ID   FGF21_MOUSE             Reviewed;         210 AA.
AC   Q9JJN1;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   16-NOV-2011, entry version 81.
DE   RecName: Full=Fibroblast growth factor 21;
DE            Short=FGF-21;
DE   Flags: Precursor;
GN   Name=Fgf21;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   MEDLINE=20461777; PubMed=10858549; DOI=10.1016/S0167-4781(00)00067-1;
RA   Nishimura T., Nakatake Y., Konishi M., Itoh N.;
RT   "Identification of a novel FGF, FGF-21, preferentially expressed in
RT   the liver.";
RL   Biochim. Biophys. Acta 1492:203-206(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Pancreas;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=15902306; DOI=10.1172/JCI23606;
RA   Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R.,
RA   Galbreath E.J., Sandusky G.E., Hammond L.J., Moyers J.S., Owens R.A.,
RA   Gromada J., Brozinick J.T., Hawkins E.D., Wroblewski V.J., Li D.-S.,
RA   Mehrbod F., Jaskunas S.R., Shanafelt A.B.;
RT   "FGF-21 as a novel metabolic regulator.";
RL   J. Clin. Invest. 115:1627-1635(2005).
CC   -!- FUNCTION: Stimulates glucose uptake in differentiated adipocytes
CC       via the induction of glucose transporter SLC2A1/GLUT1 expression
CC       (but not SLC2A4/GLUT4 expression). Activity probably requires the
CC       presence of KLB.
CC   -!- SUBUNIT: Interacts (via C-terminus) with KLB; this interaction is
CC       direct. Interacts with FGFR4 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: Most abundantly expressed in the liver, also
CC       expressed in the thymus at lower levels.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
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DR   EMBL; AB025718; BAA99416.1; -; mRNA.
DR   EMBL; AK007574; BAB25115.1; -; mRNA.
DR   EMBL; BC049592; AAH49592.1; -; mRNA.
DR   IPI; IPI00122041; -.
DR   RefSeq; NP_064397.1; NM_020013.4.
DR   UniGene; Mm.143736; -.
DR   ProteinModelPortal; Q9JJN1; -.
DR   SMR; Q9JJN1; 43-173.
DR   STRING; Q9JJN1; -.
DR   PRIDE; Q9JJN1; -.
DR   Ensembl; ENSMUST00000033099; ENSMUSP00000033099; ENSMUSG00000030827.
DR   GeneID; 56636; -.
DR   KEGG; mmu:56636; -.
DR   UCSC; uc009gwe.1; mouse.
DR   CTD; 26291; -.
DR   MGI; MGI:1861377; Fgf21.
DR   eggNOG; roNOG15489; -.
DR   GeneTree; ENSGT00530000063469; -.
DR   HOGENOM; HBG126920; -.
DR   HOVERGEN; HBG051612; -.
DR   InParanoid; Q9JJN1; -.
DR   OMA; HPIPDSS; -.
DR   OrthoDB; EOG4T1HNJ; -.
DR   PhylomeDB; Q9JJN1; -.
DR   NextBio; 313077; -.
DR   ArrayExpress; Q9JJN1; -.
DR   Bgee; Q9JJN1; -.
DR   CleanEx; MM_FGF21; -.
DR   Genevestigator; Q9JJN1; -.
DR   GermOnline; ENSMUSG00000030827; Mus musculus.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR017338; Fibroblast_GF_15/19/21.
DR   InterPro; IPR002209; GF_heparin-bd.
DR   InterPro; IPR002348; IL1_HBGF.
DR   KO; K04358; -.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PIRSF; PIRSF037961; FGF-19_FGF-21; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   PRINTS; PR00262; IL1HBGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; Cytok_IL1_like; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL        1     28       Potential.
FT   CHAIN        29    210       Fibroblast growth factor 21.
FT                                /FTId=PRO_0000008995.
SQ   SEQUENCE   210 AA;  23237 MW;  AE02AABA6477E6F0 CRC64;
     MEWMRSRVGT LGLWVRLLLA VFLLGVYQAY PIPDSSPLLQ FGGQVRQRYL YTDDDQDTEA
     HLEIREDGTV VGAAHRSPES LLELKALKPG VIQILGVKAS RFLCQQPDGA LYGSPHFDPE
     ACSFRELLLE DGYNVYQSEA HGLPLRLPQK DSPNQDATSW GPVRFLPMPG LLHEPQDQAG
     FLPPEPPDVG SSDPLSMVEP LQGRSPSYAS
//