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Protein
Submitted name:

Betacellulin

Gene

Btc

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: RGD
  • growth factor activity Source: RGD

GO - Biological processi

  • cell differentiation Source: RGD
  • DNA replication Source: RGD
  • epidermal growth factor receptor signaling pathway Source: RGD
  • negative regulation of apoptotic process Source: Ensembl
  • positive regulation of cell differentiation Source: RGD
  • positive regulation of fibroblast proliferation Source: RGD
  • positive regulation of mitotic nuclear division Source: RGD
  • positive regulation of urine volume Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-1227986 Signaling by ERBB2
R-RNO-1236394 Signaling by ERBB4
R-RNO-1250196 SHC1 events in ERBB2 signaling
R-RNO-1250342 PI3K events in ERBB4 signaling
R-RNO-1250347 SHC1 events in ERBB4 signaling
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-1963640 GRB2 events in ERBB2 signaling
R-RNO-1963642 PI3K events in ERBB2 signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6785631 ERBB2 Regulates Cell Motility
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8847993 ERBB2 Activates PTK6 Signaling
R-RNO-8863795 Downregulation of ERBB2 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
BetacellulinImported
Gene namesi
Name:BtcImported
Synonyms:BTCImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620275 Btc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei119 – 143HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_501410813332 – 177Sequence analysisAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi95 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000002728

Interactioni

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: RGD
  • growth factor activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003686

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 105EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IWUI Eukaryota
ENOG41126JP LUCA
GeneTreeiENSGT00730000110951
HOGENOMiHOG000237352
HOVERGENiHBG004905
KOiK09783
OMAiILHCVVA
OrthoDBiEOG091G0RK4
TreeFamiTF332938

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015497 EGF_rcpt_ligand
PANTHERiPTHR10740 PTHR10740, 1 hit
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JJM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTAPGSGV SSLPLLLALV LGLVILQCVV ADGNTTRTPE TNGSLCGAPG
60 70 80 90 100
ENCTGTTPRQ KSKTHFSRCP KQYKHYCIHG RCRFVMDEQT PSCICEKGYF
110 120 130 140 150
GARCEQVDLF YLQQDRGQIL VVCLIGVMVL FIILVIGVCT CCHPLRKHRK
160 170
KKKEEKMETL SKDKTPISED IQETNIA
Length:177
Mass (Da):19,579
Last modified:October 1, 2000 - v1
Checksum:iFAB2AF1F844E114D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07014503 Genomic DNA No translation available.
AABR07014504 Genomic DNA No translation available.
AB028862 mRNA Translation: BAA96731.1
RefSeqiNP_071592.1, NM_022256.2
UniGeneiRn.53987

Genome annotation databases

EnsembliENSRNOT00000003686; ENSRNOP00000003686; ENSRNOG00000002728
GeneIDi64022
KEGGirno:64022
UCSCiRGD:620275 rat

Similar proteinsi

Entry informationi

Entry nameiQ9JJM4_RAT
AccessioniPrimary (citable) accession number: Q9JJM4
Secondary accession number(s): F1LPG4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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