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Protein

Ribonuclease 4

Gene

Rnase4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This RNase has marked specificity towards the 3' side of uridine nucleotides.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Active sitei41 – 411Proton acceptorBy similarity
Binding sitei94 – 941SubstrateBy similarity
Binding sitei111 – 1111SubstrateBy similarity
Active sitei145 – 1451Proton donorBy similarity

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. cellular response to starvation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 4 (EC:3.1.27.-)
Short name:
RNase 4
Gene namesi
Name:Rnase4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1926217. Rnase4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929By similarityAdd
BLAST
Chaini30 – 148119Ribonuclease 4PRO_0000030885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301Pyrrolidone carboxylic acidBy similarity
Disulfide bondi54 ↔ 110By similarity
Disulfide bondi68 ↔ 121By similarity
Disulfide bondi86 ↔ 136By similarity
Disulfide bondi93 ↔ 100By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ9JJH1.
PRIDEiQ9JJH1.

Expressioni

Gene expression databases

CleanExiMM_RNASE4.
GenevestigatoriQ9JJH1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022428.

Structurei

3D structure databases

ProteinModelPortaliQ9JJH1.
SMRiQ9JJH1. Positions 30-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 735Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42321.
HOGENOMiHOG000276883.
HOVERGENiHBG008396.
InParanoidiQ9JJH1.
PhylomeDBiQ9JJH1.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDLQRTQSL LLLLVLTLLG LGLVQPSYGQ DRMYQRFLRQ HVDPQATGGN
60 70 80 90 100
DNYCNVMMQR RKMTSVQCKR FNTFIHEDIW NIRGICSTTN ILCKNGQMNC
110 120 130 140
HEGVVKVTDC RETGNSKAPN CRYRARTSTR RVVIACEGDP EVPVHFDR
Length:148
Mass (Da):17,025
Last modified:September 30, 2000 - v1
Checksum:i470DB6629AFC87A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041044 mRNA. Translation: BAA96476.1.
BC005569 mRNA. Translation: AAH05569.1.
CCDSiCCDS27035.1.
UniGeneiMm.202665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041044 mRNA. Translation: BAA96476.1.
BC005569 mRNA. Translation: AAH05569.1.
CCDSiCCDS27035.1.
UniGeneiMm.202665.

3D structure databases

ProteinModelPortaliQ9JJH1.
SMRiQ9JJH1. Positions 30-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022428.

Proteomic databases

PaxDbiQ9JJH1.
PRIDEiQ9JJH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1926217. Rnase4.

Phylogenomic databases

eggNOGiNOG42321.
HOGENOMiHOG000276883.
HOVERGENiHBG008396.
InParanoidiQ9JJH1.
PhylomeDBiQ9JJH1.

Miscellaneous databases

ChiTaRSiRnase4. mouse.
PROiQ9JJH1.
SOURCEiSearch...

Gene expression databases

CleanExiMM_RNASE4.
GenevestigatoriQ9JJH1.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ikegawa S., Nakamura Y.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiRNAS4_MOUSE
AccessioniPrimary (citable) accession number: Q9JJH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 18, 2001
Last sequence update: September 30, 2000
Last modified: March 3, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.