Reviewed,
UniProtKB/Swiss-Prot Q9JJN1 (FGF21_MOUSE)
Last modified
January 19, 2010.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Fibroblast growth factor 21 Short name=FGF-21 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 210 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB. Ref.4 |
| Subunit structure | Interacts (via C-terminus) with KLB; this interaction is direct By similarity. |
| Subcellular location | Secreted Potential. |
| Tissue specificity | Most abundantly expressed in the liver, also expressed in the thymus at lower levels. Ref.1 |
| Sequence similarities | Belongs to the heparin-binding growth factors family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Growth factor |
| Gene Ontology (GO) | |
| Biological process | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Inferred from genetic interaction. Source: MGI positive regulation of cell proliferationInferred from genetic interaction. Source: MGI |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB025718 mRNA. Translation: BAA99416.1. AK007574 mRNA. Translation: BAB25115.1. BC049592 mRNA. Translation: AAH49592.1. |
| IPI | IPI00122041. |
| RefSeq | NP_064397.1. |
| UniGene | Mm.143736 |
3D structure databases | |
| SMR | Q9JJN1. Positions 45-175. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9JJN1. |
Proteomic databases | |
| PRIDE | Q9JJN1. |
Genome annotation databases | |
| Ensembl | ENSMUST00000033099; ENSMUSP00000033099; ENSMUSG00000030827; Mus musculus. [Genome view] |
| GeneID | 56636. |
| KEGG | mmu:56636. |
| UCSC | uc009gwe.1. mouse. |
Organism-specific databases | |
| CTD | 56636. |
| MGI | MGI:1861377. Fgf21. |
Phylogenomic databases | |
| eggNOG | roNOG15489. |
| HOGENOM | HBG126920. |
| HOVERGEN | Q9JJN1. |
| InParanoid | Q9JJN1. |
| OMA | HPIPDSS. |
| OrthoDB | EOG9HHRMK. |
| PhylomeDB | Q9JJN1. |
Gene expression databases | |
| ArrayExpress | Q9JJN1. |
| Bgee | Q9JJN1. |
| CleanEx | MM_FGF21. |
| Genevestigator | Q9JJN1. |
| GermOnline | ENSMUSG00000030827. Mus musculus. |
Family and domain databases | |
| InterPro | IPR008996. Cytokine_IL1-like. IPR017338. Fibroblast_GF_15/19/21. IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view] |
| PANTHER | PTHR11486. IL1_HBGF. 1 hit. |
| Pfam | PF00167. FGF. 1 hit. [Graphical view] |
| PIRSF | PIRSF037961. FGF-19_FGF-21. 1 hit. |
| PRINTS | PR00263. HBGFFGF. PR00262. IL1HBGF. |
| SMART | SM00442. FGF. 1 hit. [Graphical view] |
| PROSITE | PS00247. HBGF_FGF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 313077. |
| SOURCE | Search... |
Entry information
| Entry name | FGF21_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9JJN1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


