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Protein

Tumor protein 63

Gene

Tp63

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter (By similarity).By similarity1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi244 – 2441ZincBy similarity
Metal bindingi247 – 2471ZincBy similarity
Metal bindingi308 – 3081ZincBy similarity
Metal bindingi312 – 3121ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi170 – 362193By similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Apoptosis, Notch signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-6804759. Regulation of TP53 Activity through Association with Co-factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein 63
Short name:
p63
Alternative name(s):
Keratinocyte transcription factor KET
Transformation-related protein 63
Short name:
TP63
Tumor protein p73-like
Short name:
p73L
Gene namesi
Name:Tp63
Synonyms:Ket, P63, Tp73l, Trp63
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi620863. Tp63.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: GO_Central
  • cytosol Source: GO_Central
  • dendrite Source: RGD
  • neuron projection Source: RGD
  • nuclear chromatin Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: RGD
  • protein complex Source: RGD
  • rough endoplasmic reticulum Source: RGD
  • transcription factor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Tumor protein 63PRO_0000185731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki676 – 676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

May be sumoylated.By similarity
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9JJP6.

PTM databases

PhosphoSiteiQ9JJP6.

Expressioni

Tissue specificityi

Widely expressed, notably in thymus, prostate, placenta, and skeletal muscle, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast and prostate express high levels of DeltaN-type isoforms.2 Publications

Gene expression databases

ExpressionAtlasiQ9JJP6. baseline and differential.
GenevisibleiQ9JJP6. RN.

Interactioni

Subunit structurei

Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Interacts with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Interacts with WWP1. Interacts with PDS5A. Interacts (via activation domain) with NOC2L (By similarity).By similarity

GO - Molecular functioni

  • p53 binding Source: GO_Central
  • protein domain specific binding Source: RGD

Protein-protein interaction databases

MINTiMINT-125750.
STRINGi10116.ENSRNOP00000033463.

Structurei

3D structure databases

ProteinModelPortaliQ9JJP6.
SMRiQ9JJP6. Positions 164-362, 544-610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini541 – 60767SAMAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 107107Transcription activationBy similarityAdd
BLAST
Regioni352 – 38837Interaction with HIPK2By similarityAdd
BLAST
Regioni394 – 44350OligomerizationBy similarityAdd
BLAST
Regioni610 – 68071Transactivation inhibitionBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi437 – 4448Poly-Gln

Domaini

The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms.By similarity

Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

eggNOGiENOG410IGE4. Eukaryota.
ENOG410XV9W. LUCA.
GeneTreeiENSGT00390000015092.
HOVERGENiHBG005201.
InParanoidiQ9JJP6.
KOiK10149.
OMAiVPSSHCT.
PhylomeDBiQ9JJP6.
TreeFamiTF106101.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR032645. Tp63.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 2 hits.
PTHR11447:SF8. PTHR11447:SF8. 2 hits.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF47769. SSF47769. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JJP6-1) [UniParc]FASTAAdd to basket

Also known as: TA2-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFETSRCAT LQYCPDPYIQ RFIETPSHFS WKESYYRSAM SQSTQTSEFL
60 70 80 90 100
SPEVFQHIWD FLEQPICSVQ PIDLNFVDEP SENGATNKIE ISMDCIRMQD
110 120 130 140 150
SDLSDPMWPQ YTNLGLLNGM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA
160 170 180 190 200
QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK
210 220 230 240 250
LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS
260 270 280 290 300
REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT
310 320 330 340 350
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR
360 370 380 390 400
DRKADEDSIR KQQVSDSAKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL
410 420 430 440 450
LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ
460 470 480 490 500
TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTMPEGMG
510 520 530 540 550
ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV
560 570 580 590 600
SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG
610 620 630 640 650
ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI
660 670 680
SFPPRDEWND FNFDMDSRRN KQQRIKEEGE
Note: Produced by alternative promoter usage.
Length:680
Mass (Da):76,760
Last modified:October 1, 2000 - v1
Checksum:iAC45DABB88F61400
GO
Isoform 2 (identifier: Q9JJP6-2) [UniParc]FASTAAdd to basket

Also known as: DeltaN-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLESNAQTQFSE

Note: Produced by alternative promoter usage.
Show »
Length:586
Mass (Da):65,732
Checksum:i78AB8CC4F52BA743
GO
Isoform 3 (identifier: Q9JJP6-3) [UniParc]FASTAAdd to basket

Also known as: TA2-beta

The sequence of this isoform differs from the canonical sequence as follows:
     551-680: SFLARLGCSS...KQQRIKEEGE → RIWQV

Note: Produced by alternative splicing of isoform 1.
Show »
Length:555
Mass (Da):62,427
Checksum:i65D8854E2387C74C
GO
Isoform 4 (identifier: Q9JJP6-4) [UniParc]FASTAAdd to basket

Also known as: DeltaN-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLESNAQTQFSE
     551-680: SFLARLGCSS...KQQRIKEEGE → RIWQV

Note: Produced by alternative splicing of isoform 2.
Show »
Length:461
Mass (Da):51,398
Checksum:iB5F898EBE7E4F97A
GO
Isoform 5 (identifier: Q9JJP6-5) [UniParc]FASTAAdd to basket

Also known as: TA2-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     450-680: QTSMQSQSSY...KQQRIKEEGE → HLLSACFRNE...SNPPNHSVYP

Note: Produced by alternative splicing of isoform 1.
Show »
Length:487
Mass (Da):55,499
Checksum:iA688F392F32B3039
GO
Isoform 6 (identifier: Q9JJP6-6) [UniParc]FASTAAdd to basket

Also known as: DeltaN-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLESNAQTQFSE
     450-680: QTSMQSQSSY...KQQRIKEEGE → HLLSACFRNE...SNPPNHSVYP

Note: Produced by alternative splicing of isoform 2.
Show »
Length:393
Mass (Da):44,471
Checksum:i1A310CA62CB276DB
GO
Isoform 7 (identifier: Q9JJP6-7) [UniParc]FASTAAdd to basket

Also known as: TA1-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MNFETSRCATLQYCPDPYIQR → MPSC

Note: Produced by alternative promoter usage.
Show »
Length:663
Mass (Da):74,660
Checksum:iC953BBAC389D5B70
GO
Isoform 8 (identifier: Q9JJP6-8) [UniParc]FASTAAdd to basket

Also known as: TA1-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MNFETSRCATLQYCPDPYIQR → MPSC
     551-680: SFLARLGCSS...KQQRIKEEGE → RIWQV

Note: Produced by alternative splicing of isoform 7.
Show »
Length:538
Mass (Da):60,326
Checksum:i66D0CA19786BF21B
GO
Isoform 9 (identifier: Q9JJP6-9) [UniParc]FASTAAdd to basket

Also known as: TA1-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MNFETSRCATLQYCPDPYIQR → MPSC
     450-680: QTSMQSQSSY...KQQRIKEEGE → HLLSACFRNE...SNPPNHSVYP

Note: Produced by alternative splicing of isoform 7.
Show »
Length:470
Mass (Da):53,399
Checksum:i96B7ED2FB30DD394
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 108108MNFET…SDPMW → MLYLESNAQTQFSE in isoform 2, isoform 4 and isoform 6. 1 PublicationVSP_012475Add
BLAST
Alternative sequencei1 – 2121MNFET…PYIQR → MPSC in isoform 7, isoform 8 and isoform 9. 1 PublicationVSP_012476Add
BLAST
Alternative sequencei450 – 680231QTSMQ…KEEGE → HLLSACFRNELVESRREAPT QSDVFFRHSNPPNHSVYP in isoform 5, isoform 6 and isoform 9. 1 PublicationVSP_012477Add
BLAST
Alternative sequencei551 – 680130SFLAR…KEEGE → RIWQV in isoform 3, isoform 4 and isoform 8. 1 PublicationVSP_012478Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10258 mRNA. Translation: CAB88216.1.
AJ277446 mRNA. Translation: CAC37098.1.
AJ277447 mRNA. Translation: CAC37099.1.
AJ277448 mRNA. Translation: CAC37100.1.
AJ277449 mRNA. Translation: CAC37101.1.
AJ277450 mRNA. Translation: CAC37102.1.
AJ277451 mRNA. Translation: CAC37103.1.
AJ277452 mRNA. Translation: CAC37104.1.
AJ277453 mRNA. Translation: CAC37105.1.
RefSeqiNP_001120811.1. NM_001127339.1. [Q9JJP6-3]
NP_001120813.1. NM_001127341.1. [Q9JJP6-5]
NP_001120814.1. NM_001127342.1. [Q9JJP6-2]
NP_001120815.1. NM_001127343.1. [Q9JJP6-4]
NP_001120816.1. NM_001127344.1. [Q9JJP6-6]
NP_062094.1. NM_019221.3. [Q9JJP6-1]
XP_008767013.1. XM_008768791.1. [Q9JJP6-1]
UniGeneiRn.42907.

Genome annotation databases

EnsembliENSRNOT00000002636; ENSRNOP00000002636; ENSRNOG00000001924. [Q9JJP6-2]
ENSRNOT00000036179; ENSRNOP00000032308; ENSRNOG00000001924. [Q9JJP6-5]
ENSRNOT00000036193; ENSRNOP00000033463; ENSRNOG00000001924. [Q9JJP6-1]
ENSRNOT00000067251; ENSRNOP00000059178; ENSRNOG00000001924. [Q9JJP6-3]
ENSRNOT00000068116; ENSRNOP00000061884; ENSRNOG00000001924. [Q9JJP6-4]
GeneIDi246334.
KEGGirno:246334.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10258 mRNA. Translation: CAB88216.1.
AJ277446 mRNA. Translation: CAC37098.1.
AJ277447 mRNA. Translation: CAC37099.1.
AJ277448 mRNA. Translation: CAC37100.1.
AJ277449 mRNA. Translation: CAC37101.1.
AJ277450 mRNA. Translation: CAC37102.1.
AJ277451 mRNA. Translation: CAC37103.1.
AJ277452 mRNA. Translation: CAC37104.1.
AJ277453 mRNA. Translation: CAC37105.1.
RefSeqiNP_001120811.1. NM_001127339.1. [Q9JJP6-3]
NP_001120813.1. NM_001127341.1. [Q9JJP6-5]
NP_001120814.1. NM_001127342.1. [Q9JJP6-2]
NP_001120815.1. NM_001127343.1. [Q9JJP6-4]
NP_001120816.1. NM_001127344.1. [Q9JJP6-6]
NP_062094.1. NM_019221.3. [Q9JJP6-1]
XP_008767013.1. XM_008768791.1. [Q9JJP6-1]
UniGeneiRn.42907.

3D structure databases

ProteinModelPortaliQ9JJP6.
SMRiQ9JJP6. Positions 164-362, 544-610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-125750.
STRINGi10116.ENSRNOP00000033463.

PTM databases

PhosphoSiteiQ9JJP6.

Proteomic databases

PaxDbiQ9JJP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002636; ENSRNOP00000002636; ENSRNOG00000001924. [Q9JJP6-2]
ENSRNOT00000036179; ENSRNOP00000032308; ENSRNOG00000001924. [Q9JJP6-5]
ENSRNOT00000036193; ENSRNOP00000033463; ENSRNOG00000001924. [Q9JJP6-1]
ENSRNOT00000067251; ENSRNOP00000059178; ENSRNOG00000001924. [Q9JJP6-3]
ENSRNOT00000068116; ENSRNOP00000061884; ENSRNOG00000001924. [Q9JJP6-4]
GeneIDi246334.
KEGGirno:246334.

Organism-specific databases

CTDi8626.
RGDi620863. Tp63.

Phylogenomic databases

eggNOGiENOG410IGE4. Eukaryota.
ENOG410XV9W. LUCA.
GeneTreeiENSGT00390000015092.
HOVERGENiHBG005201.
InParanoidiQ9JJP6.
KOiK10149.
OMAiVPSSHCT.
PhylomeDBiQ9JJP6.
TreeFamiTF106101.

Enzyme and pathway databases

ReactomeiR-RNO-6804759. Regulation of TP53 Activity through Association with Co-factors.

Miscellaneous databases

PROiQ9JJP6.

Gene expression databases

ExpressionAtlasiQ9JJP6. baseline and differential.
GenevisibleiQ9JJP6. RN.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR032645. Tp63.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 2 hits.
PTHR11447:SF8. PTHR11447:SF8. 2 hits.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF47769. SSF47769. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel protein with strong homology to the tumor suppressor p53."
    Schmale H., Bamberger C.
    Oncogene 15:1363-1367(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Tongue epithelium.
  2. "Identification and tissue distribution of novel KET/p63 splice variants."
    Bamberger C., Schmale H.
    FEBS Lett. 501:121-126(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5; 6; 7; 8 AND 9), FUNCTION, TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Tongue.

Entry informationi

Entry nameiP63_RAT
AccessioniPrimary (citable) accession number: Q9JJP6
Secondary accession number(s): Q99JD6
, Q99JD7, Q99JD8, Q99JD9, Q99JE0, Q99JE1, Q99JE2, Q99JE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.