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Q9JJV4 (CCG4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent calcium channel gamma-4 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-4 subunit
Transmembrane AMPAR regulatory protein gamma-4
Short name=TARP gamma-4
Gene names
Name:Cacng4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Ref.3

Subunit structure

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.2.

Sequence similarities

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Voltage-dependent calcium channel gamma-4 subunit
PRO_0000164679

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 3021Helical; Potential
Topological domain31 – 10777Extracellular Potential
Transmembrane108 – 12821Helical; Potential
Topological domain129 – 1368Cytoplasmic Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 18629Extracellular Potential
Transmembrane187 – 20721Helical; Potential
Topological domain208 – 327120Cytoplasmic Potential

Amino acid modifications

Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation451N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9JJV4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 6BFB38B546FBCA86

FASTA32736,535
        10         20         30         40         50         60 
MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD GPPPRRARGD 

        70         80         90        100        110        120 
LTHSGLWRVC CIEGIYRGHC FRINHFPEDN DYDHDSSEYL LRIVRASSVF PILSTILLLL 

       130        140        150        160        170        180 
GGLCIGAGRI YSRKNNIVLS AGILFVAAGL SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN 

       190        200        210        220        230        240 
YGWSFYFGAL SFIVAETVGV LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR 

       250        260        270        280        290        300 
RRSRSSSRST EASPSRDASP VGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQDAGF 

       310        320 
LQMHDFFQQD LKEGFHVSML NRRTTPV 

« Hide

References

[1]"A family of gamma-like calcium channel subunits."
Klugbauer N., Dai S., Specht V., Lacinova L., Marais E., Bohn G., Hofmann F.
FEBS Lett. 470:189-197(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Kinetic modification of the alpha(1I) subunit-mediated T-type Ca(2+) channel by a human neuronal Ca(2+) channel gamma subunit."
Green P.J., Warre R., Hayes P.D., McNaughton N.C., Medhurst A.D., Pangalos M., Duckworth D.M., Randall A.D.
J. Physiol. (Lond.) 533:467-478(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
[3]"TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating."
Milstein A.D., Zhou W., Karimzadegan S., Bredt D.S., Nicoll R.A.
Neuron 55:905-918(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ272045 mRNA. Translation: CAB86386.1.
CCDSCCDS25571.1.
RefSeqNP_062304.1. NM_019431.2.
UniGeneMm.103724.

3D structure databases

ProteinModelPortalQ9JJV4.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9JJV4.

Proteomic databases

PaxDbQ9JJV4.
PRIDEQ9JJV4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021066; ENSMUSP00000021066; ENSMUSG00000020723.
GeneID54377.
KEGGmmu:54377.
UCSCuc007maz.1. mouse.

Organism-specific databases

CTD27092.
MGIMGI:1859167. Cacng4.

Phylogenomic databases

eggNOGNOG45952.
GeneTreeENSGT00550000074547.
HOGENOMHOG000233440.
HOVERGENHBG003682.
InParanoidQ9JJV4.
KOK04869.
OMACIGAGRF.
OrthoDBEOG7TQV1Q.
PhylomeDBQ9JJV4.
TreeFamTF327980.

Gene expression databases

ArrayExpressQ9JJV4.
BgeeQ9JJV4.
GenevestigatorQ9JJV4.

Family and domain databases

InterProIPR004031. PMP22/EMP/MP20/Claudin.
IPR005423. VDCC_g4su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01792. VDCCGAMMA.
PR01603. VDCCGAMMA4.
ProtoNetSearch...

Other

NextBio311192.
PROQ9JJV4.
SOURCESearch...

Entry information

Entry nameCCG4_MOUSE
AccessionPrimary (citable) accession number: Q9JJV4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot