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Protein

General receptor for phosphoinositides 1-associated scaffold protein

Gene

Grasp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.By similarity

GO - Biological processi

  • intracellular protein transport Source: MGI
  • signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
General receptor for phosphoinositides 1-associated scaffold protein
Short name:
GRP1-associated scaffold protein
Gene namesi
Name:Grasp
ORF Names:MNCb-4428
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1860303. Grasp.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nuclear envelope lumen Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875851 – 392General receptor for phosphoinositides 1-associated scaffold proteinAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphothreonineCombined sources1
Modified residuei93PhosphoserineBy similarity1
Modified residuei236PhosphotyrosineBy similarity1
Modified residuei269Omega-N-methylarginineCombined sources1
Modified residuei384PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JJA9.
PaxDbiQ9JJA9.
PeptideAtlasiQ9JJA9.
PRIDEiQ9JJA9.

PTM databases

iPTMnetiQ9JJA9.
PhosphoSitePlusiQ9JJA9.

Expressioni

Tissue specificityi

Highly expressed in brain, heart and lung, and to a lower extent in embryo, kidney and ovary.2 Publications

Gene expression databases

BgeeiENSMUSG00000000531.
GenevisibleiQ9JJA9. MM.

Interactioni

Subunit structurei

Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with GRM2, GRM3 and GRM5 (By similarity). Interacts with PSCD3.By similarity1 Publication

Protein-protein interaction databases

BioGridi207817. 2 interactors.
STRINGi10090.ENSMUSP00000000543.

Structurei

3D structure databases

ProteinModelPortaliQ9JJA9.
SMRiQ9JJA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 189PDZPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni180 – 257Interaction with PSCD31 PublicationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi294 – 323Pro-richAdd BLAST30

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG410ZJVP. LUCA.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiQ9JJA9.
OMAiSVEMCTF.
OrthoDBiEOG091G0NRM.
PhylomeDBiQ9JJA9.
TreeFamiTF316315.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRRLRKLQ QKEEATAAPD PAGRAPDSEA ARAAPLPSGP PAAAAPPGAP
60 70 80 90 100
GEELYAALED YHPAELYRAL AVSGGTLPRR KGSGFRWKNF TQSPEQQRKV
110 120 130 140 150
LTLEKGDNQT FGFEIQTYGL HHREEQRVEM VTFVCRVHES SPAQLAGLTP
160 170 180 190 200
GDTIASVNGL NVEGIRHREI VDIIKASGNV LRLETLYGTS IRKAELEARL
210 220 230 240 250
QYLKQTLYEK WGEYRSLMVQ EQRLVHGLVV KDPSIYDTLE SVRSCLYGAG
260 270 280 290 300
LLPGSLPFGP LLAAPGSARG GARRAKGDTD DAVYHTCFFG GAEPQALPPP
310 320 330 340 350
PPPARALGPS SAETPASVLF PAPRSTLSRS ASVRCAGPGG GGGAPGALWT
360 370 380 390
EAREQALCGA GLRKTKYRSF RRRLLKFIPG LNRSLEEEES QL
Length:392
Mass (Da):42,337
Last modified:September 27, 2005 - v2
Checksum:i52144F07D36B57FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299P → L in BAA95086 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236099 mRNA. Translation: AAF36997.1.
AB041603 mRNA. Translation: BAA95086.1.
BC046307 mRNA. Translation: AAH46307.1.
CCDSiCCDS27847.1.
RefSeqiNP_062391.3. NM_019518.3.
UniGeneiMm.276573.

Genome annotation databases

EnsembliENSMUST00000000543; ENSMUSP00000000543; ENSMUSG00000000531.
GeneIDi56149.
KEGGimmu:56149.
UCSCiuc007xsu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236099 mRNA. Translation: AAF36997.1.
AB041603 mRNA. Translation: BAA95086.1.
BC046307 mRNA. Translation: AAH46307.1.
CCDSiCCDS27847.1.
RefSeqiNP_062391.3. NM_019518.3.
UniGeneiMm.276573.

3D structure databases

ProteinModelPortaliQ9JJA9.
SMRiQ9JJA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207817. 2 interactors.
STRINGi10090.ENSMUSP00000000543.

PTM databases

iPTMnetiQ9JJA9.
PhosphoSitePlusiQ9JJA9.

Proteomic databases

MaxQBiQ9JJA9.
PaxDbiQ9JJA9.
PeptideAtlasiQ9JJA9.
PRIDEiQ9JJA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000543; ENSMUSP00000000543; ENSMUSG00000000531.
GeneIDi56149.
KEGGimmu:56149.
UCSCiuc007xsu.1. mouse.

Organism-specific databases

CTDi160622.
MGIiMGI:1860303. Grasp.

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG410ZJVP. LUCA.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiQ9JJA9.
OMAiSVEMCTF.
OrthoDBiEOG091G0NRM.
PhylomeDBiQ9JJA9.
TreeFamiTF316315.

Miscellaneous databases

PROiQ9JJA9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000531.
GenevisibleiQ9JJA9. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRASP_MOUSE
AccessioniPrimary (citable) accession number: Q9JJA9
Secondary accession number(s): Q9JKL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.