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Q9JJT0 (RCL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA 3'-terminal phosphate cyclase-like protein
Gene names
Name:Rcl1
Synonyms:Rnac
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.

Ontologies

Keywords
   Biological processRibosome biogenesis
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processrRNA processing

Inferred from sequence alignment Ref.1. Source: MGI

   Cellular_componentnucleolus

Inferred from direct assay Ref.1. Source: MGI

   Molecular_functioncatalytic activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373RNA 3'-terminal phosphate cyclase-like protein
PRO_0000156439

Sequences

Sequence LengthMass (Da)Tools
Q9JJT0 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 3BE97CA47A8CEFA1

FASTA37340,841
        10         20         30         40         50         60 
MATQAHSLSY AGCNFLRQRL VLSTLSGRPV KIRRIRARDD NPGLRDFEAS FIRLLDKITN 

        70         80         90        100        110        120 
GSRIEINQTG TTLYYQPGLL YGGSVEHDCS VLRGIGYYLE ALLCLAPFMK HPLKIVLRGV 

       130        140        150        160        170        180 
TNDQVDPSVD VLKATALPLL KQFGIDGESF ELKILRRGMP PGGGGEVLFS CPVRKVLKPV 

       190        200        210        220        230        240 
QLTDPGKIKR IRGMAYSVRV SPQMANRIVD SARSILNKFI PDIYIYTDHM KGVSSGKSPG 

       250        260        270        280        290        300 
FGLSLVAETT NGTFLSAELA SNPQGQGAAV LPEDLGRNCA KLLLEEIYRG GCVDSTNQSL 

       310        320        330        340        350        360 
VLLLMTLGQQ DVSKVLLGPL SPYTIEFLRH LKSFFQVMFK VETKPCGEEL KGGDKVLMTC 

       370 
VGIGFSNLSK TLK 

« Hide

References

« Hide 'large scale' references
[1]"Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis."
Billy E., Wegierski T., Nasr F., Filipowicz W.
EMBO J. 19:2115-2126(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Tongue.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ276895 mRNA. Translation: CAB89817.1.
AK009709 mRNA. Translation: BAB26454.1.
BC004574 mRNA. Translation: AAH04574.1.
RefSeqNP_067500.1. NM_021525.2.
UniGeneMm.28630.

3D structure databases

ProteinModelPortalQ9JJT0.
SMRQ9JJT0. Positions 8-367.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9JJT0.

Proteomic databases

PaxDbQ9JJT0.
PRIDEQ9JJT0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000064393; ENSMUSP00000067579; ENSMUSG00000024785.
GeneID59028.
KEGGmmu:59028.
UCSCuc008hda.1. mouse.

Organism-specific databases

CTD10171.
MGIMGI:1913275. Rcl1.

Phylogenomic databases

eggNOGCOG0430.
GeneTreeENSGT00530000063404.
HOGENOMHOG000157670.
HOVERGENHBG014327.
InParanoidQ9JJT0.
KOK11108.
OMAFMKHPLR.
OrthoDBEOG72NRQ9.
PhylomeDBQ9JJT0.
TreeFamTF300831.

Gene expression databases

BgeeQ9JJT0.
CleanExMM_RCL1.
GenevestigatorQ9JJT0.

Family and domain databases

Gene3D3.65.10.20. 2 hits.
InterProIPR013791. RNA3'-term_phos_cycl_insert.
IPR023797. RNA3'_phos_cyclase_dom.
IPR000228. RNA3'_term_phos_cyc.
IPR016443. RNA3'_term_phos_cyc_type_2.
IPR020719. RNA3'_term_phos_cycl-like_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PANTHERPTHR11096. PTHR11096. 1 hit.
PfamPF01137. RTC. 1 hit.
PF05189. RTC_insert. 1 hit.
[Graphical view]
PIRSFPIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR03400. 18S_RNA_Rcl1p. 1 hit.
PROSITEPS01287. RTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRCL1. mouse.
NextBio314610.
PROQ9JJT0.
SOURCESearch...

Entry information

Entry nameRCL1_MOUSE
AccessionPrimary (citable) accession number: Q9JJT0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot