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Q9JJH7

- TRPM5_MOUSE

UniProt

Q9JJH7 - TRPM5_MOUSE

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Protein

Transient receptor potential cation channel subfamily M member 5

Gene

Trpm5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Voltage-modulated Ca2+-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na+, K+ and Cs+ ions equally well. Activated directly by increases in intracellular Ca2+, but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca2+. Also activated by a fast intracellular Ca2+ increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.8 Publications

Enzyme regulationi

Phosphatidylinositol 4,5-bisphosphate (PIP2) is able to partially restore sensitivity to Ca2+ after desensitization. Inhibited by flufenamic acid with an IC50 of 24.5 µM and spermine with an IC50 of 37 µM.2 Publications

GO - Molecular functioni

  1. calcium activated cation channel activity Source: MGI
  2. potassium channel activity Source: MGI
  3. sodium channel activity Source: MGI
  4. voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  1. cation transmembrane transport Source: GOC
  2. ion transmembrane transport Source: MGI
  3. potassium ion transmembrane transport Source: GOC
  4. sensory perception of taste Source: InterPro
  5. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 5
Alternative name(s):
Long transient receptor potential channel 5
Short name:
LTrpC-5
Short name:
LTrpC5
MLSN1- and TRP-related gene 1 protein
Gene namesi
Name:Trpm5Imported
Synonyms:Ltrpc5Imported, Mtr1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1861718. Trpm5.

Subcellular locationi

Cell membrane Sequence Analysis; Multi-pass membrane protein By similaritySequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show diminished behavioral and nerve responses to bitter, sweet and umami tastes.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi831 – 8311E → Q: Reduces sensitivity to block by extracellular acidification. Sensitivity to block by low extracellular pH is nearly abolished; when associated with N-935. 1 Publication
Mutagenesisi897 – 8971H → N: Shows normal sensitivity to acid block and significant recovery from acid-enhanced inactivation. 1 Publication
Mutagenesisi935 – 9351H → N: Reduces sensitivity to block by extracellular acidification. Sensitivity to block by low extracellular pH is nearly abolished; when associated with Q-831. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11581158Transient receptor potential cation channel subfamily M member 5PRO_0000328934Add
BLAST

Proteomic databases

PRIDEiQ9JJH7.

PTM databases

PhosphoSiteiQ9JJH7.

Expressioni

Tissue specificityi

Strongly expressed in liver, heart, testis, brain and kidney. Detected in fetal liver, kidney, spleen, brain, heart and lung, and in adult skin, eyes, spleen, stomach, small intestine, colon, lung, bladder, pancreas and thymus. Biallelically expressed at all stages and tissues examined. Also expressed in subsets of taste receptor cells of the tongue, in olfactory sensory neurons of the main olfactory epithelium and in the vomeronasal organ.4 Publications

Gene expression databases

BgeeiQ9JJH7.
GenevestigatoriQ9JJH7.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 645645CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini667 – 73266ExtracellularSequence AnalysisAdd
BLAST
Topological domaini754 – 81057CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini832 – 8343ExtracellularSequence Analysis
Topological domaini856 – 87116CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini893 – 95361ExtracellularSequence AnalysisAdd
BLAST
Topological domaini975 – 1158184CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei646 – 66621HelicalSequence AnalysisAdd
BLAST
Transmembranei733 – 75321HelicalSequence AnalysisAdd
BLAST
Transmembranei811 – 83121HelicalSequence AnalysisAdd
BLAST
Transmembranei835 – 85521HelicalSequence AnalysisAdd
BLAST
Transmembranei872 – 89221HelicalSequence AnalysisAdd
BLAST
Transmembranei954 – 97421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili552 – 57221Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253824.
GeneTreeiENSGT00760000119127.
HOVERGENiHBG108337.
InParanoidiQ9JJH7.
KOiK04980.
OMAiECYSNSE.
OrthoDBiEOG725DH1.
PhylomeDBiQ9JJH7.
TreeFamiTF314204.

Family and domain databases

InterProiIPR029577. TRPM5.
[Graphical view]
PANTHERiPTHR13800:SF5. PTHR13800:SF5. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 16 Publications (identifier: Q9JJH7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTTQSSCPG SPPDTEDGWE PILCRGEINF GGSGKKRGKF VKVPSSVAPS
60 70 80 90 100
VLFELLLTEW HLPAPNLVVS LVGEERPLAM KSWLRDVLRK GLVKAAQSTG
110 120 130 140 150
AWILTSALHV GLARHVGQAV RDHSLASTST KIRVVAIGMA SLDRILHRQL
160 170 180 190 200
LDGVHQKEDT PIHYPADEGN IQGPLCPLDS NLSHFILVES GALGSGNDGL
210 220 230 240 250
TELQLSLEKH ISQQRTGYGG TSCIQIPVLC LLVNGDPNTL ERISRAVEQA
260 270 280 290 300
APWLILAGSG GIADVLAALV SQPHLLVPQV AEKQFREKFP SECFSWEAIV
310 320 330 340 350
HWTELLQNIA AHPHLLTVYD FEQEGSEDLD TVILKALVKA CKSHSQEAQD
360 370 380 390 400
YLDELKLAVA WDRVDIAKSE IFNGDVEWKS CDLEEVMTDA LVSNKPDFVR
410 420 430 440 450
LFVDSGADMA EFLTYGRLQQ LYHSVSPKSL LFELLQRKHE EGRLTLAGLG
460 470 480 490 500
AQQARELPIG LPAFSLHEVS RVLKDFLHDA CRGFYQDGRR MEERGPPKRP
510 520 530 540 550
AGQKWLPDLS RKSEDPWRDL FLWAVLQNRY EMATYFWAMG REGVAAALAA
560 570 580 590 600
CKIIKEMSHL EKEAEVARTM REAKYEQLAL DLFSECYGNS EDRAFALLVR
610 620 630 640 650
RNHSWSRTTC LHLATEADAK AFFAHDGVQA FLTKIWWGDM ATGTPILRLL
660 670 680 690 700
GAFTCPALIY TNLISFSEDA PQRMDLEDLQ EPDSLDMEKS FLCSRGGQLE
710 720 730 740 750
KLTEAPRAPG DLGPQAAFLL TRWRKFWGAP VTVFLGNVVM YFAFLFLFTY
760 770 780 790 800
VLLVDFRPPP QGPSGSEVTL YFWVFTLVLE EIRQGFFTDE DTHLVKKFTL
810 820 830 840 850
YVEDNWNKCD MVAIFLFIVG VTCRMVPSVF EAGRTVLAID FMVFTLRLIH
860 870 880 890 900
IFAIHKQLGP KIIIVERMMK DVFFFLFFLS VWLVAYGVTT QALLHPHDGR
910 920 930 940 950
LEWIFRRVLY RPYLQIFGQI PLDEIDEARV NCSLHPLLLE SSASCPNLYA
960 970 980 990 1000
NWLVILLLVT FLLVTNVLLM NLLIAMFSYT FQVVQGNADM FWKFQRYHLI
1010 1020 1030 1040 1050
VEYHGRPALA PPFILLSHLS LVLKQVFRKE AQHKRQHLER DLPDPLDQKI
1060 1070 1080 1090 1100
ITWETVQKEN FLSTMEKRRR DSEGEVLRKT AHRVDLIAKY IGGLREQEKR
1110 1120 1130 1140 1150
IKCLESQANY CMLLLSSMTD TLAPGGTYSS SQNCGCRSQP ASARDREYLE

SGLPPSDT
Length:1,158
Mass (Da):130,844
Last modified:October 1, 2000 - v1
Checksum:iF0A5237EC67867CE
GO
Isoform 21 Publication (identifier: Q9JJH7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1108-1116: ANYCMLLLS → SKYGFRPWE
     1117-1158: Missing.

Show »
Length:1,116
Mass (Da):126,609
Checksum:i32DFFABCF2835E48
GO
Isoform 31 Publication (identifier: Q9JJH7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     978-1000: SYTFQVVQGNADMFWKFQRYHLI → RVLTETGPMSWYFAAVSSGLDLQ
     1001-1158: Missing.

Show »
Length:1,000
Mass (Da):112,460
Checksum:iBB107610176E6660
GO

Sequence cautioni

The sequence CAB94717.2 differs from that shown. Reason: Frameshift at position 1130.
The sequence CAC19456.1 differs from that shown. Reason: Frameshift at position 1130.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241C → S in AAI33713. (PubMed:15489334)Curated
Sequence conflicti612 – 6121H → P in CAB94717. (PubMed:10915772)Curated
Sequence conflicti871 – 8711D → E in BAE36157. (PubMed:16141072)Curated
Sequence conflicti897 – 8971H → N in AAI33713. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei978 – 100023SYTFQ…RYHLI → RVLTETGPMSWYFAAVSSGL DLQ in isoform 3. 1 PublicationVSP_052744Add
BLAST
Alternative sequencei1001 – 1158158Missing in isoform 3. 1 PublicationVSP_052745Add
BLAST
Alternative sequencei1108 – 11169ANYCMLLLS → SKYGFRPWE in isoform 2. 1 PublicationVSP_052746
Alternative sequencei1117 – 115842Missing in isoform 2. 1 PublicationVSP_052747Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039952 mRNA. Translation: BAA96877.1.
AF228681 mRNA. Translation: AAF98120.1.
AJ251835 Genomic DNA. Translation: CAC19456.1. Frameshift.
AJ251835 Genomic DNA. Translation: CAC19457.1.
AJ271092 mRNA. Translation: CAB94717.2. Frameshift.
AY280364 mRNA. Translation: AAP44476.1.
AY280365 mRNA. Translation: AAP44477.1.
BC133712 mRNA. Translation: AAI33713.1.
AK161030 mRNA. Translation: BAE36157.1.
CCDSiCCDS52462.1. [Q9JJH7-1]
RefSeqiNP_064673.2. NM_020277.2. [Q9JJH7-1]
XP_006508708.1. XM_006508645.1. [Q9JJH7-1]
XP_006508709.1. XM_006508646.1. [Q9JJH7-3]
UniGeneiMm.286668.

Genome annotation databases

EnsembliENSMUST00000009390; ENSMUSP00000009390; ENSMUSG00000009246. [Q9JJH7-1]
ENSMUST00000150867; ENSMUSP00000114302; ENSMUSG00000009246. [Q9JJH7-3]
GeneIDi56843.
KEGGimmu:56843.
UCSCiuc009koz.1. mouse. [Q9JJH7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039952 mRNA. Translation: BAA96877.1 .
AF228681 mRNA. Translation: AAF98120.1 .
AJ251835 Genomic DNA. Translation: CAC19456.1 . Frameshift.
AJ251835 Genomic DNA. Translation: CAC19457.1 .
AJ271092 mRNA. Translation: CAB94717.2 . Frameshift.
AY280364 mRNA. Translation: AAP44476.1 .
AY280365 mRNA. Translation: AAP44477.1 .
BC133712 mRNA. Translation: AAI33713.1 .
AK161030 mRNA. Translation: BAE36157.1 .
CCDSi CCDS52462.1. [Q9JJH7-1 ]
RefSeqi NP_064673.2. NM_020277.2. [Q9JJH7-1 ]
XP_006508708.1. XM_006508645.1. [Q9JJH7-1 ]
XP_006508709.1. XM_006508646.1. [Q9JJH7-3 ]
UniGenei Mm.286668.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 497.

PTM databases

PhosphoSitei Q9JJH7.

Proteomic databases

PRIDEi Q9JJH7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000009390 ; ENSMUSP00000009390 ; ENSMUSG00000009246 . [Q9JJH7-1 ]
ENSMUST00000150867 ; ENSMUSP00000114302 ; ENSMUSG00000009246 . [Q9JJH7-3 ]
GeneIDi 56843.
KEGGi mmu:56843.
UCSCi uc009koz.1. mouse. [Q9JJH7-1 ]

Organism-specific databases

CTDi 29850.
MGIi MGI:1861718. Trpm5.

Phylogenomic databases

eggNOGi NOG253824.
GeneTreei ENSGT00760000119127.
HOVERGENi HBG108337.
InParanoidi Q9JJH7.
KOi K04980.
OMAi ECYSNSE.
OrthoDBi EOG725DH1.
PhylomeDBi Q9JJH7.
TreeFami TF314204.

Enzyme and pathway databases

Reactomei REACT_227861. TRP channels.

Miscellaneous databases

NextBioi 313391.
PROi Q9JJH7.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJH7.
Genevestigatori Q9JJH7.

Family and domain databases

InterProi IPR029577. TRPM5.
[Graphical view ]
PANTHERi PTHR13800:SF5. PTHR13800:SF5. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human."
    Yatsuki H., Watanabe H., Hattori M., Joh K., Soejima H., Komoda H., Xin Z., Zhu X., Higashimoto K., Nishimura M., Kuratomi S., Sasaki H., Sakaki Y., Mukai T.
    DNA Res. 7:195-206(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family."
    Enklaar T., Esswein M., Oswald M., Hilbert K., Winterpacht A., Higgins M., Zabel B., Prawitt D.
    Genomics 67:179-187(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse."
    Paulsen M., El-Maarri O., Engemann S., Stroedicke M., Franck O., Davies K., Reinhardt R., Reik W., Walter J.
    Hum. Mol. Genet. 9:1829-1841(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
    Strain: 129/SvImported.
  4. "TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel."
    Hofmann T., Chubanov V., Gudermann T., Montell C.
    Curr. Biol. 13:1153-1158(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION.
    Tissue: TestisImported.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 441-1158 (ISOFORM 1).
    Strain: C57BL/6JImported.
    Tissue: Embryonic liverImported.
  7. "A transient receptor potential channel expressed in taste receptor cells."
    Perez C.A., Huang L., Rong M., Kozak J.A., Preuss A.K., Zhang H., Max M., Margolskee R.F.
    Nat. Neurosci. 5:1169-1176(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5."
    Liu D., Liman E.R.
    Proc. Natl. Acad. Sci. U.S.A. 100:15160-15165(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION.
  9. "Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice."
    Ullrich N.D., Voets T., Prenen J., Vennekens R., Talavera K., Droogmans G., Nilius B.
    Cell Calcium 37:267-278(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION.
  10. "Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains."
    Liu D., Zhang Z., Liman E.R.
    J. Biol. Chem. 280:20691-20699(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF GLU-831; HIS-897 AND HIS-935.
  11. "Heat activation of TRPM5 underlies thermal sensitivity of sweet taste."
    Talavera K., Yasumatsu K., Voets T., Droogmans G., Shigemura N., Ninomiya Y., Margolskee R.F., Nilius B.
    Nature 438:1022-1025(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells."
    Oike H., Wakamori M., Mori Y., Nakanishi H., Taguchi R., Misaka T., Matsumoto I., Abe K.
    Biochim. Biophys. Acta 1761:1078-1084(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  14. "TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells."
    Kaske S., Krasteva G., Koenig P., Kummer W., Hofmann T., Gudermann T., Chubanov V.
    BMC Neurosci. 8:49-49(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  15. "The transduction channel TRPM5 is gated by intracellular calcium in taste cells."
    Zhang Z., Zhao Z., Margolskee R., Liman E.
    J. Neurosci. 27:5777-5786(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  16. "Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals."
    Lin W., Margolskee R., Donnert G., Hell S.W., Restrepo D.
    Proc. Natl. Acad. Sci. U.S.A. 104:2471-2476(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTRPM5_MOUSE
AccessioniPrimary (citable) accession number: Q9JJH7
Secondary accession number(s): A3KN89
, Q3TU14, Q7TPL4, Q99NF9, Q9EPM3, Q9EPM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3