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Q9JJH1

- RNAS4_MOUSE

UniProt

Q9JJH1 - RNAS4_MOUSE

Protein

Ribonuclease 4

Gene

Rnase4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    This RNase has marked specificity towards the 3' side of uridine nucleotides.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391SubstrateBy similarity
    Active sitei41 – 411Proton acceptorBy similarity
    Binding sitei94 – 941SubstrateBy similarity
    Binding sitei111 – 1111SubstrateBy similarity
    Active sitei145 – 1451Proton donorBy similarity

    GO - Molecular functioni

    1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
    2. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. cellular response to starvation Source: MGI

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 4 (EC:3.1.27.-)
    Short name:
    RNase 4
    Gene namesi
    Name:Rnase4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1926217. Rnase4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929By similarityAdd
    BLAST
    Chaini30 – 148119Ribonuclease 4PRO_0000030885Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei30 – 301Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi54 ↔ 110By similarity
    Disulfide bondi68 ↔ 121By similarity
    Disulfide bondi86 ↔ 136By similarity
    Disulfide bondi93 ↔ 100By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Proteomic databases

    PaxDbiQ9JJH1.
    PRIDEiQ9JJH1.

    Expressioni

    Gene expression databases

    CleanExiMM_RNASE4.
    GenevestigatoriQ9JJH1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000022428.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJH1.
    SMRiQ9JJH1. Positions 30-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni69 – 735Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the pancreatic ribonuclease family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42321.
    HOGENOMiHOG000276883.
    HOVERGENiHBG008396.
    InParanoidiQ9JJH1.
    PhylomeDBiQ9JJH1.

    Family and domain databases

    Gene3Di3.10.130.10. 1 hit.
    InterProiIPR001427. RNaseA.
    IPR023411. RNaseA_AS.
    IPR023412. RNaseA_domain.
    [Graphical view]
    PANTHERiPTHR11437. PTHR11437. 1 hit.
    PfamiPF00074. RnaseA. 1 hit.
    [Graphical view]
    PRINTSiPR00794. RIBONUCLEASE.
    ProDomiPD000535. RNaseA. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00092. RNAse_Pc. 1 hit.
    [Graphical view]
    SUPFAMiSSF54076. SSF54076. 1 hit.
    PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JJH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMDLQRTQSL LLLLVLTLLG LGLVQPSYGQ DRMYQRFLRQ HVDPQATGGN    50
    DNYCNVMMQR RKMTSVQCKR FNTFIHEDIW NIRGICSTTN ILCKNGQMNC 100
    HEGVVKVTDC RETGNSKAPN CRYRARTSTR RVVIACEGDP EVPVHFDR 148
    Length:148
    Mass (Da):17,025
    Last modified:October 1, 2000 - v1
    Checksum:i470DB6629AFC87A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041044 mRNA. Translation: BAA96476.1.
    BC005569 mRNA. Translation: AAH05569.1.
    CCDSiCCDS27035.1.
    UniGeneiMm.202665.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041044 mRNA. Translation: BAA96476.1 .
    BC005569 mRNA. Translation: AAH05569.1 .
    CCDSi CCDS27035.1.
    UniGenei Mm.202665.

    3D structure databases

    ProteinModelPortali Q9JJH1.
    SMRi Q9JJH1. Positions 30-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000022428.

    Proteomic databases

    PaxDbi Q9JJH1.
    PRIDEi Q9JJH1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1926217. Rnase4.

    Phylogenomic databases

    eggNOGi NOG42321.
    HOGENOMi HOG000276883.
    HOVERGENi HBG008396.
    InParanoidi Q9JJH1.
    PhylomeDBi Q9JJH1.

    Miscellaneous databases

    ChiTaRSi RNASE4. mouse.
    PROi Q9JJH1.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_RNASE4.
    Genevestigatori Q9JJH1.

    Family and domain databases

    Gene3Di 3.10.130.10. 1 hit.
    InterProi IPR001427. RNaseA.
    IPR023411. RNaseA_AS.
    IPR023412. RNaseA_domain.
    [Graphical view ]
    PANTHERi PTHR11437. PTHR11437. 1 hit.
    Pfami PF00074. RnaseA. 1 hit.
    [Graphical view ]
    PRINTSi PR00794. RIBONUCLEASE.
    ProDomi PD000535. RNaseA. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00092. RNAse_Pc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54076. SSF54076. 1 hit.
    PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ikegawa S., Nakamura Y.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiRNAS4_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 19, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3