Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9JJH1 (RNAS4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 4

Short name=RNase 4
EC=3.1.27.-
Gene names
Name:Rnase4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This RNase has marked specificity towards the 3' side of uridine nucleotides By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the pancreatic ribonuclease family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 By similarity
Chain30 – 148119Ribonuclease 4
PRO_0000030885

Regions

Region69 – 735Substrate binding By similarity

Sites

Active site411Proton acceptor By similarity
Active site1451Proton donor By similarity
Binding site391Substrate By similarity
Binding site941Substrate By similarity
Binding site1111Substrate By similarity

Amino acid modifications

Modified residue301Pyrrolidone carboxylic acid By similarity
Disulfide bond54 ↔ 110 By similarity
Disulfide bond68 ↔ 121 By similarity
Disulfide bond86 ↔ 136 By similarity
Disulfide bond93 ↔ 100 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JJH1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 470DB6629AFC87A3

FASTA14817,025
        10         20         30         40         50         60 
MMDLQRTQSL LLLLVLTLLG LGLVQPSYGQ DRMYQRFLRQ HVDPQATGGN DNYCNVMMQR 

        70         80         90        100        110        120 
RKMTSVQCKR FNTFIHEDIW NIRGICSTTN ILCKNGQMNC HEGVVKVTDC RETGNSKAPN 

       130        140 
CRYRARTSTR RVVIACEGDP EVPVHFDR 

« Hide

References

« Hide 'large scale' references
[1]Ikegawa S., Nakamura Y.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB041044 mRNA. Translation: BAA96476.1.
BC005569 mRNA. Translation: AAH05569.1.
UniGeneMm.202665.

3D structure databases

ProteinModelPortalQ9JJH1.
SMRQ9JJH1. Positions 30-147.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000022428.

Proteomic databases

PaxDbQ9JJH1.
PRIDEQ9JJH1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1926217. Rnase4.

Phylogenomic databases

eggNOGNOG42321.
HOGENOMHOG000276883.
HOVERGENHBG008396.
InParanoidQ9JJH1.

Gene expression databases

CleanExMM_RNASE4.
GenevestigatorQ9JJH1.

Family and domain databases

Gene3D3.10.130.10. 1 hit.
InterProIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERPTHR11437. PTHR11437. 1 hit.
PfamPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSPR00794. RIBONUCLEASE.
ProDomPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMSSF54076. SSF54076. 1 hit.
PROSITEPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRNASE4. mouse.
PROQ9JJH1.
SOURCESearch...

Entry information

Entry nameRNAS4_MOUSE
AccessionPrimary (citable) accession number: Q9JJH1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot