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Protein

Beta-crystallin B3

Gene

Crybb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin B3
Alternative name(s):
Beta-B3 crystallin
Cleaved into the following chain:
Gene namesi
Name:Crybb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:102717. Crybb3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004217751 – 211Beta-crystallin B3Add BLAST211
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00000575612 – 211Beta-crystallin B3, N-terminally processedAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylalanine; in Beta-crystallin B3, N-terminally processedBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9JJU9.
PaxDbiQ9JJU9.
PRIDEiQ9JJU9.

PTM databases

iPTMnetiQ9JJU9.
PhosphoSitePlusiQ9JJU9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029352.
CleanExiMM_CRYBB3.
ExpressionAtlasiQ9JJU9. baseline and differential.
GenevisibleiQ9JJU9. MM.

Interactioni

Subunit structurei

Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075440.

Structurei

3D structure databases

ProteinModelPortaliQ9JJU9.
SMRiQ9JJU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 63Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST40
Domaini64 – 108Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST45
Domaini114 – 155Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST42
Domaini156 – 198Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 23N-terminal armAdd BLAST22
Regioni109 – 113Connecting peptide5
Regioni200 – 211C-terminal armAdd BLAST12

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJYD. Eukaryota.
ENOG410Y7P1. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234388.
HOVERGENiHBG003364.
InParanoidiQ9JJU9.
OMAiEYPRWST.
OrthoDBiEOG091G0JIZ.
PhylomeDBiQ9JJU9.
TreeFamiTF331401.

Family and domain databases

InterProiView protein in InterPro
IPR001064. Beta/gamma_crystallin.
IPR033115. CRYBB3.
IPR011024. G_crystallin-rel.
PANTHERiPTHR11818:SF78. PTHR11818:SF78. 1 hit.
PfamiView protein in Pfam
PF00030. Crystall. 2 hits.
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiView protein in SMART
SM00247. XTALbg. 2 hits.
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiView protein in PROSITE
PS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQHGAPEQ AAAGKSHGGL GGSYKVTVYE LENFQGKRCE LSAECPNLTD
60 70 80 90 100
SLLEKVGSIQ VESGPWLAFE RRAFRGEQFV LEKGDYPRWD AWSSSRRSDI
110 120 130 140 150
LLSLRPLHID GPDHKLHLFE NPAFSGRKME IVDDDVPSLW AHGFQDRVAS
160 170 180 190 200
IRVINGTWVG YEFPGYRGRQ YVFERGEFRH WNEWDANQPQ LQSVRRIRDQ
210
KWHKRGCFLS S
Length:211
Mass (Da):24,291
Last modified:January 23, 2007 - v3
Checksum:i2F23F47987102196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272229 mRNA. Translation: CAB75587.1.
BC031442 mRNA. Translation: AAH31442.1.
BC058522 mRNA. Translation: AAH58522.1.
CCDSiCCDS19547.1.
RefSeqiNP_001153122.1. NM_001159650.1.
NP_067327.1. NM_021352.3.
XP_006534825.1. XM_006534762.2.
UniGeneiMm.378899.

Genome annotation databases

EnsembliENSMUST00000076069; ENSMUSP00000075440; ENSMUSG00000029352.
ENSMUST00000117143; ENSMUSP00000113347; ENSMUSG00000029352.
ENSMUST00000118226; ENSMUSP00000112618; ENSMUSG00000029352.
ENSMUST00000119627; ENSMUSP00000113572; ENSMUSG00000029352.
ENSMUST00000120506; ENSMUSP00000112718; ENSMUSG00000029352.
GeneIDi12962.
KEGGimmu:12962.
UCSCiuc012ebl.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCRBB3_MOUSE
AccessioniPrimary (citable) accession number: Q9JJU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families