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Protein

THAP domain-containing protein 11

Gene

Thap11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers.1 Publication

Miscellaneous

Was named 'Ronin' (a masterless Japanese samurai) by PubMed:18585351 because of its lack of apparent relationship to known 'master' regulator of pluripotency.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 80THAP-typePROSITE-ProRule annotationAdd BLAST80

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 11
Alternative name(s):
Ronin
Gene namesi
Name:Thap11
ORF Names:MNCb-2032
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1930964. Thap11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show periimplantational lethality and have defects in the inner cell mass. Conditional knockout prevents the growth of ES cells while forced expression allows ES cells to proliferate without differentiation under conditions that normally do not promote self-renewal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686541 – 305THAP domain-containing protein 11Add BLAST305

Proteomic databases

MaxQBiQ9JJD0.
PaxDbiQ9JJD0.
PeptideAtlasiQ9JJD0.
PRIDEiQ9JJD0.

PTM databases

iPTMnetiQ9JJD0.
PhosphoSitePlusiQ9JJD0.

Expressioni

Tissue specificityi

Mainly restricted to pluripotent cells of the developing embryo, to oocytes, and to certain regions of the adult brain.1 Publication

Developmental stagei

First appears at the 2-cell stage, intensifies during the 8-cell and compact morula stages, but subsides in the blastocyst.1 Publication

Gene expression databases

BgeeiENSMUSG00000036442.
CleanExiMM_THAP11.
GenevisibleiQ9JJD0. MM.

Interactioni

Subunit structurei

Interacts (via coiled coil domain) with HCFC1.1 Publication

Protein-protein interaction databases

ELMiQ9JJD0.
STRINGi10090.ENSMUSP00000048994.

Structurei

3D structure databases

ProteinModelPortaliQ9JJD0.
SMRiQ9JJD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili246 – 296Sequence analysisAdd BLAST51

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi234 – 237HCFC1-binding motif (HBM)By similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi95 – 100Poly-Ala6
Compositional biasi104 – 137Gln-richAdd BLAST34
Compositional biasi188 – 212Ala-richAdd BLAST25

Sequence similaritiesi

Belongs to the THAP11 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 80THAP-typePROSITE-ProRule annotationAdd BLAST80

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IFX3. Eukaryota.
ENOG4111FSQ. LUCA.
GeneTreeiENSGT00390000006585.
HOGENOMiHOG000154562.
HOVERGENiHBG062269.
InParanoidiQ9JJD0.
OMAiCYNNSHR.
OrthoDBiEOG091G19Z0.
PhylomeDBiQ9JJD0.
TreeFamiTF331359.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR011990. TPR-like_helical_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR006612. Znf_C2CH.
PfamiView protein in Pfam
PF05485. THAP. 1 hit.
SMARTiView protein in SMART
SM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
PROSITEiView protein in PROSITE
PS50950. ZF_THAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JJD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGFTCCVPG CYNNSHRDKA LHFYTFPKDA ELRRLWLKNV SRAGVSGCFS
60 70 80 90 100
TFQPTTGHRL CSVHFQGGRK TYTVRVPTIF PLRGVNERKV ARRPAGAAAA
110 120 130 140 150
RRRQQQQQQQ QQQQQQQQLQ QQQPSPSSST AQTTQLQPNL VSASAAVLLT
160 170 180 190 200
LQAAVDSNQA PGSVVPVSTT PSGDDVKPID LTVQVEFAAA EGAAAAAAAS
210 220 230 240 250
ELEAATAGLE AAECTLGPQL VVVGEEGFPD TGSDHSYSLS SGTTEEELLR
260 270 280 290 300
KLNEQRDILA LMEVKMKEMK GSIRHLRLTE AKLREELREK DRLLAMAVIR

KKHGM
Length:305
Mass (Da):33,276
Last modified:October 1, 2000 - v1
Checksum:i8586597DABC8601A
GO

Sequence cautioni

The sequence AAH03949 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041579 mRNA. Translation: BAA95063.1.
AK165981 mRNA. Translation: BAE38498.1.
AK170457 mRNA. Translation: BAE41810.1.
CH466525 Genomic DNA. Translation: EDL11318.1.
BC003949 mRNA. Translation: AAH03949.1. Different initiation.
BC138966 mRNA. Translation: AAI38967.1.
BC138987 mRNA. Translation: AAI38988.1.
CCDSiCCDS22616.1.
RefSeqiNP_067488.1. NM_021513.2.
UniGeneiMm.286598.

Genome annotation databases

EnsembliENSMUST00000040445; ENSMUSP00000048994; ENSMUSG00000036442.
GeneIDi59016.
KEGGimmu:59016.
UCSCiuc009nei.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiTHA11_MOUSE
AccessioniPrimary (citable) accession number: Q9JJD0
Secondary accession number(s): Q3TCZ5, Q99KZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families