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Q9JJQ0 (PIGB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GPI mannosyltransferase 3

EC=2.4.1.-
Alternative name(s):
GPI mannosyltransferase III
Short name=GPI-MT-III
Phosphatidylinositol-glycan biosynthesis class B protein
Short name=PIG-B
Gene names
Name:Pigb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly By similarity.

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 22 family. PIGB subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542GPI mannosyltransferase 3
PRO_0000246252

Regions

Transmembrane52 – 7221Helical; Potential
Transmembrane125 – 14521Helical; Potential
Transmembrane213 – 23321Helical; Potential
Transmembrane244 – 26421Helical; Potential
Transmembrane304 – 32421Helical; Potential
Transmembrane327 – 34721Helical; Potential
Transmembrane351 – 37121Helical; Potential
Transmembrane376 – 39621Helical; Potential

Amino acid modifications

Glycosylation4801N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2081V → I in BAA94827. Ref.1
Sequence conflict4071I → V in AAH52658. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9JJQ0 [UniParc].

Last modified July 25, 2006. Version 2.
Checksum: D426F71B01011437

FASTA54263,120
        10         20         30         40         50         60 
MESQAADYNP ASRNLHGSSG EMKLRRRKSR QYVSAQEKRS PRRGLLGENT YLVLFTIALR 

        70         80         90        100        110        120 
ILNCFLVQTS FVPDEYWQSL EVAHRMVFSY GYLTWEWTER LRGYTYPLIF ASIYKVLHLL 

       130        140        150        160        170        180 
GKDSVQFLIW IPRLGQALLS AVADIRLYSL LKQLENQEVA QWVFLCQLCS WFTWYCCTRT 

       190        200        210        220        230        240 
LTNTMETSLT ALALFYYPLE GSRSVNSVKY SLLVALACVV RPTALIPWVP LLFRHFYQEQ 

       250        260        270        280        290        300 
RKLHLTLHHF LPVGFITFSL SLIIDRIFFG QWTLVQLNFL KFNVLQNLGT FYGSHPWHWY 

       310        320        330        340        350        360 
LSQGFPVVLG THLPFFIHGC FLAPRRLHIL LLTVLWTLLV YSMLGHKEFR FIYPVLPFCM 

       370        380        390        400        410        420 
VFCGYSLAHL KTWRKAALSF LLLSNVPLAF YTGLVHQRGT LDVMNHIQKV CPRGPDPASA 

       430        440        450        460        470        480 
SVFIMMPCHS TPYYSHVHCP LSMRFLQCPP DLTGKTQYLD EADMFYLNPL RWLQQEFHSN 

       490        500        510        520        530        540 
ASLPTHLVTF NVLEKEINTF LTSGNYERAA TFFHTHWPER RTGSHIHVYE RRLPGRVNTG 


GN 

« Hide

References

« Hide 'large scale' references
[1]"PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor."
Takahashi M., Inoue N., Ohishi K., Maeda Y., Nakamura N., Endo Y., Fujita T., Takeda J., Kinoshita T.
EMBO J. 15:4254-4261(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Egg.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D84436 mRNA. Translation: BAA94827.1.
AK153819 mRNA. Translation: BAE32195.1.
BC052658 mRNA. Translation: AAH52658.1.
CCDSCCDS40687.1.
RefSeqNP_061377.2. NM_018889.3.
UniGeneMm.139905.

3D structure databases

ProteinModelPortalQ9JJQ0.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT22. Glycosyltransferase Family 22.

PTM databases

PhosphoSiteQ9JJQ0.

Proteomic databases

PaxDbQ9JJQ0.
PRIDEQ9JJQ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000098566; ENSMUSP00000096165; ENSMUSG00000079469.
ENSMUST00000183746; ENSMUSP00000138885; ENSMUSG00000079469.
ENSMUST00000184035; ENSMUSP00000139269; ENSMUSG00000079469.
ENSMUST00000184389; ENSMUSP00000139076; ENSMUSG00000079469.
GeneID55981.
KEGGmmu:55981.
UCSCuc009qqs.1. mouse.

Organism-specific databases

CTD9488.
MGIMGI:1891825. Pigb.

Phylogenomic databases

eggNOGNOG276773.
GeneTreeENSGT00550000075012.
HOGENOMHOG000189846.
HOVERGENHBG082136.
InParanoidQ9JJQ0.
KOK05286.
OMAGIRSYVY.
OrthoDBEOG761BV9.
PhylomeDBQ9JJQ0.
TreeFamTF313518.

Enzyme and pathway databases

UniPathwayUPA00196.

Gene expression databases

BgeeQ9JJQ0.
GenevestigatorQ9JJQ0.

Family and domain databases

InterProIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERPTHR22760. PTHR22760. 1 hit.
PfamPF03901. Glyco_transf_22. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311682.
PROQ9JJQ0.
SOURCESearch...

Entry information

Entry namePIGB_MOUSE
AccessionPrimary (citable) accession number: Q9JJQ0
Secondary accession number(s): Q3U585, Q7TQ01
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot