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Q9JJT0

- RCL1_MOUSE

UniProt

Q9JJT0 - RCL1_MOUSE

Protein

RNA 3'-terminal phosphate cyclase-like protein

Gene

Rcl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA By similarity.By similarity

    GO - Molecular functioni

    1. catalytic activity Source: InterPro

    GO - Biological processi

    1. rRNA processing Source: MGI

    Keywords - Biological processi

    Ribosome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA 3'-terminal phosphate cyclase-like protein
    Gene namesi
    Name:Rcl1
    Synonyms:Rnac
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1913275. Rcl1.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373RNA 3'-terminal phosphate cyclase-like proteinPRO_0000156439Add
    BLAST

    Proteomic databases

    PaxDbiQ9JJT0.
    PRIDEiQ9JJT0.

    PTM databases

    PhosphoSiteiQ9JJT0.

    Expressioni

    Gene expression databases

    BgeeiQ9JJT0.
    CleanExiMM_RCL1.
    GenevestigatoriQ9JJT0.

    Interactioni

    Protein-protein interaction databases

    BioGridi208495. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJT0.
    SMRiQ9JJT0. Positions 8-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0430.
    GeneTreeiENSGT00530000063404.
    HOGENOMiHOG000157670.
    HOVERGENiHBG014327.
    InParanoidiQ9JJT0.
    KOiK11108.
    OMAiFMKHPLR.
    OrthoDBiEOG72NRQ9.
    PhylomeDBiQ9JJT0.
    TreeFamiTF300831.

    Family and domain databases

    Gene3Di3.65.10.20. 2 hits.
    InterProiIPR013791. RNA3'-term_phos_cycl_insert.
    IPR023797. RNA3'_phos_cyclase_dom.
    IPR000228. RNA3'_term_phos_cyc.
    IPR016443. RNA3'_term_phos_cyc_type_2.
    IPR020719. RNA3'_term_phos_cycl-like_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view]
    PANTHERiPTHR11096. PTHR11096. 1 hit.
    PfamiPF01137. RTC. 1 hit.
    PF05189. RTC_insert. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
    SUPFAMiSSF55205. SSF55205. 1 hit.
    TIGRFAMsiTIGR03400. 18S_RNA_Rcl1p. 1 hit.
    PROSITEiPS01287. RTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JJT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATQAHSLSY AGCNFLRQRL VLSTLSGRPV KIRRIRARDD NPGLRDFEAS    50
    FIRLLDKITN GSRIEINQTG TTLYYQPGLL YGGSVEHDCS VLRGIGYYLE 100
    ALLCLAPFMK HPLKIVLRGV TNDQVDPSVD VLKATALPLL KQFGIDGESF 150
    ELKILRRGMP PGGGGEVLFS CPVRKVLKPV QLTDPGKIKR IRGMAYSVRV 200
    SPQMANRIVD SARSILNKFI PDIYIYTDHM KGVSSGKSPG FGLSLVAETT 250
    NGTFLSAELA SNPQGQGAAV LPEDLGRNCA KLLLEEIYRG GCVDSTNQSL 300
    VLLLMTLGQQ DVSKVLLGPL SPYTIEFLRH LKSFFQVMFK VETKPCGEEL 350
    KGGDKVLMTC VGIGFSNLSK TLK 373
    Length:373
    Mass (Da):40,841
    Last modified:October 1, 2000 - v1
    Checksum:i3BE97CA47A8CEFA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ276895 mRNA. Translation: CAB89817.1.
    AK009709 mRNA. Translation: BAB26454.1.
    BC004574 mRNA. Translation: AAH04574.1.
    CCDSiCCDS29731.1.
    RefSeqiNP_067500.1. NM_021525.2.
    UniGeneiMm.28630.

    Genome annotation databases

    EnsembliENSMUST00000064393; ENSMUSP00000067579; ENSMUSG00000024785.
    GeneIDi59028.
    KEGGimmu:59028.
    UCSCiuc008hda.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ276895 mRNA. Translation: CAB89817.1 .
    AK009709 mRNA. Translation: BAB26454.1 .
    BC004574 mRNA. Translation: AAH04574.1 .
    CCDSi CCDS29731.1.
    RefSeqi NP_067500.1. NM_021525.2.
    UniGenei Mm.28630.

    3D structure databases

    ProteinModelPortali Q9JJT0.
    SMRi Q9JJT0. Positions 8-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208495. 1 interaction.

    PTM databases

    PhosphoSitei Q9JJT0.

    Proteomic databases

    PaxDbi Q9JJT0.
    PRIDEi Q9JJT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000064393 ; ENSMUSP00000067579 ; ENSMUSG00000024785 .
    GeneIDi 59028.
    KEGGi mmu:59028.
    UCSCi uc008hda.1. mouse.

    Organism-specific databases

    CTDi 10171.
    MGIi MGI:1913275. Rcl1.

    Phylogenomic databases

    eggNOGi COG0430.
    GeneTreei ENSGT00530000063404.
    HOGENOMi HOG000157670.
    HOVERGENi HBG014327.
    InParanoidi Q9JJT0.
    KOi K11108.
    OMAi FMKHPLR.
    OrthoDBi EOG72NRQ9.
    PhylomeDBi Q9JJT0.
    TreeFami TF300831.

    Miscellaneous databases

    ChiTaRSi RCL1. mouse.
    NextBioi 314610.
    PROi Q9JJT0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JJT0.
    CleanExi MM_RCL1.
    Genevestigatori Q9JJT0.

    Family and domain databases

    Gene3Di 3.65.10.20. 2 hits.
    InterProi IPR013791. RNA3'-term_phos_cycl_insert.
    IPR023797. RNA3'_phos_cyclase_dom.
    IPR000228. RNA3'_term_phos_cyc.
    IPR016443. RNA3'_term_phos_cyc_type_2.
    IPR020719. RNA3'_term_phos_cycl-like_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view ]
    PANTHERi PTHR11096. PTHR11096. 1 hit.
    Pfami PF01137. RTC. 1 hit.
    PF05189. RTC_insert. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
    SUPFAMi SSF55205. SSF55205. 1 hit.
    TIGRFAMsi TIGR03400. 18S_RNA_Rcl1p. 1 hit.
    PROSITEi PS01287. RTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis."
      Billy E., Wegierski T., Nasr F., Filipowicz W.
      EMBO J. 19:2115-2126(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Tongue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiRCL1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3