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Protein

Fibroblast growth factor 21

Gene

Fgf21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 21
Short name:
FGF-21
Gene namesi
Name:Fgf21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1861377 Fgf21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000899529 – 210Fibroblast growth factor 21Add BLAST182

Proteomic databases

PaxDbiQ9JJN1
PRIDEiQ9JJN1

Expressioni

Tissue specificityi

Most abundantly expressed in the liver, also expressed in the thymus at lower levels.1 Publication

Gene expression databases

BgeeiENSMUSG00000030827
CleanExiMM_FGF21
GenevisibleiQ9JJN1 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60919N
IntActiQ9JJN1, 2 interactors
STRINGi10090.ENSMUSP00000033099

Structurei

3D structure databases

ProteinModelPortaliQ9JJN1
SMRiQ9JJN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00530000063469
HOGENOMiHOG000112572
HOVERGENiHBG051612
InParanoidiQ9JJN1
KOiK22429
OMAiYNIYHSE
OrthoDBiEOG091G0NAY
PhylomeDBiQ9JJN1
TreeFamiTF335872

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR035444 FGF15/19/21
IPR028292 FGF21
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF81 PTHR11486:SF81, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PIRSFiPIRSF037961 FGF-19_FGF-21, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWMRSRVGT LGLWVRLLLA VFLLGVYQAY PIPDSSPLLQ FGGQVRQRYL
60 70 80 90 100
YTDDDQDTEA HLEIREDGTV VGAAHRSPES LLELKALKPG VIQILGVKAS
110 120 130 140 150
RFLCQQPDGA LYGSPHFDPE ACSFRELLLE DGYNVYQSEA HGLPLRLPQK
160 170 180 190 200
DSPNQDATSW GPVRFLPMPG LLHEPQDQAG FLPPEPPDVG SSDPLSMVEP
210
LQGRSPSYAS
Length:210
Mass (Da):23,237
Last modified:October 1, 2000 - v1
Checksum:iAE02AABA6477E6F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025718 mRNA Translation: BAA99416.1
AK007574 mRNA Translation: BAB25115.1
BC049592 mRNA Translation: AAH49592.1
CCDSiCCDS21253.1
RefSeqiNP_064397.1, NM_020013.4
XP_011249181.1, XM_011250879.1
XP_011249182.1, XM_011250880.1
UniGeneiMm.143736

Genome annotation databases

EnsembliENSMUST00000033099; ENSMUSP00000033099; ENSMUSG00000030827
GeneIDi56636
KEGGimmu:56636
UCSCiuc009gwe.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFGF21_MOUSE
AccessioniPrimary (citable) accession number: Q9JJN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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