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Protein

Probable G-protein coupled receptor 27

Gene

Gpr27

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 27
Alternative name(s):
Super conserved receptor expressed in brain 1
Gene namesi
Name:Gpr27
Synonyms:Sreb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi71067. Gpr27.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini46 – 5611CytoplasmicSequence analysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence analysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 14021CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini162 – 18322ExtracellularSequence analysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini205 – 28783CytoplasmicSequence analysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini309 – 32214ExtracellularSequence analysisAdd
BLAST
Transmembranei323 – 34321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini344 – 37734CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Probable G-protein coupled receptor 27PRO_0000069550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 173PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JJH3.

Expressioni

Tissue specificityi

Expressed as a 3.0 kb transcript, in whole brain, hippocampus, striatum, frontal cortex, thalamus, pons and hypothalamus. A lower molecular weight transcript was detected in all regions examined, except the hypothalamus.1 Publication

Gene expression databases

GenevisibleiQ9JJH3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014455.

Structurei

3D structure databases

ProteinModelPortaliQ9JJH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiQ9JJH3.
KOiK04301.
OMAiQATLPCD.
OrthoDBiEOG73NG3K.
PhylomeDBiQ9JJH3.
TreeFamiTF331163.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANASEPGGG GGGAEAAALG LRLATLSLLL CVSLAGNVLF ALLIVRERSL
60 70 80 90 100
HRAPYYLLLD LCLADGLRAL ACLPAVMLAA RRAAAAAGTP PGALGCKLLA
110 120 130 140 150
FLAALFCFHA AFLLLGVGVT RYLAIAHHRF YAERLAGWPC AAMLVCAAWA
160 170 180 190 200
LALAAAFPPV LDGGGADDED APCALEQRPD GAPGALGFLL LLAAVVGATH
210 220 230 240 250
LVYLRLLFFI HDRRKMRPAR LVPAVSHDWT FHGPGATGQA AANWTAGFGR
260 270 280 290 300
GPTPPALVGI RPAGPGRGAR RLLVLEEFKT EKRLCKMFYA ITLLFLLLWG
310 320 330 340 350
PYVVASYLRV LVRPGAVPQA YLTASVWLTF AQAGINPVVC FLFNRELRDC
360 370
FRAQFPCCQS PQATQATLPC DLKGIGL
Length:377
Mass (Da):39,892
Last modified:October 1, 2000 - v1
Checksum:iEC32C271C982D47B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040802 mRNA. Translation: BAA96648.1.
RefSeqiNP_075587.1. NM_023099.1.
UniGeneiRn.54454.

Genome annotation databases

EnsembliENSRNOT00000014455; ENSRNOP00000014455; ENSRNOG00000010880.
GeneIDi65275.
KEGGirno:65275.
UCSCiRGD:71067. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040802 mRNA. Translation: BAA96648.1.
RefSeqiNP_075587.1. NM_023099.1.
UniGeneiRn.54454.

3D structure databases

ProteinModelPortaliQ9JJH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014455.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9JJH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014455; ENSRNOP00000014455; ENSRNOG00000010880.
GeneIDi65275.
KEGGirno:65275.
UCSCiRGD:71067. rat.

Organism-specific databases

CTDi2850.
RGDi71067. Gpr27.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiQ9JJH3.
KOiK04301.
OMAiQATLPCD.
OrthoDBiEOG73NG3K.
PhylomeDBiQ9JJH3.
TreeFamiTF331163.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ9JJH3.

Gene expression databases

GenevisibleiQ9JJH3. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system."
    Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.
    Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR27_RAT
AccessioniPrimary (citable) accession number: Q9JJH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.