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Q9JJN4

- SCO2A_MOUSE

UniProt

Q9JJN4 - SCO2A_MOUSE

Protein

Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial

Gene

Oxct2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate By similarity. Probably play and important roles in the energy metabolism of spermatozoa.By similarity

    Catalytic activityi

    Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei342 – 34215-glutamyl coenzyme A thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. 3-oxoacid CoA-transferase activity Source: MGI

    GO - Biological processi

    1. cellular ketone body metabolic process Source: MGI
    2. ketone body catabolic process Source: InterPro
    3. succinyl-CoA metabolic process Source: MGI

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    BRENDAi2.8.3.5. 3474.
    UniPathwayiUPA00929; UER00894.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial (EC:2.8.3.5)
    Alternative name(s):
    3-oxoacid CoA-transferase 2A
    Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1
    Short name:
    SCOT-t1
    Gene namesi
    Name:Oxct2a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1891061. Oxct2a.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionBy similarityAdd
    BLAST
    Chaini40 – 520481Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrialPRO_0000366209Add
    BLAST

    Proteomic databases

    PaxDbiQ9JJN4.
    PRIDEiQ9JJN4.

    Expressioni

    Gene expression databases

    BgeeiQ9JJN4.
    GenevestigatoriQ9JJN4.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJN4.
    SMRiQ9JJN4. Positions 42-516.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 3-oxoacid CoA-transferase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1788.
    GeneTreeiENSGT00390000009130.
    HOGENOMiHOG000221244.
    HOVERGENiHBG002310.
    InParanoidiQ9JJN4.
    KOiK01027.
    OMAiIRERMAQ.
    OrthoDBiEOG7XH6PR.
    PhylomeDBiQ9JJN4.
    TreeFamiTF313991.

    Family and domain databases

    InterProiIPR012792. 3-oxoacid_CoA-transf_A.
    IPR012791. 3-oxoacid_CoA-transf_B.
    IPR014388. 3-oxoacid_CoA-transferase.
    IPR004165. CoA_trans_fam_I.
    IPR004164. CoA_transf_AS.
    IPR004163. CoA_transf_BS.
    [Graphical view]
    PANTHERiPTHR13707. PTHR13707. 1 hit.
    PfamiPF01144. CoA_trans. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000858. SCOT-t. 1 hit.
    SMARTiSM00882. CoA_trans. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR02429. pcaI_scoA_fam. 1 hit.
    TIGR02428. pcaJ_scoB_fam. 1 hit.
    PROSITEiPS01273. COA_TRANSF_1. 1 hit.
    PS01274. COA_TRANSF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JJN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALRLLAWA LPRGVSALRP PPALPHRLIR RYVSDRSGSV HFYTDPVKAV    50
    EGVKDGSTVM LGGFGLCGIP ENLIGALKTK GVKDLKIVSS NVGVDDFGLG 100
    ILLASKQVRR VVCSYLGENA LCEKLYLAGE LELEMTPQGT LAERIRAGGT 150
    GVPAFYTPTG YGTLVQEGGS PIRYAPDGHL ITLSEPREVR EFQGRFYLLE 200
    HAIRADFALI KGWKADRSGN VIFRGSARNF NVPMCKAADI SVVEVEEIVD 250
    VGTFAPEDIH VPNIYVDRVI KGPKFEKRIE RLTTRDSKPA PGSKDNDPSR 300
    TRIIKRAALE FQDGMYANLG IGIPVLASNY ISPKMTVYLH SENGILGLGP 350
    FPLKNEVDAD VINAGKQTVT VVPGGCFFAS DDSFAMIRGG HLQLTMLGAM 400
    QVSQYGDLAN WMVPGKKVKG MGGAMDLVSS KKTRVVVTME HCTKTKQPKI 450
    LKKCTMPLTG KRCVDLIITE KAVFEVNHSK GLTLVELWEG SSVDDIKATT 500
    ACSFAVSPNL KPMQQIKLDA 520
    Length:520
    Mass (Da):56,473
    Last modified:March 1, 2001 - v2
    Checksum:i16BAE0F546AFB993
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB022180 mRNA. Translation: BAA97654.2.
    AB105454 Genomic DNA. Translation: BAC87737.1.
    AK077075 mRNA. Translation: BAC36595.1.
    AL606917 Genomic DNA. Translation: CAM46094.1.
    BC137887 mRNA. Translation: AAI37888.1.
    BC137888 mRNA. Translation: AAI37889.1.
    CCDSiCCDS18617.1.
    RefSeqiNP_071316.1. NM_022033.4.
    UniGeneiMm.270287.

    Genome annotation databases

    EnsembliENSMUST00000102640; ENSMUSP00000099700; ENSMUSG00000076436.
    GeneIDi64059.
    KEGGimmu:64059.
    UCSCiuc008uph.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB022180 mRNA. Translation: BAA97654.2 .
    AB105454 Genomic DNA. Translation: BAC87737.1 .
    AK077075 mRNA. Translation: BAC36595.1 .
    AL606917 Genomic DNA. Translation: CAM46094.1 .
    BC137887 mRNA. Translation: AAI37888.1 .
    BC137888 mRNA. Translation: AAI37889.1 .
    CCDSi CCDS18617.1.
    RefSeqi NP_071316.1. NM_022033.4.
    UniGenei Mm.270287.

    3D structure databases

    ProteinModelPortali Q9JJN4.
    SMRi Q9JJN4. Positions 42-516.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9JJN4.
    PRIDEi Q9JJN4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102640 ; ENSMUSP00000099700 ; ENSMUSG00000076436 .
    GeneIDi 64059.
    KEGGi mmu:64059.
    UCSCi uc008uph.3. mouse.

    Organism-specific databases

    CTDi 64059.
    MGIi MGI:1891061. Oxct2a.

    Phylogenomic databases

    eggNOGi COG1788.
    GeneTreei ENSGT00390000009130.
    HOGENOMi HOG000221244.
    HOVERGENi HBG002310.
    InParanoidi Q9JJN4.
    KOi K01027.
    OMAi IRERMAQ.
    OrthoDBi EOG7XH6PR.
    PhylomeDBi Q9JJN4.
    TreeFami TF313991.

    Enzyme and pathway databases

    UniPathwayi UPA00929 ; UER00894 .
    BRENDAi 2.8.3.5. 3474.

    Miscellaneous databases

    NextBioi 319883.
    PROi Q9JJN4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JJN4.
    Genevestigatori Q9JJN4.

    Family and domain databases

    InterProi IPR012792. 3-oxoacid_CoA-transf_A.
    IPR012791. 3-oxoacid_CoA-transf_B.
    IPR014388. 3-oxoacid_CoA-transferase.
    IPR004165. CoA_trans_fam_I.
    IPR004164. CoA_transf_AS.
    IPR004163. CoA_transf_BS.
    [Graphical view ]
    PANTHERi PTHR13707. PTHR13707. 1 hit.
    Pfami PF01144. CoA_trans. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000858. SCOT-t. 1 hit.
    SMARTi SM00882. CoA_trans. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR02429. pcaI_scoA_fam. 1 hit.
    TIGR02428. pcaJ_scoB_fam. 1 hit.
    PROSITEi PS01273. COA_TRANSF_1. 1 hit.
    PS01274. COA_TRANSF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of haploid germ cell-specific succinyl CoA:3-oxo acid CoA transferase (scot-t1 and scot-t2)."
      Tanaka H., Koga M., Yomogida K., Iguchi N., Nozaki M., Onishi M., Egydio de Carvalho C., Nakamura Y., Miyagawa Y., Takeyama M., Matsumiya K., Okuyama A., Nishimune Y.
      (In) Robaire B., Chemes H., Morales C.R. (eds.); Andrology in the 21th Century. Proceeding of the VIIth International Congress of Andrology, pp.157-161, Medimond Press, Montreal (2001)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Testis.
    2. "Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b."
      Onishi M., Yasunaga T., Tanaka H., Nishimune Y., Nozaki M.
      Genomics 83:647-657(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiSCO2A_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJN4
    Secondary accession number(s): B9EHG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3