Q9JJV5 (CCG3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent calcium channel gamma-3 subunit

Alternative name(s):
Neuronal voltage-gated calcium channel gamma-3 subunit
Transmembrane AMPAR regulatory protein gamma-3
Short name=TARP gamma-3

Gene names

Name:

Cacng3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.
Subunit structure	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	calcium channel activity Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Voltage-dependent calcium channel gamma-3 subunit		PRO_0000164676
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Transmembrane	135 – 155	21	Helical; Potential
	Transmembrane	181 – 201	21	Helical; Potential
Amino acid modifications
	Modified residue	248	1	Phosphoserine Ref.4
Experimental info
	Sequence conflict	61	1	S → F in CAB86385. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9JJV5 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: FB4EA036C494B6AD	FASTA	315	35,516
	10 20 30 40 50 60 MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET SRKNEEVMTH 70 80 90 100 110 120 SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA VRASSVFPIL SVTLLFFGGL 130 140 150 160 170 180 CVAASEFHRS RHSVILSAGI FFVSAGLSNI IGIIVYISAN AGDPGQRDSK KSYSYGWSFY 190 200 210 220 230 240 FGAFSFIIAE IVGVVAVHIY IEKHQQLRAR SHSELLKKST FARLPPYRYR FRRRSSSRST 250 260 270 280 290 300 EPRSRDLSPI SKGFHTIPST DISMFTLSRD PSKLTMGTLL NSDRDHAFLQ FHNSTPKEFK 310 ESLHNNPANR RTTPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of gamma-like calcium channel subunits." Klugbauer N., Dai S., Specht V., Lacinova L., Marais E., Bohn G., Hofmann F. FEBS Lett. 470:189-197(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ272044 mRNA. Translation: CAB86385.1. CH466531 Genomic DNA. Translation: EDL17281.1. BC138673 mRNA. Translation: AAI38674.1. BC145971 mRNA. Translation: AAI45972.1.
IPI	IPI00122300.
RefSeq	NP_062303.2. NM_019430.2.
UniGene	Mm.444212.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000081664.
PTM databases
PhosphoSite	Q9JJV5.
Proteomic databases
PaxDb	Q9JJV5.
PRIDE	Q9JJV5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000084615; ENSMUSP00000081664; ENSMUSG00000066189.
GeneID	54376.
KEGG	mmu:54376.
Organism-specific databases
CTD	10368.
MGI	MGI:1859165. Cacng3.
Phylogenomic databases
eggNOG	NOG48125.
GeneTree	ENSGT00550000074547.
HOGENOM	HOG000233440.
HOVERGEN	HBG003682.
InParanoid	A6H6R5.
KO	K04868.
OMA	DSLHNNP.
OrthoDB	EOG4P5K9M.
Gene expression databases
Bgee	Q9JJV5.
Genevestigator	Q9JJV5.
GermOnline	ENSMUSG00000066189. Mus musculus.
Family and domain databases
InterPro	IPR004031. PMP22/EMP/MP20/Claudin. IPR008368. VDCC_gsu. [Graphical view]
Pfam	PF00822. PMP22_Claudin. 1 hit. [Graphical view]
PRINTS	PR01792. VDCCGAMMA.
ProtoNet	Search...
Other
NextBio	311188.
SOURCE	Search...

Entry information

Entry name

CCG3_MOUSE

Accession

Primary (citable) accession number: Q9JJV5
Secondary accession number(s): A6H6R5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program