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Q9JJM9 (SEPT5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Septin-5
Alternative name(s):
Cell division control-related protein 1
Short name=CDCrel-1
Peanut-like protein 1
Gene names
Name:Sept5
Synonyms:Pnutl1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential. May play a role in platelet secretion By similarity.

Subunit structure

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2 and SEPT5. In platelets, associated with a complex containing STX4. Interacts with PARK2. This interaction leads to SEPT5 ubiquitination and degradation By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity.

Tissue specificity

Expressed in brain and testis and at lower level in heart, spleen, lung and kidney. Ref.1

Sequence similarities

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

Contains 1 septin-type G (guanine nucleotide-binding) domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   LigandGTP-binding
Nucleotide-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of exocytosis

Inferred from mutant phenotype PubMed 10321247. Source: RGD

regulation of exocytosis

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcleavage furrow

Inferred from direct assay PubMed 17685441. Source: UniProtKB

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

septin complex

Inferred from direct assay PubMed 17685441. Source: UniProtKB

stress fiber

Inferred from direct assay PubMed 17685441. Source: UniProtKB

synaptic vesicle

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionGDP binding

Inferred from direct assay PubMed 17685441. Source: UniProtKB

GTP binding

Inferred from direct assay PubMed 17685441. Source: UniProtKB

phosphatidylinositol binding

Inferred from direct assay PubMed 17685441. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 17685441. Source: UniProtKB

protein homodimerization activity

Inferred from physical interaction PubMed 17685441. Source: UniProtKB

syntaxin binding

Inferred from mutant phenotype PubMed 10321247. Source: RGD

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9JJM9-1)

Also known as: CDCrel-1F;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9JJM9-2)

Also known as: CDCrel-1A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MSTGLRYKSKLATPEDKQ → MDSLAAPQDRLVEQLLSPRTQAQRRLK
Isoform 3 (identifier: Q9JJM9-3)

Also known as: CDCrel-1AI;

The sequence of this isoform differs from the canonical sequence as follows:
     352-356: LRRMQ → GRAGR
     357-369: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Septin-5
PRO_0000173524

Regions

Domain41 – 314274Septin-type G
Nucleotide binding51 – 588GTP By similarity
Nucleotide binding190 – 1989GTP By similarity
Coiled coil338 – 36932 Potential

Sites

Binding site851GTP By similarity
Binding site1111GTP; via amide nitrogen By similarity
Binding site2481GTP; via amide nitrogen and carbonyl oxygen By similarity
Binding site2631GTP By similarity

Amino acid modifications

Modified residue2251Phosphoserine By similarity
Modified residue3271Phosphoserine By similarity
Modified residue3361Phosphothreonine By similarity

Natural variations

Alternative sequence1 – 1818MSTGL…PEDKQ → MDSLAAPQDRLVEQLLSPRT QAQRRLK in isoform 2.
VSP_016539
Alternative sequence352 – 3565LRRMQ → GRAGR in isoform 3.
VSP_016540
Alternative sequence357 – 36913Missing in isoform 3.
VSP_016541

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (CDCrel-1F) [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: FBE46DDAAB7DFC77

FASTA36942,852
        10         20         30         40         50         60 
MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL 

        70         80         90        100        110        120 
VHSLFLTDLY KDRKLLSAEE RINQTVEILK HTVDIEEKGV KLKLTIVDTP GFGDAVNNFE 

       130        140        150        160        170        180 
CWKPITDYVD QQFEQYFRDE SGLNRKNIQD NRVHCCLYFI SPFGHGLRPV DVGFMKALHE 

       190        200        210        220        230        240 
KVNIVPLIAK ADCLVPSEIR KLKDRIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE 

       250        260        270        280        290        300 
SAPFAVIGSN TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC 

       310        320        330        340        350        360 
DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDSE TEKLIRMKDE ELRRMQEMLQ 


KMKQRMQDQ 

« Hide

Isoform 2 (CDCrel-1A) [UniParc].

Checksum: B3341620323B4A49
Show »

FASTA37843,920
Isoform 3 (CDCrel-1AI) [UniParc].

Checksum: 87B852E69B406761
Show »

FASTA35640,989

References

[1]"Reciprocal expression of infant- and adult preferring transcripts of CDCrel-1 septin in the rat neocortex."
Tada S., Kajii Y., Sato M., Nishikawa T.
Biochem. Biophys. Res. Commun. 273:723-728(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
Strain: Wistar.
Tissue: Neonatal brain.
[2]Lubec G., Diao W.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 23-36 AND 297-308, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB027143 mRNA. Translation: BAA98051.1.
AB027144 mRNA. Translation: BAB87114.1.
AB027145 mRNA. Translation: BAA98052.1.
RefSeqNP_446383.3. NM_053931.3. [Q9JJM9-2]
UniGeneRn.96497.

3D structure databases

ProteinModelPortalQ9JJM9.
SMRQ9JJM9. Positions 27-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9JJM9. 3 interactions.
STRING10116.ENSRNOP00000042895.

PTM databases

PhosphoSiteQ9JJM9.

Proteomic databases

PRIDEQ9JJM9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID116728.
KEGGrno:116728.

Organism-specific databases

CTD5413.
RGD621763. Sept5.

Phylogenomic databases

HOGENOMHOG000233586.
HOVERGENHBG065093.
KOK04557.

Gene expression databases

GenevestigatorQ9JJM9.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERPTHR18884. PTHR18884. 1 hit.
PfamPF00735. Septin. 1 hit.
[Graphical view]
PIRSFPIRSF006698. Septin. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio619662.
PROQ9JJM9.

Entry information

Entry nameSEPT5_RAT
AccessionPrimary (citable) accession number: Q9JJM9
Secondary accession number(s): Q8R2F7, Q9JJM8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families