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Protein

Voltage-dependent calcium channel gamma-like subunit

Gene

Tmem37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). Modulates calcium current when coexpressed with CACNA1G.By similarity1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Protein family/group databases

TCDBi8.A.16.6.1. the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-like subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-like subunit
Transmembrane protein 37
Gene namesi
Name:Tmem37
Synonyms:Cacng5, Pr, Pr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2157899. Tmem37.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646931 – 211Voltage-dependent calcium channel gamma-like subunitAdd BLAST211

Proteomic databases

PaxDbiQ9JJV3.
PRIDEiQ9JJV3.

PTM databases

iPTMnetiQ9JJV3.
PhosphoSitePlusiQ9JJV3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050777.
CleanExiMM_TMEM37.
GenevisibleiQ9JJV3. MM.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9JJV3.
SMRiQ9JJV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8N. Eukaryota.
ENOG4111WUN. LUCA.
GeneTreeiENSGT00390000006225.
HOGENOMiHOG000111447.
HOVERGENiHBG028482.
InParanoidiQ9JJV3.
OMAiMFWCEFT.
OrthoDBiEOG091G0ROD.
PhylomeDBiQ9JJV3.
TreeFamiTF333259.

Family and domain databases

InterProiIPR029372. Tmem37.
[Graphical view]
PANTHERiPTHR31767:SF0. PTHR31767:SF0. 1 hit.
PfamiPF15108. TMEM37. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAIGAQAHK LLGLKRPHRS FFESFIRTLI IVCTALAVVL SSVSICDGHW
60 70 80 90 100
LLVEDHLFGL WYFCTIGNHS EPHCLRDLSQ AHMPGLAVGM GLARSVAAMA
110 120 130 140 150
VVAAIFGLEM LIVSQVCEDV RSRRKWAIGS YLLLVAFILS SGGLLTFIIL
160 170 180 190 200
LKNQINLLGF TLMFWCEFTA SFLFFLNAAS GLHINSLTQP WDPPAGTLAY
210
RKRGYDGTSL I
Length:211
Mass (Da):23,230
Last modified:October 1, 2000 - v1
Checksum:iA1A05270E971CC03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272046 mRNA. Translation: CAB86387.1.
AK002424 mRNA. Translation: BAB22091.1.
AK050134 mRNA. Translation: BAC34086.1.
AK086093 mRNA. Translation: BAC39608.1.
BC024613 mRNA. Translation: AAH24613.1.
CCDSiCCDS15229.1.
RefSeqiNP_062305.1. NM_019432.2.
UniGeneiMm.24750.

Genome annotation databases

EnsembliENSMUST00000056089; ENSMUSP00000050862; ENSMUSG00000050777.
GeneIDi170706.
KEGGimmu:170706.
UCSCiuc007cjd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272046 mRNA. Translation: CAB86387.1.
AK002424 mRNA. Translation: BAB22091.1.
AK050134 mRNA. Translation: BAC34086.1.
AK086093 mRNA. Translation: BAC39608.1.
BC024613 mRNA. Translation: AAH24613.1.
CCDSiCCDS15229.1.
RefSeqiNP_062305.1. NM_019432.2.
UniGeneiMm.24750.

3D structure databases

ProteinModelPortaliQ9JJV3.
SMRiQ9JJV3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.A.16.6.1. the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.

PTM databases

iPTMnetiQ9JJV3.
PhosphoSitePlusiQ9JJV3.

Proteomic databases

PaxDbiQ9JJV3.
PRIDEiQ9JJV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056089; ENSMUSP00000050862; ENSMUSG00000050777.
GeneIDi170706.
KEGGimmu:170706.
UCSCiuc007cjd.1. mouse.

Organism-specific databases

CTDi140738.
MGIiMGI:2157899. Tmem37.

Phylogenomic databases

eggNOGiENOG410IE8N. Eukaryota.
ENOG4111WUN. LUCA.
GeneTreeiENSGT00390000006225.
HOGENOMiHOG000111447.
HOVERGENiHBG028482.
InParanoidiQ9JJV3.
OMAiMFWCEFT.
OrthoDBiEOG091G0ROD.
PhylomeDBiQ9JJV3.
TreeFamiTF333259.

Miscellaneous databases

PROiQ9JJV3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050777.
CleanExiMM_TMEM37.
GenevisibleiQ9JJV3. MM.

Family and domain databases

InterProiIPR029372. Tmem37.
[Graphical view]
PANTHERiPTHR31767:SF0. PTHR31767:SF0. 1 hit.
PfamiPF15108. TMEM37. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCGL_MOUSE
AccessioniPrimary (citable) accession number: Q9JJV3
Secondary accession number(s): Q543K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.