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Q9JJN1 (FGF21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 16, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 21
Short name=FGF-21
Gene names
Name:Fgf21
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB. Ref.4

Subunit structure

Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4 By similarity.

Subcellular location

Secreted Potential.

Tissue specificity

Most abundantly expressed in the liver, also expressed in the thymus at lower levels. Ref.1

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionfibroblast growth factor receptor binding

Inferred from electronic annotation. Source: InterPro

growth factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 210182Fibroblast growth factor 21
PRO_0000008995

Sequences

Sequence LengthMass (Da)Tools
Q9JJN1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: AE02AABA6477E6F0

FASTA21023,237
        10         20         30         40         50         60 
MEWMRSRVGT LGLWVRLLLA VFLLGVYQAY PIPDSSPLLQ FGGQVRQRYL YTDDDQDTEA 

        70         80         90        100        110        120 
HLEIREDGTV VGAAHRSPES LLELKALKPG VIQILGVKAS RFLCQQPDGA LYGSPHFDPE 

       130        140        150        160        170        180 
ACSFRELLLE DGYNVYQSEA HGLPLRLPQK DSPNQDATSW GPVRFLPMPG LLHEPQDQAG 

       190        200        210 
FLPPEPPDVG SSDPLSMVEP LQGRSPSYAS

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel FGF, FGF-21, preferentially expressed in the liver."
Nishimura T., Nakatake Y., Konishi M., Itoh N.
Biochim. Biophys. Acta 1492:203-206(2000) [PubMed: 10858549] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Pancreas.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"FGF-21 as a novel metabolic regulator."
Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R., Galbreath E.J., Sandusky G.E., Hammond L.J., Moyers J.S., Owens R.A., Gromada J., Brozinick J.T., Hawkins E.D., Wroblewski V.J., Li D.-S., Mehrbod F., Jaskunas S.R., Shanafelt A.B.
J. Clin. Invest. 115:1627-1635(2005) [PubMed: 15902306] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB025718 mRNA. Translation: BAA99416.1.
AK007574 mRNA. Translation: BAB25115.1.
BC049592 mRNA. Translation: AAH49592.1.
IPIIPI00122041.
RefSeqNP_064397.1. NM_020013.4.
XP_003689537.1. XM_003689489.1.
UniGeneMm.143736.

3D structure databases

ProteinModelPortalQ9JJN1.
SMRQ9JJN1. Positions 43-173.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9JJN1.

Proteomic databases

PRIDEQ9JJN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033099; ENSMUSP00000033099; ENSMUSG00000030827.
GeneID100862558.
56636.
KEGGmmu:56636.
UCSCuc009gwe.1. mouse.

Organism-specific databases

CTD26291.
MGIMGI:1861377. Fgf21.

Phylogenomic databases

eggNOGNOG311125.
GeneTreeENSGT00530000063469.
HOGENOMHOG000112572.
HOVERGENHBG051612.
InParanoidQ9JJN1.
KOK04358.
OMAHPIPDSS.
OrthoDBEOG4T1HNJ.

Gene expression databases

ArrayExpressQ9JJN1.
BgeeQ9JJN1.
CleanExMM_FGF21.
GenevestigatorQ9JJN1.
GermOnlineENSMUSG00000030827. Mus musculus.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR017338. Fibroblast_GF_15/19/21.
IPR002209. GF_heparin-bd.
IPR002348. IL1_HBGF.
[Graphical view]
PANTHERPTHR11486. IL1_HBGF. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PIRSFPIRSF037961. FGF-19_FGF-21. 1 hit.
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. Cytok_IL1_like. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio313077.
SOURCESearch...

Entry information

Entry nameFGF21_MOUSE
AccessionPrimary (citable) accession number: Q9JJN1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 16, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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