EA036C494B6AD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611S → F in CAB86385 (PubMed:10734232).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272044 mRNA. Translation: CAB86385.1.
CH466531 Genomic DNA. Translation: EDL17281.1.
BC138673 mRNA. Translation: AAI38674.1.
BC145971 mRNA. Translation: AAI45972.1.
CCDSiCCDS21816.1.
RefSeqiNP_062303.2. NM_019430.2.
UniGeneiMm.444212.

Genome annotation databases

EnsembliENSMUST00000084615; ENSMUSP00000081664; ENSMUSG00000066189.
GeneIDi54376.
KEGGimmu:54376.
UCSCiuc009jov.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272044 mRNA. Translation: CAB86385.1.
CH466531 Genomic DNA. Translation: EDL17281.1.
BC138673 mRNA. Translation: AAI38674.1.
BC145971 mRNA. Translation: AAI45972.1.
CCDSiCCDS21816.1.
RefSeqiNP_062303.2. NM_019430.2.
UniGeneiMm.444212.

3D structure databases

ProteinModelPortaliQ9JJV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081664.

PTM databases

PhosphoSiteiQ9JJV5.

Proteomic databases

PaxDbiQ9JJV5.
PRIDEiQ9JJV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084615; ENSMUSP00000081664; ENSMUSG00000066189.
GeneIDi54376.
KEGGimmu:54376.
UCSCiuc009jov.3. mouse.

Organism-specific databases

CTDi10368.
MGIiMGI:1859165. Cacng3.

Phylogenomic databases

eggNOGiNOG48125.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ9JJV5.
KOiK04868.
OMAiKHNVILS.
OrthoDBiEOG7TQV1Q.
TreeFamiTF327980.

Miscellaneous databases

NextBioi311188.
PROiQ9JJV5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJV5.
ExpressionAtlasiQ9JJV5. baseline and differential.
GenevestigatoriQ9JJV5.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCCG3_MOUSE
AccessioniPrimary (citable) accession number: Q9JJV5
Secondary accession number(s): A6H6R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: July 27, 2011
Last modified: May 27, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.