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Protein

Calcium-binding protein 8

Gene

Caln1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi49 – 601PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi85 – 962PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 8
Short name:
CaBP8
Alternative name(s):
Calneuron I
Calneuron-1
Gene namesi
Name:Caln1
Synonyms:Cabp8
ORF Names:MNCb-0849
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2155987. Caln1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 192CytoplasmicSequence analysisAdd BLAST192
Transmembranei193 – 213Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini214 – 219ExtracellularSequence analysis6

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735301 – 219Calcium-binding protein 8Add BLAST219

Proteomic databases

PaxDbiQ9JJG7.
PRIDEiQ9JJG7.

PTM databases

iPTMnetiQ9JJG7.
PhosphoSitePlusiQ9JJG7.

Expressioni

Tissue specificityi

Brain-specific. High expression in the cerebellum, hippocampus, and cortex.

Developmental stagei

Shows little prenatal expression, with highest expression at postnatal day 21.

Gene expression databases

BgeeiENSMUSG00000060371.
CleanExiMM_CALN1.
ExpressionAtlasiQ9JJG7. baseline and differential.
GenevisibleiQ9JJG7. MM.

Interactioni

Subunit structurei

Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083193.

Structurei

3D structure databases

ProteinModelPortaliQ9JJG7.
SMRiQ9JJG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 71EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini72 – 107EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Domaini

The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.By similarity

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00740000115520.
HOGENOMiHOG000252990.
InParanoidiQ9JJG7.
PhylomeDBiQ9JJG7.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFHHVTAGL LYKGNYLNRS LSAGSDSEQL ANISVEELDE IREAFRVLDR
60 70 80 90 100
DGNGFISKQE LGMAMRSLGY MPSEVELAII MQRLDMDGDG QVDFDEFMTI
110 120 130 140 150
LGPKLVSSEG RDGFLGNTID SIFWQFDMQR VTLEELKHIL YHAFRDHLTM
160 170 180 190 200
KDIENIIINE EESLNETSGN CQTEFEGVHS QKQNRQTCVR KSLICAFAMA
210
FIISVMLIAA NQILRSGME
Length:219
Mass (Da):24,823
Last modified:October 1, 2000 - v1
Checksum:iF43DA0D17FEB250F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282251 mRNA. Translation: AAK15156.1.
AB041539 mRNA. Translation: BAA95024.1.
BC057129 mRNA. Translation: AAH57129.1.
BC058963 mRNA. Translation: AAH58963.1.
CCDSiCCDS19714.1.
RefSeqiNP_067346.1. NM_021371.2.
NP_851388.1. NM_181045.1.
XP_006504436.1. XM_006504373.2.
XP_006504437.1. XM_006504374.2.
UniGeneiMm.320206.
Mm.40875.

Genome annotation databases

EnsembliENSMUST00000111287; ENSMUSP00000106918; ENSMUSG00000060371.
ENSMUST00000111288; ENSMUSP00000106919; ENSMUSG00000060371.
GeneIDi140904.
KEGGimmu:140904.
UCSCiuc008zuo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282251 mRNA. Translation: AAK15156.1.
AB041539 mRNA. Translation: BAA95024.1.
BC057129 mRNA. Translation: AAH57129.1.
BC058963 mRNA. Translation: AAH58963.1.
CCDSiCCDS19714.1.
RefSeqiNP_067346.1. NM_021371.2.
NP_851388.1. NM_181045.1.
XP_006504436.1. XM_006504373.2.
XP_006504437.1. XM_006504374.2.
UniGeneiMm.320206.
Mm.40875.

3D structure databases

ProteinModelPortaliQ9JJG7.
SMRiQ9JJG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083193.

PTM databases

iPTMnetiQ9JJG7.
PhosphoSitePlusiQ9JJG7.

Proteomic databases

PaxDbiQ9JJG7.
PRIDEiQ9JJG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111287; ENSMUSP00000106918; ENSMUSG00000060371.
ENSMUST00000111288; ENSMUSP00000106919; ENSMUSG00000060371.
GeneIDi140904.
KEGGimmu:140904.
UCSCiuc008zuo.2. mouse.

Organism-specific databases

CTDi83698.
MGIiMGI:2155987. Caln1.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00740000115520.
HOGENOMiHOG000252990.
InParanoidiQ9JJG7.
PhylomeDBiQ9JJG7.

Miscellaneous databases

ChiTaRSiCaln1. mouse.
PROiQ9JJG7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060371.
CleanExiMM_CALN1.
ExpressionAtlasiQ9JJG7. baseline and differential.
GenevisibleiQ9JJG7. MM.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCABP8_MOUSE
AccessioniPrimary (citable) accession number: Q9JJG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.