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Q9JJN1

- FGF21_MOUSE

UniProt

Q9JJN1 - FGF21_MOUSE

Protein

Fibroblast growth factor 21

Gene

Fgf21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB.1 Publication

    GO - Biological processi

    1. positive regulation of cell proliferation Source: MGI
    2. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    3. positive regulation of glucose import Source: Ensembl
    4. positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 21
    Short name:
    FGF-21
    Gene namesi
    Name:Fgf21
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1861377. Fgf21.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 210182Fibroblast growth factor 21PRO_0000008995Add
    BLAST

    Proteomic databases

    PRIDEiQ9JJN1.

    Expressioni

    Tissue specificityi

    Most abundantly expressed in the liver, also expressed in the thymus at lower levels.1 Publication

    Gene expression databases

    BgeeiQ9JJN1.
    CleanExiMM_FGF21.
    GenevestigatoriQ9JJN1.

    Interactioni

    Subunit structurei

    Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4 By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-60919N.
    STRINGi10090.ENSMUSP00000033099.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJN1.
    SMRiQ9JJN1. Positions 61-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG311125.
    GeneTreeiENSGT00530000063469.
    HOGENOMiHOG000112572.
    HOVERGENiHBG051612.
    InParanoidiQ9JJN1.
    KOiK04358.
    OMAiTLYGSLH.
    OrthoDBiEOG7X6M1F.
    PhylomeDBiQ9JJN1.
    TreeFamiTF335872.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028292. FGF21.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF62. PTHR11486:SF62. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JJN1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEWMRSRVGT LGLWVRLLLA VFLLGVYQAY PIPDSSPLLQ FGGQVRQRYL    50
    YTDDDQDTEA HLEIREDGTV VGAAHRSPES LLELKALKPG VIQILGVKAS 100
    RFLCQQPDGA LYGSPHFDPE ACSFRELLLE DGYNVYQSEA HGLPLRLPQK 150
    DSPNQDATSW GPVRFLPMPG LLHEPQDQAG FLPPEPPDVG SSDPLSMVEP 200
    LQGRSPSYAS 210
    Length:210
    Mass (Da):23,237
    Last modified:October 1, 2000 - v1
    Checksum:iAE02AABA6477E6F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025718 mRNA. Translation: BAA99416.1.
    AK007574 mRNA. Translation: BAB25115.1.
    BC049592 mRNA. Translation: AAH49592.1.
    CCDSiCCDS21253.1.
    RefSeqiNP_064397.1. NM_020013.4.
    UniGeneiMm.143736.

    Genome annotation databases

    EnsembliENSMUST00000033099; ENSMUSP00000033099; ENSMUSG00000030827.
    GeneIDi56636.
    KEGGimmu:56636.
    UCSCiuc009gwe.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025718 mRNA. Translation: BAA99416.1 .
    AK007574 mRNA. Translation: BAB25115.1 .
    BC049592 mRNA. Translation: AAH49592.1 .
    CCDSi CCDS21253.1.
    RefSeqi NP_064397.1. NM_020013.4.
    UniGenei Mm.143736.

    3D structure databases

    ProteinModelPortali Q9JJN1.
    SMRi Q9JJN1. Positions 61-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60919N.
    STRINGi 10090.ENSMUSP00000033099.

    Proteomic databases

    PRIDEi Q9JJN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033099 ; ENSMUSP00000033099 ; ENSMUSG00000030827 .
    GeneIDi 56636.
    KEGGi mmu:56636.
    UCSCi uc009gwe.1. mouse.

    Organism-specific databases

    CTDi 26291.
    MGIi MGI:1861377. Fgf21.

    Phylogenomic databases

    eggNOGi NOG311125.
    GeneTreei ENSGT00530000063469.
    HOGENOMi HOG000112572.
    HOVERGENi HBG051612.
    InParanoidi Q9JJN1.
    KOi K04358.
    OMAi TLYGSLH.
    OrthoDBi EOG7X6M1F.
    PhylomeDBi Q9JJN1.
    TreeFami TF335872.

    Miscellaneous databases

    NextBioi 313077.
    PROi Q9JJN1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JJN1.
    CleanExi MM_FGF21.
    Genevestigatori Q9JJN1.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028292. FGF21.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF62. PTHR11486:SF62. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel FGF, FGF-21, preferentially expressed in the liver."
      Nishimura T., Nakatake Y., Konishi M., Itoh N.
      Biochim. Biophys. Acta 1492:203-206(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pancreas.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: FUNCTION.

    Entry informationi

    Entry nameiFGF21_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3