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Q9JJV4

- CCG4_MOUSE

UniProt

Q9JJV4 - CCG4_MOUSE

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Protein
Voltage-dependent calcium channel gamma-4 subunit
Gene
Cacng4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.1 Publication

GO - Molecular functioni

  1. voltage-gated calcium channel activity Source: InterPro

GO - Biological processi

  1. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
  2. transmission of nerve impulse Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-4 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-4 subunit
Transmembrane AMPAR regulatory protein gamma-4
Short name:
TARP gamma-4
Gene namesi
Name:Cacng4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1859167. Cacng4.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Cytoplasmic Reviewed prediction
Transmembranei10 – 3021Helical; Reviewed prediction
Add
BLAST
Topological domaini31 – 10777Extracellular Reviewed prediction
Add
BLAST
Transmembranei108 – 12821Helical; Reviewed prediction
Add
BLAST
Topological domaini129 – 1368Cytoplasmic Reviewed prediction
Transmembranei137 – 15721Helical; Reviewed prediction
Add
BLAST
Topological domaini158 – 18629Extracellular Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST
Topological domaini208 – 327120Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
  2. voltage-gated calcium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Voltage-dependent calcium channel gamma-4 subunit
PRO_0000164679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi45 – 451N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JJV4.
PRIDEiQ9JJV4.

PTM databases

PhosphoSiteiQ9JJV4.

Expressioni

Gene expression databases

ArrayExpressiQ9JJV4.
BgeeiQ9JJV4.
GenevestigatoriQ9JJV4.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9JJV4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45952.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ9JJV4.
KOiK04869.
OMAiCIGAGRF.
OrthoDBiEOG7TQV1Q.
PhylomeDBiQ9JJV4.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005423. VDCC_g4su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01603. VDCCGAMMA4.

Sequencei

Sequence statusi: Complete.

Q9JJV4-1 [UniParc]FASTAAdd to Basket

« Hide

MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD    50
GPPPRRARGD LTHSGLWRVC CIEGIYRGHC FRINHFPEDN DYDHDSSEYL 100
LRIVRASSVF PILSTILLLL GGLCIGAGRI YSRKNNIVLS AGILFVAAGL 150
SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN YGWSFYFGAL SFIVAETVGV 200
LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR RRSRSSSRST 250
EASPSRDASP VGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQDAGF 300
LQMHDFFQQD LKEGFHVSML NRRTTPV 327
Length:327
Mass (Da):36,535
Last modified:October 1, 2000 - v1
Checksum:i6BFB38B546FBCA86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ272045 mRNA. Translation: CAB86386.1.
CCDSiCCDS25571.1.
RefSeqiNP_062304.1. NM_019431.2.
UniGeneiMm.103724.

Genome annotation databases

EnsembliENSMUST00000021066; ENSMUSP00000021066; ENSMUSG00000020723.
GeneIDi54377.
KEGGimmu:54377.
UCSCiuc007maz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ272045 mRNA. Translation: CAB86386.1 .
CCDSi CCDS25571.1.
RefSeqi NP_062304.1. NM_019431.2.
UniGenei Mm.103724.

3D structure databases

ProteinModelPortali Q9JJV4.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JJV4.

Proteomic databases

PaxDbi Q9JJV4.
PRIDEi Q9JJV4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021066 ; ENSMUSP00000021066 ; ENSMUSG00000020723 .
GeneIDi 54377.
KEGGi mmu:54377.
UCSCi uc007maz.1. mouse.

Organism-specific databases

CTDi 27092.
MGIi MGI:1859167. Cacng4.

Phylogenomic databases

eggNOGi NOG45952.
GeneTreei ENSGT00550000074547.
HOGENOMi HOG000233440.
HOVERGENi HBG003682.
InParanoidi Q9JJV4.
KOi K04869.
OMAi CIGAGRF.
OrthoDBi EOG7TQV1Q.
PhylomeDBi Q9JJV4.
TreeFami TF327980.

Enzyme and pathway databases

Reactomei REACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Miscellaneous databases

NextBioi 311192.
PROi Q9JJV4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JJV4.
Bgeei Q9JJV4.
Genevestigatori Q9JJV4.

Family and domain databases

InterProi IPR004031. PMP22/EMP/MP20/Claudin.
IPR005423. VDCC_g4su.
IPR008368. VDCC_gsu.
[Graphical view ]
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01792. VDCCGAMMA.
PR01603. VDCCGAMMA4.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Kinetic modification of the alpha(1I) subunit-mediated T-type Ca(2+) channel by a human neuronal Ca(2+) channel gamma subunit."
    Green P.J., Warre R., Hayes P.D., McNaughton N.C., Medhurst A.D., Pangalos M., Duckworth D.M., Randall A.D.
    J. Physiol. (Lond.) 533:467-478(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
  3. "TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating."
    Milstein A.D., Zhou W., Karimzadegan S., Bredt D.S., Nicoll R.A.
    Neuron 55:905-918(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCCG4_MOUSE
AccessioniPrimary (citable) accession number: Q9JJV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi