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Q9JJS7

- P2RY4_MOUSE

UniProt

Q9JJS7 - P2RY4_MOUSE

Protein

P2Y purinoceptor 4

Gene

P2ry4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. ATP binding Source: Ensembl
    2. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
    3. pyrimidine nucleotide binding Source: MGI
    4. UTP-activated nucleotide receptor activity Source: MGI

    GO - Biological processi

    1. transepithelial chloride transport Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2Y purinoceptor 4
    Short name:
    P2Y4
    Gene namesi
    Name:P2ry4
    Synonyms:P2y4r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1926594. P2ry4.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361P2Y purinoceptor 4PRO_0000070022Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi104 ↔ 181PROSITE-ProRule annotation
    Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylation of Ser-329 and Ser-330 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium-activated kinases By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ9JJS7.

    PTM databases

    PhosphoSiteiQ9JJS7.

    Expressioni

    Tissue specificityi

    Expressed in the liver, intestine, stomach, bladder and lung.

    Gene expression databases

    ArrayExpressiQ9JJS7.
    BgeeiQ9JJS7.
    CleanExiMM_P2RY4.
    GenevestigatoriQ9JJS7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJS7.
    SMRiQ9JJS7. Positions 30-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini59 – 6810CytoplasmicSequence Analysis
    Topological domaini92 – 10817ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini128 – 14922CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 19222ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 24224CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 28318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini306 – 36156CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5828Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei69 – 9123Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 12719Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei193 – 21826Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26523Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30522Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG270952.
    GeneTreeiENSGT00750000117601.
    HOGENOMiHOG000231307.
    HOVERGENiHBG101120.
    InParanoidiQ9JJS7.
    KOiK04271.
    OMAiEFKFILL.
    OrthoDBiEOG7QNVM4.
    PhylomeDBiQ9JJS7.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000018. P2Y4_rcpt.
    [Graphical view]
    PANTHERiPTHR24231:SF21. PTHR24231:SF21. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01066. P2Y4PRNOCPTR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JJS7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSADSLLFT SLGPSPSSGD GDCKFNEEFK FILLPLSYAV VFVLGLALNA    50
    PTLWLFLFRL RPWDATATYM FHLALSDTLY VLSLPTLVYY YAARNHWPFG 100
    TGFCKFVRFL FYWNLYCSVL FLTCISVHRY MGICHPLRAI RWGRPRFAGL 150
    LCLGVWLVVA GCLVPNLFFV TTNANGTTIL CHDTTLPEEF DHYVYFSSTI 200
    MVLLFGFPFL ITLVCYGLMA RRLYRPLPGA GQSSSRLRSL RTIAVVLTVF 250
    AVCFVPFHIT RTIYYLARLL NAECRVLNIV NVVYKVTRPL ASANSCLDPV 300
    LYLFTGDKYR NQLQQLCRGS TPKRRTTASS LALVTLHEES ISRWADIHQD 350
    SIFPAYEGDR L 361
    Length:361
    Mass (Da):41,034
    Last modified:October 1, 2000 - v1
    Checksum:i3E8EA84B65BC0A20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277752 Genomic DNA. Translation: CAB91043.1.
    AK076364 mRNA. Translation: BAC36314.1.
    CCDSiCCDS30303.1.
    RefSeqiNP_065646.1. NM_020621.4.
    XP_006528238.1. XM_006528175.1.
    XP_006528239.1. XM_006528176.1.
    XP_006528240.1. XM_006528177.1.
    XP_006528241.1. XM_006528178.1.
    UniGeneiMm.117118.

    Genome annotation databases

    EnsembliENSMUST00000053373; ENSMUSP00000055869; ENSMUSG00000044359.
    GeneIDi57385.
    KEGGimmu:57385.
    UCSCiuc009twc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277752 Genomic DNA. Translation: CAB91043.1 .
    AK076364 mRNA. Translation: BAC36314.1 .
    CCDSi CCDS30303.1.
    RefSeqi NP_065646.1. NM_020621.4.
    XP_006528238.1. XM_006528175.1.
    XP_006528239.1. XM_006528176.1.
    XP_006528240.1. XM_006528177.1.
    XP_006528241.1. XM_006528178.1.
    UniGenei Mm.117118.

    3D structure databases

    ProteinModelPortali Q9JJS7.
    SMRi Q9JJS7. Positions 30-321.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 325.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9JJS7.

    Proteomic databases

    PRIDEi Q9JJS7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053373 ; ENSMUSP00000055869 ; ENSMUSG00000044359 .
    GeneIDi 57385.
    KEGGi mmu:57385.
    UCSCi uc009twc.1. mouse.

    Organism-specific databases

    CTDi 5030.
    MGIi MGI:1926594. P2ry4.

    Phylogenomic databases

    eggNOGi NOG270952.
    GeneTreei ENSGT00750000117601.
    HOGENOMi HOG000231307.
    HOVERGENi HBG101120.
    InParanoidi Q9JJS7.
    KOi K04271.
    OMAi EFKFILL.
    OrthoDBi EOG7QNVM4.
    PhylomeDBi Q9JJS7.
    TreeFami TF350009.

    Miscellaneous databases

    NextBioi 313762.
    PROi Q9JJS7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JJS7.
    Bgeei Q9JJS7.
    CleanExi MM_P2RY4.
    Genevestigatori Q9JJS7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000018. P2Y4_rcpt.
    [Graphical view ]
    PANTHERi PTHR24231:SF21. PTHR24231:SF21. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01066. P2Y4PRNOCPTR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor."
      Suarez-Huerta N., Pouillon V., Boeynaems J.-M., Robaye B.
      Eur. J. Pharmacol. 416:197-202(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJ.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Skin.

    Entry informationi

    Entry nameiP2RY4_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3