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Protein

Beta-crystallin B3

Gene

Crybb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin B3
Alternative name(s):
Beta-B3 crystallin
Cleaved into the following chain:
Gene namesi
Name:Crybb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:102717. Crybb3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Beta-crystallin B3PRO_0000057561Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 211210Beta-crystallin B3, N-terminally processedPRO_0000421775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylalanine; in Beta-crystallin B3, N-terminally processedBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9JJU9.
PaxDbiQ9JJU9.
PRIDEiQ9JJU9.

PTM databases

iPTMnetiQ9JJU9.
PhosphoSiteiQ9JJU9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029352.
CleanExiMM_CRYBB3.
ExpressionAtlasiQ9JJU9. baseline and differential.
GenevisibleiQ9JJU9. MM.

Interactioni

Subunit structurei

Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075440.

Structurei

3D structure databases

ProteinModelPortaliQ9JJU9.
SMRiQ9JJU9. Positions 23-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 6340Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini64 – 10845Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini114 – 15542Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini156 – 19843Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2323N-terminal armAdd
BLAST
Regioni109 – 1135Connecting peptide
Regioni200 – 21112C-terminal armAdd
BLAST

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJYD. Eukaryota.
ENOG410Y7P1. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234388.
HOVERGENiHBG003364.
InParanoidiQ9JJU9.
OMAiFGGRKME.
OrthoDBiEOG091G0JIZ.
PhylomeDBiQ9JJU9.
TreeFamiTF331401.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR033115. CRYBB3.
IPR011024. G_crystallin-rel.
[Graphical view]
PANTHERiPTHR11818:SF13. PTHR11818:SF13. 1 hit.
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQHGAPEQ AAAGKSHGGL GGSYKVTVYE LENFQGKRCE LSAECPNLTD
60 70 80 90 100
SLLEKVGSIQ VESGPWLAFE RRAFRGEQFV LEKGDYPRWD AWSSSRRSDI
110 120 130 140 150
LLSLRPLHID GPDHKLHLFE NPAFSGRKME IVDDDVPSLW AHGFQDRVAS
160 170 180 190 200
IRVINGTWVG YEFPGYRGRQ YVFERGEFRH WNEWDANQPQ LQSVRRIRDQ
210
KWHKRGCFLS S
Length:211
Mass (Da):24,291
Last modified:January 23, 2007 - v3
Checksum:i2F23F47987102196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272229 mRNA. Translation: CAB75587.1.
BC031442 mRNA. Translation: AAH31442.1.
BC058522 mRNA. Translation: AAH58522.1.
CCDSiCCDS19547.1.
RefSeqiNP_001153122.1. NM_001159650.1.
NP_067327.1. NM_021352.3.
XP_006534825.1. XM_006534762.2.
UniGeneiMm.378899.

Genome annotation databases

EnsembliENSMUST00000076069; ENSMUSP00000075440; ENSMUSG00000029352.
ENSMUST00000117143; ENSMUSP00000113347; ENSMUSG00000029352.
ENSMUST00000118226; ENSMUSP00000112618; ENSMUSG00000029352.
ENSMUST00000119627; ENSMUSP00000113572; ENSMUSG00000029352.
ENSMUST00000120506; ENSMUSP00000112718; ENSMUSG00000029352.
GeneIDi12962.
KEGGimmu:12962.
UCSCiuc012ebl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272229 mRNA. Translation: CAB75587.1.
BC031442 mRNA. Translation: AAH31442.1.
BC058522 mRNA. Translation: AAH58522.1.
CCDSiCCDS19547.1.
RefSeqiNP_001153122.1. NM_001159650.1.
NP_067327.1. NM_021352.3.
XP_006534825.1. XM_006534762.2.
UniGeneiMm.378899.

3D structure databases

ProteinModelPortaliQ9JJU9.
SMRiQ9JJU9. Positions 23-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075440.

PTM databases

iPTMnetiQ9JJU9.
PhosphoSiteiQ9JJU9.

Proteomic databases

MaxQBiQ9JJU9.
PaxDbiQ9JJU9.
PRIDEiQ9JJU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076069; ENSMUSP00000075440; ENSMUSG00000029352.
ENSMUST00000117143; ENSMUSP00000113347; ENSMUSG00000029352.
ENSMUST00000118226; ENSMUSP00000112618; ENSMUSG00000029352.
ENSMUST00000119627; ENSMUSP00000113572; ENSMUSG00000029352.
ENSMUST00000120506; ENSMUSP00000112718; ENSMUSG00000029352.
GeneIDi12962.
KEGGimmu:12962.
UCSCiuc012ebl.1. mouse.

Organism-specific databases

CTDi1417.
MGIiMGI:102717. Crybb3.

Phylogenomic databases

eggNOGiENOG410IJYD. Eukaryota.
ENOG410Y7P1. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234388.
HOVERGENiHBG003364.
InParanoidiQ9JJU9.
OMAiFGGRKME.
OrthoDBiEOG091G0JIZ.
PhylomeDBiQ9JJU9.
TreeFamiTF331401.

Miscellaneous databases

ChiTaRSiCrybb3. mouse.
PROiQ9JJU9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029352.
CleanExiMM_CRYBB3.
ExpressionAtlasiQ9JJU9. baseline and differential.
GenevisibleiQ9JJU9. MM.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR033115. CRYBB3.
IPR011024. G_crystallin-rel.
[Graphical view]
PANTHERiPTHR11818:SF13. PTHR11818:SF13. 1 hit.
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRBB3_MOUSE
AccessioniPrimary (citable) accession number: Q9JJU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.