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Protein

Neuromedin-U receptor 1

Gene

Nmur1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.2 Publications

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 1
Short name:
NMU-R1
Alternative name(s):
G-protein coupled receptor 66
G-protein coupled receptor FM-3
Gene namesi
Name:Nmur1
Synonyms:Gpr66
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619867. Nmur1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 59ExtracellularSequence analysisAdd BLAST59
Transmembranei60 – 80Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 117Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini118 – 137ExtracellularSequence analysisAdd BLAST20
Transmembranei138 – 158Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini159 – 181CytoplasmicSequence analysisAdd BLAST23
Transmembranei182 – 202Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini203 – 235ExtracellularSequence analysisAdd BLAST33
Transmembranei236 – 256Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini257 – 294CytoplasmicSequence analysisAdd BLAST38
Transmembranei295 – 315Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini316 – 331ExtracellularSequence analysisAdd BLAST16
Transmembranei332 – 352Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini353 – 425CytoplasmicSequence analysisAdd BLAST73

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699081 – 425Neuromedin-U receptor 1Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi134 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiF1LQC9.
Q9JJI5.
PRIDEiQ9JJI5.

PTM databases

PhosphoSitePlusiQ9JJI5.

Expressioni

Tissue specificityi

Highly expressed in the small intestine and lung. Low expression in the central nervous system.1 Publication

Gene expression databases

BgeeiENSRNOG00000018521.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025024.

Structurei

3D structure databases

ProteinModelPortaliQ9JJI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ9JJI5.
OrthoDBiEOG091G0ZDG.
TreeFamiTF318522.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005391. NeuromedU_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01566. NEUROMEDNU1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPCLNCSF FPGQLSPNAS TGLLSCNDSE FKEHFDLEDL NLTHEDLRLK
60 70 80 90 100
YLGPQQVKQF LPICVTYLLI FVVGTLGNGL TCTVILRQKA MHTPTNFYLF
110 120 130 140 150
SLAVSDLLVL LVGLPLELYE MQHNYPFQLG AGGCYFRILL LETVCLASVL
160 170 180 190 200
NVTALSVERY VAVVHPLQAK SVMTRTHVRR MLGAIWVFAI LFSLPNTSLH
210 220 230 240 250
GLSPLYVPCR GPVPDSVTCT LVRPQFFYKL VIQTTILLFF CLPMVTISVL
260 270 280 290 300
YLLIGLRLRR ERILLQEEVK GRISAAARQA SHRSIQLRDR ERRQVTKMLI
310 320 330 340 350
ALVIVFGTCW VPFHADRLMW SMVSHWTDGL RLAFQSVHLA SGVFLYLGSA
360 370 380 390 400
ANPVLYNLMS TRFRESFRET LGLGTRCCHR HQPRHDSHSH LRLTTVSTLC
410 420
DRNSRDVPLA ENRDPGCEQE TDPPE
Length:425
Mass (Da):48,129
Last modified:March 16, 2016 - v2
Checksum:i16DD0173D5DBB23E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14Q → M in BAA99387 (PubMed:10783389).Curated1
Sequence conflicti263I → M in BAA99387 (PubMed:10783389).Curated1
Sequence conflicti354V → E in BAA99387 (PubMed:10783389).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112440 Genomic DNA. No translation available.
AB038649 mRNA. Translation: BAA99387.1.
AF242873 mRNA. Translation: AAF82754.1.
UniGeneiRn.54457.

Genome annotation databases

UCSCiRGD:619867. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112440 Genomic DNA. No translation available.
AB038649 mRNA. Translation: BAA99387.1.
AF242873 mRNA. Translation: AAF82754.1.
UniGeneiRn.54457.

3D structure databases

ProteinModelPortaliQ9JJI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025024.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9JJI5.

Proteomic databases

PaxDbiF1LQC9.
Q9JJI5.
PRIDEiQ9JJI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:619867. rat.

Organism-specific databases

RGDi619867. Nmur1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ9JJI5.
OrthoDBiEOG091G0ZDG.
TreeFamiTF318522.

Miscellaneous databases

PROiQ9JJI5.

Gene expression databases

BgeeiENSRNOG00000018521.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005391. NeuromedU_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01566. NEUROMEDNU1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMUR1_RAT
AccessioniPrimary (citable) accession number: Q9JJI5
Secondary accession number(s): F1LQC9, Q9JIB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 16, 2016
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.