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Q9JJV4

- CCG4_MOUSE

UniProt

Q9JJV4 - CCG4_MOUSE

Protein

Voltage-dependent calcium channel gamma-4 subunit

Gene

Cacng4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.1 Publication

    GO - Molecular functioni

    1. voltage-gated calcium channel activity Source: InterPro

    GO - Biological processi

    1. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
    2. transmission of nerve impulse Source: MGI

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-4 subunit
    Alternative name(s):
    Neuronal voltage-gated calcium channel gamma-4 subunit
    Transmembrane AMPAR regulatory protein gamma-4
    Short name:
    TARP gamma-4
    Gene namesi
    Name:Cacng4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1859167. Cacng4.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
    2. voltage-gated calcium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Voltage-dependent calcium channel gamma-4 subunitPRO_0000164679Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9JJV4.
    PRIDEiQ9JJV4.

    PTM databases

    PhosphoSiteiQ9JJV4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JJV4.
    BgeeiQ9JJV4.
    GenevestigatoriQ9JJV4.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJV4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini31 – 10777ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini129 – 1368CytoplasmicSequence Analysis
    Topological domaini158 – 18629ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 327120CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45952.
    GeneTreeiENSGT00550000074547.
    HOGENOMiHOG000233440.
    HOVERGENiHBG003682.
    InParanoidiQ9JJV4.
    KOiK04869.
    OMAiCIGAGRF.
    OrthoDBiEOG7TQV1Q.
    PhylomeDBiQ9JJV4.
    TreeFamiTF327980.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR005423. VDCC_g4su.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.
    PR01603. VDCCGAMMA4.

    Sequencei

    Sequence statusi: Complete.

    Q9JJV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD    50
    GPPPRRARGD LTHSGLWRVC CIEGIYRGHC FRINHFPEDN DYDHDSSEYL 100
    LRIVRASSVF PILSTILLLL GGLCIGAGRI YSRKNNIVLS AGILFVAAGL 150
    SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN YGWSFYFGAL SFIVAETVGV 200
    LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR RRSRSSSRST 250
    EASPSRDASP VGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQDAGF 300
    LQMHDFFQQD LKEGFHVSML NRRTTPV 327
    Length:327
    Mass (Da):36,535
    Last modified:October 1, 2000 - v1
    Checksum:i6BFB38B546FBCA86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272045 mRNA. Translation: CAB86386.1.
    CCDSiCCDS25571.1.
    RefSeqiNP_062304.1. NM_019431.2.
    UniGeneiMm.103724.

    Genome annotation databases

    EnsembliENSMUST00000021066; ENSMUSP00000021066; ENSMUSG00000020723.
    GeneIDi54377.
    KEGGimmu:54377.
    UCSCiuc007maz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272045 mRNA. Translation: CAB86386.1 .
    CCDSi CCDS25571.1.
    RefSeqi NP_062304.1. NM_019431.2.
    UniGenei Mm.103724.

    3D structure databases

    ProteinModelPortali Q9JJV4.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JJV4.

    Proteomic databases

    PaxDbi Q9JJV4.
    PRIDEi Q9JJV4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021066 ; ENSMUSP00000021066 ; ENSMUSG00000020723 .
    GeneIDi 54377.
    KEGGi mmu:54377.
    UCSCi uc007maz.1. mouse.

    Organism-specific databases

    CTDi 27092.
    MGIi MGI:1859167. Cacng4.

    Phylogenomic databases

    eggNOGi NOG45952.
    GeneTreei ENSGT00550000074547.
    HOGENOMi HOG000233440.
    HOVERGENi HBG003682.
    InParanoidi Q9JJV4.
    KOi K04869.
    OMAi CIGAGRF.
    OrthoDBi EOG7TQV1Q.
    PhylomeDBi Q9JJV4.
    TreeFami TF327980.

    Enzyme and pathway databases

    Reactomei REACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

    Miscellaneous databases

    NextBioi 311192.
    PROi Q9JJV4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JJV4.
    Bgeei Q9JJV4.
    Genevestigatori Q9JJV4.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR005423. VDCC_g4su.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    PR01603. VDCCGAMMA4.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Kinetic modification of the alpha(1I) subunit-mediated T-type Ca(2+) channel by a human neuronal Ca(2+) channel gamma subunit."
      Green P.J., Warre R., Hayes P.D., McNaughton N.C., Medhurst A.D., Pangalos M., Duckworth D.M., Randall A.D.
      J. Physiol. (Lond.) 533:467-478(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
    3. "TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating."
      Milstein A.D., Zhou W., Karimzadegan S., Bredt D.S., Nicoll R.A.
      Neuron 55:905-918(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCCG4_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3