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Protein

LanC-like protein 2

Gene

Lancl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
LanC-like protein 2
Alternative name(s):
Testis-specific adriamycin sensitivity protein
Gene namesi
Name:Lancl2
Synonyms:Tasp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1919085. Lancl2.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Cell membrane By similarity

  • Note: Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 450449LanC-like protein 2PRO_0000191273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei198 – 1981PhosphotyrosineCombined sources

Post-translational modificationi

Myristoylated. Essential for membrane association.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9JJK2.
MaxQBiQ9JJK2.
PaxDbiQ9JJK2.
PRIDEiQ9JJK2.

PTM databases

iPTMnetiQ9JJK2.
PhosphoSiteiQ9JJK2.
SwissPalmiQ9JJK2.

Expressioni

Gene expression databases

BgeeiQ9JJK2.
ExpressionAtlasiQ9JJK2. baseline and differential.
GenevisibleiQ9JJK2. MM.

Interactioni

Subunit structurei

Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association.By similarity

Protein-protein interaction databases

BioGridi214964. 2 interactions.
IntActiQ9JJK2. 4 interactions.
MINTiMINT-1728509.
STRINGi10090.ENSMUSP00000052146.

Structurei

3D structure databases

ProteinModelPortaliQ9JJK2.
SMRiQ9JJK2. Positions 18-444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 1413Interaction with inositol phospholipidsBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the LanC-like protein family.Curated

Phylogenomic databases

eggNOGiKOG2787. Eukaryota.
ENOG410XQIA. LUCA.
GeneTreeiENSGT00530000063186.
HOGENOMiHOG000240926.
HOVERGENiHBG065387.
InParanoidiQ9JJK2.
OMAiNPFPDYE.
OrthoDBiEOG71VSTN.
PhylomeDBiQ9JJK2.
TreeFamiTF300068.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR007822. LANC-like.
IPR020464. LanC-like_prot_euk.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01951. LANCEUKARYTE.
PR01950. LANCSUPER.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETMSKRLK FHLGEAEMEE RSFPNPFPDY EAAASAAGLA AGSAEETGRV
60 70 80 90 100
CPLPTTEDPG LPFHPNGKIV PNFIKRIQTK IKDLLQQMEE GLKTADPHDC
110 120 130 140 150
SAYTGWTGIA LLYLQLYRVT GDQTYLLRSL DYVKRTLRNL SGRRVTFLCG
160 170 180 190 200
DAGPLAVGAV IYHKLKSECE SQECITKLLQ MHRTIVCQES ELPDELLYGR
210 220 230 240 250
AGYLYALLYL NTEIGPGTVG ETAIKEVVSA IIESGKSLSR EERKSERCPL
260 270 280 290 300
LYQWHRKQYV GAAHGMAGIY YMLMQPEAKV DQETLTEMVK PSIDYVRHKK
310 320 330 340 350
FRSGNYPSSL SNETDRLVHW CHGAPGVIHV LLQAYQVFKE EKYLKEAMEC
360 370 380 390 400
SDVIWQRGLL RKGYGICHGT SGNGYSFLSL YRLTQDKKYL YRACKFAEWC
410 420 430 440 450
LDYGAHGCRI PDRPYSLFEG MAGAVHFLSD ILVPETARFP AFELGFLQKD
Length:450
Mass (Da):50,777
Last modified:October 1, 2000 - v1
Checksum:i854EF4684C34643F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035967 mRNA. Translation: BAA96801.1.
BC016072 mRNA. Translation: AAH16072.1.
CCDSiCCDS20185.1.
RefSeqiNP_598498.1. NM_133737.2.
UniGeneiMm.274904.

Genome annotation databases

EnsembliENSMUST00000050077; ENSMUSP00000052146; ENSMUSG00000062190.
ENSMUST00000072954; ENSMUSP00000072723; ENSMUSG00000062190.
GeneIDi71835.
KEGGimmu:71835.
UCSCiuc009ccn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035967 mRNA. Translation: BAA96801.1.
BC016072 mRNA. Translation: AAH16072.1.
CCDSiCCDS20185.1.
RefSeqiNP_598498.1. NM_133737.2.
UniGeneiMm.274904.

3D structure databases

ProteinModelPortaliQ9JJK2.
SMRiQ9JJK2. Positions 18-444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214964. 2 interactions.
IntActiQ9JJK2. 4 interactions.
MINTiMINT-1728509.
STRINGi10090.ENSMUSP00000052146.

PTM databases

iPTMnetiQ9JJK2.
PhosphoSiteiQ9JJK2.
SwissPalmiQ9JJK2.

Proteomic databases

EPDiQ9JJK2.
MaxQBiQ9JJK2.
PaxDbiQ9JJK2.
PRIDEiQ9JJK2.

Protocols and materials databases

DNASUi71835.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050077; ENSMUSP00000052146; ENSMUSG00000062190.
ENSMUST00000072954; ENSMUSP00000072723; ENSMUSG00000062190.
GeneIDi71835.
KEGGimmu:71835.
UCSCiuc009ccn.2. mouse.

Organism-specific databases

CTDi55915.
MGIiMGI:1919085. Lancl2.

Phylogenomic databases

eggNOGiKOG2787. Eukaryota.
ENOG410XQIA. LUCA.
GeneTreeiENSGT00530000063186.
HOGENOMiHOG000240926.
HOVERGENiHBG065387.
InParanoidiQ9JJK2.
OMAiNPFPDYE.
OrthoDBiEOG71VSTN.
PhylomeDBiQ9JJK2.
TreeFamiTF300068.

Miscellaneous databases

PROiQ9JJK2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJK2.
ExpressionAtlasiQ9JJK2. baseline and differential.
GenevisibleiQ9JJK2. MM.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR007822. LANC-like.
IPR020464. LanC-like_prot_euk.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01951. LANCEUKARYTE.
PR01950. LANCSUPER.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and identification of genes whose downregulation result in anticancer drug resistance."
    Sugimoto Y., Tsukahara S., Ishikawa E., Tsuruo T.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye and Retina.
  3. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-198, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiLANC2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.