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Protein

Platelet glycoprotein Ib beta chain

Gene

Gp1bb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

ReactomeiR-RNO-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-RNO-430116. GP1b-IX-V activation signalling.
R-RNO-75892. Platelet Adhesion to exposed collagen.
R-RNO-76009. Platelet Aggregation (Plug Formation).

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein Ib beta chain
Short name:
GP-Ib beta
Short name:
GPIb-beta
Short name:
GPIbB
Alternative name(s):
CD_antigen: CD42c
Gene namesi
Name:Gp1bb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621050. Gp1bb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 150124ExtracellularSequence analysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence analysisAdd
BLAST
Topological domaini172 – 20635CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 206180Platelet glycoprotein Ib beta chainPRO_0000326528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 32By similarity
Disulfide bondi30 ↔ 39By similarity
Disulfide bondi93 ↔ 118By similarity
Disulfide bondi95 ↔ 141By similarity
Disulfide bondi147 – 147Interchain (with C-608 or C-609 in GP1BA)By similarity
Modified residuei186 – 1861PhosphoserineBy similarity
Modified residuei191 – 1911Phosphoserine; by PKABy similarity
Modified residuei193 – 1931PhosphothreonineBy similarity
Modified residuei200 – 2001PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JJM7.
PRIDEiQ9JJM7.

PTM databases

iPTMnetiQ9JJM7.

Expressioni

Gene expression databases

GenevisibleiQ9JJM7. RN.

Interactioni

Subunit structurei

Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage (By similarity).By similarity

Protein-protein interaction databases

BioGridi250594. 1 interaction.
STRINGi10116.ENSRNOP00000043041.

Structurei

3D structure databases

ProteinModelPortaliQ9JJM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 5529LRRNTAdd
BLAST
Repeati60 – 8324LRRAdd
BLAST
Domaini89 – 14355LRRCTAdd
BLAST

Sequence similaritiesi

Contains 1 LRR (leucine-rich) repeat.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000064244.
HOGENOMiHOG000060136.
HOVERGENiHBG051791.
InParanoidiQ9JJM7.
KOiK06262.
OMAiYRDLRCA.
OrthoDBiEOG75MVZ1.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR000372. LRRNT.
[Graphical view]
PfamiPF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRPRGALS LLLLLLAPPS RPASGCPAPC RCSETRVDCG RRGLTWASLP
60 70 80 90 100
AAFPPDTTEL VLTDNNLTAL PPGLLDTLPA LRRVHLGANP WRCDCRLLPL
110 120 130 140 150
RAWLAGRPER EFYRDLRCVA PLALRGRLLP YVAEDELRAA CAPGLLCWGA
160 170 180 190 200
LVAQLALLVL GLLHALLLAL LLSRLRRLRA QARARSTREF SLTAPLVAES

AGGGAS
Length:206
Mass (Da):22,175
Last modified:October 1, 2000 - v1
Checksum:i38ECE6E99DEF22B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027146 mRNA. Translation: BAA98053.1.
RefSeqiNP_446382.1. NM_053930.4.
UniGeneiRn.96497.

Genome annotation databases

EnsembliENSRNOT00000040954; ENSRNOP00000043041; ENSRNOG00000046981.
GeneIDi116727.
KEGGirno:116727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027146 mRNA. Translation: BAA98053.1.
RefSeqiNP_446382.1. NM_053930.4.
UniGeneiRn.96497.

3D structure databases

ProteinModelPortaliQ9JJM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250594. 1 interaction.
STRINGi10116.ENSRNOP00000043041.

PTM databases

iPTMnetiQ9JJM7.

Proteomic databases

PaxDbiQ9JJM7.
PRIDEiQ9JJM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000040954; ENSRNOP00000043041; ENSRNOG00000046981.
GeneIDi116727.
KEGGirno:116727.

Organism-specific databases

CTDi2812.
RGDi621050. Gp1bb.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000064244.
HOGENOMiHOG000060136.
HOVERGENiHBG051791.
InParanoidiQ9JJM7.
KOiK06262.
OMAiYRDLRCA.
OrthoDBiEOG75MVZ1.

Enzyme and pathway databases

ReactomeiR-RNO-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-RNO-430116. GP1b-IX-V activation signalling.
R-RNO-75892. Platelet Adhesion to exposed collagen.
R-RNO-76009. Platelet Aggregation (Plug Formation).

Miscellaneous databases

PROiQ9JJM7.

Gene expression databases

GenevisibleiQ9JJM7. RN.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR000372. LRRNT.
[Graphical view]
PfamiPF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Reciprocal expression of infant- and adult preferring transcripts of CDCrel-1 septin in the rat neocortex."
    Tada S., Kajii Y., Sato M., Nishikawa T.
    Biochem. Biophys. Res. Commun. 273:723-728(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain cortex.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGP1BB_RAT
AccessioniPrimary (citable) accession number: Q9JJM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.