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Protein

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Gene

Herpud1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.By similarity

GO - Molecular functioni

  1. ion channel binding Source: MGI

GO - Biological processi

  1. endoplasmic reticulum calcium ion homeostasis Source: MGI
  2. endoplasmic reticulum unfolded protein response Source: MGI
  3. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  4. negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: MGI
  5. negative regulation of intrinsic apoptotic signaling pathway Source: MGI
  6. positive regulation of ER-associated ubiquitin-dependent protein catabolic process Source: MGI
  7. positive regulation of protein binding Source: MGI
  8. regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
  9. regulation of ER-associated ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
  10. regulation of protein ubiquitination Source: MGI
  11. ubiquitin-dependent protein catabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
Gene namesi
Name:Herpud1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1927406. Herpud1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 263263CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Topological domaini285 – 2895LumenalSequence Analysis
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Topological domaini311 – 39181CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: ParkinsonsUK-UCL
  2. endoplasmic reticulum membrane Source: MGI
  3. integral component of membrane Source: MGI
  4. Lewy body core Source: MGI
  5. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 proteinPRO_0000114921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei135 – 1351PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JJK5.
PaxDbiQ9JJK5.
PRIDEiQ9JJK5.

PTM databases

PhosphoSiteiQ9JJK5.

Expressioni

Gene expression databases

BgeeiQ9JJK5.
ExpressionAtlasiQ9JJK5. baseline and differential.
GenevestigatoriQ9JJK5.

Interactioni

Subunit structurei

Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211038. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9JJK5.
SMRiQ9JJK5. Positions 10-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 7263Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259558.
GeneTreeiENSGT00390000017671.
HOGENOMiHOG000252989.
HOVERGENiHBG051899.
InParanoidiQ9JJK5.
KOiK14027.
OMAiLSGDRSW.
OrthoDBiEOG7QRQWK.
TreeFamiTF324319.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEPQPEPV TLLVKSPNQR HRDLELSGDR SWSVSRLKAH LSRVYPERPR
60 70 80 90 100
PEDQRLIYSG KLLLDHQCLQ DLLPKQEKRH VLHLVCNVKN PSKMPETSTK
110 120 130 140 150
GAESTEQPDN SNQTQHPGDS SSDGLRQREV LRNLSPSGWE NISRPEAVQQ
160 170 180 190 200
TFQGLGPGFS GYTTYGWLQL SWFQQIYARQ YYMQYLAATA ASGTFVPTPS
210 220 230 240 250
AQEIPVVSTP APAPIHNQFP AENQPANQNA AAQAVVNPGA NQNLRMNAQG
260 270 280 290 300
GPLVEEDDEI NRDWLDWTYS AATFSVFLSI LYFYSSLSRF LMVMGATVVM
310 320 330 340 350
YLHHVGWFPF RQRPVQNFPD DGGPRDAANQ DPNNNLQGGM DPEMEDPNRL
360 370 380 390
PPDREVLDPE HTSPSFMSTA WLVFKTFFAS LLPEGPPALA N
Length:391
Mass (Da):43,907
Last modified:October 1, 2000 - v1
Checksum:i7F707DBF9B1A3A12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034991 mRNA. Translation: BAB07892.1.
CCDSiCCDS22541.1.
RefSeqiNP_071726.1. NM_022331.1.
UniGeneiMm.29151.

Genome annotation databases

EnsembliENSMUST00000161576; ENSMUSP00000124201; ENSMUSG00000031770.
GeneIDi64209.
KEGGimmu:64209.
UCSCiuc009mwg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034991 mRNA. Translation: BAB07892.1.
CCDSiCCDS22541.1.
RefSeqiNP_071726.1. NM_022331.1.
UniGeneiMm.29151.

3D structure databases

ProteinModelPortaliQ9JJK5.
SMRiQ9JJK5. Positions 10-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211038. 3 interactions.

PTM databases

PhosphoSiteiQ9JJK5.

Proteomic databases

MaxQBiQ9JJK5.
PaxDbiQ9JJK5.
PRIDEiQ9JJK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161576; ENSMUSP00000124201; ENSMUSG00000031770.
GeneIDi64209.
KEGGimmu:64209.
UCSCiuc009mwg.1. mouse.

Organism-specific databases

CTDi9709.
MGIiMGI:1927406. Herpud1.

Phylogenomic databases

eggNOGiNOG259558.
GeneTreeiENSGT00390000017671.
HOGENOMiHOG000252989.
HOVERGENiHBG051899.
InParanoidiQ9JJK5.
KOiK14027.
OMAiLSGDRSW.
OrthoDBiEOG7QRQWK.
TreeFamiTF324319.

Miscellaneous databases

ChiTaRSiHerpud1. mouse.
NextBioi319954.
PROiQ9JJK5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJK5.
ExpressionAtlasiQ9JJK5. baseline and differential.
GenevestigatoriQ9JJK5.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress."
    Kokame K., Agarwala K.L., Kato H., Miyata T.
    J. Biol. Chem. 275:32846-32853(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHERP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: April 1, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.