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Protein

Solute carrier organic anion transporter family member 1B2

Gene

Slco1b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159418. Recycling of bile acids and salts.
R-MMU-879518. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1B2
Alternative name(s):
Liver-specific organic anion transporter 1
Short name:
LST-1
SLC21A6
Solute carrier family 21 member 10
Gene namesi
Name:Slco1b2
Synonyms:Oatp1b2, Slc21a10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1351899. Slco1b2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 46Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini47 – 65ExtracellularSequence analysisAdd BLAST19
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 92CytoplasmicSequence analysis6
Transmembranei93 – 117Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini118 – 163ExtracellularSequence analysisAdd BLAST46
Transmembranei164 – 192Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini193 – 211CytoplasmicSequence analysisAdd BLAST19
Transmembranei212 – 232Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini233 – 250ExtracellularSequence analysisAdd BLAST18
Transmembranei251 – 275Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini276 – 326CytoplasmicSequence analysisAdd BLAST51
Transmembranei327 – 348Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini349 – 368ExtracellularSequence analysisAdd BLAST20
Transmembranei369 – 392Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini393 – 396CytoplasmicSequence analysis4
Transmembranei397 – 420Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini421 – 533ExtracellularSequence analysisAdd BLAST113
Transmembranei534 – 556Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini557 – 565CytoplasmicSequence analysis9
Transmembranei566 – 591Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini592 – 625ExtracellularSequence analysisAdd BLAST34
Transmembranei626 – 643Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini644 – 689CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

  • basolateral plasma membrane Source: Ensembl
  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910511 – 689Solute carrier organic anion transporter family member 1B2Add BLAST689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi132N-linked (GlcNAc...)Sequence analysis1
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Modified residuei288PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Disulfide bondi454 ↔ 480PROSITE-ProRule annotation
Disulfide bondi458 ↔ 469PROSITE-ProRule annotation
Disulfide bondi460 ↔ 484PROSITE-ProRule annotation
Glycosylationi513N-linked (GlcNAc...)Sequence analysis1
Modified residuei662PhosphothreonineCombined sources1
Modified residuei680PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JJL3.
PeptideAtlasiQ9JJL3.
PRIDEiQ9JJL3.

PTM databases

iPTMnetiQ9JJL3.
PhosphoSitePlusiQ9JJL3.
SwissPalmiQ9JJL3.

Expressioni

Tissue specificityi

Liver specific.

Gene expression databases

BgeeiENSMUSG00000030236.
ExpressionAtlasiQ9JJL3. baseline and differential.
GenevisibleiQ9JJL3. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-1838447.
STRINGi10090.ENSMUSP00000044326.

Structurei

3D structure databases

ProteinModelPortaliQ9JJL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini448 – 505Kazal-likePROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9JJL3.
KOiK05043.
OMAiTLHTIAM.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9JJL3.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JJL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQTQHPSKA AQPLRSEKTR HCDGFRIFLA ALSFSYICKA LGGVIMKSSI
60 70 80 90 100
TQIERRFDIP SSISGLIDGG FEIGNLLVIV FVSYFGSKLH RPKLIGTGCF
110 120 130 140 150
IMGIGSILTA LPHFFMGYYR YATENDISSL HNSTLTCLVN QTTSLTGTSP
160 170 180 190 200
EIMEKGCEKG SNSYTWIYVL MGNMLRGIGE TPIVPLGVSY IDDFAKEGNS
210 220 230 240 250
SMYLGTLHTI AMIGPILGFI MSSVFAKLYV DVGYVDLRSV RITPQDARWV
260 270 280 290 300
GAWWLGFIVN GLLCIICSIP FFFLPKIPKR SQKERKNSAS LHVLKTDEDK
310 320 330 340 350
NPVTNPTTQE KQAPANLTGF LWSLRSILTN EQYVIFLILT LLQISSFIGS
360 370 380 390 400
FTYLFKFIEQ QFGQTASQAN FLLGVITIPT MASGMFLGGY LIKRLKLTLL
410 420 430 440 450
GITKFVFFTT TMAYVFYLSY FLLICENKAF AGLTLTYDGM NPVDSHIDVP
460 470 480 490 500
LSYCNSDCIC DKNQWEPVCG ENGVTYISPC LAGCKSFRGD KKLMNIEFYD
510 520 530 540 550
CSCVSGSGFQ KGNHSARLGE CPRDKCKTKY YFYITFQVII SFFTALGSTS
560 570 580 590 600
LMLILIRSVQ PELKSLGMGF HSLVVRTLGG ILAPVYYGAL IDRTCMKWSV
610 620 630 640 650
TSCGARGACR LYNSRLFGMI YVGLSIALKT PILLLYVALI YVMKRKMKRN
660 670 680
DNKILENGRK FTDEGNPEPV NNNGYSCVPS DEKNSETPL
Length:689
Mass (Da):76,729
Last modified:October 1, 2000 - v1
Checksum:i46FBBA1C98FFB97A
GO
Isoform 2 (identifier: Q9JJL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     398-398: T → TAKLYVDVGYVDLRSVRITP

Note: No experimental confirmation available.
Show »
Length:708
Mass (Da):78,875
Checksum:i1E234D5B5C7F2988
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti455N → H in AAF74719 (Ref. 2) Curated1
Sequence conflicti481L → R in AAF74719 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006149398T → TAKLYVDVGYVDLRSVRITP in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031959 mRNA. Translation: BAB03272.1.
AB037202 Genomic DNA. Translation: BAA98050.1. Sequence problems.
AF250912 mRNA. Translation: AAF74719.1.
CCDSiCCDS20678.1. [Q9JJL3-1]
PIRiJC7286.
RefSeqiNP_065241.1. NM_020495.1. [Q9JJL3-1]
XP_006507026.1. XM_006506963.2. [Q9JJL3-1]
XP_017177100.1. XM_017321611.1. [Q9JJL3-1]
UniGeneiMm.272223.

Genome annotation databases

EnsembliENSMUST00000042812; ENSMUSP00000044326; ENSMUSG00000030236. [Q9JJL3-1]
GeneIDi28253.
KEGGimmu:28253.
UCSCiuc009eoq.1. mouse. [Q9JJL3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031959 mRNA. Translation: BAB03272.1.
AB037202 Genomic DNA. Translation: BAA98050.1. Sequence problems.
AF250912 mRNA. Translation: AAF74719.1.
CCDSiCCDS20678.1. [Q9JJL3-1]
PIRiJC7286.
RefSeqiNP_065241.1. NM_020495.1. [Q9JJL3-1]
XP_006507026.1. XM_006506963.2. [Q9JJL3-1]
XP_017177100.1. XM_017321611.1. [Q9JJL3-1]
UniGeneiMm.272223.

3D structure databases

ProteinModelPortaliQ9JJL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1838447.
STRINGi10090.ENSMUSP00000044326.

PTM databases

iPTMnetiQ9JJL3.
PhosphoSitePlusiQ9JJL3.
SwissPalmiQ9JJL3.

Proteomic databases

PaxDbiQ9JJL3.
PeptideAtlasiQ9JJL3.
PRIDEiQ9JJL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042812; ENSMUSP00000044326; ENSMUSG00000030236. [Q9JJL3-1]
GeneIDi28253.
KEGGimmu:28253.
UCSCiuc009eoq.1. mouse. [Q9JJL3-1]

Organism-specific databases

CTDi28253.
MGIiMGI:1351899. Slco1b2.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9JJL3.
KOiK05043.
OMAiTLHTIAM.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9JJL3.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiR-MMU-159418. Recycling of bile acids and salts.
R-MMU-879518. Transport of organic anions.

Miscellaneous databases

PROiQ9JJL3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030236.
ExpressionAtlasiQ9JJL3. baseline and differential.
GenevisibleiQ9JJL3. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO1B2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJL3
Secondary accession number(s): Q9JI79, Q9JJJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.