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Q9JJQ0

- PIGB_MOUSE

UniProt

Q9JJQ0 - PIGB_MOUSE

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Protein
GPI mannosyltransferase 3
Gene
Pigb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly By similarity.

Pathwayi

GO - Molecular functioni

  1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

GO - Biological processi

  1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
  2. GPI anchor metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 3 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase III
Short name:
GPI-MT-III
Phosphatidylinositol-glycan biosynthesis class B protein
Short name:
PIG-B
Gene namesi
Name:Pigb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1891825. Pigb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7221Helical; Reviewed prediction
Add
BLAST
Transmembranei125 – 14521Helical; Reviewed prediction
Add
BLAST
Transmembranei213 – 23321Helical; Reviewed prediction
Add
BLAST
Transmembranei244 – 26421Helical; Reviewed prediction
Add
BLAST
Transmembranei304 – 32421Helical; Reviewed prediction
Add
BLAST
Transmembranei327 – 34721Helical; Reviewed prediction
Add
BLAST
Transmembranei351 – 37121Helical; Reviewed prediction
Add
BLAST
Transmembranei376 – 39621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542GPI mannosyltransferase 3
PRO_0000246252Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi480 – 4801N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JJQ0.
PRIDEiQ9JJQ0.

PTM databases

PhosphoSiteiQ9JJQ0.

Expressioni

Gene expression databases

BgeeiQ9JJQ0.
GenevestigatoriQ9JJQ0.

Structurei

3D structure databases

ProteinModelPortaliQ9JJQ0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276773.
GeneTreeiENSGT00550000075012.
HOGENOMiHOG000189846.
HOVERGENiHBG082136.
InParanoidiQ9JJQ0.
KOiK05286.
OMAiGIRSYVY.
OrthoDBiEOG761BV9.
PhylomeDBiQ9JJQ0.
TreeFamiTF313518.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJQ0-1 [UniParc]FASTAAdd to Basket

« Hide

MESQAADYNP ASRNLHGSSG EMKLRRRKSR QYVSAQEKRS PRRGLLGENT    50
YLVLFTIALR ILNCFLVQTS FVPDEYWQSL EVAHRMVFSY GYLTWEWTER 100
LRGYTYPLIF ASIYKVLHLL GKDSVQFLIW IPRLGQALLS AVADIRLYSL 150
LKQLENQEVA QWVFLCQLCS WFTWYCCTRT LTNTMETSLT ALALFYYPLE 200
GSRSVNSVKY SLLVALACVV RPTALIPWVP LLFRHFYQEQ RKLHLTLHHF 250
LPVGFITFSL SLIIDRIFFG QWTLVQLNFL KFNVLQNLGT FYGSHPWHWY 300
LSQGFPVVLG THLPFFIHGC FLAPRRLHIL LLTVLWTLLV YSMLGHKEFR 350
FIYPVLPFCM VFCGYSLAHL KTWRKAALSF LLLSNVPLAF YTGLVHQRGT 400
LDVMNHIQKV CPRGPDPASA SVFIMMPCHS TPYYSHVHCP LSMRFLQCPP 450
DLTGKTQYLD EADMFYLNPL RWLQQEFHSN ASLPTHLVTF NVLEKEINTF 500
LTSGNYERAA TFFHTHWPER RTGSHIHVYE RRLPGRVNTG GN 542
Length:542
Mass (Da):63,120
Last modified:July 25, 2006 - v2
Checksum:iD426F71B01011437
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081V → I in BAA94827. 1 Publication
Sequence conflicti407 – 4071I → V in AAH52658. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D84436 mRNA. Translation: BAA94827.1.
AK153819 mRNA. Translation: BAE32195.1.
BC052658 mRNA. Translation: AAH52658.1.
CCDSiCCDS40687.1.
RefSeqiNP_061377.2. NM_018889.3.
UniGeneiMm.139905.

Genome annotation databases

EnsembliENSMUST00000098566; ENSMUSP00000096165; ENSMUSG00000079469.
ENSMUST00000183746; ENSMUSP00000138885; ENSMUSG00000079469.
ENSMUST00000184035; ENSMUSP00000139269; ENSMUSG00000079469.
ENSMUST00000184389; ENSMUSP00000139076; ENSMUSG00000079469.
GeneIDi55981.
KEGGimmu:55981.
UCSCiuc009qqs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D84436 mRNA. Translation: BAA94827.1 .
AK153819 mRNA. Translation: BAE32195.1 .
BC052658 mRNA. Translation: AAH52658.1 .
CCDSi CCDS40687.1.
RefSeqi NP_061377.2. NM_018889.3.
UniGenei Mm.139905.

3D structure databases

ProteinModelPortali Q9JJQ0.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT22. Glycosyltransferase Family 22.

PTM databases

PhosphoSitei Q9JJQ0.

Proteomic databases

PaxDbi Q9JJQ0.
PRIDEi Q9JJQ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000098566 ; ENSMUSP00000096165 ; ENSMUSG00000079469 .
ENSMUST00000183746 ; ENSMUSP00000138885 ; ENSMUSG00000079469 .
ENSMUST00000184035 ; ENSMUSP00000139269 ; ENSMUSG00000079469 .
ENSMUST00000184389 ; ENSMUSP00000139076 ; ENSMUSG00000079469 .
GeneIDi 55981.
KEGGi mmu:55981.
UCSCi uc009qqs.1. mouse.

Organism-specific databases

CTDi 9488.
MGIi MGI:1891825. Pigb.

Phylogenomic databases

eggNOGi NOG276773.
GeneTreei ENSGT00550000075012.
HOGENOMi HOG000189846.
HOVERGENi HBG082136.
InParanoidi Q9JJQ0.
KOi K05286.
OMAi GIRSYVY.
OrthoDBi EOG761BV9.
PhylomeDBi Q9JJQ0.
TreeFami TF313518.

Enzyme and pathway databases

UniPathwayi UPA00196 .

Miscellaneous databases

NextBioi 311682.
PROi Q9JJQ0.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJQ0.
Genevestigatori Q9JJQ0.

Family and domain databases

InterProi IPR005599. GPI_mannosylTrfase.
[Graphical view ]
PANTHERi PTHR22760. PTHR22760. 1 hit.
Pfami PF03901. Glyco_transf_22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor."
    Takahashi M., Inoue N., Ohishi K., Maeda Y., Nakamura N., Endo Y., Fujita T., Takeda J., Kinoshita T.
    EMBO J. 15:4254-4261(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.

Entry informationi

Entry nameiPIGB_MOUSE
AccessioniPrimary (citable) accession number: Q9JJQ0
Secondary accession number(s): Q3U585, Q7TQ01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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