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Q9JJK5

- HERP1_MOUSE

UniProt

Q9JJK5 - HERP1_MOUSE

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Protein

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Gene

Herpud1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.By similarity

GO - Biological processi

  1. cellular calcium ion homeostasis Source: Ensembl
  2. endoplasmic reticulum unfolded protein response Source: MGI
  3. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  4. positive regulation of protein binding Source: MGI
  5. regulation of protein ubiquitination Source: MGI
  6. ubiquitin-dependent protein catabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Unfolded protein response

Enzyme and pathway databases

ReactomeiREACT_90370. ATF4 activates genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
Gene namesi
Name:Herpud1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1927406. Herpud1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. endoplasmic reticulum membrane Source: MGI
  3. integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 proteinPRO_0000114921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9JJK5.
PaxDbiQ9JJK5.
PRIDEiQ9JJK5.

PTM databases

PhosphoSiteiQ9JJK5.

Expressioni

Gene expression databases

BgeeiQ9JJK5.
ExpressionAtlasiQ9JJK5. baseline and differential.
GenevestigatoriQ9JJK5.

Interactioni

Subunit structurei

Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6 By similarity.By similarity

Protein-protein interaction databases

BioGridi211038. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9JJK5.
SMRiQ9JJK5. Positions 10-90.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 263263CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini285 – 2895LumenalSequence Analysis
Topological domaini311 – 39181CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 7263Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259558.
GeneTreeiENSGT00390000017671.
HOGENOMiHOG000252989.
HOVERGENiHBG051899.
InParanoidiQ9JJK5.
KOiK14027.
OMAiLSGDRSW.
OrthoDBiEOG7QRQWK.
TreeFamiTF324319.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJK5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPEPQPEPV TLLVKSPNQR HRDLELSGDR SWSVSRLKAH LSRVYPERPR
60 70 80 90 100
PEDQRLIYSG KLLLDHQCLQ DLLPKQEKRH VLHLVCNVKN PSKMPETSTK
110 120 130 140 150
GAESTEQPDN SNQTQHPGDS SSDGLRQREV LRNLSPSGWE NISRPEAVQQ
160 170 180 190 200
TFQGLGPGFS GYTTYGWLQL SWFQQIYARQ YYMQYLAATA ASGTFVPTPS
210 220 230 240 250
AQEIPVVSTP APAPIHNQFP AENQPANQNA AAQAVVNPGA NQNLRMNAQG
260 270 280 290 300
GPLVEEDDEI NRDWLDWTYS AATFSVFLSI LYFYSSLSRF LMVMGATVVM
310 320 330 340 350
YLHHVGWFPF RQRPVQNFPD DGGPRDAANQ DPNNNLQGGM DPEMEDPNRL
360 370 380 390
PPDREVLDPE HTSPSFMSTA WLVFKTFFAS LLPEGPPALA N
Length:391
Mass (Da):43,907
Last modified:October 1, 2000 - v1
Checksum:i7F707DBF9B1A3A12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB034991 mRNA. Translation: BAB07892.1.
CCDSiCCDS22541.1.
RefSeqiNP_071726.1. NM_022331.1.
UniGeneiMm.29151.

Genome annotation databases

EnsembliENSMUST00000161576; ENSMUSP00000124201; ENSMUSG00000031770.
GeneIDi64209.
KEGGimmu:64209.
UCSCiuc009mwg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB034991 mRNA. Translation: BAB07892.1 .
CCDSi CCDS22541.1.
RefSeqi NP_071726.1. NM_022331.1.
UniGenei Mm.29151.

3D structure databases

ProteinModelPortali Q9JJK5.
SMRi Q9JJK5. Positions 10-90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211038. 3 interactions.

PTM databases

PhosphoSitei Q9JJK5.

Proteomic databases

MaxQBi Q9JJK5.
PaxDbi Q9JJK5.
PRIDEi Q9JJK5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000161576 ; ENSMUSP00000124201 ; ENSMUSG00000031770 .
GeneIDi 64209.
KEGGi mmu:64209.
UCSCi uc009mwg.1. mouse.

Organism-specific databases

CTDi 9709.
MGIi MGI:1927406. Herpud1.

Phylogenomic databases

eggNOGi NOG259558.
GeneTreei ENSGT00390000017671.
HOGENOMi HOG000252989.
HOVERGENi HBG051899.
InParanoidi Q9JJK5.
KOi K14027.
OMAi LSGDRSW.
OrthoDBi EOG7QRQWK.
TreeFami TF324319.

Enzyme and pathway databases

Reactomei REACT_90370. ATF4 activates genes.

Miscellaneous databases

ChiTaRSi HERPUD1. mouse.
NextBioi 319954.
PROi Q9JJK5.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJK5.
ExpressionAtlasi Q9JJK5. baseline and differential.
Genevestigatori Q9JJK5.

Family and domain databases

InterProi IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00240. ubiquitin. 1 hit.
[Graphical view ]
SMARTi SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50053. UBIQUITIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress."
    Kokame K., Agarwala K.L., Kato H., Miyata T.
    J. Biol. Chem. 275:32846-32853(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHERP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3