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Protein

Progestin and adipoQ receptor family member 4

Gene

Paqr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. receptor activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Progestin and adipoQ receptor family member 4
Alternative name(s):
Progestin and adipoQ receptor family member IV
Gene namesi
Name:Paqr4
ORF Names:MNCb-0914
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1923748. Paqr4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Progestin and adipoQ receptor family member 4PRO_0000218849Add
BLAST

Proteomic databases

MaxQBiQ9JJE4.
PRIDEiQ9JJE4.

Expressioni

Gene expression databases

BgeeiQ9JJE4.
CleanExiMM_PAQR4.
GenevestigatoriQ9JJE4.

Structurei

3D structure databases

ProteinModelPortaliQ9JJE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000006893.
HOVERGENiHBG053505.
InParanoidiQ9JJE4.
OMAiCHQGGSP.
OrthoDBiEOG7PK905.
PhylomeDBiQ9JJE4.
TreeFamiTF323692.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLTGPRLL DWASSPPHLQ FNKFVLTGYR PASSGSGCLR SLFYLHNELG
60 70 80 90 100
NIYTHGLALL GFLVLVPMTM PWSQLGKDGW LGGTHCVACL VPPAASVLYH
110 120 130 140 150
LFMCHQGGSP VYTRLLALDM CGVCLVNTLG ALPIIHCTLA CRPWLRPAAL
160 170 180 190 200
MGYTALSGVA GWRALTAPST SARLRAFGWQ AGARLLVFGA RGVGLGSGAP
210 220 230 240 250
GSLPCYLRMD ALALLGGLVN VARLPERWGP GRFDYWGNSH QIMHLLSVGS
260 270
ILQLHAGVVP DLLWAAHHAC PPD
Length:273
Mass (Da):29,215
Last modified:October 1, 2000 - v1
Checksum:i2D7568D439C351FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424293 mRNA. Translation: AAR08381.1.
AB041564 mRNA. Translation: BAA95048.1.
AK005142 mRNA. Translation: BAB23839.1.
AK033625 mRNA. Translation: BAC28398.1.
AK044092 mRNA. Translation: BAC31770.1.
AK044486 mRNA. Translation: BAC31947.1.
AK152676 mRNA. Translation: BAE31408.1.
BC011185 mRNA. Translation: AAH11185.1.
BC026921 mRNA. Translation: AAH26921.1.
CCDSiCCDS28461.1.
RefSeqiNP_076313.1. NM_023824.3.
UniGeneiMm.491253.

Genome annotation databases

EnsembliENSMUST00000024702; ENSMUSP00000024702; ENSMUSG00000023909.
GeneIDi76498.
KEGGimmu:76498.
UCSCiuc008atb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424293 mRNA. Translation: AAR08381.1.
AB041564 mRNA. Translation: BAA95048.1.
AK005142 mRNA. Translation: BAB23839.1.
AK033625 mRNA. Translation: BAC28398.1.
AK044092 mRNA. Translation: BAC31770.1.
AK044486 mRNA. Translation: BAC31947.1.
AK152676 mRNA. Translation: BAE31408.1.
BC011185 mRNA. Translation: AAH11185.1.
BC026921 mRNA. Translation: AAH26921.1.
CCDSiCCDS28461.1.
RefSeqiNP_076313.1. NM_023824.3.
UniGeneiMm.491253.

3D structure databases

ProteinModelPortaliQ9JJE4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ9JJE4.
PRIDEiQ9JJE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024702; ENSMUSP00000024702; ENSMUSG00000023909.
GeneIDi76498.
KEGGimmu:76498.
UCSCiuc008atb.1. mouse.

Organism-specific databases

CTDi124222.
MGIiMGI:1923748. Paqr4.

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000006893.
HOVERGENiHBG053505.
InParanoidiQ9JJE4.
OMAiCHQGGSP.
OrthoDBiEOG7PK905.
PhylomeDBiQ9JJE4.
TreeFamiTF323692.

Miscellaneous databases

NextBioi345258.
PROiQ9JJE4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJE4.
CleanExiMM_PAQR4.
GenevestigatoriQ9JJE4.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Brain cortex, Cecum, Cerebellum and Retina.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Eye and Liver.

Entry informationi

Entry nameiPAQR4_MOUSE
AccessioniPrimary (citable) accession number: Q9JJE4
Secondary accession number(s): Q3U7G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.