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Q9JJV5 (CCG3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent calcium channel gamma-3 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-3 subunit
Transmembrane AMPAR regulatory protein gamma-3
Short name=TARP gamma-3
Gene names
Name:Cacng3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.

Subunit structure

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Voltage-dependent calcium channel gamma-3 subunit
PRO_0000164676

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane104 – 12421Helical; Potential
Transmembrane135 – 15521Helical; Potential
Transmembrane181 – 20121Helical; Potential

Experimental info

Sequence conflict611S → F in CAB86385. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9JJV5 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: FB4EA036C494B6AD

FASTA31535,516
        10         20         30         40         50         60 
MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET SRKNEEVMTH 

        70         80         90        100        110        120 
SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA VRASSVFPIL SVTLLFFGGL 

       130        140        150        160        170        180 
CVAASEFHRS RHSVILSAGI FFVSAGLSNI IGIIVYISAN AGDPGQRDSK KSYSYGWSFY 

       190        200        210        220        230        240 
FGAFSFIIAE IVGVVAVHIY IEKHQQLRAR SHSELLKKST FARLPPYRYR FRRRSSSRST 

       250        260        270        280        290        300 
EPRSRDLSPI SKGFHTIPST DISMFTLSRD PSKLTMGTLL NSDRDHAFLQ FHNSTPKEFK 

       310 
ESLHNNPANR RTTPV 

« Hide

References

« Hide 'large scale' references
[1]"A family of gamma-like calcium channel subunits."
Klugbauer N., Dai S., Specht V., Lacinova L., Marais E., Bohn G., Hofmann F.
FEBS Lett. 470:189-197(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ272044 mRNA. Translation: CAB86385.1.
CH466531 Genomic DNA. Translation: EDL17281.1.
BC138673 mRNA. Translation: AAI38674.1.
BC145971 mRNA. Translation: AAI45972.1.
CCDSCCDS21816.1.
RefSeqNP_062303.2. NM_019430.2.
UniGeneMm.444212.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000081664.

PTM databases

PhosphoSiteQ9JJV5.

Proteomic databases

PaxDbQ9JJV5.
PRIDEQ9JJV5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000084615; ENSMUSP00000081664; ENSMUSG00000066189.
GeneID54376.
KEGGmmu:54376.
UCSCuc009jov.3. mouse.

Organism-specific databases

CTD10368.
MGIMGI:1859165. Cacng3.

Phylogenomic databases

eggNOGNOG48125.
GeneTreeENSGT00550000074547.
HOGENOMHOG000233440.
HOVERGENHBG003682.
InParanoidA6H6R5.
KOK04868.
OMAKHNVILS.
OrthoDBEOG7TQV1Q.
TreeFamTF327980.

Gene expression databases

BgeeQ9JJV5.
GenevestigatorQ9JJV5.

Family and domain databases

InterProIPR004031. PMP22/EMP/MP20/Claudin.
IPR008368. VDCC_gsu.
[Graphical view]
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01792. VDCCGAMMA.
ProtoNetSearch...

Other

NextBio311188.
PROQ9JJV5.
SOURCESearch...

Entry information

Entry nameCCG3_MOUSE
AccessionPrimary (citable) accession number: Q9JJV5
Secondary accession number(s): A6H6R5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot