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Protein
Submitted name:

Betacellulin

Gene

Btc

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: RGD
  • growth factor activity Source: RGD

GO - Biological processi

  • cell differentiation Source: RGD
  • DNA replication Source: RGD
  • epidermal growth factor receptor signaling pathway Source: RGD
  • negative regulation of apoptotic process Source: Ensembl
  • positive regulation of cell differentiation Source: RGD
  • positive regulation of fibroblast proliferation Source: RGD
  • positive regulation of mitotic nuclear division Source: RGD
  • positive regulation of urine volume Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-1227986. Signaling by ERBB2.
R-RNO-1236394. Signaling by ERBB4.
R-RNO-1250196. SHC1 events in ERBB2 signaling.
R-RNO-1250342. PI3K events in ERBB4 signaling.
R-RNO-1250347. SHC1 events in ERBB4 signaling.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-1963640. GRB2 events in ERBB2 signaling.
R-RNO-1963642. PI3K events in ERBB2 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
BetacellulinImported
Submitted name:
Protein BtcImported
Gene namesi
Name:BtcImported
Synonyms:BTCImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620275. Btc.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei119 – 14325HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 177146Sequence analysisPRO_5007215898Add
BLAST

Interactioni

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: RGD
  • growth factor activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003686.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 10541EGF-likeInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IWUI. Eukaryota.
ENOG41126JP. LUCA.
GeneTreeiENSGT00730000110951.
HOGENOMiHOG000237352.
HOVERGENiHBG004905.
KOiK09783.
OMAiIGARCER.
OrthoDBiEOG7VQJGP.
TreeFamiTF332938.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PfamiPF00008. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTAPGSGV SSLPLLLALV LGLVILQCVV ADGNTTRTPE TNGSLCGAPG
60 70 80 90 100
ENCTGTTPRQ KSKTHFSRCP KQYKHYCIHG RCRFVMDEQT PSCICEKGYF
110 120 130 140 150
GARCEQVDLF YLQQDRGQIL VVCLIGVMVL FIILVIGVCT CCHPLRKHRK
160 170
KKKEEKMETL SKDKTPISED IQETNIA
Length:177
Mass (Da):19,579
Last modified:October 1, 2000 - v1
Checksum:iFAB2AF1F844E114D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07014503 Genomic DNA. No translation available.
AABR07014504 Genomic DNA. No translation available.
AB028862 mRNA. Translation: BAA96731.1.
RefSeqiNP_071592.1. NM_022256.2.
UniGeneiRn.53987.

Genome annotation databases

EnsembliENSRNOT00000003686; ENSRNOP00000003686; ENSRNOG00000002728.
GeneIDi64022.
KEGGirno:64022.
UCSCiRGD:620275. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07014503 Genomic DNA. No translation available.
AABR07014504 Genomic DNA. No translation available.
AB028862 mRNA. Translation: BAA96731.1.
RefSeqiNP_071592.1. NM_022256.2.
UniGeneiRn.53987.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003686.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003686; ENSRNOP00000003686; ENSRNOG00000002728.
GeneIDi64022.
KEGGirno:64022.
UCSCiRGD:620275. rat.

Organism-specific databases

CTDi685.
RGDi620275. Btc.

Phylogenomic databases

eggNOGiENOG410IWUI. Eukaryota.
ENOG41126JP. LUCA.
GeneTreeiENSGT00730000110951.
HOGENOMiHOG000237352.
HOVERGENiHBG004905.
KOiK09783.
OMAiIGARCER.
OrthoDBiEOG7VQJGP.
TreeFamiTF332938.

Enzyme and pathway databases

ReactomeiR-RNO-1227986. Signaling by ERBB2.
R-RNO-1236394. Signaling by ERBB4.
R-RNO-1250196. SHC1 events in ERBB2 signaling.
R-RNO-1250342. PI3K events in ERBB4 signaling.
R-RNO-1250347. SHC1 events in ERBB4 signaling.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-1963640. GRB2 events in ERBB2 signaling.
R-RNO-1963642. PI3K events in ERBB2 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

NextBioi35576122.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PfamiPF00008. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of rat betacellulin cDNA."
    Tada H., Seno M., Yamada H., Sasada R., Igarashi K.
    Biochim. Biophys. Acta 1492:285-288(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: KidneyImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9JJM4_RAT
AccessioniPrimary (citable) accession number: Q9JJM4
Secondary accession number(s): F1LPG4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.