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Protein

RNA 3'-terminal phosphate cyclase-like protein

Gene

Rcl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 3'-terminal phosphate cyclase-like protein
Gene namesi
Name:Rcl1
Synonyms:Rnac
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1913275 Rcl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001564391 – 373RNA 3'-terminal phosphate cyclase-like proteinAdd BLAST373

Proteomic databases

EPDiQ9JJT0
MaxQBiQ9JJT0
PaxDbiQ9JJT0
PeptideAtlasiQ9JJT0
PRIDEiQ9JJT0

PTM databases

iPTMnetiQ9JJT0
PhosphoSitePlusiQ9JJT0

Expressioni

Gene expression databases

BgeeiENSMUSG00000024785
CleanExiMM_RCL1
GenevisibleiQ9JJT0 MM

Interactioni

Protein-protein interaction databases

BioGridi208495, 2 interactors
STRINGi10090.ENSMUSP00000067579

Structurei

3D structure databases

ProteinModelPortaliQ9JJT0
SMRiQ9JJT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3980 Eukaryota
COG0430 LUCA
GeneTreeiENSGT00530000063404
HOGENOMiHOG000157670
HOVERGENiHBG014327
InParanoidiQ9JJT0
KOiK11108
OMAiGEVFFSC
OrthoDBiEOG091G092A
PhylomeDBiQ9JJT0
TreeFamiTF300831

Family and domain databases

CDDicd00875 RNA_Cyclase_Class_I, 1 hit
Gene3Di3.30.360.20, 1 hit
3.65.10.20, 2 hits
InterProiView protein in InterPro
IPR013791 RNA3'-term_phos_cycl_insert
IPR023797 RNA3'_phos_cyclase_dom
IPR037136 RNA3'_phos_cyclase_dom_sf
IPR000228 RNA3'_term_phos_cyc
IPR016443 RNA3'_term_phos_cyc_type_2
IPR020719 RNA3'_term_phos_cycl-like_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR036553 RPTC_insert
PANTHERiPTHR11096 PTHR11096, 1 hit
PTHR11096:SF1 PTHR11096:SF1, 1 hit
PfamiView protein in Pfam
PF01137 RTC, 1 hit
PF05189 RTC_insert, 1 hit
PIRSFiPIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit
SUPFAMiSSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR03400 18S_RNA_Rcl1p, 1 hit
PROSITEiView protein in PROSITE
PS01287 RTC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JJT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQAHSLSY AGCNFLRQRL VLSTLSGRPV KIRRIRARDD NPGLRDFEAS
60 70 80 90 100
FIRLLDKITN GSRIEINQTG TTLYYQPGLL YGGSVEHDCS VLRGIGYYLE
110 120 130 140 150
ALLCLAPFMK HPLKIVLRGV TNDQVDPSVD VLKATALPLL KQFGIDGESF
160 170 180 190 200
ELKILRRGMP PGGGGEVLFS CPVRKVLKPV QLTDPGKIKR IRGMAYSVRV
210 220 230 240 250
SPQMANRIVD SARSILNKFI PDIYIYTDHM KGVSSGKSPG FGLSLVAETT
260 270 280 290 300
NGTFLSAELA SNPQGQGAAV LPEDLGRNCA KLLLEEIYRG GCVDSTNQSL
310 320 330 340 350
VLLLMTLGQQ DVSKVLLGPL SPYTIEFLRH LKSFFQVMFK VETKPCGEEL
360 370
KGGDKVLMTC VGIGFSNLSK TLK
Length:373
Mass (Da):40,841
Last modified:October 1, 2000 - v1
Checksum:i3BE97CA47A8CEFA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276895 mRNA Translation: CAB89817.1
AK009709 mRNA Translation: BAB26454.1
BC004574 mRNA Translation: AAH04574.1
CCDSiCCDS29731.1
RefSeqiNP_067500.1, NM_021525.2
UniGeneiMm.28630

Genome annotation databases

EnsembliENSMUST00000064393; ENSMUSP00000067579; ENSMUSG00000024785
GeneIDi59028
KEGGimmu:59028
UCSCiuc008hda.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRCL1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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