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Protein

Nitric oxide-associated protein 1

Gene

Noa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.2 Publications

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mitochondrial translation Source: UniProtKB
  • regulation of cell death Source: UniProtKB
  • regulation of cellular respiration Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nitric oxide-associated protein 1
Gene namesi
Name:Noa1
ORF Names:MNCb-4931
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914306. Noa1.

Subcellular locationi

GO - Cellular componenti

  • extrinsic component of mitochondrial inner membrane Source: Ensembl
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Mice display mid-gestation lethality associated with a severe developmental defect of the embryo and trophoblast. Primary embryonic fibroblasts isolated from mutant E9.5 embryos show deficient mitochondrial synthesis and a global defect of oxidative phosphorylation.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi353 – 3531K → R: Loss of ability to regulate activity of mitochondrial respiratory chain complexes. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Nitric oxide-associated protein 1PRO_0000232511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JJG9.
MaxQBiQ9JJG9.
PaxDbiQ9JJG9.
PRIDEiQ9JJG9.

PTM databases

iPTMnetiQ9JJG9.
PhosphoSiteiQ9JJG9.

Expressioni

Tissue specificityi

Expressed in tissues associated with high mitochondria content including testes, heart, liver, brain and thymus. Also expressed in various bone cell lines.1 Publication

Developmental stagei

At E10.5, weak but widespread expression. By E12.5 prominently expressed in the liver and also detected in developing CNS and dorsal root ganglia. At E14.5, expression is intensified in bone.1 Publication

Gene expression databases

BgeeiQ9JJG9.
CleanExiMM_2610024G14RIK.
GenevisibleiQ9JJG9. MM.

Interactioni

Subunit structurei

Homodimer or multimer. Interacts with mitochondrial complex I, DAP3, MRPL12 and MRPS27.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045948.

Structurei

3D structure databases

ProteinModelPortaliQ9JJG9.
SMRiQ9JJG9. Positions 216-394, 495-650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini203 – 504302CP-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOA1 subfamily.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1249. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00390000001695.
HOGENOMiHOG000026785.
HOVERGENiHBG068278.
InParanoidiQ9JJG9.
KOiK19832.
OMAiVPCNGCG.
OrthoDBiEOG7ZD1V2.
PhylomeDBiQ9JJG9.
TreeFamiTF314460.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPARLACGL LCGLRRGPAP AAACYGPARW LLEGKCEVPI RQRASSLGRR
60 70 80 90 100
VPPSSTATED YAEGPDTEER FLFPEYVPER TPEEQVRELQ ELRELQQLQQ
110 120 130 140 150
EKERERLQQR EERLQQKLRA GFRTLPVPEF PDASVPPSGI YCSGCGAELH
160 170 180 190 200
CQHPGLPGYL PEEKFRDAAQ AEGGPARTVC QRCWLLVHHG RALRLQVSRD
210 220 230 240 250
QYLELVSAAL RRPGPALVLY MVNLLDLPDA LLPDLPKLVG PKQLIVLGNK
260 270 280 290 300
VDLLPQDAPG YLKRLRKRLW DDCIRAGLVV APGHQGPQYP AGDEPLEEIK
310 320 330 340 350
NQNPSSRSRT VVKDVRLISA KTGYGVEEMI SALQRSWRYR GDVYLVGTTN
360 370 380 390 400
AGKSTLFNTL LESDYCTAKG SEAIDRATIS PWPGTTLNLL KFPICNPTPY
410 420 430 440 450
RMFKRQRRLQ EDATKAEEDL SEEEQSQLNQ LKKHGYIVGR VGRTFSYSRE
460 470 480 490 500
QDEVPFEFDA DSLAFDMGSE PVVSVCKSTK QIELTPEDVK DAHWFYDTPG
510 520 530 540 550
ITKESCILNL LTEKEINTVL PTHSIIPRTF VLKPGMVLFL GGIARIDFLQ
560 570 580 590 600
GNQSAWFTVV ASNFLPVHIT SLDKADALYE KHAGHELLLV PMGGKERMAQ
610 620 630 640 650
FPPLVAEDIT LKGGGKFEAV ADIKFSSAGW VAVTPYSEGT LHLRGHTPEG
660 670 680 690
TALTVHPPVL PYIVNVKGQR MKKSVAYKTK KPPSLVHNLK KHR
Length:693
Mass (Da):77,379
Last modified:October 1, 2000 - v1
Checksum:i946AB1752263903C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81C → R in BAE43128 (PubMed:16141072).Curated
Sequence conflicti259 – 2591P → T in BAE43128 (PubMed:16141072).Curated
Sequence conflicti563 – 5631N → S in BAE34011 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041537 mRNA. Translation: BAA95022.1.
AK017793 mRNA. Translation: BAB30935.1.
AK157246 mRNA. Translation: BAE34011.1.
AK172681 mRNA. Translation: BAE43128.1.
BC005689 mRNA. Translation: AAH05689.1.
BC017154 mRNA. Translation: AAH17154.1.
CCDSiCCDS19373.1.
RefSeqiNP_062810.1. NM_019836.3.
UniGeneiMm.129136.

Genome annotation databases

EnsembliENSMUST00000047860; ENSMUSP00000045948; ENSMUSG00000036285.
GeneIDi56412.
KEGGimmu:56412.
UCSCiuc008xwc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041537 mRNA. Translation: BAA95022.1.
AK017793 mRNA. Translation: BAB30935.1.
AK157246 mRNA. Translation: BAE34011.1.
AK172681 mRNA. Translation: BAE43128.1.
BC005689 mRNA. Translation: AAH05689.1.
BC017154 mRNA. Translation: AAH17154.1.
CCDSiCCDS19373.1.
RefSeqiNP_062810.1. NM_019836.3.
UniGeneiMm.129136.

3D structure databases

ProteinModelPortaliQ9JJG9.
SMRiQ9JJG9. Positions 216-394, 495-650.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045948.

PTM databases

iPTMnetiQ9JJG9.
PhosphoSiteiQ9JJG9.

Proteomic databases

EPDiQ9JJG9.
MaxQBiQ9JJG9.
PaxDbiQ9JJG9.
PRIDEiQ9JJG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047860; ENSMUSP00000045948; ENSMUSG00000036285.
GeneIDi56412.
KEGGimmu:56412.
UCSCiuc008xwc.2. mouse.

Organism-specific databases

CTDi84273.
MGIiMGI:1914306. Noa1.

Phylogenomic databases

eggNOGiKOG1249. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00390000001695.
HOGENOMiHOG000026785.
HOVERGENiHBG068278.
InParanoidiQ9JJG9.
KOiK19832.
OMAiVPCNGCG.
OrthoDBiEOG7ZD1V2.
PhylomeDBiQ9JJG9.
TreeFamiTF314460.

Miscellaneous databases

PROiQ9JJG9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJG9.
CleanExiMM_2610024G14RIK.
GenevisibleiQ9JJG9. MM.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryo and Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor and Salivary gland.
  4. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells."
    Parihar A., Parihar M.S., Chen Z., Ghafourifar P.
    Life Sci. 82:1077-1082(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-353.
  6. Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiNOA1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJG9
Secondary accession number(s): Q3T996, Q3U044, Q99JU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.