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Protein

Transforming acidic coiled-coil-containing protein 2

Gene

Tacc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules (By similarity).By similarity2 Publications

GO - Molecular functioni

  • nuclear hormone receptor binding Source: MGI
  • protein domain specific binding Source: MGI

GO - Biological processi

  • astral microtubule organization Source: MGI
  • cell proliferation Source: MGI
  • cerebral cortex development Source: MGI
  • interkinetic nuclear migration Source: MGI
  • microtubule cytoskeleton organization Source: MGI
  • neurogenesis Source: MGI
  • regulation of microtubule-based process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming acidic coiled-coil-containing protein 2
Gene namesi
Name:Tacc2
ORF Names:MNCb-3527
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1928899. Tacc2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice develop normally, are fertile, and do not present elevated tumorization rates. Cells deficient in TACC2 divide normally and do not show any change in the frequency of apoptosis induction.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11491149Transforming acidic coiled-coil-containing protein 2PRO_0000179989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001PhosphoserineBy similarity
Modified residuei265 – 2651PhosphoserineBy similarity
Modified residuei354 – 3541PhosphoserineCombined sources
Modified residuei419 – 4191PhosphoserineBy similarity
Modified residuei439 – 4391PhosphothreonineBy similarity
Modified residuei510 – 5101PhosphoserineCombined sources
Modified residuei514 – 5141PhosphoserineCombined sources
Modified residuei516 – 5161PhosphothreonineCombined sources
Modified residuei552 – 5521PhosphoserineCombined sources
Modified residuei582 – 5821PhosphoserineBy similarity
Modified residuei585 – 5851PhosphoserineCombined sources
Modified residuei587 – 5871PhosphoserineBy similarity
Modified residuei596 – 5961PhosphoserineBy similarity
Modified residuei653 – 6531PhosphothreonineBy similarity
Modified residuei657 – 6571PhosphothreonineBy similarity
Modified residuei714 – 7141PhosphoserineCombined sources
Modified residuei755 – 7551PhosphothreonineCombined sources
Modified residuei759 – 7591PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated; which is required for localization in centrosome.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JJG0.
MaxQBiQ9JJG0.
PaxDbiQ9JJG0.
PRIDEiQ9JJG0.

PTM databases

iPTMnetiQ9JJG0.

Expressioni

Tissue specificityi

Expressed in brain, kidney, lung, thymus and ovary. Not detectable in normal tissues at protein level.1 Publication

Interactioni

Subunit structurei

Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF (By similarity). Interacts with CCDC100/CEP120.By similarity1 Publication

GO - Molecular functioni

  • nuclear hormone receptor binding Source: MGI
  • protein domain specific binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081561.

Structurei

3D structure databases

ProteinModelPortaliQ9JJG0.
SMRiQ9JJG0. Positions 1103-1146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini508 – 59689SPAZAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili877 – 90529Sequence analysisAdd
BLAST
Coiled coili948 – 1148201Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi157 – 1659Poly-Pro
Compositional biasi610 – 6134Poly-Lys

Sequence similaritiesi

Belongs to the TACC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIVK. Eukaryota.
ENOG410YMFS. LUCA.
GeneTreeiENSGT00530000063855.
HOGENOMiHOG000294120.
HOVERGENiHBG055954.
InParanoidiQ9JJG0.
KOiK14282.
PhylomeDBiQ9JJG0.

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PfamiPF05010. TACC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JJG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNENSTSDH QRTSSVQSPR SLQPPGKSQS LQKQQGDLPG SCAGSIPGTD
60 70 80 90 100
DVIQPAAPVD PGHPPLAGIG SNQGEVCTSL QLSYTIVTVQ SASPSAARAS
110 120 130 140 150
PAPLAPEHTA SAPSAAGPGV EVTPTGSPQH LAKNEPRSSD SEEAFETPES
160 170 180 190 200
TTPVKAPPAP PPPPPEVTPE PEVIDPPAPE EPGCISEPPV VVPDGPRSSE
210 220 230 240 250
SVEGSPFRPS HSSSAVFDED KPIASSGTYN LDFDSIELVD NFQSLEPCSA
260 270 280 290 300
DSKGQECKVS TRRKSTESVP PSKSTLSRSL SLQASDFDGA SCPGSPEAGT
310 320 330 340 350
LTTDACGTGS NSASSTLKRT KKTRPPSLKK KQATKKPTET PPVKETQQEP
360 370 380 390 400
GEESPVPSEE HLAPETKTES ATPEGAGCTL SDDTPLESPA VPTATCPLTL
410 420 430 440 450
ESAEDVSPLV SGGGRVQNSP PVGRKSVPLT TASEAVEVTL SDSGGQEDLP
460 470 480 490 500
AKGLSVRLEF DYSEDKGSWE SQQENAPPTK KIGKKPVAKM PLRRPKMKKT
510 520 530 540 550
PEKLDNTPAS PPRSPTEPSD TPIAKGTYTF DIDKWDDPNF NPFSSTSKMQ
560 570 580 590 600
ESPKLSQQSY NFDPDACEES LDPFKASSKT PSSPSKSPAS FEIPASTTEA
610 620 630 640 650
DGDGLNKPAK KKKTPLKTMV EDVMSVCSLF DTFRVKKSPK RSPLSDPPSQ
660 670 680 690 700
DPTPAATPEA PSAISTVVHA TDEEKLAVTS QKWTCMTVDL DADKQDFPQP
710 720 730 740 750
SDLSNFVNET KFNSPSEELD YRNSYEIEYM EKLGSSLPQD DDTPKKQALY
760 770 780 790 800
LMFDTPQESP VKSPPVRMSD SPTPCSGSSF EDTEALVNAA TKLQHPVARG
810 820 830 840 850
LPSSQEPLLQ VPEKPSQKEL EAMALGTPAE AIEITAPEGA FASADTLLSR
860 870 880 890 900
LAHPASLCGA LGYLEPDLAE KNPPVFAQKL QEELEFAVMR IEALKLARQI
910 920 930 940 950
ALASRSRQDT KREAAHPPDV SISKTALYSR IGSTEVEKPP GLLFQQPDLD
960 970 980 990 1000
SALQVARAEV IAKEREVSEW RDKYEESRRE VVEMRKIVAE YEKTIAQMIP
1010 1020 1030 1040 1050
GTERKILSHQ TVQQLVLEKE QALADLNSVE KSLADLFRRY EKMKEVLEGF
1060 1070 1080 1090 1100
RKNEEVLKKC AQEYLSRVKK EEQRYQALKV HAEEKLDRAN AEIAQVRGKA
1110 1120 1130 1140
QQEQAAYQAS LRKEQLRVDA LERTLEQKNK EIEELTKICD ELIAKMGKS
Length:1,149
Mass (Da):124,130
Last modified:January 9, 2007 - v2
Checksum:i9B4A46B38747898E
GO
Isoform 2 (identifier: Q9JJG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     115-137: AAGPGVEVTPTGSPQHLAKNEPR → MGGSQSLQPAPASDLNLEVSEAM

Show »
Length:1,035
Mass (Da):112,716
Checksum:i0698015282F94C78
GO
Isoform 3 (identifier: Q9JJG0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     115-137: AAGPGVEVTPTGSPQHLAKNEPR → MGGSQSLQPAPASDLNLEVSEAM
     619-630: Missing.
     835-911: Missing.
     1000-1007: PGTERKIL → EDEQREKSI

Show »
Length:947
Mass (Da):103,276
Checksum:i7C90DFA1A41C7E05
GO
Isoform 4 (identifier: Q9JJG0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-489: Missing.
     619-630: Missing.
     717-717: E → EGKQLGGQPDPHLALENTVPRGQRARK
     835-911: Missing.
     1000-1007: PGTERKIL → EDEQREKSI

Show »
Length:598
Mass (Da):67,057
Checksum:i3624051C22F57997
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti681 – 6811Q → K in BAC34486 (PubMed:16141072).Curated
Sequence conflicti1129 – 11324NKEI → DKQR in BAC34486 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 489489Missing in isoform 4. 1 PublicationVSP_022159Add
BLAST
Alternative sequencei1 – 114114Missing in isoform 2 and isoform 3. 2 PublicationsVSP_022160Add
BLAST
Alternative sequencei115 – 13723AAGPG…KNEPR → MGGSQSLQPAPASDLNLEVS EAM in isoform 2 and isoform 3. 2 PublicationsVSP_022161Add
BLAST
Alternative sequencei619 – 63012Missing in isoform 3 and isoform 4. 2 PublicationsVSP_022162Add
BLAST
Alternative sequencei717 – 7171E → EGKQLGGQPDPHLALENTVP RGQRARK in isoform 4. 1 PublicationVSP_022163
Alternative sequencei835 – 91177Missing in isoform 3 and isoform 4. 2 PublicationsVSP_022164Add
BLAST
Alternative sequencei1000 – 10078PGTERKIL → EDEQREKSI in isoform 3 and isoform 4. 2 PublicationsVSP_022165

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177410 mRNA. Translation: AAO18641.1.
AB041546 mRNA. Translation: BAA95031.1.
AK050985 mRNA. Translation: BAC34486.1.
AK165603 mRNA. Translation: BAE38287.1.
BC004057 mRNA. Translation: AAH04057.1.
RefSeqiNP_067289.2. NM_021314.4.
NP_996738.2. NM_206856.3.
XP_006508154.1. XM_006508091.2. [Q9JJG0-3]
UniGeneiMm.86322.

Genome annotation databases

EnsembliENSMUST00000207282; ENSMUSP00000146848; ENSMUSG00000030852. [Q9JJG0-3]
GeneIDi57752.
KEGGimmu:57752.
UCSCiuc009kag.1. mouse. [Q9JJG0-3]
uc009kan.1. mouse. [Q9JJG0-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177410 mRNA. Translation: AAO18641.1.
AB041546 mRNA. Translation: BAA95031.1.
AK050985 mRNA. Translation: BAC34486.1.
AK165603 mRNA. Translation: BAE38287.1.
BC004057 mRNA. Translation: AAH04057.1.
RefSeqiNP_067289.2. NM_021314.4.
NP_996738.2. NM_206856.3.
XP_006508154.1. XM_006508091.2. [Q9JJG0-3]
UniGeneiMm.86322.

3D structure databases

ProteinModelPortaliQ9JJG0.
SMRiQ9JJG0. Positions 1103-1146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081561.

PTM databases

iPTMnetiQ9JJG0.

Proteomic databases

EPDiQ9JJG0.
MaxQBiQ9JJG0.
PaxDbiQ9JJG0.
PRIDEiQ9JJG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000207282; ENSMUSP00000146848; ENSMUSG00000030852. [Q9JJG0-3]
GeneIDi57752.
KEGGimmu:57752.
UCSCiuc009kag.1. mouse. [Q9JJG0-3]
uc009kan.1. mouse. [Q9JJG0-4]

Organism-specific databases

CTDi10579.
MGIiMGI:1928899. Tacc2.

Phylogenomic databases

eggNOGiENOG410IIVK. Eukaryota.
ENOG410YMFS. LUCA.
GeneTreeiENSGT00530000063855.
HOGENOMiHOG000294120.
HOVERGENiHBG055954.
InParanoidiQ9JJG0.
KOiK14282.
PhylomeDBiQ9JJG0.

Miscellaneous databases

NextBioi313904.
PROiQ9JJG0.
SOURCEiSearch...

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PfamiPF05010. TACC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms."
    Still I.H., Vettaikkorumakankauv A.K., DiMatteo A., Liang P.
    BMC Evol. Biol. 4:16-16(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Strain: Czech II.
    Tissue: Mammary gland.
  5. "The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer."
    Schuendeln M.M., Piekorz R.P., Wichmann C., Lee Y., McKinnon P.J., Boyd K., Takahashi Y., Ihle J.N.
    Mol. Cell. Biol. 24:6403-6409(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  6. "Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool."
    Xie Z., Moy L.Y., Sanada K., Zhou Y., Buchman J.J., Tsai L.-H.
    Neuron 56:79-93(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CCDC100, SUBCELLULAR LOCATION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-510 AND SER-714, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354; SER-510; SER-514; THR-516; SER-552; SER-585; SER-714 AND THR-755, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas and Testis.

Entry informationi

Entry nameiTACC2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJG0
Secondary accession number(s): Q3TN02
, Q811U0, Q8BQD4, Q99KQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 9, 2007
Last modified: May 11, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.