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Q9JJK5 (HERP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
Gene names
Name:Herpud1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins By similarity.

Subunit structure

Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Contains 1 ubiquitin-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
PRO_0000114921

Regions

Topological domain1 – 263263Cytoplasmic Potential
Transmembrane264 – 28421Helical; Potential
Topological domain285 – 2895Lumenal Potential
Transmembrane290 – 31021Helical; Potential
Topological domain311 – 39181Cytoplasmic Potential
Domain10 – 7263Ubiquitin-like

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JJK5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 7F707DBF9B1A3A12

FASTA39143,907
        10         20         30         40         50         60 
MEPEPQPEPV TLLVKSPNQR HRDLELSGDR SWSVSRLKAH LSRVYPERPR PEDQRLIYSG 

        70         80         90        100        110        120 
KLLLDHQCLQ DLLPKQEKRH VLHLVCNVKN PSKMPETSTK GAESTEQPDN SNQTQHPGDS 

       130        140        150        160        170        180 
SSDGLRQREV LRNLSPSGWE NISRPEAVQQ TFQGLGPGFS GYTTYGWLQL SWFQQIYARQ 

       190        200        210        220        230        240 
YYMQYLAATA ASGTFVPTPS AQEIPVVSTP APAPIHNQFP AENQPANQNA AAQAVVNPGA 

       250        260        270        280        290        300 
NQNLRMNAQG GPLVEEDDEI NRDWLDWTYS AATFSVFLSI LYFYSSLSRF LMVMGATVVM 

       310        320        330        340        350        360 
YLHHVGWFPF RQRPVQNFPD DGGPRDAANQ DPNNNLQGGM DPEMEDPNRL PPDREVLDPE 

       370        380        390 
HTSPSFMSTA WLVFKTFFAS LLPEGPPALA N 

« Hide

References

[1]"Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress."
Kokame K., Agarwala K.L., Kato H., Miyata T.
J. Biol. Chem. 275:32846-32853(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB034991 mRNA. Translation: BAB07892.1.
CCDSCCDS22541.1.
RefSeqNP_071726.1. NM_022331.1.
UniGeneMm.29151.

3D structure databases

ProteinModelPortalQ9JJK5.
SMRQ9JJK5. Positions 10-90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid211038. 3 interactions.

PTM databases

PhosphoSiteQ9JJK5.

Proteomic databases

MaxQBQ9JJK5.
PaxDbQ9JJK5.
PRIDEQ9JJK5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000161576; ENSMUSP00000124201; ENSMUSG00000031770.
GeneID64209.
KEGGmmu:64209.
UCSCuc009mwg.1. mouse.

Organism-specific databases

CTD9709.
MGIMGI:1927406. Herpud1.

Phylogenomic databases

eggNOGNOG259558.
GeneTreeENSGT00390000017671.
HOGENOMHOG000252989.
HOVERGENHBG051899.
InParanoidQ9JJK5.
KOK14027.
OMALSGDRSW.
OrthoDBEOG7QRQWK.
TreeFamTF324319.

Gene expression databases

ArrayExpressQ9JJK5.
BgeeQ9JJK5.
GenevestigatorQ9JJK5.

Family and domain databases

InterProIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMSSF54236. SSF54236. 1 hit.
PROSITEPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHERPUD1. mouse.
NextBio319954.
PROQ9JJK5.
SOURCESearch...

Entry information

Entry nameHERP1_MOUSE
AccessionPrimary (citable) accession number: Q9JJK5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot