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Q9JJN1

- FGF21_MOUSE

UniProt

Q9JJN1 - FGF21_MOUSE

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Protein
Fibroblast growth factor 21
Gene
Fgf21
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB.1 Publication

GO - Biological processi

  1. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  2. positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: MGI
  3. positive regulation of cell proliferation Source: MGI
  4. positive regulation of glucose import Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 21
Short name:
FGF-21
Gene namesi
Name:Fgf21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1861377. Fgf21.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 210182Fibroblast growth factor 21
PRO_0000008995Add
BLAST

Proteomic databases

PRIDEiQ9JJN1.

Expressioni

Tissue specificityi

Most abundantly expressed in the liver, also expressed in the thymus at lower levels.1 Publication

Gene expression databases

BgeeiQ9JJN1.
CleanExiMM_FGF21.
GenevestigatoriQ9JJN1.

Interactioni

Subunit structurei

Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033099.

Structurei

3D structure databases

ProteinModelPortaliQ9JJN1.
SMRiQ9JJN1. Positions 61-169.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG311125.
GeneTreeiENSGT00530000063469.
HOGENOMiHOG000112572.
HOVERGENiHBG051612.
InParanoidiQ9JJN1.
KOiK04358.
OMAiTLYGSLH.
OrthoDBiEOG7X6M1F.
PhylomeDBiQ9JJN1.
TreeFamiTF335872.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028292. FGF21.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF62. PTHR11486:SF62. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJN1-1 [UniParc]FASTAAdd to Basket

« Hide

MEWMRSRVGT LGLWVRLLLA VFLLGVYQAY PIPDSSPLLQ FGGQVRQRYL    50
YTDDDQDTEA HLEIREDGTV VGAAHRSPES LLELKALKPG VIQILGVKAS 100
RFLCQQPDGA LYGSPHFDPE ACSFRELLLE DGYNVYQSEA HGLPLRLPQK 150
DSPNQDATSW GPVRFLPMPG LLHEPQDQAG FLPPEPPDVG SSDPLSMVEP 200
LQGRSPSYAS 210
Length:210
Mass (Da):23,237
Last modified:October 1, 2000 - v1
Checksum:iAE02AABA6477E6F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025718 mRNA. Translation: BAA99416.1.
AK007574 mRNA. Translation: BAB25115.1.
BC049592 mRNA. Translation: AAH49592.1.
CCDSiCCDS21253.1.
RefSeqiNP_064397.1. NM_020013.4.
UniGeneiMm.143736.

Genome annotation databases

EnsembliENSMUST00000033099; ENSMUSP00000033099; ENSMUSG00000030827.
GeneIDi56636.
KEGGimmu:56636.
UCSCiuc009gwe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025718 mRNA. Translation: BAA99416.1 .
AK007574 mRNA. Translation: BAB25115.1 .
BC049592 mRNA. Translation: AAH49592.1 .
CCDSi CCDS21253.1.
RefSeqi NP_064397.1. NM_020013.4.
UniGenei Mm.143736.

3D structure databases

ProteinModelPortali Q9JJN1.
SMRi Q9JJN1. Positions 61-169.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033099.

Proteomic databases

PRIDEi Q9JJN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033099 ; ENSMUSP00000033099 ; ENSMUSG00000030827 .
GeneIDi 56636.
KEGGi mmu:56636.
UCSCi uc009gwe.1. mouse.

Organism-specific databases

CTDi 26291.
MGIi MGI:1861377. Fgf21.

Phylogenomic databases

eggNOGi NOG311125.
GeneTreei ENSGT00530000063469.
HOGENOMi HOG000112572.
HOVERGENi HBG051612.
InParanoidi Q9JJN1.
KOi K04358.
OMAi TLYGSLH.
OrthoDBi EOG7X6M1F.
PhylomeDBi Q9JJN1.
TreeFami TF335872.

Miscellaneous databases

NextBioi 313077.
PROi Q9JJN1.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJN1.
CleanExi MM_FGF21.
Genevestigatori Q9JJN1.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028292. FGF21.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF62. PTHR11486:SF62. 1 hit.
Pfami PF00167. FGF. 1 hit.
[Graphical view ]
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel FGF, FGF-21, preferentially expressed in the liver."
    Nishimura T., Nakatake Y., Konishi M., Itoh N.
    Biochim. Biophys. Acta 1492:203-206(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: FUNCTION.

Entry informationi

Entry nameiFGF21_MOUSE
AccessioniPrimary (citable) accession number: Q9JJN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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