Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JJM9

- SEPT5_RAT

UniProt

Q9JJM9 - SEPT5_RAT

Protein

Septin-5

Gene

Sept5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential. May play a role in platelet secretion By similarity.By similarityCurated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851GTPBy similarity
    Binding sitei111 – 1111GTP; via amide nitrogenBy similarity
    Binding sitei248 – 2481GTP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei263 – 2631GTPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi51 – 588GTPBy similarity
    Nucleotide bindingi190 – 1989GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTP binding Source: UniProtKB
    3. phosphatidylinositol binding Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. protein homodimerization activity Source: UniProtKB
    6. syntaxin binding Source: RGD

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. positive regulation of exocytosis Source: RGD
    4. regulation of exocytosis Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Septin-5
    Alternative name(s):
    Cell division control-related protein 1
    Short name:
    CDCrel-1
    Peanut-like protein 1
    Gene namesi
    Name:Sept5
    Synonyms:Pnutl1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621763. Sept5.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cleavage furrow Source: UniProtKB
    2. plasma membrane Source: UniProtKB
    3. septin complex Source: UniProtKB
    4. stress fiber Source: UniProtKB
    5. synaptic vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Septin-5PRO_0000173524Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei225 – 2251PhosphoserineBy similarity
    Modified residuei327 – 3271PhosphoserineBy similarity
    Modified residuei336 – 3361PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9JJM9.

    PTM databases

    PhosphoSiteiQ9JJM9.

    Expressioni

    Tissue specificityi

    Expressed in brain and testis and at lower level in heart, spleen, lung and kidney.1 Publication

    Gene expression databases

    GenevestigatoriQ9JJM9.

    Interactioni

    Subunit structurei

    Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2 and SEPT5. In platelets, associated with a complex containing STX4. Interacts with PARK2. This interaction leads to SEPT5 ubiquitination and degradation By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9JJM9. 3 interactions.
    STRINGi10116.ENSRNOP00000042895.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJM9.
    SMRiQ9JJM9. Positions 27-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 314274Septin-type GAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili338 – 36932Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    HOGENOMiHOG000233586.
    HOVERGENiHBG065093.
    KOiK04557.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    [Graphical view]
    PANTHERiPTHR18884. PTHR18884. 1 hit.
    PfamiPF00735. Septin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006698. Septin. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51719. G_SEPTIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JJM9-1) [UniParc]FASTAAdd to Basket

    Also known as: CDCrel-1F

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA    50
    GESGLGKSTL VHSLFLTDLY KDRKLLSAEE RINQTVEILK HTVDIEEKGV 100
    KLKLTIVDTP GFGDAVNNFE CWKPITDYVD QQFEQYFRDE SGLNRKNIQD 150
    NRVHCCLYFI SPFGHGLRPV DVGFMKALHE KVNIVPLIAK ADCLVPSEIR 200
    KLKDRIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE SAPFAVIGSN 250
    TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC 300
    DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDSE TEKLIRMKDE 350
    ELRRMQEMLQ KMKQRMQDQ 369
    Length:369
    Mass (Da):42,852
    Last modified:December 6, 2005 - v2
    Checksum:iFBE46DDAAB7DFC77
    GO
    Isoform 2 (identifier: Q9JJM9-2) [UniParc]FASTAAdd to Basket

    Also known as: CDCrel-1A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: MSTGLRYKSKLATPEDKQ → MDSLAAPQDRLVEQLLSPRTQAQRRLK

    Show »
    Length:378
    Mass (Da):43,920
    Checksum:iB3341620323B4A49
    GO
    Isoform 3 (identifier: Q9JJM9-3) [UniParc]FASTAAdd to Basket

    Also known as: CDCrel-1AI

    The sequence of this isoform differs from the canonical sequence as follows:
         352-356: LRRMQ → GRAGR
         357-369: Missing.

    Show »
    Length:356
    Mass (Da):40,989
    Checksum:i87B852E69B406761
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1818MSTGL…PEDKQ → MDSLAAPQDRLVEQLLSPRT QAQRRLK in isoform 2. 1 PublicationVSP_016539Add
    BLAST
    Alternative sequencei352 – 3565LRRMQ → GRAGR in isoform 3. 1 PublicationVSP_016540
    Alternative sequencei357 – 36913Missing in isoform 3. 1 PublicationVSP_016541Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027143 mRNA. Translation: BAA98051.1.
    AB027144 mRNA. Translation: BAB87114.1.
    AB027145 mRNA. Translation: BAA98052.1.
    RefSeqiNP_446383.3. NM_053931.3. [Q9JJM9-2]
    UniGeneiRn.96497.

    Genome annotation databases

    GeneIDi116728.
    KEGGirno:116728.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027143 mRNA. Translation: BAA98051.1 .
    AB027144 mRNA. Translation: BAB87114.1 .
    AB027145 mRNA. Translation: BAA98052.1 .
    RefSeqi NP_446383.3. NM_053931.3. [Q9JJM9-2 ]
    UniGenei Rn.96497.

    3D structure databases

    ProteinModelPortali Q9JJM9.
    SMRi Q9JJM9. Positions 27-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JJM9. 3 interactions.
    STRINGi 10116.ENSRNOP00000042895.

    PTM databases

    PhosphoSitei Q9JJM9.

    Proteomic databases

    PRIDEi Q9JJM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 116728.
    KEGGi rno:116728.

    Organism-specific databases

    CTDi 5413.
    RGDi 621763. Sept5.

    Phylogenomic databases

    HOGENOMi HOG000233586.
    HOVERGENi HBG065093.
    KOi K04557.

    Miscellaneous databases

    NextBioi 619662.
    PROi Q9JJM9.

    Gene expression databases

    Genevestigatori Q9JJM9.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    [Graphical view ]
    PANTHERi PTHR18884. PTHR18884. 1 hit.
    Pfami PF00735. Septin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006698. Septin. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51719. G_SEPTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reciprocal expression of infant- and adult preferring transcripts of CDCrel-1 septin in the rat neocortex."
      Tada S., Kajii Y., Sato M., Nishikawa T.
      Biochem. Biophys. Res. Commun. 273:723-728(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
      Strain: Wistar.
      Tissue: Neonatal brain.
    2. Lubec G., Diao W.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 23-36 AND 297-308, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiSEPT5_RAT
    AccessioniPrimary (citable) accession number: Q9JJM9
    Secondary accession number(s): Q8R2F7, Q9JJM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3