Q9JJH1 (RNAS4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease 4
Short name=RNase 4
EC=3.1.27.-

Gene names

Name:

Rnase4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This RNase has marked specificity towards the 3' side of uridine nucleotides By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the pancreatic ribonuclease family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Endonuclease Hydrolase Nuclease
PTM	Disulfide bond Pyrrolidone carboxylic acid
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro pancreatic ribonuclease activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	By similarity
	Chain	30 – 148	119	Ribonuclease 4		PRO_0000030885
Regions
	Region	69 – 73	5	Substrate binding By similarity
Sites
	Active site	41	1	Proton acceptor By similarity
	Active site	145	1	Proton donor By similarity
	Binding site	39	1	Substrate By similarity
	Binding site	94	1	Substrate By similarity
	Binding site	111	1	Substrate By similarity
Amino acid modifications
	Modified residue	30	1	Pyrrolidone carboxylic acid By similarity
	Disulfide bond	54 ↔ 110		By similarity
	Disulfide bond	68 ↔ 121		By similarity
	Disulfide bond	86 ↔ 136		By similarity
	Disulfide bond	93 ↔ 100		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9JJH1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 470DB6629AFC87A3	FASTA	148	17,025
	10 20 30 40 50 60 MMDLQRTQSL LLLLVLTLLG LGLVQPSYGQ DRMYQRFLRQ HVDPQATGGN DNYCNVMMQR 70 80 90 100 110 120 RKMTSVQCKR FNTFIHEDIW NIRGICSTTN ILCKNGQMNC HEGVVKVTDC RETGNSKAPN 130 140 CRYRARTSTR RVVIACEGDP EVPVHFDR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Ikegawa S., Nakamura Y. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB041044 mRNA. Translation: BAA96476.1. BC005569 mRNA. Translation: AAH05569.1.
IPI	IPI00121837.
UniGene	Mm.202665.
3D structure databases
ProteinModelPortal	Q9JJH1.
SMR	Q9JJH1. Positions 30-147.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000022428.
Proteomic databases
PaxDb	Q9JJH1.
PRIDE	Q9JJH1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1926217. Rnase4.
Phylogenomic databases
eggNOG	NOG42321.
HOGENOM	HOG000276883.
HOVERGEN	HBG008396.
InParanoid	Q9JJH1.
OrthoDB	EOG4TMR3F.
Gene expression databases
CleanEx	MM_RNASE4.
Genevestigator	Q9JJH1.
GermOnline	ENSMUSG00000021876. Mus musculus.
Family and domain databases
Gene3D	3.10.130.10. 1 hit.
InterPro	IPR001427. RNaseA. IPR023411. RNaseA_AS. IPR023412. RNaseA_domain. [Graphical view]
PANTHER	PTHR11437. PTHR11437. 1 hit.
Pfam	PF00074. RnaseA. 1 hit. [Graphical view]
PRINTS	PR00794. RIBONUCLEASE.
ProDom	PD000535. RNaseA. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00092. RNAse_Pc. 1 hit. [Graphical view]
SUPFAM	SSF54076. RNaseA. 1 hit.
PROSITE	PS00127. RNASE_PANCREATIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RNASE4. mouse.
SOURCE	Search...

Entry information

Entry name

RNAS4_MOUSE

Accession

Primary (citable) accession number: Q9JJH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 19, 2001
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program