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Q9JJK5

- HERP1_MOUSE

UniProt

Q9JJK5 - HERP1_MOUSE

Protein

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Gene

Herpud1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: Ensembl
    2. endoplasmic reticulum unfolded protein response Source: MGI
    3. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    4. positive regulation of protein binding Source: MGI
    5. regulation of protein ubiquitination Source: MGI
    6. ubiquitin-dependent protein catabolic process Source: MGI

    Keywords - Biological processi

    Unfolded protein response

    Enzyme and pathway databases

    ReactomeiREACT_90370. ATF4 activates genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Gene namesi
    Name:Herpud1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1927406. Herpud1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. endoplasmic reticulum membrane Source: MGI
    3. integral component of membrane Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 proteinPRO_0000114921Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9JJK5.
    PaxDbiQ9JJK5.
    PRIDEiQ9JJK5.

    PTM databases

    PhosphoSiteiQ9JJK5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JJK5.
    BgeeiQ9JJK5.
    GenevestigatoriQ9JJK5.

    Interactioni

    Subunit structurei

    Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi211038. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJK5.
    SMRiQ9JJK5. Positions 10-90.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 263263CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini285 – 2895LumenalSequence Analysis
    Topological domaini311 – 39181CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 7263Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259558.
    GeneTreeiENSGT00390000017671.
    HOGENOMiHOG000252989.
    HOVERGENiHBG051899.
    InParanoidiQ9JJK5.
    KOiK14027.
    OMAiLSGDRSW.
    OrthoDBiEOG7QRQWK.
    TreeFamiTF324319.

    Family and domain databases

    InterProiIPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JJK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPEPQPEPV TLLVKSPNQR HRDLELSGDR SWSVSRLKAH LSRVYPERPR    50
    PEDQRLIYSG KLLLDHQCLQ DLLPKQEKRH VLHLVCNVKN PSKMPETSTK 100
    GAESTEQPDN SNQTQHPGDS SSDGLRQREV LRNLSPSGWE NISRPEAVQQ 150
    TFQGLGPGFS GYTTYGWLQL SWFQQIYARQ YYMQYLAATA ASGTFVPTPS 200
    AQEIPVVSTP APAPIHNQFP AENQPANQNA AAQAVVNPGA NQNLRMNAQG 250
    GPLVEEDDEI NRDWLDWTYS AATFSVFLSI LYFYSSLSRF LMVMGATVVM 300
    YLHHVGWFPF RQRPVQNFPD DGGPRDAANQ DPNNNLQGGM DPEMEDPNRL 350
    PPDREVLDPE HTSPSFMSTA WLVFKTFFAS LLPEGPPALA N 391
    Length:391
    Mass (Da):43,907
    Last modified:October 1, 2000 - v1
    Checksum:i7F707DBF9B1A3A12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB034991 mRNA. Translation: BAB07892.1.
    CCDSiCCDS22541.1.
    RefSeqiNP_071726.1. NM_022331.1.
    UniGeneiMm.29151.

    Genome annotation databases

    EnsembliENSMUST00000161576; ENSMUSP00000124201; ENSMUSG00000031770.
    GeneIDi64209.
    KEGGimmu:64209.
    UCSCiuc009mwg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB034991 mRNA. Translation: BAB07892.1 .
    CCDSi CCDS22541.1.
    RefSeqi NP_071726.1. NM_022331.1.
    UniGenei Mm.29151.

    3D structure databases

    ProteinModelPortali Q9JJK5.
    SMRi Q9JJK5. Positions 10-90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211038. 3 interactions.

    PTM databases

    PhosphoSitei Q9JJK5.

    Proteomic databases

    MaxQBi Q9JJK5.
    PaxDbi Q9JJK5.
    PRIDEi Q9JJK5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000161576 ; ENSMUSP00000124201 ; ENSMUSG00000031770 .
    GeneIDi 64209.
    KEGGi mmu:64209.
    UCSCi uc009mwg.1. mouse.

    Organism-specific databases

    CTDi 9709.
    MGIi MGI:1927406. Herpud1.

    Phylogenomic databases

    eggNOGi NOG259558.
    GeneTreei ENSGT00390000017671.
    HOGENOMi HOG000252989.
    HOVERGENi HBG051899.
    InParanoidi Q9JJK5.
    KOi K14027.
    OMAi LSGDRSW.
    OrthoDBi EOG7QRQWK.
    TreeFami TF324319.

    Enzyme and pathway databases

    Reactomei REACT_90370. ATF4 activates genes.

    Miscellaneous databases

    ChiTaRSi HERPUD1. mouse.
    NextBioi 319954.
    PROi Q9JJK5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JJK5.
    Bgeei Q9JJK5.
    Genevestigatori Q9JJK5.

    Family and domain databases

    InterProi IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress."
      Kokame K., Agarwala K.L., Kato H., Miyata T.
      J. Biol. Chem. 275:32846-32853(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHERP1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3