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Q9JJA9

- GRASP_MOUSE

UniProt

Q9JJA9 - GRASP_MOUSE

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Protein
General receptor for phosphoinositides 1-associated scaffold protein
Gene
Grasp, MNCb-4428
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. intracellular protein transport Source: MGI
  2. signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
General receptor for phosphoinositides 1-associated scaffold protein
Short name:
GRP1-associated scaffold protein
Gene namesi
Name:Grasp
ORF Names:MNCb-4428
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1860303. Grasp.

Subcellular locationi

Cytoplasm. Cell membrane
Note: Primarily localized to the plasma membrane but also distributed diffusely throughout the cytoplasm.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear envelope lumen Source: MGI
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392General receptor for phosphoinositides 1-associated scaffold protein
PRO_0000087585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JJA9.
PRIDEiQ9JJA9.

PTM databases

PhosphoSiteiQ9JJA9.

Expressioni

Tissue specificityi

Highly expressed in brain, heart and lung, and to a lower extent in embryo, kidney and ovary.2 Publications

Gene expression databases

BgeeiQ9JJA9.
GenevestigatoriQ9JJA9.

Interactioni

Subunit structurei

Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with GRM2, GRM3 and GRM5 By similarity. Interacts with PSCD3.1 Publication

Protein-protein interaction databases

BioGridi207817. 2 interactions.
STRINGi10090.ENSMUSP00000000543.

Structurei

3D structure databases

ProteinModelPortaliQ9JJA9.
SMRiQ9JJA9. Positions 97-191.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 18990PDZ
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 25778Interaction with PSCD3
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 32330Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiNOG244814.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiQ9JJA9.
OMAiEGFRHKE.
OrthoDBiEOG72NRQP.
PhylomeDBiQ9JJA9.
TreeFamiTF316315.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJA9-1 [UniParc]FASTAAdd to Basket

« Hide

MTLRRLRKLQ QKEEATAAPD PAGRAPDSEA ARAAPLPSGP PAAAAPPGAP    50
GEELYAALED YHPAELYRAL AVSGGTLPRR KGSGFRWKNF TQSPEQQRKV 100
LTLEKGDNQT FGFEIQTYGL HHREEQRVEM VTFVCRVHES SPAQLAGLTP 150
GDTIASVNGL NVEGIRHREI VDIIKASGNV LRLETLYGTS IRKAELEARL 200
QYLKQTLYEK WGEYRSLMVQ EQRLVHGLVV KDPSIYDTLE SVRSCLYGAG 250
LLPGSLPFGP LLAAPGSARG GARRAKGDTD DAVYHTCFFG GAEPQALPPP 300
PPPARALGPS SAETPASVLF PAPRSTLSRS ASVRCAGPGG GGGAPGALWT 350
EAREQALCGA GLRKTKYRSF RRRLLKFIPG LNRSLEEEES QL 392
Length:392
Mass (Da):42,337
Last modified:September 27, 2005 - v2
Checksum:i52144F07D36B57FE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991P → L in BAA95086. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF236099 mRNA. Translation: AAF36997.1.
AB041603 mRNA. Translation: BAA95086.1.
BC046307 mRNA. Translation: AAH46307.1.
CCDSiCCDS27847.1.
RefSeqiNP_062391.3. NM_019518.3.
UniGeneiMm.276573.

Genome annotation databases

EnsembliENSMUST00000000543; ENSMUSP00000000543; ENSMUSG00000000531.
GeneIDi56149.
KEGGimmu:56149.
UCSCiuc007xsu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF236099 mRNA. Translation: AAF36997.1 .
AB041603 mRNA. Translation: BAA95086.1 .
BC046307 mRNA. Translation: AAH46307.1 .
CCDSi CCDS27847.1.
RefSeqi NP_062391.3. NM_019518.3.
UniGenei Mm.276573.

3D structure databases

ProteinModelPortali Q9JJA9.
SMRi Q9JJA9. Positions 97-191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207817. 2 interactions.
STRINGi 10090.ENSMUSP00000000543.

PTM databases

PhosphoSitei Q9JJA9.

Proteomic databases

PaxDbi Q9JJA9.
PRIDEi Q9JJA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000543 ; ENSMUSP00000000543 ; ENSMUSG00000000531 .
GeneIDi 56149.
KEGGi mmu:56149.
UCSCi uc007xsu.1. mouse.

Organism-specific databases

CTDi 160622.
MGIi MGI:1860303. Grasp.

Phylogenomic databases

eggNOGi NOG244814.
GeneTreei ENSGT00530000063734.
HOGENOMi HOG000231871.
HOVERGENi HBG053061.
InParanoidi Q9JJA9.
OMAi EGFRHKE.
OrthoDBi EOG72NRQP.
PhylomeDBi Q9JJA9.
TreeFami TF316315.

Miscellaneous databases

NextBioi 311928.
PROi Q9JJA9.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJA9.
Genevestigatori Q9JJA9.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
[Graphical view ]
Pfami PF00595. PDZ. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors."
    Nevrivy D.J., Peterson V.J., Avram D., Ishmael J.E., Hansen S.G., Dowell P., Hruby D.E., Dawson M.I., Leid M.
    J. Biol. Chem. 275:16827-16836(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PSCD3, SUBCELLULAR LOCATION.
  2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  4. "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
    Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
    J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGRASP_MOUSE
AccessioniPrimary (citable) accession number: Q9JJA9
Secondary accession number(s): Q9JKL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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