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Protein

Achaete-scute homolog 3

Gene

Ascl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Inhibits myogenesis.

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of transcription by RNA polymerase II Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute homolog 3
Short name:
ASH-3
Short name:
mASH-3
Short name:
mASH3
Alternative name(s):
bHLH transcriptional regulator Sgn-1
Gene namesi
Name:Ascl3
Synonyms:Mash3, Sgn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1928820 Ascl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271341 – 174Achaete-scute homolog 3Add BLAST174

Proteomic databases

PaxDbiQ9JJR7
PRIDEiQ9JJR7

PTM databases

PhosphoSitePlusiQ9JJR7

Expressioni

Tissue specificityi

Specifically expressed in the salivary duct cells.

Gene expression databases

BgeeiENSMUSG00000035951
CleanExiMM_ASCL3
GenevisibleiQ9JJR7 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208173, 5 interactors
STRINGi10090.ENSMUSP00000037702

Structurei

3D structure databases

ProteinModelPortaliQ9JJR7
SMRiQ9JJR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 144bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00530000063321
HOGENOMiHOG000034089
HOVERGENiHBG050591
InParanoidiQ9JJR7
KOiK09067
OMAiGYAQLRH
OrthoDBiEOG091G0OGL
PhylomeDBiQ9JJR7
TreeFamiTF322889

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR015660 MASH1/Ascl1a-like
PANTHERiPTHR13935 PTHR13935, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JJR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRSYPSPP DRLSVFAESA HLPLSRPFYL DPMVTVHLCP ETPVPASYTD
60 70 80 90 100
ELPLLPFSSD TLIMNNYGDP YPFPFPMPYT NYRRCDYTYG PAFIRKRNER
110 120 130 140 150
ERQRVKCVNE GYARLRRHLP EDYLEKRLSK VETLRAAIKY ISYLQSLLYP
160 170
DESETKKNPR TASCGSLDPA LRVI
Length:174
Mass (Da):20,245
Last modified:October 1, 2000 - v1
Checksum:iD89E56C8A9D3440B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277605 mRNA Translation: CAC37689.1
AB046448 mRNA Translation: BAB83911.1
AJ400878 Genomic DNA Translation: CAB92296.1
BC104346 mRNA Translation: AAI04347.1
BC104347 mRNA Translation: AAI04348.1
CCDSiCCDS21737.1
RefSeqiNP_064435.1, NM_020051.1
UniGeneiMm.29275

Genome annotation databases

EnsembliENSMUST00000035372; ENSMUSP00000037702; ENSMUSG00000035951
GeneIDi56787
KEGGimmu:56787
UCSCiuc009jeb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiASCL3_MOUSE
AccessioniPrimary (citable) accession number: Q9JJR7
Secondary accession number(s): Q3SXE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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