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Q9JJT0

- RCL1_MOUSE

UniProt

Q9JJT0 - RCL1_MOUSE

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Protein

RNA 3'-terminal phosphate cyclase-like protein

Gene
Rcl1, Rnac
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA By similarity.

GO - Molecular functioni

  1. catalytic activity Source: InterPro

GO - Biological processi

  1. rRNA processing Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 3'-terminal phosphate cyclase-like protein
Gene namesi
Name:Rcl1
Synonyms:Rnac
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1913275. Rcl1.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373RNA 3'-terminal phosphate cyclase-like proteinPRO_0000156439Add
BLAST

Proteomic databases

PaxDbiQ9JJT0.
PRIDEiQ9JJT0.

PTM databases

PhosphoSiteiQ9JJT0.

Expressioni

Gene expression databases

BgeeiQ9JJT0.
CleanExiMM_RCL1.
GenevestigatoriQ9JJT0.

Interactioni

Protein-protein interaction databases

BioGridi208495. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9JJT0.
SMRiQ9JJT0. Positions 8-367.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0430.
GeneTreeiENSGT00530000063404.
HOGENOMiHOG000157670.
HOVERGENiHBG014327.
InParanoidiQ9JJT0.
KOiK11108.
OMAiFMKHPLR.
OrthoDBiEOG72NRQ9.
PhylomeDBiQ9JJT0.
TreeFamiTF300831.

Family and domain databases

Gene3Di3.65.10.20. 2 hits.
InterProiIPR013791. RNA3'-term_phos_cycl_insert.
IPR023797. RNA3'_phos_cyclase_dom.
IPR000228. RNA3'_term_phos_cyc.
IPR016443. RNA3'_term_phos_cyc_type_2.
IPR020719. RNA3'_term_phos_cycl-like_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PANTHERiPTHR11096. PTHR11096. 1 hit.
PfamiPF01137. RTC. 1 hit.
PF05189. RTC_insert. 1 hit.
[Graphical view]
PIRSFiPIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR03400. 18S_RNA_Rcl1p. 1 hit.
PROSITEiPS01287. RTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJT0-1 [UniParc]FASTAAdd to Basket

« Hide

MATQAHSLSY AGCNFLRQRL VLSTLSGRPV KIRRIRARDD NPGLRDFEAS    50
FIRLLDKITN GSRIEINQTG TTLYYQPGLL YGGSVEHDCS VLRGIGYYLE 100
ALLCLAPFMK HPLKIVLRGV TNDQVDPSVD VLKATALPLL KQFGIDGESF 150
ELKILRRGMP PGGGGEVLFS CPVRKVLKPV QLTDPGKIKR IRGMAYSVRV 200
SPQMANRIVD SARSILNKFI PDIYIYTDHM KGVSSGKSPG FGLSLVAETT 250
NGTFLSAELA SNPQGQGAAV LPEDLGRNCA KLLLEEIYRG GCVDSTNQSL 300
VLLLMTLGQQ DVSKVLLGPL SPYTIEFLRH LKSFFQVMFK VETKPCGEEL 350
KGGDKVLMTC VGIGFSNLSK TLK 373
Length:373
Mass (Da):40,841
Last modified:October 1, 2000 - v1
Checksum:i3BE97CA47A8CEFA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ276895 mRNA. Translation: CAB89817.1.
AK009709 mRNA. Translation: BAB26454.1.
BC004574 mRNA. Translation: AAH04574.1.
CCDSiCCDS29731.1.
RefSeqiNP_067500.1. NM_021525.2.
UniGeneiMm.28630.

Genome annotation databases

EnsembliENSMUST00000064393; ENSMUSP00000067579; ENSMUSG00000024785.
GeneIDi59028.
KEGGimmu:59028.
UCSCiuc008hda.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ276895 mRNA. Translation: CAB89817.1 .
AK009709 mRNA. Translation: BAB26454.1 .
BC004574 mRNA. Translation: AAH04574.1 .
CCDSi CCDS29731.1.
RefSeqi NP_067500.1. NM_021525.2.
UniGenei Mm.28630.

3D structure databases

ProteinModelPortali Q9JJT0.
SMRi Q9JJT0. Positions 8-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208495. 1 interaction.

PTM databases

PhosphoSitei Q9JJT0.

Proteomic databases

PaxDbi Q9JJT0.
PRIDEi Q9JJT0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000064393 ; ENSMUSP00000067579 ; ENSMUSG00000024785 .
GeneIDi 59028.
KEGGi mmu:59028.
UCSCi uc008hda.1. mouse.

Organism-specific databases

CTDi 10171.
MGIi MGI:1913275. Rcl1.

Phylogenomic databases

eggNOGi COG0430.
GeneTreei ENSGT00530000063404.
HOGENOMi HOG000157670.
HOVERGENi HBG014327.
InParanoidi Q9JJT0.
KOi K11108.
OMAi FMKHPLR.
OrthoDBi EOG72NRQ9.
PhylomeDBi Q9JJT0.
TreeFami TF300831.

Miscellaneous databases

ChiTaRSi RCL1. mouse.
NextBioi 314610.
PROi Q9JJT0.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJT0.
CleanExi MM_RCL1.
Genevestigatori Q9JJT0.

Family and domain databases

Gene3Di 3.65.10.20. 2 hits.
InterProi IPR013791. RNA3'-term_phos_cycl_insert.
IPR023797. RNA3'_phos_cyclase_dom.
IPR000228. RNA3'_term_phos_cyc.
IPR016443. RNA3'_term_phos_cyc_type_2.
IPR020719. RNA3'_term_phos_cycl-like_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view ]
PANTHERi PTHR11096. PTHR11096. 1 hit.
Pfami PF01137. RTC. 1 hit.
PF05189. RTC_insert. 1 hit.
[Graphical view ]
PIRSFi PIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR03400. 18S_RNA_Rcl1p. 1 hit.
PROSITEi PS01287. RTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis."
    Billy E., Wegierski T., Nasr F., Filipowicz W.
    EMBO J. 19:2115-2126(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.

Entry informationi

Entry nameiRCL1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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