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Protein

Beta-crystallin A2

Gene

Cryba2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI
  • structural constituent of eye lens Source: MGI

GO - Biological processi

  • lens development in camera-type eye Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin A2
Alternative name(s):
Beta-A2 crystallin
Gene namesi
Name:Cryba2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104336. Cryba2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000575401 – 197Beta-crystallin A2Add BLAST197

Proteomic databases

MaxQBiQ9JJV1.
PaxDbiQ9JJV1.
PRIDEiQ9JJV1.

PTM databases

PhosphoSitePlusiQ9JJV1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006546.
CleanExiMM_CRYBA2.
ExpressionAtlasiQ9JJV1. baseline and differential.
GenevisibleiQ9JJV1. MM.

Interactioni

Subunit structurei

Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006721.

Structurei

3D structure databases

ProteinModelPortaliQ9JJV1.
SMRiQ9JJV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 52Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST41
Domaini53 – 99Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST47
Domaini106 – 147Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST42
Domaini148 – 196Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 11N-terminal armAdd BLAST11
Regioni100 – 105Connecting peptide6

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IH1M. Eukaryota.
ENOG4110S6G. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234388.
HOVERGENiHBG003364.
InParanoidiQ9JJV1.
OMAiWVAFEYP.
OrthoDBiEOG091G0JYH.
PhylomeDBiQ9JJV1.
TreeFamiTF331401.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPAPGSA PVCLTLWDEE DFQGRRCRLL SDCANVCERG ALRRVRSVKV
60 70 80 90 100
ENGAWVAFEY PDFQGQQFIL EKGDYPCWSA WSGSSGHHSN QLLSFRPVLC
110 120 130 140 150
ANHSDSRVTL FEGENFQGCK FELSDDYPSL PSMGWTSKDV GSLKVSSGAW
160 170 180 190
VAYQYPGYRG YQYVLERDRH SGEFRTYSDF GTQAHTGQLQ SIRRVQH
Length:197
Mass (Da):22,237
Last modified:January 23, 2007 - v3
Checksum:iA0C8DE0730AA18D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272227 mRNA. Translation: CAB75585.1.
AK021374 mRNA. Translation: BAB32389.1.
AY160973 mRNA. Translation: AAN78172.1.
BC052746 mRNA. Translation: AAH52746.1.
BC056989 mRNA. Translation: AAH56989.1.
CCDSiCCDS15059.1.
RefSeqiNP_067516.1. NM_021541.3.
XP_006495719.1. XM_006495656.3.
UniGeneiMm.86656.

Genome annotation databases

EnsembliENSMUST00000006721; ENSMUSP00000006721; ENSMUSG00000006546.
GeneIDi12958.
KEGGimmu:12958.
UCSCiuc007bni.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272227 mRNA. Translation: CAB75585.1.
AK021374 mRNA. Translation: BAB32389.1.
AY160973 mRNA. Translation: AAN78172.1.
BC052746 mRNA. Translation: AAH52746.1.
BC056989 mRNA. Translation: AAH56989.1.
CCDSiCCDS15059.1.
RefSeqiNP_067516.1. NM_021541.3.
XP_006495719.1. XM_006495656.3.
UniGeneiMm.86656.

3D structure databases

ProteinModelPortaliQ9JJV1.
SMRiQ9JJV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006721.

PTM databases

PhosphoSitePlusiQ9JJV1.

Proteomic databases

MaxQBiQ9JJV1.
PaxDbiQ9JJV1.
PRIDEiQ9JJV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006721; ENSMUSP00000006721; ENSMUSG00000006546.
GeneIDi12958.
KEGGimmu:12958.
UCSCiuc007bni.2. mouse.

Organism-specific databases

CTDi1412.
MGIiMGI:104336. Cryba2.

Phylogenomic databases

eggNOGiENOG410IH1M. Eukaryota.
ENOG4110S6G. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234388.
HOVERGENiHBG003364.
InParanoidiQ9JJV1.
OMAiWVAFEYP.
OrthoDBiEOG091G0JYH.
PhylomeDBiQ9JJV1.
TreeFamiTF331401.

Miscellaneous databases

PROiQ9JJV1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006546.
CleanExiMM_CRYBA2.
ExpressionAtlasiQ9JJV1. baseline and differential.
GenevisibleiQ9JJV1. MM.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRBA2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJV1
Secondary accession number(s): Q540J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.