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Protein

Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial

Gene

Oxct2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa.By similarity

Catalytic activityi

Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.PROSITE-ProRule annotation

Pathwayi: succinyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes acetoacetyl-CoA from succinyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial (Oxct2a), Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (Oxct1), Succinyl-CoA:3-ketoacid-coenzyme A transferase (Oxct1), Succinyl-CoA:3-ketoacid-coenzyme A transferase (Oxct1), Succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial (Oxct2b), Succinyl-CoA:3-ketoacid-coenzyme A transferase (Oxct2b), Succinyl-CoA:3-ketoacid-coenzyme A transferase (Oxct1)
This subpathway is part of the pathway succinyl-CoA degradation, which is itself part of Ketone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetyl-CoA from succinyl-CoA, the pathway succinyl-CoA degradation and in Ketone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3425-glutamyl coenzyme A thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • 3-oxoacid CoA-transferase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.8.3.5 3474
ReactomeiR-MMU-77108 Utilization of Ketone Bodies
UniPathwayiUPA00929; UER00894

Names & Taxonomyi

Protein namesi
Recommended name:
Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial (EC:2.8.3.5)
Alternative name(s):
3-oxoacid CoA-transferase 2A
Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1
Short name:
SCOT-t1
Gene namesi
Name:Oxct2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1891061 Oxct2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionBy similarityAdd BLAST39
ChainiPRO_000036620940 – 520Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrialAdd BLAST481

Proteomic databases

PaxDbiQ9JJN4
PeptideAtlasiQ9JJN4
PRIDEiQ9JJN4

PTM databases

PhosphoSitePlusiQ9JJN4

Expressioni

Gene expression databases

BgeeiENSMUSG00000076436
GenevisibleiQ9JJN4 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099700

Structurei

3D structure databases

ProteinModelPortaliQ9JJN4
SMRiQ9JJN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-oxoacid CoA-transferase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3822 Eukaryota
COG1788 LUCA
COG2057 LUCA
GeneTreeiENSGT00390000009130
HOGENOMiHOG000221244
HOVERGENiHBG002310
InParanoidiQ9JJN4
KOiK01027
OMAiWMLPGKV
OrthoDBiEOG091G0D3X
PhylomeDBiQ9JJN4
TreeFamiTF313991

Family and domain databases

InterProiView protein in InterPro
IPR012792 3-oxoacid_CoA-transf_A
IPR012791 3-oxoacid_CoA-transf_B
IPR014388 3-oxoacid_CoA-transferase
IPR004165 CoA_trans_fam_I
IPR004164 CoA_transf_AS
IPR004163 CoA_transf_BS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR13707 PTHR13707, 1 hit
PfamiView protein in Pfam
PF01144 CoA_trans, 2 hits
PIRSFiPIRSF000858 SCOT-t, 1 hit
SMARTiView protein in SMART
SM00882 CoA_trans, 2 hits
SUPFAMiSSF100950 SSF100950, 2 hits
TIGRFAMsiTIGR02429 pcaI_scoA_fam, 1 hit
TIGR02428 pcaJ_scoB_fam, 1 hit
PROSITEiView protein in PROSITE
PS01273 COA_TRANSF_1, 1 hit
PS01274 COA_TRANSF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALRLLAWA LPRGVSALRP PPALPHRLIR RYVSDRSGSV HFYTDPVKAV
60 70 80 90 100
EGVKDGSTVM LGGFGLCGIP ENLIGALKTK GVKDLKIVSS NVGVDDFGLG
110 120 130 140 150
ILLASKQVRR VVCSYLGENA LCEKLYLAGE LELEMTPQGT LAERIRAGGT
160 170 180 190 200
GVPAFYTPTG YGTLVQEGGS PIRYAPDGHL ITLSEPREVR EFQGRFYLLE
210 220 230 240 250
HAIRADFALI KGWKADRSGN VIFRGSARNF NVPMCKAADI SVVEVEEIVD
260 270 280 290 300
VGTFAPEDIH VPNIYVDRVI KGPKFEKRIE RLTTRDSKPA PGSKDNDPSR
310 320 330 340 350
TRIIKRAALE FQDGMYANLG IGIPVLASNY ISPKMTVYLH SENGILGLGP
360 370 380 390 400
FPLKNEVDAD VINAGKQTVT VVPGGCFFAS DDSFAMIRGG HLQLTMLGAM
410 420 430 440 450
QVSQYGDLAN WMVPGKKVKG MGGAMDLVSS KKTRVVVTME HCTKTKQPKI
460 470 480 490 500
LKKCTMPLTG KRCVDLIITE KAVFEVNHSK GLTLVELWEG SSVDDIKATT
510 520
ACSFAVSPNL KPMQQIKLDA
Length:520
Mass (Da):56,473
Last modified:March 1, 2001 - v2
Checksum:i16BAE0F546AFB993
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022180 mRNA Translation: BAA97654.2
AB105454 Genomic DNA Translation: BAC87737.1
AK077075 mRNA Translation: BAC36595.1
AL606917 Genomic DNA Translation: CAM46094.1
BC137887 mRNA Translation: AAI37888.1
BC137888 mRNA Translation: AAI37889.1
CCDSiCCDS18617.1
RefSeqiNP_071316.1, NM_022033.4
UniGeneiMm.270287

Genome annotation databases

EnsembliENSMUST00000102640; ENSMUSP00000099700; ENSMUSG00000076436
GeneIDi64059
KEGGimmu:64059
UCSCiuc008uph.3 mouse

Similar proteinsi

Entry informationi

Entry nameiSCO2A_MOUSE
AccessioniPrimary (citable) accession number: Q9JJN4
Secondary accession number(s): B9EHG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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