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Protein

Transforming acidic coiled-coil-containing protein 2

Gene

Tacc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules (By similarity).By similarity2 Publications

GO - Molecular functioni

  • nuclear hormone receptor binding Source: MGI
  • protein domain specific binding Source: MGI

GO - Biological processi

  • astral microtubule organization Source: MGI
  • cell proliferation Source: MGI
  • cerebral cortex development Source: MGI
  • interkinetic nuclear migration Source: MGI
  • microtubule cytoskeleton organization Source: MGI
  • neurogenesis Source: MGI
  • regulation of microtubule-based process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming acidic coiled-coil-containing protein 2
Gene namesi
Name:Tacc2
ORF Names:MNCb-3527
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1928899. Tacc2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice develop normally, are fertile, and do not present elevated tumorization rates. Cells deficient in TACC2 divide normally and do not show any change in the frequency of apoptosis induction.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001799891 – 1149Transforming acidic coiled-coil-containing protein 2Add BLAST1149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100PhosphoserineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei354PhosphoserineCombined sources1
Modified residuei419PhosphoserineBy similarity1
Modified residuei439PhosphothreonineBy similarity1
Modified residuei510PhosphoserineCombined sources1
Modified residuei514PhosphoserineCombined sources1
Modified residuei516PhosphothreonineCombined sources1
Modified residuei552PhosphoserineCombined sources1
Modified residuei582PhosphoserineBy similarity1
Modified residuei585PhosphoserineCombined sources1
Modified residuei587PhosphoserineBy similarity1
Modified residuei596PhosphoserineBy similarity1
Modified residuei632PhosphothreonineBy similarity1
Modified residuei653PhosphothreonineBy similarity1
Modified residuei657PhosphothreonineBy similarity1
Modified residuei714PhosphoserineCombined sources1
Modified residuei736PhosphoserineBy similarity1
Modified residuei755PhosphothreonineCombined sources1
Modified residuei759PhosphoserineBy similarity1
Modified residuei771PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated; which is required for localization in centrosome.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JJG0.
PeptideAtlasiQ9JJG0.
PRIDEiQ9JJG0.

PTM databases

iPTMnetiQ9JJG0.

Expressioni

Tissue specificityi

Expressed in brain, kidney, lung, thymus and ovary. Not detectable in normal tissues at protein level.1 Publication

Gene expression databases

ExpressionAtlasiQ9JJG0. baseline and differential.

Interactioni

Subunit structurei

Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF (By similarity). Interacts with CCDC100/CEP120.By similarity1 Publication

GO - Molecular functioni

  • nuclear hormone receptor binding Source: MGI
  • protein domain specific binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081561.

Structurei

3D structure databases

ProteinModelPortaliQ9JJG0.
SMRiQ9JJG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini508 – 596SPAZAdd BLAST89

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili877 – 905Sequence analysisAdd BLAST29
Coiled coili948 – 1148Sequence analysisAdd BLAST201

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 165Poly-Pro9
Compositional biasi610 – 613Poly-Lys4

Sequence similaritiesi

Belongs to the TACC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIVK. Eukaryota.
ENOG410YMFS. LUCA.
GeneTreeiENSGT00530000063855.
HOGENOMiHOG000294120.
HOVERGENiHBG055954.
InParanoidiQ9JJG0.
KOiK14282.
PhylomeDBiQ9JJG0.

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PfamiPF05010. TACC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JJG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNENSTSDH QRTSSVQSPR SLQPPGKSQS LQKQQGDLPG SCAGSIPGTD
60 70 80 90 100
DVIQPAAPVD PGHPPLAGIG SNQGEVCTSL QLSYTIVTVQ SASPSAARAS
110 120 130 140 150
PAPLAPEHTA SAPSAAGPGV EVTPTGSPQH LAKNEPRSSD SEEAFETPES
160 170 180 190 200
TTPVKAPPAP PPPPPEVTPE PEVIDPPAPE EPGCISEPPV VVPDGPRSSE
210 220 230 240 250
SVEGSPFRPS HSSSAVFDED KPIASSGTYN LDFDSIELVD NFQSLEPCSA
260 270 280 290 300
DSKGQECKVS TRRKSTESVP PSKSTLSRSL SLQASDFDGA SCPGSPEAGT
310 320 330 340 350
LTTDACGTGS NSASSTLKRT KKTRPPSLKK KQATKKPTET PPVKETQQEP
360 370 380 390 400
GEESPVPSEE HLAPETKTES ATPEGAGCTL SDDTPLESPA VPTATCPLTL
410 420 430 440 450
ESAEDVSPLV SGGGRVQNSP PVGRKSVPLT TASEAVEVTL SDSGGQEDLP
460 470 480 490 500
AKGLSVRLEF DYSEDKGSWE SQQENAPPTK KIGKKPVAKM PLRRPKMKKT
510 520 530 540 550
PEKLDNTPAS PPRSPTEPSD TPIAKGTYTF DIDKWDDPNF NPFSSTSKMQ
560 570 580 590 600
ESPKLSQQSY NFDPDACEES LDPFKASSKT PSSPSKSPAS FEIPASTTEA
610 620 630 640 650
DGDGLNKPAK KKKTPLKTMV EDVMSVCSLF DTFRVKKSPK RSPLSDPPSQ
660 670 680 690 700
DPTPAATPEA PSAISTVVHA TDEEKLAVTS QKWTCMTVDL DADKQDFPQP
710 720 730 740 750
SDLSNFVNET KFNSPSEELD YRNSYEIEYM EKLGSSLPQD DDTPKKQALY
760 770 780 790 800
LMFDTPQESP VKSPPVRMSD SPTPCSGSSF EDTEALVNAA TKLQHPVARG
810 820 830 840 850
LPSSQEPLLQ VPEKPSQKEL EAMALGTPAE AIEITAPEGA FASADTLLSR
860 870 880 890 900
LAHPASLCGA LGYLEPDLAE KNPPVFAQKL QEELEFAVMR IEALKLARQI
910 920 930 940 950
ALASRSRQDT KREAAHPPDV SISKTALYSR IGSTEVEKPP GLLFQQPDLD
960 970 980 990 1000
SALQVARAEV IAKEREVSEW RDKYEESRRE VVEMRKIVAE YEKTIAQMIP
1010 1020 1030 1040 1050
GTERKILSHQ TVQQLVLEKE QALADLNSVE KSLADLFRRY EKMKEVLEGF
1060 1070 1080 1090 1100
RKNEEVLKKC AQEYLSRVKK EEQRYQALKV HAEEKLDRAN AEIAQVRGKA
1110 1120 1130 1140
QQEQAAYQAS LRKEQLRVDA LERTLEQKNK EIEELTKICD ELIAKMGKS
Length:1,149
Mass (Da):124,130
Last modified:January 9, 2007 - v2
Checksum:i9B4A46B38747898E
GO
Isoform 2 (identifier: Q9JJG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     115-137: AAGPGVEVTPTGSPQHLAKNEPR → MGGSQSLQPAPASDLNLEVSEAM

Show »
Length:1,035
Mass (Da):112,716
Checksum:i0698015282F94C78
GO
Isoform 3 (identifier: Q9JJG0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     115-137: AAGPGVEVTPTGSPQHLAKNEPR → MGGSQSLQPAPASDLNLEVSEAM
     619-630: Missing.
     835-911: Missing.
     1000-1007: PGTERKIL → EDEQREKSI

Show »
Length:947
Mass (Da):103,276
Checksum:i7C90DFA1A41C7E05
GO
Isoform 4 (identifier: Q9JJG0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-489: Missing.
     619-630: Missing.
     717-717: E → EGKQLGGQPDPHLALENTVPRGQRARK
     835-911: Missing.
     1000-1007: PGTERKIL → EDEQREKSI

Show »
Length:598
Mass (Da):67,057
Checksum:i3624051C22F57997
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti681Q → K in BAC34486 (PubMed:16141072).Curated1
Sequence conflicti1129 – 1132NKEI → DKQR in BAC34486 (PubMed:16141072).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0221591 – 489Missing in isoform 4. 1 PublicationAdd BLAST489
Alternative sequenceiVSP_0221601 – 114Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST114
Alternative sequenceiVSP_022161115 – 137AAGPG…KNEPR → MGGSQSLQPAPASDLNLEVS EAM in isoform 2 and isoform 3. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_022162619 – 630Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_022163717E → EGKQLGGQPDPHLALENTVP RGQRARK in isoform 4. 1 Publication1
Alternative sequenceiVSP_022164835 – 911Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST77
Alternative sequenceiVSP_0221651000 – 1007PGTERKIL → EDEQREKSI in isoform 3 and isoform 4. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177410 mRNA. Translation: AAO18641.1.
AB041546 mRNA. Translation: BAA95031.1.
AK050985 mRNA. Translation: BAC34486.1.
AK165603 mRNA. Translation: BAE38287.1.
BC004057 mRNA. Translation: AAH04057.1.
RefSeqiNP_067289.2. NM_021314.4.
NP_996738.2. NM_206856.3.
XP_006508154.1. XM_006508091.3. [Q9JJG0-3]
UniGeneiMm.86322.

Genome annotation databases

EnsembliENSMUST00000207282; ENSMUSP00000146848; ENSMUSG00000030852. [Q9JJG0-3]
GeneIDi57752.
KEGGimmu:57752.
UCSCiuc009kag.1. mouse. [Q9JJG0-3]
uc009kan.1. mouse. [Q9JJG0-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177410 mRNA. Translation: AAO18641.1.
AB041546 mRNA. Translation: BAA95031.1.
AK050985 mRNA. Translation: BAC34486.1.
AK165603 mRNA. Translation: BAE38287.1.
BC004057 mRNA. Translation: AAH04057.1.
RefSeqiNP_067289.2. NM_021314.4.
NP_996738.2. NM_206856.3.
XP_006508154.1. XM_006508091.3. [Q9JJG0-3]
UniGeneiMm.86322.

3D structure databases

ProteinModelPortaliQ9JJG0.
SMRiQ9JJG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081561.

PTM databases

iPTMnetiQ9JJG0.

Proteomic databases

PaxDbiQ9JJG0.
PeptideAtlasiQ9JJG0.
PRIDEiQ9JJG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000207282; ENSMUSP00000146848; ENSMUSG00000030852. [Q9JJG0-3]
GeneIDi57752.
KEGGimmu:57752.
UCSCiuc009kag.1. mouse. [Q9JJG0-3]
uc009kan.1. mouse. [Q9JJG0-4]

Organism-specific databases

CTDi10579.
MGIiMGI:1928899. Tacc2.

Phylogenomic databases

eggNOGiENOG410IIVK. Eukaryota.
ENOG410YMFS. LUCA.
GeneTreeiENSGT00530000063855.
HOGENOMiHOG000294120.
HOVERGENiHBG055954.
InParanoidiQ9JJG0.
KOiK14282.
PhylomeDBiQ9JJG0.

Miscellaneous databases

PROiQ9JJG0.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ9JJG0. baseline and differential.

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PfamiPF05010. TACC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTACC2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJG0
Secondary accession number(s): Q3TN02
, Q811U0, Q8BQD4, Q99KQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 9, 2007
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.