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Protein

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

Gene

Herpud2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could be involved in the unfolded protein response (UPR) pathway.By similarity

GO - Biological processi

  • response to unfolded protein Source: UniProtKB-KW
  • spermatogenesis Source: BHF-UCL

Keywordsi

Biological processUnfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
Gene namesi
Name:Herpud2
ORF Names:MNCb-2040
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1915393 Herpud2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002806281 – 404Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 proteinAdd BLAST404

Proteomic databases

MaxQBiQ9JJC9
PaxDbiQ9JJC9
PeptideAtlasiQ9JJC9
PRIDEiQ9JJC9

PTM databases

iPTMnetiQ9JJC9
PhosphoSitePlusiQ9JJC9

Expressioni

Gene expression databases

BgeeiENSMUSG00000008429
CleanExiMM_HERPUD2
GenevisibleiQ9JJC9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008573

Structurei

3D structure databases

ProteinModelPortaliQ9JJC9
SMRiQ9JJC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 89Ubiquitin-likePROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 137Ser-richAdd BLAST50

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4583 Eukaryota
ENOG410ZJAF LUCA
GeneTreeiENSGT00390000017671
HOGENOMiHOG000252989
HOVERGENiHBG051899
InParanoidiQ9JJC9
OMAiSPLQMIW
OrthoDBiEOG091G0P9J
PhylomeDBiQ9JJC9
TreeFamiTF324319

Family and domain databases

InterProiView protein in InterPro
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JJC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL
60 70 80 90 100
TKDQRLVYSG RLLPDHLQLK DILRKQDEYH MVHLVCASRS PPSSPKSSTD
110 120 130 140 150
RGSHEALASS TSSNSDHSDS TTPSPSQESL SLVTGSSEGL RQRTLSQAQT
160 170 180 190 200
DPAQSHQFPY VIQGNVDHQF PGQGVPPAFP VYPALSPLQM LWWQQMYAHQ
210 220 230 240 250
YYMQYQAAVS AQATSSAGSA QRAASSPLNL AHVPGEEPPP APNLVAQENG
260 270 280 290 300
PMNENVQMNA QGGPVLNEED LNRDWLDWVY TFSRAAVLLS IVYFYSSFSR
310 320 330 340 350
FIMVMGAMLL VYLHQAGWFP FRQEGGQQQA PNNVDANNDG HNANNLELEE
360 370 380 390 400
MERLMDDGLE DESGEDAGED ASAAQRPGLM ASAWSFITTF FTSLIPEGPP

QVAN
Length:404
Mass (Da):44,501
Last modified:October 1, 2000 - v1
Checksum:iEECBEEEB7ADD76C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218G → S in AAH29691 (PubMed:15489334).Curated1
Sequence conflicti267N → K in BAB31889 (PubMed:16141072).Curated1
Sequence conflicti339D → P in BAB27742 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041580 mRNA Translation: BAA95064.1
AK011625 mRNA Translation: BAB27742.1
AK019862 mRNA Translation: BAB31889.1
AK135935 mRNA Translation: BAE22730.1
BC029691 mRNA Translation: AAH29691.1
BC043693 mRNA Translation: AAH43693.1
CCDSiCCDS22934.1
RefSeqiNP_065611.1, NM_020586.2
UniGeneiMm.142843

Genome annotation databases

EnsembliENSMUST00000008573; ENSMUSP00000008573; ENSMUSG00000008429
GeneIDi80517
KEGGimmu:80517
UCSCiuc009oph.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHERP2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJC9
Secondary accession number(s): Q8K2W2, Q9CSZ4, Q9D2D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health