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Protein

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

Gene

Herpud2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Could be involved in the unfolded protein response (UPR) pathway.By similarity

GO - Biological processi

  • response to unfolded protein Source: UniProtKB-KW
  • spermatogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
Gene namesi
Name:Herpud2
ORF Names:MNCb-2040
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1915393. Herpud2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei301 – 32121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 proteinPRO_0000280628Add
BLAST

Proteomic databases

MaxQBiQ9JJC9.
PaxDbiQ9JJC9.
PRIDEiQ9JJC9.

PTM databases

iPTMnetiQ9JJC9.
PhosphoSiteiQ9JJC9.

Expressioni

Gene expression databases

BgeeiQ9JJC9.
CleanExiMM_HERPUD2.
GenevisibleiQ9JJC9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008573.

Structurei

3D structure databases

ProteinModelPortaliQ9JJC9.
SMRiQ9JJC9. Positions 9-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 8980Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi88 – 13750Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4583. Eukaryota.
ENOG410ZJAF. LUCA.
GeneTreeiENSGT00390000017671.
HOGENOMiHOG000252989.
HOVERGENiHBG051899.
InParanoidiQ9JJC9.
OMAiNRESHEA.
OrthoDBiEOG7QRQWK.
PhylomeDBiQ9JJC9.
TreeFamiTF324319.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL
60 70 80 90 100
TKDQRLVYSG RLLPDHLQLK DILRKQDEYH MVHLVCASRS PPSSPKSSTD
110 120 130 140 150
RGSHEALASS TSSNSDHSDS TTPSPSQESL SLVTGSSEGL RQRTLSQAQT
160 170 180 190 200
DPAQSHQFPY VIQGNVDHQF PGQGVPPAFP VYPALSPLQM LWWQQMYAHQ
210 220 230 240 250
YYMQYQAAVS AQATSSAGSA QRAASSPLNL AHVPGEEPPP APNLVAQENG
260 270 280 290 300
PMNENVQMNA QGGPVLNEED LNRDWLDWVY TFSRAAVLLS IVYFYSSFSR
310 320 330 340 350
FIMVMGAMLL VYLHQAGWFP FRQEGGQQQA PNNVDANNDG HNANNLELEE
360 370 380 390 400
MERLMDDGLE DESGEDAGED ASAAQRPGLM ASAWSFITTF FTSLIPEGPP

QVAN
Length:404
Mass (Da):44,501
Last modified:October 1, 2000 - v1
Checksum:iEECBEEEB7ADD76C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181G → S in AAH29691 (PubMed:15489334).Curated
Sequence conflicti267 – 2671N → K in BAB31889 (PubMed:16141072).Curated
Sequence conflicti339 – 3391D → P in BAB27742 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041580 mRNA. Translation: BAA95064.1.
AK011625 mRNA. Translation: BAB27742.1.
AK019862 mRNA. Translation: BAB31889.1.
AK135935 mRNA. Translation: BAE22730.1.
BC029691 mRNA. Translation: AAH29691.1.
BC043693 mRNA. Translation: AAH43693.1.
CCDSiCCDS22934.1.
RefSeqiNP_065611.1. NM_020586.2.
UniGeneiMm.142843.

Genome annotation databases

EnsembliENSMUST00000008573; ENSMUSP00000008573; ENSMUSG00000008429.
GeneIDi80517.
KEGGimmu:80517.
UCSCiuc009oph.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041580 mRNA. Translation: BAA95064.1.
AK011625 mRNA. Translation: BAB27742.1.
AK019862 mRNA. Translation: BAB31889.1.
AK135935 mRNA. Translation: BAE22730.1.
BC029691 mRNA. Translation: AAH29691.1.
BC043693 mRNA. Translation: AAH43693.1.
CCDSiCCDS22934.1.
RefSeqiNP_065611.1. NM_020586.2.
UniGeneiMm.142843.

3D structure databases

ProteinModelPortaliQ9JJC9.
SMRiQ9JJC9. Positions 9-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008573.

PTM databases

iPTMnetiQ9JJC9.
PhosphoSiteiQ9JJC9.

Proteomic databases

MaxQBiQ9JJC9.
PaxDbiQ9JJC9.
PRIDEiQ9JJC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008573; ENSMUSP00000008573; ENSMUSG00000008429.
GeneIDi80517.
KEGGimmu:80517.
UCSCiuc009oph.2. mouse.

Organism-specific databases

CTDi64224.
MGIiMGI:1915393. Herpud2.

Phylogenomic databases

eggNOGiKOG4583. Eukaryota.
ENOG410ZJAF. LUCA.
GeneTreeiENSGT00390000017671.
HOGENOMiHOG000252989.
HOVERGENiHBG051899.
InParanoidiQ9JJC9.
OMAiNRESHEA.
OrthoDBiEOG7QRQWK.
PhylomeDBiQ9JJC9.
TreeFamiTF324319.

Miscellaneous databases

ChiTaRSiHerpud2. mouse.
NextBioi350043.
PROiQ9JJC9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJC9.
CleanExiMM_HERPUD2.
GenevisibleiQ9JJC9. MM.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg, Embryo, Ovary and Uterus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiHERP2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJC9
Secondary accession number(s): Q8K2W2, Q9CSZ4, Q9D2D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2000
Last modified: January 20, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.