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Protein

Voltage-dependent calcium channel gamma-4 subunit

Gene

Cacng4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.1 Publication

GO - Molecular functioni

GO - Biological processi

  • calcium ion transmembrane transport Source: GO_Central
  • regulation of AMPA receptor activity Source: UniProtKB
  • transmission of nerve impulse Source: MGI

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-112308 Presynaptic depolarization and calcium channel opening
R-MMU-399719 Trafficking of AMPA receptors
R-MMU-5576892 Phase 0 - rapid depolarisation
R-MMU-5576893 Phase 2 - plateau phase
R-MMU-5682910 LGI-ADAM interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-4 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-4 subunit
Transmembrane AMPAR regulatory protein gamma-4
Short name:
TARP gamma-4
Gene namesi
Name:Cacng4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1859167 Cacng4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 107ExtracellularSequence analysisAdd BLAST77
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 136CytoplasmicSequence analysis8
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 186ExtracellularSequence analysisAdd BLAST29
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 327CytoplasmicSequence analysisAdd BLAST120

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646791 – 327Voltage-dependent calcium channel gamma-4 subunitAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei259PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JJV4
PRIDEiQ9JJV4

PTM databases

iPTMnetiQ9JJV4
PhosphoSitePlusiQ9JJV4

Expressioni

Gene expression databases

BgeeiENSMUSG00000020723
ExpressionAtlasiQ9JJV4 baseline and differential
GenevisibleiQ9JJV4 MM

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021066

Structurei

3D structure databases

ProteinModelPortaliQ9JJV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJYN Eukaryota
ENOG4111W1R LUCA
GeneTreeiENSGT00550000074547
HOGENOMiHOG000233440
HOVERGENiHBG003682
InParanoidiQ9JJV4
KOiK04869
OMAiICNGTNL
OrthoDBiEOG091G0D2Z
PhylomeDBiQ9JJV4
TreeFamiTF327980

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR005423 VDCC_g4su
IPR008368 VDCC_gsu
PANTHERiPTHR12107:SF7 PTHR12107:SF7, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01792 VDCCGAMMA
PR01603 VDCCGAMMA4

Sequencei

Sequence statusi: Complete.

Q9JJV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD
60 70 80 90 100
GPPPRRARGD LTHSGLWRVC CIEGIYRGHC FRINHFPEDN DYDHDSSEYL
110 120 130 140 150
LRIVRASSVF PILSTILLLL GGLCIGAGRI YSRKNNIVLS AGILFVAAGL
160 170 180 190 200
SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN YGWSFYFGAL SFIVAETVGV
210 220 230 240 250
LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR RRSRSSSRST
260 270 280 290 300
EASPSRDASP VGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQDAGF
310 320
LQMHDFFQQD LKEGFHVSML NRRTTPV
Length:327
Mass (Da):36,535
Last modified:October 1, 2000 - v1
Checksum:i6BFB38B546FBCA86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272045 mRNA Translation: CAB86386.1
CCDSiCCDS25571.1
RefSeqiNP_062304.1, NM_019431.2
UniGeneiMm.103724

Genome annotation databases

EnsembliENSMUST00000021066; ENSMUSP00000021066; ENSMUSG00000020723
GeneIDi54377
KEGGimmu:54377
UCSCiuc007maz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCCG4_MOUSE
AccessioniPrimary (citable) accession number: Q9JJV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health