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Protein

Septin-5

Gene

Sept5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85GTPBy similarity1
Binding sitei111GTP; via amide nitrogenBy similarity1
Binding sitei248GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei263GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 58GTPBy similarity8
Nucleotide bindingi190 – 198GTPBy similarity9

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTP binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • syntaxin binding Source: RGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • positive regulation of exocytosis Source: RGD
  • regulation of exocytosis Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-5
Alternative name(s):
Cell division control-related protein 1
Short name:
CDCrel-1
Peanut-like protein 1
Gene namesi
Name:Sept5
Synonyms:Pnutl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi621763 Sept5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735241 – 369Septin-5Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphothreonineCombined sources1
Modified residuei168Omega-N-methylarginineBy similarity1
Modified residuei225PhosphoserineCombined sources1
Modified residuei327PhosphoserineBy similarity1
Modified residuei336PhosphothreonineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9JJM9
PRIDEiQ9JJM9

PTM databases

iPTMnetiQ9JJM9
PhosphoSitePlusiQ9JJM9

Expressioni

Tissue specificityi

Expressed in brain and testis and at lower level in heart, spleen, lung and kidney.1 Publication

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2 and SEPT5. In platelets, associated with a complex containing STX4. Interacts with PRKN. This interaction leads to SEPT5 ubiquitination and degradation (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • syntaxin binding Source: RGD

Protein-protein interaction databases

IntActiQ9JJM9, 3 interactors
STRINGi10116.ENSRNOP00000039995

Structurei

3D structure databases

ProteinModelPortaliQ9JJM9
SMRiQ9JJM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 314Septin-type GPROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 58G1 motifPROSITE-ProRule annotation8
Regioni108 – 111G3 motifPROSITE-ProRule annotation4
Regioni189 – 192G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili338 – 369Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ9JJM9

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030647 SEPT5
IPR016491 Septin
PANTHERiPTHR18884:SF68 PTHR18884:SF68, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JJM9-1) [UniParc]FASTAAdd to basket
Also known as: CDCrel-1F

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA
60 70 80 90 100
GESGLGKSTL VHSLFLTDLY KDRKLLSAEE RINQTVEILK HTVDIEEKGV
110 120 130 140 150
KLKLTIVDTP GFGDAVNNFE CWKPITDYVD QQFEQYFRDE SGLNRKNIQD
160 170 180 190 200
NRVHCCLYFI SPFGHGLRPV DVGFMKALHE KVNIVPLIAK ADCLVPSEIR
210 220 230 240 250
KLKDRIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE SAPFAVIGSN
260 270 280 290 300
TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC
310 320 330 340 350
DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDSE TEKLIRMKDE
360
ELRRMQEMLQ KMKQRMQDQ
Length:369
Mass (Da):42,852
Last modified:December 6, 2005 - v2
Checksum:iFBE46DDAAB7DFC77
GO
Isoform 2 (identifier: Q9JJM9-2) [UniParc]FASTAAdd to basket
Also known as: CDCrel-1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MSTGLRYKSKLATPEDKQ → MDSLAAPQDRLVEQLLSPRTQAQRRLK

Show »
Length:378
Mass (Da):43,920
Checksum:iB3341620323B4A49
GO
Isoform 3 (identifier: Q9JJM9-3) [UniParc]FASTAAdd to basket
Also known as: CDCrel-1AI

The sequence of this isoform differs from the canonical sequence as follows:
     352-356: LRRMQ → GRAGR
     357-369: Missing.

Show »
Length:356
Mass (Da):40,989
Checksum:i87B852E69B406761
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0165391 – 18MSTGL…PEDKQ → MDSLAAPQDRLVEQLLSPRT QAQRRLK in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_016540352 – 356LRRMQ → GRAGR in isoform 3. 1 Publication5
Alternative sequenceiVSP_016541357 – 369Missing in isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027143 mRNA Translation: BAA98051.1
AB027144 mRNA Translation: BAB87114.1
AB027145 mRNA Translation: BAA98052.1
UniGeneiRn.96497

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiSEPT5_RAT
AccessioniPrimary (citable) accession number: Q9JJM9
Secondary accession number(s): Q8R2F7, Q9JJM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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