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Protein

Fatty acid desaturase 3

Gene

Fads3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid desaturase 3 (EC:1.14.19.-)
Gene namesi
Name:Fads3
ORF Names:MNCb-0629
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1928740. Fads3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 134134CytoplasmicSequence analysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence analysisAdd
BLAST
Topological domaini156 – 1638LumenalSequence analysis
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 26884CytoplasmicSequence analysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence analysisAdd
BLAST
Topological domaini290 – 31021LumenalSequence analysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence analysisAdd
BLAST
Topological domaini332 – 449118CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Fatty acid desaturase 3PRO_0000307109Add
BLAST

Proteomic databases

MaxQBiQ9JJE7.
PaxDbiQ9JJE7.
PRIDEiQ9JJE7.

PTM databases

iPTMnetiQ9JJE7.
PhosphoSiteiQ9JJE7.
SwissPalmiQ9JJE7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024664.
CleanExiMM_FADS3.
ExpressionAtlasiQ9JJE7. baseline and differential.
GenevisibleiQ9JJE7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9JJE7. 2 interactions.
MINTiMINT-4114355.
STRINGi10090.ENSMUSP00000111659.

Structurei

3D structure databases

ProteinModelPortaliQ9JJE7.
SMRiQ9JJE7. Positions 27-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10178Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi186 – 1905Histidine box-1
Motifi223 – 2275Histidine box-2
Motifi387 – 3915Histidine box-3

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesi

Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4232. Eukaryota.
ENOG410XVSZ. LUCA.
GeneTreeiENSGT00510000046574.
HOVERGENiHBG002839.
InParanoidiQ9JJE7.
KOiK10225.
OMAiPSLFIDW.
OrthoDBiEOG091G0E0W.
PhylomeDBiQ9JJE7.
TreeFamiTF313604.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR012171. Fatty_acid_desaturase.
IPR005804. Fatty_acid_desaturase_dom.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF015921. FA_sphinglp_des. 1 hit.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiPS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGVGEPGGG PGPREGPAPL GAPLPIFRWE QIRQHDLPGD KWLVIERRVY
60 70 80 90 100
DISRWAQRHP GGSRLIGHHG AEDATDAFHA FHQDLHFVRK FLKPLLIGEL
110 120 130 140 150
APEEPSQDGA QNAQLIEDFR ALRQAAEDMK LFEADTTFFA LLLGHILAME
160 170 180 190 200
LLAWLIIYLL GPGWVSSILA ALILAISQAQ CWCLQHDLGH ASIFTKSRWN
210 220 230 240 250
HVAQQFVMGQ LKGFSAHWWN FRHFQHHAKP NIFHKDPDVT VAPVFLLGES
260 270 280 290 300
SVEYGKKKRR YLPYNHQHLY FFLIGPPLLT LVNFEVENLA YMLVCMQWTD
310 320 330 340 350
LLWAASFYSR FFLSYSPFYG ATGTLLLFVA VRVLESHWFV WITQMNHIPK
360 370 380 390 400
EIGHEKHRDW ASSQLAATCN VEPSLFIDWF SGHLNFQIEH HLFPTMPRHN
410 420 430 440
YRRVAPLVKA FCAKHGLHYE VKPFLTALVD IIGSLKKSGD IWLDAYLHQ
Length:449
Mass (Da):51,469
Last modified:October 2, 2007 - v2
Checksum:i0E0B74EC8C9E5199
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361T → S in BAC37908 (PubMed:16141072).Curated
Sequence conflicti205 – 2051Q → R in BAA95044 (Ref. 1) Curated
Sequence conflicti367 – 3671A → P in BAC26393 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041560 mRNA. Translation: BAA95044.1.
AK080414 mRNA. Translation: BAC37908.1.
AK029318 mRNA. Translation: BAC26393.1.
BC055950 mRNA. Translation: AAH55950.1.
CCDSiCCDS29570.1.
RefSeqiNP_068690.3. NM_021890.3.
UniGeneiMm.253875.

Genome annotation databases

EnsembliENSMUST00000115995; ENSMUSP00000111659; ENSMUSG00000024664.
GeneIDi60527.
KEGGimmu:60527.
UCSCiuc008goz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041560 mRNA. Translation: BAA95044.1.
AK080414 mRNA. Translation: BAC37908.1.
AK029318 mRNA. Translation: BAC26393.1.
BC055950 mRNA. Translation: AAH55950.1.
CCDSiCCDS29570.1.
RefSeqiNP_068690.3. NM_021890.3.
UniGeneiMm.253875.

3D structure databases

ProteinModelPortaliQ9JJE7.
SMRiQ9JJE7. Positions 27-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JJE7. 2 interactions.
MINTiMINT-4114355.
STRINGi10090.ENSMUSP00000111659.

PTM databases

iPTMnetiQ9JJE7.
PhosphoSiteiQ9JJE7.
SwissPalmiQ9JJE7.

Proteomic databases

MaxQBiQ9JJE7.
PaxDbiQ9JJE7.
PRIDEiQ9JJE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115995; ENSMUSP00000111659; ENSMUSG00000024664.
GeneIDi60527.
KEGGimmu:60527.
UCSCiuc008goz.1. mouse.

Organism-specific databases

CTDi3995.
MGIiMGI:1928740. Fads3.

Phylogenomic databases

eggNOGiKOG4232. Eukaryota.
ENOG410XVSZ. LUCA.
GeneTreeiENSGT00510000046574.
HOVERGENiHBG002839.
InParanoidiQ9JJE7.
KOiK10225.
OMAiPSLFIDW.
OrthoDBiEOG091G0E0W.
PhylomeDBiQ9JJE7.
TreeFamiTF313604.

Miscellaneous databases

PROiQ9JJE7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024664.
CleanExiMM_FADS3.
ExpressionAtlasiQ9JJE7. baseline and differential.
GenevisibleiQ9JJE7. MM.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR012171. Fatty_acid_desaturase.
IPR005804. Fatty_acid_desaturase_dom.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF015921. FA_sphinglp_des. 1 hit.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiPS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFADS3_MOUSE
AccessioniPrimary (citable) accession number: Q9JJE7
Secondary accession number(s): Q7TND7, Q8C4Y5, Q8CDZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 7, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.