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Protein

Solute carrier organic anion transporter family member 1B2

Gene

Slco1b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_300927. Recycling of bile acids and salts.
REACT_318911. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1B2
Alternative name(s):
Liver-specific organic anion transporter 1
Short name:
LST-1
SLC21A6
Solute carrier family 21 member 10
Gene namesi
Name:Slco1b2
Synonyms:Oatp1b2, Slc21a10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1351899. Slco1b2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei27 – 4620Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 6519ExtracellularSequence AnalysisAdd
BLAST
Transmembranei66 – 8621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini87 – 926CytoplasmicSequence Analysis
Transmembranei93 – 11725Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini118 – 16346ExtracellularSequence AnalysisAdd
BLAST
Transmembranei164 – 19229Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini193 – 21119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini233 – 25018ExtracellularSequence AnalysisAdd
BLAST
Transmembranei251 – 27525Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini276 – 32651CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei327 – 34822Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini349 – 36820ExtracellularSequence AnalysisAdd
BLAST
Transmembranei369 – 39224Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini393 – 3964CytoplasmicSequence Analysis
Transmembranei397 – 42024Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini421 – 533113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei534 – 55623Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini557 – 5659CytoplasmicSequence Analysis
Transmembranei566 – 59126Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini592 – 62534ExtracellularSequence AnalysisAdd
BLAST
Transmembranei626 – 64318Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini644 – 68946CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: Ensembl
  • integral component of plasma membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Solute carrier organic anion transporter family member 1B2PRO_0000191051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
Modified residuei288 – 2881Phosphoserine2 Publications
Modified residuei290 – 2901Phosphoserine2 Publications
Disulfide bondi454 ↔ 480PROSITE-ProRule annotation
Disulfide bondi458 ↔ 469PROSITE-ProRule annotation
Disulfide bondi460 ↔ 484PROSITE-ProRule annotation
Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis
Modified residuei662 – 6621Phosphothreonine1 Publication
Modified residuei680 – 6801PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JJL3.
PRIDEiQ9JJL3.

PTM databases

PhosphoSiteiQ9JJL3.

Expressioni

Tissue specificityi

Liver specific.

Gene expression databases

BgeeiQ9JJL3.
GenevisibleiQ9JJL3. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-1838447.
STRINGi10090.ENSMUSP00000044326.

Structurei

3D structure databases

ProteinModelPortaliQ9JJL3.
SMRiQ9JJL3. Positions 457-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini448 – 50558Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG322696.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9JJL3.
KOiK05043.
OMAiDKNQWEP.
OrthoDBiEOG7GFB4C.
PhylomeDBiQ9JJL3.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JJL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQTQHPSKA AQPLRSEKTR HCDGFRIFLA ALSFSYICKA LGGVIMKSSI
60 70 80 90 100
TQIERRFDIP SSISGLIDGG FEIGNLLVIV FVSYFGSKLH RPKLIGTGCF
110 120 130 140 150
IMGIGSILTA LPHFFMGYYR YATENDISSL HNSTLTCLVN QTTSLTGTSP
160 170 180 190 200
EIMEKGCEKG SNSYTWIYVL MGNMLRGIGE TPIVPLGVSY IDDFAKEGNS
210 220 230 240 250
SMYLGTLHTI AMIGPILGFI MSSVFAKLYV DVGYVDLRSV RITPQDARWV
260 270 280 290 300
GAWWLGFIVN GLLCIICSIP FFFLPKIPKR SQKERKNSAS LHVLKTDEDK
310 320 330 340 350
NPVTNPTTQE KQAPANLTGF LWSLRSILTN EQYVIFLILT LLQISSFIGS
360 370 380 390 400
FTYLFKFIEQ QFGQTASQAN FLLGVITIPT MASGMFLGGY LIKRLKLTLL
410 420 430 440 450
GITKFVFFTT TMAYVFYLSY FLLICENKAF AGLTLTYDGM NPVDSHIDVP
460 470 480 490 500
LSYCNSDCIC DKNQWEPVCG ENGVTYISPC LAGCKSFRGD KKLMNIEFYD
510 520 530 540 550
CSCVSGSGFQ KGNHSARLGE CPRDKCKTKY YFYITFQVII SFFTALGSTS
560 570 580 590 600
LMLILIRSVQ PELKSLGMGF HSLVVRTLGG ILAPVYYGAL IDRTCMKWSV
610 620 630 640 650
TSCGARGACR LYNSRLFGMI YVGLSIALKT PILLLYVALI YVMKRKMKRN
660 670 680
DNKILENGRK FTDEGNPEPV NNNGYSCVPS DEKNSETPL
Length:689
Mass (Da):76,729
Last modified:October 1, 2000 - v1
Checksum:i46FBBA1C98FFB97A
GO
Isoform 2 (identifier: Q9JJL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     398-398: T → TAKLYVDVGYVDLRSVRITP

Note: No experimental confirmation available.
Show »
Length:708
Mass (Da):78,875
Checksum:i1E234D5B5C7F2988
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti455 – 4551N → H in AAF74719 (Ref. 2) Curated
Sequence conflicti481 – 4811L → R in AAF74719 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei398 – 3981T → TAKLYVDVGYVDLRSVRITP in isoform 2. CuratedVSP_006149

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031959 mRNA. Translation: BAB03272.1.
AB037202 Genomic DNA. Translation: BAA98050.1. Sequence problems.
AF250912 mRNA. Translation: AAF74719.1.
CCDSiCCDS20678.1. [Q9JJL3-1]
PIRiJC7286.
RefSeqiNP_065241.1. NM_020495.1. [Q9JJL3-1]
XP_006507026.1. XM_006506963.2. [Q9JJL3-1]
UniGeneiMm.272223.

Genome annotation databases

EnsembliENSMUST00000042812; ENSMUSP00000044326; ENSMUSG00000030236. [Q9JJL3-1]
GeneIDi28253.
KEGGimmu:28253.
UCSCiuc009eoq.1. mouse. [Q9JJL3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031959 mRNA. Translation: BAB03272.1.
AB037202 Genomic DNA. Translation: BAA98050.1. Sequence problems.
AF250912 mRNA. Translation: AAF74719.1.
CCDSiCCDS20678.1. [Q9JJL3-1]
PIRiJC7286.
RefSeqiNP_065241.1. NM_020495.1. [Q9JJL3-1]
XP_006507026.1. XM_006506963.2. [Q9JJL3-1]
UniGeneiMm.272223.

3D structure databases

ProteinModelPortaliQ9JJL3.
SMRiQ9JJL3. Positions 457-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1838447.
STRINGi10090.ENSMUSP00000044326.

PTM databases

PhosphoSiteiQ9JJL3.

Proteomic databases

PaxDbiQ9JJL3.
PRIDEiQ9JJL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042812; ENSMUSP00000044326; ENSMUSG00000030236. [Q9JJL3-1]
GeneIDi28253.
KEGGimmu:28253.
UCSCiuc009eoq.1. mouse. [Q9JJL3-1]

Organism-specific databases

CTDi28253.
MGIiMGI:1351899. Slco1b2.

Phylogenomic databases

eggNOGiNOG322696.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9JJL3.
KOiK05043.
OMAiDKNQWEP.
OrthoDBiEOG7GFB4C.
PhylomeDBiQ9JJL3.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiREACT_300927. Recycling of bile acids and salts.
REACT_318911. Transport of organic anions.

Miscellaneous databases

NextBioi306838.
PROiQ9JJL3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJL3.
GenevisibleiQ9JJL3. MM.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1)."
    Ogura K., Choudhuri S., Klaassen C.D.
    Biochem. Biophys. Res. Commun. 272:563-570(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: 129/SvJ and BALB/c.
    Tissue: Liver.
  2. "Molecular cloning of mouse hepatic liver-specific transporter (lst-1/oatp-c/slc21a6)."
    Ananthnarayanan M., Balasubramanian N.V.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 245-689 (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Liver.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-290 AND THR-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288 AND SER-290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSO1B2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJL3
Secondary accession number(s): Q9JI79, Q9JJJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.