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Q9JJH1

- RNAS4_MOUSE

UniProt

Q9JJH1 - RNAS4_MOUSE

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Protein

Ribonuclease 4

Gene

Rnase4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

This RNase has marked specificity towards the 3' side of uridine nucleotides.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Active sitei41 – 411Proton acceptorBy similarity
Binding sitei94 – 941SubstrateBy similarity
Binding sitei111 – 1111SubstrateBy similarity
Active sitei145 – 1451Proton donorBy similarity

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. cellular response to starvation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 4 (EC:3.1.27.-)
Short name:
RNase 4
Gene namesi
Name:Rnase4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1926217. Rnase4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929By similarityAdd
BLAST
Chaini30 – 148119Ribonuclease 4PRO_0000030885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301Pyrrolidone carboxylic acidBy similarity
Disulfide bondi54 ↔ 110By similarity
Disulfide bondi68 ↔ 121By similarity
Disulfide bondi86 ↔ 136By similarity
Disulfide bondi93 ↔ 100By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ9JJH1.
PRIDEiQ9JJH1.

Expressioni

Gene expression databases

CleanExiMM_RNASE4.
GenevestigatoriQ9JJH1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022428.

Structurei

3D structure databases

ProteinModelPortaliQ9JJH1.
SMRiQ9JJH1. Positions 30-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 735Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42321.
HOGENOMiHOG000276883.
HOVERGENiHBG008396.
InParanoidiQ9JJH1.
PhylomeDBiQ9JJH1.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMDLQRTQSL LLLLVLTLLG LGLVQPSYGQ DRMYQRFLRQ HVDPQATGGN
60 70 80 90 100
DNYCNVMMQR RKMTSVQCKR FNTFIHEDIW NIRGICSTTN ILCKNGQMNC
110 120 130 140
HEGVVKVTDC RETGNSKAPN CRYRARTSTR RVVIACEGDP EVPVHFDR
Length:148
Mass (Da):17,025
Last modified:October 1, 2000 - v1
Checksum:i470DB6629AFC87A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041044 mRNA. Translation: BAA96476.1.
BC005569 mRNA. Translation: AAH05569.1.
CCDSiCCDS27035.1.
UniGeneiMm.202665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041044 mRNA. Translation: BAA96476.1 .
BC005569 mRNA. Translation: AAH05569.1 .
CCDSi CCDS27035.1.
UniGenei Mm.202665.

3D structure databases

ProteinModelPortali Q9JJH1.
SMRi Q9JJH1. Positions 30-147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022428.

Proteomic databases

PaxDbi Q9JJH1.
PRIDEi Q9JJH1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1926217. Rnase4.

Phylogenomic databases

eggNOGi NOG42321.
HOGENOMi HOG000276883.
HOVERGENi HBG008396.
InParanoidi Q9JJH1.
PhylomeDBi Q9JJH1.

Miscellaneous databases

ChiTaRSi RNASE4. mouse.
PROi Q9JJH1.
SOURCEi Search...

Gene expression databases

CleanExi MM_RNASE4.
Genevestigatori Q9JJH1.

Family and domain databases

Gene3Di 3.10.130.10. 1 hit.
InterProi IPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view ]
PANTHERi PTHR11437. PTHR11437. 1 hit.
Pfami PF00074. RnaseA. 1 hit.
[Graphical view ]
PRINTSi PR00794. RIBONUCLEASE.
ProDomi PD000535. RNaseA. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00092. RNAse_Pc. 1 hit.
[Graphical view ]
SUPFAMi SSF54076. SSF54076. 1 hit.
PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Ikegawa S., Nakamura Y.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiRNAS4_MOUSE
AccessioniPrimary (citable) accession number: Q9JJH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3