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Q9JJL3

- SO1B2_MOUSE

UniProt

Q9JJL3 - SO1B2_MOUSE

Protein

Solute carrier organic anion transporter family member 1B2

Gene

Slco1b2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Mediates the Na+-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2.By similarity

    GO - Molecular functioni

    1. bile acid transmembrane transporter activity Source: Ensembl
    2. drug transmembrane transporter activity Source: Ensembl
    3. oligopeptide transporter activity Source: Ensembl
    4. organic anion transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. liver development Source: Ensembl
    2. response to antibiotic Source: Ensembl
    3. response to cytokine Source: Ensembl
    4. response to glucocorticoid Source: Ensembl
    5. response to lipopolysaccharide Source: Ensembl
    6. response to peptide hormone Source: Ensembl

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_210189. Transport of organic anions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 1B2
    Alternative name(s):
    Liver-specific organic anion transporter 1
    Short name:
    LST-1
    SLC21A6
    Solute carrier family 21 member 10
    Gene namesi
    Name:Slco1b2
    Synonyms:Oatp1b2, Slc21a10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1351899. Slco1b2.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 689689Solute carrier organic anion transporter family member 1B2PRO_0000191051Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Modified residuei288 – 2881Phosphoserine2 Publications
    Modified residuei290 – 2901Phosphoserine2 Publications
    Disulfide bondi454 ↔ 480PROSITE-ProRule annotation
    Disulfide bondi458 ↔ 469PROSITE-ProRule annotation
    Disulfide bondi460 ↔ 484PROSITE-ProRule annotation
    Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis
    Modified residuei662 – 6621Phosphothreonine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9JJL3.
    PRIDEiQ9JJL3.

    PTM databases

    PhosphoSiteiQ9JJL3.

    Expressioni

    Tissue specificityi

    Liver specific.

    Gene expression databases

    BgeeiQ9JJL3.
    GenevestigatoriQ9JJL3.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1838447.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJL3.
    SMRiQ9JJL3. Positions 458-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini47 – 6519ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini87 – 926CytoplasmicSequence Analysis
    Topological domaini118 – 16346ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini193 – 21119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini233 – 25018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini276 – 32651CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini349 – 36820ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini393 – 3964CytoplasmicSequence Analysis
    Topological domaini421 – 533113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini557 – 5659CytoplasmicSequence Analysis
    Topological domaini592 – 62534ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini644 – 68946CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4620Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei93 – 11725Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei164 – 19229Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei251 – 27525Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei327 – 34822Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei369 – 39224Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei397 – 42024Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei534 – 55623Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei566 – 59126Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei626 – 64318Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini448 – 50558Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG322696.
    GeneTreeiENSGT00740000115555.
    HOGENOMiHOG000231269.
    HOVERGENiHBG063896.
    InParanoidiQ9JJL3.
    KOiK05043.
    OMAiHVFKTNE.
    OrthoDBiEOG7GFB4C.
    PhylomeDBiQ9JJL3.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JJL3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDQTQHPSKA AQPLRSEKTR HCDGFRIFLA ALSFSYICKA LGGVIMKSSI    50
    TQIERRFDIP SSISGLIDGG FEIGNLLVIV FVSYFGSKLH RPKLIGTGCF 100
    IMGIGSILTA LPHFFMGYYR YATENDISSL HNSTLTCLVN QTTSLTGTSP 150
    EIMEKGCEKG SNSYTWIYVL MGNMLRGIGE TPIVPLGVSY IDDFAKEGNS 200
    SMYLGTLHTI AMIGPILGFI MSSVFAKLYV DVGYVDLRSV RITPQDARWV 250
    GAWWLGFIVN GLLCIICSIP FFFLPKIPKR SQKERKNSAS LHVLKTDEDK 300
    NPVTNPTTQE KQAPANLTGF LWSLRSILTN EQYVIFLILT LLQISSFIGS 350
    FTYLFKFIEQ QFGQTASQAN FLLGVITIPT MASGMFLGGY LIKRLKLTLL 400
    GITKFVFFTT TMAYVFYLSY FLLICENKAF AGLTLTYDGM NPVDSHIDVP 450
    LSYCNSDCIC DKNQWEPVCG ENGVTYISPC LAGCKSFRGD KKLMNIEFYD 500
    CSCVSGSGFQ KGNHSARLGE CPRDKCKTKY YFYITFQVII SFFTALGSTS 550
    LMLILIRSVQ PELKSLGMGF HSLVVRTLGG ILAPVYYGAL IDRTCMKWSV 600
    TSCGARGACR LYNSRLFGMI YVGLSIALKT PILLLYVALI YVMKRKMKRN 650
    DNKILENGRK FTDEGNPEPV NNNGYSCVPS DEKNSETPL 689
    Length:689
    Mass (Da):76,729
    Last modified:October 1, 2000 - v1
    Checksum:i46FBBA1C98FFB97A
    GO
    Isoform 2 (identifier: Q9JJL3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         398-398: T → TAKLYVDVGYVDLRSVRITP

    Note: No experimental confirmation available.

    Show »
    Length:708
    Mass (Da):78,875
    Checksum:i1E234D5B5C7F2988
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti455 – 4551N → H in AAF74719. 1 PublicationCurated
    Sequence conflicti481 – 4811L → R in AAF74719. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei398 – 3981T → TAKLYVDVGYVDLRSVRITP in isoform 2. CuratedVSP_006149

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031959 mRNA. Translation: BAB03272.1.
    AB037202 Genomic DNA. Translation: BAA98050.1. Sequence problems.
    AF250912 mRNA. Translation: AAF74719.1.
    CCDSiCCDS20678.1. [Q9JJL3-1]
    PIRiJC7286.
    RefSeqiNP_065241.1. NM_020495.1. [Q9JJL3-1]
    XP_006507026.1. XM_006506963.1. [Q9JJL3-1]
    UniGeneiMm.272223.

    Genome annotation databases

    EnsembliENSMUST00000042812; ENSMUSP00000044326; ENSMUSG00000030236. [Q9JJL3-1]
    GeneIDi28253.
    KEGGimmu:28253.
    UCSCiuc009eoq.1. mouse. [Q9JJL3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031959 mRNA. Translation: BAB03272.1 .
    AB037202 Genomic DNA. Translation: BAA98050.1 . Sequence problems.
    AF250912 mRNA. Translation: AAF74719.1 .
    CCDSi CCDS20678.1. [Q9JJL3-1 ]
    PIRi JC7286.
    RefSeqi NP_065241.1. NM_020495.1. [Q9JJL3-1 ]
    XP_006507026.1. XM_006506963.1. [Q9JJL3-1 ]
    UniGenei Mm.272223.

    3D structure databases

    ProteinModelPortali Q9JJL3.
    SMRi Q9JJL3. Positions 458-483.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1838447.

    PTM databases

    PhosphoSitei Q9JJL3.

    Proteomic databases

    PaxDbi Q9JJL3.
    PRIDEi Q9JJL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042812 ; ENSMUSP00000044326 ; ENSMUSG00000030236 . [Q9JJL3-1 ]
    GeneIDi 28253.
    KEGGi mmu:28253.
    UCSCi uc009eoq.1. mouse. [Q9JJL3-1 ]

    Organism-specific databases

    CTDi 28253.
    MGIi MGI:1351899. Slco1b2.

    Phylogenomic databases

    eggNOGi NOG322696.
    GeneTreei ENSGT00740000115555.
    HOGENOMi HOG000231269.
    HOVERGENi HBG063896.
    InParanoidi Q9JJL3.
    KOi K05043.
    OMAi HVFKTNE.
    OrthoDBi EOG7GFB4C.
    PhylomeDBi Q9JJL3.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_210189. Transport of organic anions.

    Miscellaneous databases

    NextBioi 306838.
    PROi Q9JJL3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JJL3.
    Genevestigatori Q9JJL3.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1)."
      Ogura K., Choudhuri S., Klaassen C.D.
      Biochem. Biophys. Res. Commun. 272:563-570(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: 129/SvJ and BALB/c.
      Tissue: Liver.
    2. "Molecular cloning of mouse hepatic liver-specific transporter (lst-1/oatp-c/slc21a6)."
      Ananthnarayanan M., Balasubramanian N.V.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 245-689 (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Liver.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-290 AND THR-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288 AND SER-290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSO1B2_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJL3
    Secondary accession number(s): Q9JI79, Q9JJJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3