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Protein

Beta-crystallin A2

Gene

Cryba2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI
  • structural constituent of eye lens Source: MGI

GO - Biological processi

  • lens development in camera-type eye Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin A2
Alternative name(s):
Beta-A2 crystallin
Gene namesi
Name:Cryba2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104336. Cryba2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Beta-crystallin A2PRO_0000057540Add
BLAST

Proteomic databases

MaxQBiQ9JJV1.
PaxDbiQ9JJV1.
PRIDEiQ9JJV1.

PTM databases

PhosphoSiteiQ9JJV1.

Expressioni

Gene expression databases

BgeeiQ9JJV1.
CleanExiMM_CRYBA2.
ExpressionAtlasiQ9JJV1. baseline and differential.
GenevisibleiQ9JJV1. MM.

Interactioni

Subunit structurei

Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006721.

Structurei

3D structure databases

ProteinModelPortaliQ9JJV1.
SMRiQ9JJV1. Positions 9-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 5241Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini53 – 9947Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini106 – 14742Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini148 – 19649Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1111N-terminal armAdd
BLAST
Regioni100 – 1056Connecting peptide

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IH1M. Eukaryota.
ENOG4110S6G. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234388.
HOVERGENiHBG003364.
InParanoidiQ9JJV1.
OMAiWVAFEYP.
OrthoDBiEOG7K9K40.
PhylomeDBiQ9JJV1.
TreeFamiTF331401.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPAPGSA PVCLTLWDEE DFQGRRCRLL SDCANVCERG ALRRVRSVKV
60 70 80 90 100
ENGAWVAFEY PDFQGQQFIL EKGDYPCWSA WSGSSGHHSN QLLSFRPVLC
110 120 130 140 150
ANHSDSRVTL FEGENFQGCK FELSDDYPSL PSMGWTSKDV GSLKVSSGAW
160 170 180 190
VAYQYPGYRG YQYVLERDRH SGEFRTYSDF GTQAHTGQLQ SIRRVQH
Length:197
Mass (Da):22,237
Last modified:January 23, 2007 - v3
Checksum:iA0C8DE0730AA18D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272227 mRNA. Translation: CAB75585.1.
AK021374 mRNA. Translation: BAB32389.1.
AY160973 mRNA. Translation: AAN78172.1.
BC052746 mRNA. Translation: AAH52746.1.
BC056989 mRNA. Translation: AAH56989.1.
CCDSiCCDS15059.1.
RefSeqiNP_067516.1. NM_021541.3.
XP_006495719.1. XM_006495656.2.
XP_006495720.1. XM_006495657.2.
XP_006495721.1. XM_006495658.1.
XP_006495722.1. XM_006495659.1.
XP_006495723.1. XM_006495660.1.
UniGeneiMm.86656.

Genome annotation databases

EnsembliENSMUST00000006721; ENSMUSP00000006721; ENSMUSG00000006546.
GeneIDi12958.
KEGGimmu:12958.
UCSCiuc007bni.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272227 mRNA. Translation: CAB75585.1.
AK021374 mRNA. Translation: BAB32389.1.
AY160973 mRNA. Translation: AAN78172.1.
BC052746 mRNA. Translation: AAH52746.1.
BC056989 mRNA. Translation: AAH56989.1.
CCDSiCCDS15059.1.
RefSeqiNP_067516.1. NM_021541.3.
XP_006495719.1. XM_006495656.2.
XP_006495720.1. XM_006495657.2.
XP_006495721.1. XM_006495658.1.
XP_006495722.1. XM_006495659.1.
XP_006495723.1. XM_006495660.1.
UniGeneiMm.86656.

3D structure databases

ProteinModelPortaliQ9JJV1.
SMRiQ9JJV1. Positions 9-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006721.

PTM databases

PhosphoSiteiQ9JJV1.

Proteomic databases

MaxQBiQ9JJV1.
PaxDbiQ9JJV1.
PRIDEiQ9JJV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006721; ENSMUSP00000006721; ENSMUSG00000006546.
GeneIDi12958.
KEGGimmu:12958.
UCSCiuc007bni.2. mouse.

Organism-specific databases

CTDi1412.
MGIiMGI:104336. Cryba2.

Phylogenomic databases

eggNOGiENOG410IH1M. Eukaryota.
ENOG4110S6G. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234388.
HOVERGENiHBG003364.
InParanoidiQ9JJV1.
OMAiWVAFEYP.
OrthoDBiEOG7K9K40.
PhylomeDBiQ9JJV1.
TreeFamiTF331401.

Miscellaneous databases

NextBioi282682.
PROiQ9JJV1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJV1.
CleanExiMM_CRYBA2.
ExpressionAtlasiQ9JJV1. baseline and differential.
GenevisibleiQ9JJV1. MM.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of beta-A2-, beta-A4- and beta-B3-crystallin cDNA completes the identification of the members of this gene family in the mouse."
    Graw J.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiCRBA2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJV1
Secondary accession number(s): Q540J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.