Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JJQ0

- PIGB_MOUSE

UniProt

Q9JJQ0 - PIGB_MOUSE

Protein

GPI mannosyltransferase 3

Gene

Pigb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (25 Jul 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

    GO - Biological processi

    1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
    2. GPI anchor metabolic process Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    GPI-anchor biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00196.

    Protein family/group databases

    CAZyiGT22. Glycosyltransferase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GPI mannosyltransferase 3 (EC:2.4.1.-)
    Alternative name(s):
    GPI mannosyltransferase III
    Short name:
    GPI-MT-III
    Phosphatidylinositol-glycan biosynthesis class B protein
    Short name:
    PIG-B
    Gene namesi
    Name:Pigb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1891825. Pigb.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542GPI mannosyltransferase 3PRO_0000246252Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9JJQ0.
    PRIDEiQ9JJQ0.

    PTM databases

    PhosphoSiteiQ9JJQ0.

    Expressioni

    Gene expression databases

    BgeeiQ9JJQ0.
    GenevestigatoriQ9JJQ0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJQ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei376 – 39621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG276773.
    GeneTreeiENSGT00550000075012.
    HOGENOMiHOG000189846.
    HOVERGENiHBG082136.
    InParanoidiQ9JJQ0.
    KOiK05286.
    OMAiGIRSYVY.
    OrthoDBiEOG761BV9.
    PhylomeDBiQ9JJQ0.
    TreeFamiTF313518.

    Family and domain databases

    InterProiIPR005599. GPI_mannosylTrfase.
    [Graphical view]
    PANTHERiPTHR22760. PTHR22760. 1 hit.
    PfamiPF03901. Glyco_transf_22. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JJQ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESQAADYNP ASRNLHGSSG EMKLRRRKSR QYVSAQEKRS PRRGLLGENT    50
    YLVLFTIALR ILNCFLVQTS FVPDEYWQSL EVAHRMVFSY GYLTWEWTER 100
    LRGYTYPLIF ASIYKVLHLL GKDSVQFLIW IPRLGQALLS AVADIRLYSL 150
    LKQLENQEVA QWVFLCQLCS WFTWYCCTRT LTNTMETSLT ALALFYYPLE 200
    GSRSVNSVKY SLLVALACVV RPTALIPWVP LLFRHFYQEQ RKLHLTLHHF 250
    LPVGFITFSL SLIIDRIFFG QWTLVQLNFL KFNVLQNLGT FYGSHPWHWY 300
    LSQGFPVVLG THLPFFIHGC FLAPRRLHIL LLTVLWTLLV YSMLGHKEFR 350
    FIYPVLPFCM VFCGYSLAHL KTWRKAALSF LLLSNVPLAF YTGLVHQRGT 400
    LDVMNHIQKV CPRGPDPASA SVFIMMPCHS TPYYSHVHCP LSMRFLQCPP 450
    DLTGKTQYLD EADMFYLNPL RWLQQEFHSN ASLPTHLVTF NVLEKEINTF 500
    LTSGNYERAA TFFHTHWPER RTGSHIHVYE RRLPGRVNTG GN 542
    Length:542
    Mass (Da):63,120
    Last modified:July 25, 2006 - v2
    Checksum:iD426F71B01011437
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti208 – 2081V → I in BAA94827. (PubMed:8861954)Curated
    Sequence conflicti407 – 4071I → V in AAH52658. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D84436 mRNA. Translation: BAA94827.1.
    AK153819 mRNA. Translation: BAE32195.1.
    BC052658 mRNA. Translation: AAH52658.1.
    CCDSiCCDS40687.1.
    RefSeqiNP_061377.2. NM_018889.3.
    UniGeneiMm.139905.

    Genome annotation databases

    EnsembliENSMUST00000098566; ENSMUSP00000096165; ENSMUSG00000079469.
    ENSMUST00000183746; ENSMUSP00000138885; ENSMUSG00000079469.
    ENSMUST00000184035; ENSMUSP00000139269; ENSMUSG00000079469.
    ENSMUST00000184389; ENSMUSP00000139076; ENSMUSG00000079469.
    GeneIDi55981.
    KEGGimmu:55981.
    UCSCiuc009qqs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D84436 mRNA. Translation: BAA94827.1 .
    AK153819 mRNA. Translation: BAE32195.1 .
    BC052658 mRNA. Translation: AAH52658.1 .
    CCDSi CCDS40687.1.
    RefSeqi NP_061377.2. NM_018889.3.
    UniGenei Mm.139905.

    3D structure databases

    ProteinModelPortali Q9JJQ0.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT22. Glycosyltransferase Family 22.

    PTM databases

    PhosphoSitei Q9JJQ0.

    Proteomic databases

    PaxDbi Q9JJQ0.
    PRIDEi Q9JJQ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000098566 ; ENSMUSP00000096165 ; ENSMUSG00000079469 .
    ENSMUST00000183746 ; ENSMUSP00000138885 ; ENSMUSG00000079469 .
    ENSMUST00000184035 ; ENSMUSP00000139269 ; ENSMUSG00000079469 .
    ENSMUST00000184389 ; ENSMUSP00000139076 ; ENSMUSG00000079469 .
    GeneIDi 55981.
    KEGGi mmu:55981.
    UCSCi uc009qqs.1. mouse.

    Organism-specific databases

    CTDi 9488.
    MGIi MGI:1891825. Pigb.

    Phylogenomic databases

    eggNOGi NOG276773.
    GeneTreei ENSGT00550000075012.
    HOGENOMi HOG000189846.
    HOVERGENi HBG082136.
    InParanoidi Q9JJQ0.
    KOi K05286.
    OMAi GIRSYVY.
    OrthoDBi EOG761BV9.
    PhylomeDBi Q9JJQ0.
    TreeFami TF313518.

    Enzyme and pathway databases

    UniPathwayi UPA00196 .

    Miscellaneous databases

    NextBioi 311682.
    PROi Q9JJQ0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JJQ0.
    Genevestigatori Q9JJQ0.

    Family and domain databases

    InterProi IPR005599. GPI_mannosylTrfase.
    [Graphical view ]
    PANTHERi PTHR22760. PTHR22760. 1 hit.
    Pfami PF03901. Glyco_transf_22. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor."
      Takahashi M., Inoue N., Ohishi K., Maeda Y., Nakamura N., Endo Y., Fujita T., Takeda J., Kinoshita T.
      EMBO J. 15:4254-4261(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Egg.

    Entry informationi

    Entry nameiPIGB_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJQ0
    Secondary accession number(s): Q3U585, Q7TQ01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3