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Q9JJS7 (P2RY4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2Y purinoceptor 4

Short name=P2Y4
Gene names
Name:P2ry4
Synonyms:P2y4r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in the liver, intestine, stomach, bladder and lung.

Post-translational modification

Phosphorylation of Ser-329 and Ser-330 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium-activated kinases By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361P2Y purinoceptor 4
PRO_0000070022

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5828Helical; Name=1; Potential
Topological domain59 – 6810Cytoplasmic Potential
Transmembrane69 – 9123Helical; Name=2; Potential
Topological domain92 – 10817Extracellular Potential
Transmembrane109 – 12719Helical; Name=3; Potential
Topological domain128 – 14922Cytoplasmic Potential
Transmembrane150 – 17021Helical; Name=4; Potential
Topological domain171 – 19222Extracellular Potential
Transmembrane193 – 21826Helical; Name=5; Potential
Topological domain219 – 24224Cytoplasmic Potential
Transmembrane243 – 26523Helical; Name=6; Potential
Topological domain266 – 28318Extracellular Potential
Transmembrane284 – 30522Helical; Name=7; Potential
Topological domain306 – 36156Cytoplasmic Potential

Amino acid modifications

Glycosylation1751N-linked (GlcNAc...) Potential
Disulfide bond104 ↔ 181 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JJS7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 3E8EA84B65BC0A20

FASTA36141,034
        10         20         30         40         50         60 
MTSADSLLFT SLGPSPSSGD GDCKFNEEFK FILLPLSYAV VFVLGLALNA PTLWLFLFRL 

        70         80         90        100        110        120 
RPWDATATYM FHLALSDTLY VLSLPTLVYY YAARNHWPFG TGFCKFVRFL FYWNLYCSVL 

       130        140        150        160        170        180 
FLTCISVHRY MGICHPLRAI RWGRPRFAGL LCLGVWLVVA GCLVPNLFFV TTNANGTTIL 

       190        200        210        220        230        240 
CHDTTLPEEF DHYVYFSSTI MVLLFGFPFL ITLVCYGLMA RRLYRPLPGA GQSSSRLRSL 

       250        260        270        280        290        300 
RTIAVVLTVF AVCFVPFHIT RTIYYLARLL NAECRVLNIV NVVYKVTRPL ASANSCLDPV 

       310        320        330        340        350        360 
LYLFTGDKYR NQLQQLCRGS TPKRRTTASS LALVTLHEES ISRWADIHQD SIFPAYEGDR 


L 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor."
Suarez-Huerta N., Pouillon V., Boeynaems J.-M., Robaye B.
Eur. J. Pharmacol. 416:197-202(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/SvJ.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ277752 Genomic DNA. Translation: CAB91043.1.
AK076364 mRNA. Translation: BAC36314.1.
CCDSCCDS30303.1.
RefSeqNP_065646.1. NM_020621.4.
XP_006528238.1. XM_006528175.1.
XP_006528239.1. XM_006528176.1.
XP_006528240.1. XM_006528177.1.
XP_006528241.1. XM_006528178.1.
UniGeneMm.117118.

3D structure databases

ProteinModelPortalQ9JJS7.
SMRQ9JJS7. Positions 30-321.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY325.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9JJS7.

Proteomic databases

PRIDEQ9JJS7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000053373; ENSMUSP00000055869; ENSMUSG00000044359.
GeneID57385.
KEGGmmu:57385.
UCSCuc009twc.1. mouse.

Organism-specific databases

CTD5030.
MGIMGI:1926594. P2ry4.

Phylogenomic databases

eggNOGNOG270952.
GeneTreeENSGT00750000117601.
HOGENOMHOG000231307.
HOVERGENHBG101120.
InParanoidQ9JJS7.
KOK04271.
OMAEFKFILL.
OrthoDBEOG7QNVM4.
PhylomeDBQ9JJS7.
TreeFamTF350009.

Gene expression databases

ArrayExpressQ9JJS7.
BgeeQ9JJS7.
CleanExMM_P2RY4.
GenevestigatorQ9JJS7.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000018. P2Y4_rcpt.
[Graphical view]
PANTHERPTHR24231:SF21. PTHR24231:SF21. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01066. P2Y4PRNOCPTR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio313762.
PROQ9JJS7.
SOURCESearch...

Entry information

Entry nameP2RY4_MOUSE
AccessionPrimary (citable) accession number: Q9JJS7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries