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Q9JJS7

- P2RY4_MOUSE

UniProt

Q9JJS7 - P2RY4_MOUSE

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Protein

P2Y purinoceptor 4

Gene

P2ry4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. ATP binding Source: Ensembl
  2. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  3. pyrimidine nucleotide binding Source: MGI
  4. UTP-activated nucleotide receptor activity Source: MGI

GO - Biological processi

  1. transepithelial chloride transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_239564. P2Y receptors.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 4
Short name:
P2Y4
Gene namesi
Name:P2ry4
Synonyms:P2y4r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1926594. P2ry4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei31 – 5828Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini59 – 6810CytoplasmicSequence Analysis
Transmembranei69 – 9123Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 10817ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 12719Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini128 – 14922CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini171 – 19222ExtracellularSequence AnalysisAdd
BLAST
Transmembranei193 – 21826Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 24224CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei243 – 26523Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini266 – 28318ExtracellularSequence AnalysisAdd
BLAST
Transmembranei284 – 30522Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini306 – 36156CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361P2Y purinoceptor 4PRO_0000070022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylation of Ser-329 and Ser-330 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium-activated kinases (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9JJS7.

PTM databases

PhosphoSiteiQ9JJS7.

Expressioni

Tissue specificityi

Expressed in the liver, intestine, stomach, bladder and lung.

Gene expression databases

BgeeiQ9JJS7.
CleanExiMM_P2RY4.
ExpressionAtlasiQ9JJS7. baseline and differential.
GenevestigatoriQ9JJS7.

Structurei

3D structure databases

ProteinModelPortaliQ9JJS7.
SMRiQ9JJS7. Positions 30-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG270952.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ9JJS7.
KOiK04271.
OMAiEFKFILL.
OrthoDBiEOG7QNVM4.
PhylomeDBiQ9JJS7.
TreeFamiTF350009.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000018. P2Y4_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF21. PTHR24231:SF21. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01066. P2Y4PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJS7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSADSLLFT SLGPSPSSGD GDCKFNEEFK FILLPLSYAV VFVLGLALNA
60 70 80 90 100
PTLWLFLFRL RPWDATATYM FHLALSDTLY VLSLPTLVYY YAARNHWPFG
110 120 130 140 150
TGFCKFVRFL FYWNLYCSVL FLTCISVHRY MGICHPLRAI RWGRPRFAGL
160 170 180 190 200
LCLGVWLVVA GCLVPNLFFV TTNANGTTIL CHDTTLPEEF DHYVYFSSTI
210 220 230 240 250
MVLLFGFPFL ITLVCYGLMA RRLYRPLPGA GQSSSRLRSL RTIAVVLTVF
260 270 280 290 300
AVCFVPFHIT RTIYYLARLL NAECRVLNIV NVVYKVTRPL ASANSCLDPV
310 320 330 340 350
LYLFTGDKYR NQLQQLCRGS TPKRRTTASS LALVTLHEES ISRWADIHQD
360
SIFPAYEGDR L
Length:361
Mass (Da):41,034
Last modified:October 1, 2000 - v1
Checksum:i3E8EA84B65BC0A20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277752 Genomic DNA. Translation: CAB91043.1.
AK076364 mRNA. Translation: BAC36314.1.
CCDSiCCDS30303.1.
RefSeqiNP_065646.1. NM_020621.4.
XP_006528238.1. XM_006528175.1.
XP_006528239.1. XM_006528176.1.
XP_006528240.1. XM_006528177.1.
XP_006528241.1. XM_006528178.1.
UniGeneiMm.117118.

Genome annotation databases

EnsembliENSMUST00000053373; ENSMUSP00000055869; ENSMUSG00000044359.
GeneIDi57385.
KEGGimmu:57385.
UCSCiuc009twc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277752 Genomic DNA. Translation: CAB91043.1 .
AK076364 mRNA. Translation: BAC36314.1 .
CCDSi CCDS30303.1.
RefSeqi NP_065646.1. NM_020621.4.
XP_006528238.1. XM_006528175.1.
XP_006528239.1. XM_006528176.1.
XP_006528240.1. XM_006528177.1.
XP_006528241.1. XM_006528178.1.
UniGenei Mm.117118.

3D structure databases

ProteinModelPortali Q9JJS7.
SMRi Q9JJS7. Positions 30-313.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 325.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9JJS7.

Proteomic databases

PRIDEi Q9JJS7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053373 ; ENSMUSP00000055869 ; ENSMUSG00000044359 .
GeneIDi 57385.
KEGGi mmu:57385.
UCSCi uc009twc.1. mouse.

Organism-specific databases

CTDi 5030.
MGIi MGI:1926594. P2ry4.

Phylogenomic databases

eggNOGi NOG270952.
GeneTreei ENSGT00760000118784.
HOGENOMi HOG000231307.
HOVERGENi HBG101120.
InParanoidi Q9JJS7.
KOi K04271.
OMAi EFKFILL.
OrthoDBi EOG7QNVM4.
PhylomeDBi Q9JJS7.
TreeFami TF350009.

Enzyme and pathway databases

Reactomei REACT_239564. P2Y receptors.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 313762.
PROi Q9JJS7.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJS7.
CleanExi MM_P2RY4.
ExpressionAtlasi Q9JJS7. baseline and differential.
Genevestigatori Q9JJS7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000018. P2Y4_rcpt.
[Graphical view ]
PANTHERi PTHR24231:SF21. PTHR24231:SF21. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01066. P2Y4PRNOCPTR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor."
    Suarez-Huerta N., Pouillon V., Boeynaems J.-M., Robaye B.
    Eur. J. Pharmacol. 416:197-202(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.

Entry informationi

Entry nameiP2RY4_MOUSE
AccessioniPrimary (citable) accession number: Q9JJS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3