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Protein

Achaete-scute homolog 3

Gene

Ascl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Inhibits myogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute homolog 3
Short name:
ASH-3
Short name:
mASH-3
Short name:
mASH3
Alternative name(s):
bHLH transcriptional regulator Sgn-1
Gene namesi
Name:Ascl3
Synonyms:Mash3, Sgn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1928820. Ascl3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271341 – 174Achaete-scute homolog 3Add BLAST174

Proteomic databases

PaxDbiQ9JJR7.
PRIDEiQ9JJR7.

PTM databases

PhosphoSitePlusiQ9JJR7.

Expressioni

Tissue specificityi

Specifically expressed in the salivary duct cells.

Gene expression databases

BgeeiENSMUSG00000035951.
CleanExiMM_ASCL3.
GenevisibleiQ9JJR7. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208173. 5 interactors.
STRINGi10090.ENSMUSP00000037702.

Structurei

3D structure databases

ProteinModelPortaliQ9JJR7.
SMRiQ9JJR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 144bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00530000063321.
HOGENOMiHOG000034089.
HOVERGENiHBG050591.
InParanoidiQ9JJR7.
KOiK09067.
OMAiGYAQLRH.
OrthoDBiEOG091G0OGL.
PhylomeDBiQ9JJR7.
TreeFamiTF322889.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR036638. HLH_DNA-bd_sf.
IPR015660. MASH1/Ascl1a-like.
PANTHERiPTHR13935. PTHR13935. 1 hit.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JJR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRSYPSPP DRLSVFAESA HLPLSRPFYL DPMVTVHLCP ETPVPASYTD
60 70 80 90 100
ELPLLPFSSD TLIMNNYGDP YPFPFPMPYT NYRRCDYTYG PAFIRKRNER
110 120 130 140 150
ERQRVKCVNE GYARLRRHLP EDYLEKRLSK VETLRAAIKY ISYLQSLLYP
160 170
DESETKKNPR TASCGSLDPA LRVI
Length:174
Mass (Da):20,245
Last modified:October 1, 2000 - v1
Checksum:iD89E56C8A9D3440B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277605 mRNA. Translation: CAC37689.1.
AB046448 mRNA. Translation: BAB83911.1.
AJ400878 Genomic DNA. Translation: CAB92296.1.
BC104346 mRNA. Translation: AAI04347.1.
BC104347 mRNA. Translation: AAI04348.1.
CCDSiCCDS21737.1.
RefSeqiNP_064435.1. NM_020051.1.
UniGeneiMm.29275.

Genome annotation databases

EnsembliENSMUST00000035372; ENSMUSP00000037702; ENSMUSG00000035951.
GeneIDi56787.
KEGGimmu:56787.
UCSCiuc009jeb.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiASCL3_MOUSE
AccessioniPrimary (citable) accession number: Q9JJR7
Secondary accession number(s): Q3SXE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot