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Q9JJH1

- RNAS4_MOUSE

UniProt

Q9JJH1 - RNAS4_MOUSE

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Protein
Ribonuclease 4
Gene
Rnase4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This RNase has marked specificity towards the 3' side of uridine nucleotides By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Substrate By similarity
Active sitei41 – 411Proton acceptor By similarity
Binding sitei94 – 941Substrate By similarity
Binding sitei111 – 1111Substrate By similarity
Active sitei145 – 1451Proton donor By similarity

GO - Molecular functioni

  1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. cellular response to starvation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 4 (EC:3.1.27.-)
Short name:
RNase 4
Gene namesi
Name:Rnase4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1926217. Rnase4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 By similarity
Add
BLAST
Chaini30 – 148119Ribonuclease 4
PRO_0000030885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301Pyrrolidone carboxylic acid By similarity
Disulfide bondi54 ↔ 110 By similarity
Disulfide bondi68 ↔ 121 By similarity
Disulfide bondi86 ↔ 136 By similarity
Disulfide bondi93 ↔ 100 By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ9JJH1.
PRIDEiQ9JJH1.

Expressioni

Gene expression databases

CleanExiMM_RNASE4.
GenevestigatoriQ9JJH1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022428.

Structurei

3D structure databases

ProteinModelPortaliQ9JJH1.
SMRiQ9JJH1. Positions 30-147.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 735Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42321.
HOGENOMiHOG000276883.
HOVERGENiHBG008396.
InParanoidiQ9JJH1.
PhylomeDBiQ9JJH1.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJH1-1 [UniParc]FASTAAdd to Basket

« Hide

MMDLQRTQSL LLLLVLTLLG LGLVQPSYGQ DRMYQRFLRQ HVDPQATGGN    50
DNYCNVMMQR RKMTSVQCKR FNTFIHEDIW NIRGICSTTN ILCKNGQMNC 100
HEGVVKVTDC RETGNSKAPN CRYRARTSTR RVVIACEGDP EVPVHFDR 148
Length:148
Mass (Da):17,025
Last modified:October 1, 2000 - v1
Checksum:i470DB6629AFC87A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041044 mRNA. Translation: BAA96476.1.
BC005569 mRNA. Translation: AAH05569.1.
CCDSiCCDS27035.1.
UniGeneiMm.202665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041044 mRNA. Translation: BAA96476.1 .
BC005569 mRNA. Translation: AAH05569.1 .
CCDSi CCDS27035.1.
UniGenei Mm.202665.

3D structure databases

ProteinModelPortali Q9JJH1.
SMRi Q9JJH1. Positions 30-147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022428.

Proteomic databases

PaxDbi Q9JJH1.
PRIDEi Q9JJH1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1926217. Rnase4.

Phylogenomic databases

eggNOGi NOG42321.
HOGENOMi HOG000276883.
HOVERGENi HBG008396.
InParanoidi Q9JJH1.
PhylomeDBi Q9JJH1.

Miscellaneous databases

ChiTaRSi RNASE4. mouse.
PROi Q9JJH1.
SOURCEi Search...

Gene expression databases

CleanExi MM_RNASE4.
Genevestigatori Q9JJH1.

Family and domain databases

Gene3Di 3.10.130.10. 1 hit.
InterProi IPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view ]
PANTHERi PTHR11437. PTHR11437. 1 hit.
Pfami PF00074. RnaseA. 1 hit.
[Graphical view ]
PRINTSi PR00794. RIBONUCLEASE.
ProDomi PD000535. RNaseA. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00092. RNAse_Pc. 1 hit.
[Graphical view ]
SUPFAMi SSF54076. SSF54076. 1 hit.
PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Ikegawa S., Nakamura Y.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiRNAS4_MOUSE
AccessioniPrimary (citable) accession number: Q9JJH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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