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Protein

Aquaporin-9

Gene

Aqp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na+, K+, Cl-, and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-MMU-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-9
Short name:
AQP-9
Alternative name(s):
Aquaglyceroporin-9
Gene namesi
Name:Aqp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1891066. Aqp9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 54ExtracellularSequence analysis4
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 110CytoplasmicSequence analysisAdd BLAST35
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 158ExtracellularSequence analysisAdd BLAST27
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 189CytoplasmicSequence analysis10
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 245ExtracellularSequence analysisAdd BLAST35
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 295CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639651 – 295Aquaporin-9Add BLAST295

Proteomic databases

PaxDbiQ9JJJ3.
PRIDEiQ9JJJ3.

PTM databases

iPTMnetiQ9JJJ3.
PhosphoSitePlusiQ9JJJ3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032204.
CleanExiMM_AQP9.
ExpressionAtlasiQ9JJJ3. baseline and differential.
GenevisibleiQ9JJJ3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074063.

Structurei

3D structure databases

ProteinModelPortaliQ9JJJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi84 – 86NPA 13
Motifi216 – 218NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiQ9JJJ3.
KOiK09877.
OMAiEERICNQ.
PhylomeDBiQ9JJJ3.
TreeFamiTF313173.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR015685. Aquaporin_9.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02021. AQUAPORIN9.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSEKDRAKK NLVQRLALKS CLAKETLSEF LGTFIMIVLG CGSIAQAVLS
60 70 80 90 100
REKAGGIITI NIGFATAVVM ALYATFGVSG GHINPAVSFA MCTFGRMEWF
110 120 130 140 150
KFPFYVGAQL LGAFVGAATV FGIYYDGLMA FADGKLLITG ENGTAFIFAT
160 170 180 190 200
YPKPFVSVPG AFVDQVVSTM FLLLIVFAIF DSRNLGVPRG LEPIVIGLLI
210 220 230 240 250
IVISCSLGLN SGCAMNPARD LSPRLFTALA GWGFEVFTFG NNFWWIPVVG
260 270 280 290
PMIGAVLGGL IYVLFIQMHH SNPDPEVKAE PAENNLEKHE LSVIM
Length:295
Mass (Da):31,764
Last modified:October 1, 2000 - v1
Checksum:iE2C75A6DD45C35FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037180 mRNA. Translation: BAB03271.1.
AK050042 mRNA. Translation: BAC34044.1.
AK050325 mRNA. Translation: BAC34190.1.
CCDSiCCDS23325.1.
RefSeqiNP_071309.1. NM_022026.3.
XP_006511394.1. XM_006511331.2.
XP_006511395.1. XM_006511332.3.
XP_011241084.1. XM_011242782.2.
XP_011241085.1. XM_011242783.1.
UniGeneiMm.449427.
Mm.485117.

Genome annotation databases

EnsembliENSMUST00000074465; ENSMUSP00000074063; ENSMUSG00000032204.
ENSMUST00000113570; ENSMUSP00000109200; ENSMUSG00000032204.
GeneIDi64008.
KEGGimmu:64008.
UCSCiuc009qov.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037180 mRNA. Translation: BAB03271.1.
AK050042 mRNA. Translation: BAC34044.1.
AK050325 mRNA. Translation: BAC34190.1.
CCDSiCCDS23325.1.
RefSeqiNP_071309.1. NM_022026.3.
XP_006511394.1. XM_006511331.2.
XP_006511395.1. XM_006511332.3.
XP_011241084.1. XM_011242782.2.
XP_011241085.1. XM_011242783.1.
UniGeneiMm.449427.
Mm.485117.

3D structure databases

ProteinModelPortaliQ9JJJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074063.

PTM databases

iPTMnetiQ9JJJ3.
PhosphoSitePlusiQ9JJJ3.

Proteomic databases

PaxDbiQ9JJJ3.
PRIDEiQ9JJJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074465; ENSMUSP00000074063; ENSMUSG00000032204.
ENSMUST00000113570; ENSMUSP00000109200; ENSMUSG00000032204.
GeneIDi64008.
KEGGimmu:64008.
UCSCiuc009qov.2. mouse.

Organism-specific databases

CTDi366.
MGIiMGI:1891066. Aqp9.

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiQ9JJJ3.
KOiK09877.
OMAiEERICNQ.
PhylomeDBiQ9JJJ3.
TreeFamiTF313173.

Enzyme and pathway databases

ReactomeiR-MMU-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-MMU-432047. Passive transport by Aquaporins.

Miscellaneous databases

ChiTaRSiAqp9. mouse.
PROiQ9JJJ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032204.
CleanExiMM_AQP9.
ExpressionAtlasiQ9JJJ3. baseline and differential.
GenevisibleiQ9JJJ3. MM.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR015685. Aquaporin_9.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02021. AQUAPORIN9.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQP9_MOUSE
AccessioniPrimary (citable) accession number: Q9JJJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.