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Q9JJL3 (SO1B2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 1B2
Alternative name(s):
Liver-specific organic anion transporter 1
Short name=LST-1
SLC21A6
Solute carrier family 21 member 10
Gene names
Name:Slco1b2
Synonyms:Oatp1b2, Slc21a10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length689 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the Na+-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Liver specific.

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9JJL3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9JJL3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     398-398: T → TAKLYVDVGYVDLRSVRITP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 689689Solute carrier organic anion transporter family member 1B2
PRO_0000191051

Regions

Topological domain1 – 2626Cytoplasmic Potential
Transmembrane27 – 4620Helical; Name=1; Potential
Topological domain47 – 6519Extracellular Potential
Transmembrane66 – 8621Helical; Name=2; Potential
Topological domain87 – 926Cytoplasmic Potential
Transmembrane93 – 11725Helical; Name=3; Potential
Topological domain118 – 16346Extracellular Potential
Transmembrane164 – 19229Helical; Name=4; Potential
Topological domain193 – 21119Cytoplasmic Potential
Transmembrane212 – 23221Helical; Name=5; Potential
Topological domain233 – 25018Extracellular Potential
Transmembrane251 – 27525Helical; Name=6; Potential
Topological domain276 – 32651Cytoplasmic Potential
Transmembrane327 – 34822Helical; Name=7; Potential
Topological domain349 – 36820Extracellular Potential
Transmembrane369 – 39224Helical; Name=8; Potential
Topological domain393 – 3964Cytoplasmic Potential
Transmembrane397 – 42024Helical; Name=9; Potential
Topological domain421 – 533113Extracellular Potential
Transmembrane534 – 55623Helical; Name=10; Potential
Topological domain557 – 5659Cytoplasmic Potential
Transmembrane566 – 59126Helical; Name=11; Potential
Topological domain592 – 62534Extracellular Potential
Transmembrane626 – 64318Helical; Name=12; Potential
Topological domain644 – 68946Cytoplasmic Potential
Domain448 – 50558Kazal-like

Amino acid modifications

Modified residue2881Phosphoserine Ref.3 Ref.4
Modified residue2901Phosphoserine Ref.3 Ref.4
Modified residue6621Phosphothreonine Ref.3
Glycosylation1321N-linked (GlcNAc...) Potential
Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation5131N-linked (GlcNAc...) Potential
Disulfide bond454 ↔ 480 By similarity
Disulfide bond458 ↔ 469 By similarity
Disulfide bond460 ↔ 484 By similarity

Natural variations

Alternative sequence3981T → TAKLYVDVGYVDLRSVRITP in isoform 2.
VSP_006149

Experimental info

Sequence conflict4551N → H in AAF74719. Ref.2
Sequence conflict4811L → R in AAF74719. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 46FBBA1C98FFB97A

FASTA68976,729
        10         20         30         40         50         60 
MDQTQHPSKA AQPLRSEKTR HCDGFRIFLA ALSFSYICKA LGGVIMKSSI TQIERRFDIP 

        70         80         90        100        110        120 
SSISGLIDGG FEIGNLLVIV FVSYFGSKLH RPKLIGTGCF IMGIGSILTA LPHFFMGYYR 

       130        140        150        160        170        180 
YATENDISSL HNSTLTCLVN QTTSLTGTSP EIMEKGCEKG SNSYTWIYVL MGNMLRGIGE 

       190        200        210        220        230        240 
TPIVPLGVSY IDDFAKEGNS SMYLGTLHTI AMIGPILGFI MSSVFAKLYV DVGYVDLRSV 

       250        260        270        280        290        300 
RITPQDARWV GAWWLGFIVN GLLCIICSIP FFFLPKIPKR SQKERKNSAS LHVLKTDEDK 

       310        320        330        340        350        360 
NPVTNPTTQE KQAPANLTGF LWSLRSILTN EQYVIFLILT LLQISSFIGS FTYLFKFIEQ 

       370        380        390        400        410        420 
QFGQTASQAN FLLGVITIPT MASGMFLGGY LIKRLKLTLL GITKFVFFTT TMAYVFYLSY 

       430        440        450        460        470        480 
FLLICENKAF AGLTLTYDGM NPVDSHIDVP LSYCNSDCIC DKNQWEPVCG ENGVTYISPC 

       490        500        510        520        530        540 
LAGCKSFRGD KKLMNIEFYD CSCVSGSGFQ KGNHSARLGE CPRDKCKTKY YFYITFQVII 

       550        560        570        580        590        600 
SFFTALGSTS LMLILIRSVQ PELKSLGMGF HSLVVRTLGG ILAPVYYGAL IDRTCMKWSV 

       610        620        630        640        650        660 
TSCGARGACR LYNSRLFGMI YVGLSIALKT PILLLYVALI YVMKRKMKRN DNKILENGRK 

       670        680 
FTDEGNPEPV NNNGYSCVPS DEKNSETPL 

« Hide

Isoform 2 [UniParc].

Checksum: 1E234D5B5C7F2988
Show »

FASTA70878,875

References

« Hide 'large scale' references
[1]"Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1)."
Ogura K., Choudhuri S., Klaassen C.D.
Biochem. Biophys. Res. Commun. 272:563-570(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: 129/SvJ and BALB/c.
Tissue: Liver.
[2]"Molecular cloning of mouse hepatic liver-specific transporter (lst-1/oatp-c/slc21a6)."
Ananthnarayanan M., Balasubramanian N.V.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 245-689 (ISOFORM 2).
Strain: C57BL/6.
Tissue: Liver.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-290 AND THR-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[4]"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288 AND SER-290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB031959 mRNA. Translation: BAB03272.1.
AB037202 Genomic DNA. Translation: BAA98050.1. Sequence problems.
AF250912 mRNA. Translation: AAF74719.1.
CCDSCCDS20678.1. [Q9JJL3-1]
PIRJC7286.
RefSeqNP_065241.1. NM_020495.1. [Q9JJL3-1]
XP_006507026.1. XM_006506963.1. [Q9JJL3-1]
UniGeneMm.272223.

3D structure databases

ProteinModelPortalQ9JJL3.
SMRQ9JJL3. Positions 458-483.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1838447.

PTM databases

PhosphoSiteQ9JJL3.

Proteomic databases

PaxDbQ9JJL3.
PRIDEQ9JJL3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042812; ENSMUSP00000044326; ENSMUSG00000030236. [Q9JJL3-1]
GeneID28253.
KEGGmmu:28253.
UCSCuc009eoq.1. mouse. [Q9JJL3-1]

Organism-specific databases

CTD28253.
MGIMGI:1351899. Slco1b2.

Phylogenomic databases

eggNOGNOG322696.
GeneTreeENSGT00740000115555.
HOGENOMHOG000231269.
HOVERGENHBG063896.
InParanoidQ9JJL3.
KOK05043.
OMAHVFKTNE.
OrthoDBEOG7GFB4C.
PhylomeDBQ9JJL3.
TreeFamTF317540.

Gene expression databases

BgeeQ9JJL3.
GenevestigatorQ9JJL3.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio306838.
PROQ9JJL3.
SOURCESearch...

Entry information

Entry nameSO1B2_MOUSE
AccessionPrimary (citable) accession number: Q9JJL3
Secondary accession number(s): Q9JI79, Q9JJJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot