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Q9JJM9

- SEPT5_RAT

UniProt

Q9JJM9 - SEPT5_RAT

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Protein

Septin-5

Gene

Sept5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851GTPBy similarity
Binding sitei111 – 1111GTP; via amide nitrogenBy similarity
Binding sitei248 – 2481GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei263 – 2631GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 588GTPBy similarity
Nucleotide bindingi190 – 1989GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB
  3. phosphatidylinositol binding Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. syntaxin binding Source: RGD

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. positive regulation of exocytosis Source: RGD
  4. regulation of exocytosis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-5
Alternative name(s):
Cell division control-related protein 1
Short name:
CDCrel-1
Peanut-like protein 1
Gene namesi
Name:Sept5
Synonyms:Pnutl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621763. Sept5.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cleavage furrow Source: UniProtKB
  2. plasma membrane Source: UniProtKB
  3. septin complex Source: UniProtKB
  4. stress fiber Source: UniProtKB
  5. synaptic vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Septin-5PRO_0000173524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei225 – 2251PhosphoserineBy similarity
Modified residuei327 – 3271PhosphoserineBy similarity
Modified residuei336 – 3361PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9JJM9.

PTM databases

PhosphoSiteiQ9JJM9.

Expressioni

Tissue specificityi

Expressed in brain and testis and at lower level in heart, spleen, lung and kidney.1 Publication

Gene expression databases

GenevestigatoriQ9JJM9.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2 and SEPT5. In platelets, associated with a complex containing STX4. Interacts with PARK2. This interaction leads to SEPT5 ubiquitination and degradation (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9JJM9. 3 interactions.
STRINGi10116.ENSRNOP00000042895.

Structurei

3D structure databases

ProteinModelPortaliQ9JJM9.
SMRiQ9JJM9. Positions 27-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 314274Septin-type GAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili338 – 36932Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ9JJM9.
KOiK04557.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JJM9-1) [UniParc]FASTAAdd to Basket

Also known as: CDCrel-1F

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA
60 70 80 90 100
GESGLGKSTL VHSLFLTDLY KDRKLLSAEE RINQTVEILK HTVDIEEKGV
110 120 130 140 150
KLKLTIVDTP GFGDAVNNFE CWKPITDYVD QQFEQYFRDE SGLNRKNIQD
160 170 180 190 200
NRVHCCLYFI SPFGHGLRPV DVGFMKALHE KVNIVPLIAK ADCLVPSEIR
210 220 230 240 250
KLKDRIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE SAPFAVIGSN
260 270 280 290 300
TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC
310 320 330 340 350
DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDSE TEKLIRMKDE
360
ELRRMQEMLQ KMKQRMQDQ
Length:369
Mass (Da):42,852
Last modified:December 6, 2005 - v2
Checksum:iFBE46DDAAB7DFC77
GO
Isoform 2 (identifier: Q9JJM9-2) [UniParc]FASTAAdd to Basket

Also known as: CDCrel-1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MSTGLRYKSKLATPEDKQ → MDSLAAPQDRLVEQLLSPRTQAQRRLK

Show »
Length:378
Mass (Da):43,920
Checksum:iB3341620323B4A49
GO
Isoform 3 (identifier: Q9JJM9-3) [UniParc]FASTAAdd to Basket

Also known as: CDCrel-1AI

The sequence of this isoform differs from the canonical sequence as follows:
     352-356: LRRMQ → GRAGR
     357-369: Missing.

Show »
Length:356
Mass (Da):40,989
Checksum:i87B852E69B406761
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818MSTGL…PEDKQ → MDSLAAPQDRLVEQLLSPRT QAQRRLK in isoform 2. 1 PublicationVSP_016539Add
BLAST
Alternative sequencei352 – 3565LRRMQ → GRAGR in isoform 3. 1 PublicationVSP_016540
Alternative sequencei357 – 36913Missing in isoform 3. 1 PublicationVSP_016541Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027143 mRNA. Translation: BAA98051.1.
AB027144 mRNA. Translation: BAB87114.1.
AB027145 mRNA. Translation: BAA98052.1.
RefSeqiNP_446383.3. NM_053931.3. [Q9JJM9-2]
UniGeneiRn.96497.

Genome annotation databases

GeneIDi116728.
KEGGirno:116728.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027143 mRNA. Translation: BAA98051.1 .
AB027144 mRNA. Translation: BAB87114.1 .
AB027145 mRNA. Translation: BAA98052.1 .
RefSeqi NP_446383.3. NM_053931.3. [Q9JJM9-2 ]
UniGenei Rn.96497.

3D structure databases

ProteinModelPortali Q9JJM9.
SMRi Q9JJM9. Positions 27-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JJM9. 3 interactions.
STRINGi 10116.ENSRNOP00000042895.

PTM databases

PhosphoSitei Q9JJM9.

Proteomic databases

PRIDEi Q9JJM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 116728.
KEGGi rno:116728.

Organism-specific databases

CTDi 5413.
RGDi 621763. Sept5.

Phylogenomic databases

HOGENOMi HOG000233586.
HOVERGENi HBG065093.
InParanoidi Q9JJM9.
KOi K04557.

Miscellaneous databases

NextBioi 619662.
PROi Q9JJM9.

Gene expression databases

Genevestigatori Q9JJM9.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view ]
PANTHERi PTHR18884. PTHR18884. 1 hit.
Pfami PF00735. Septin. 1 hit.
[Graphical view ]
PIRSFi PIRSF006698. Septin. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51719. G_SEPTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Reciprocal expression of infant- and adult preferring transcripts of CDCrel-1 septin in the rat neocortex."
    Tada S., Kajii Y., Sato M., Nishikawa T.
    Biochem. Biophys. Res. Commun. 273:723-728(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Neonatal brain.
  2. Lubec G., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 23-36 AND 297-308, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiSEPT5_RAT
AccessioniPrimary (citable) accession number: Q9JJM9
Secondary accession number(s): Q8R2F7, Q9JJM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3