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Protein

General receptor for phosphoinositides 1-associated scaffold protein

Gene

Grasp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.By similarity

GO - Biological processi

  1. intracellular protein transport Source: MGI
  2. signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
General receptor for phosphoinositides 1-associated scaffold protein
Short name:
GRP1-associated scaffold protein
Gene namesi
Name:Grasp
ORF Names:MNCb-4428
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1860303. Grasp.

Subcellular locationi

Cytoplasm 1 Publication. Cell membrane 1 Publication
Note: Primarily localized to the plasma membrane but also distributed diffusely throughout the cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear envelope lumen Source: MGI
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392General receptor for phosphoinositides 1-associated scaffold proteinPRO_0000087585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JJA9.
PRIDEiQ9JJA9.

PTM databases

PhosphoSiteiQ9JJA9.

Expressioni

Tissue specificityi

Highly expressed in brain, heart and lung, and to a lower extent in embryo, kidney and ovary.2 Publications

Gene expression databases

BgeeiQ9JJA9.
GenevestigatoriQ9JJA9.

Interactioni

Subunit structurei

Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with GRM2, GRM3 and GRM5 (By similarity). Interacts with PSCD3.By similarity1 Publication

Protein-protein interaction databases

BioGridi207817. 2 interactions.
STRINGi10090.ENSMUSP00000000543.

Structurei

3D structure databases

ProteinModelPortaliQ9JJA9.
SMRiQ9JJA9. Positions 97-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 18990PDZPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 25778Interaction with PSCD3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 32330Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG244814.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiQ9JJA9.
OMAiEGFRHKE.
OrthoDBiEOG72NRQP.
PhylomeDBiQ9JJA9.
TreeFamiTF316315.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRRLRKLQ QKEEATAAPD PAGRAPDSEA ARAAPLPSGP PAAAAPPGAP
60 70 80 90 100
GEELYAALED YHPAELYRAL AVSGGTLPRR KGSGFRWKNF TQSPEQQRKV
110 120 130 140 150
LTLEKGDNQT FGFEIQTYGL HHREEQRVEM VTFVCRVHES SPAQLAGLTP
160 170 180 190 200
GDTIASVNGL NVEGIRHREI VDIIKASGNV LRLETLYGTS IRKAELEARL
210 220 230 240 250
QYLKQTLYEK WGEYRSLMVQ EQRLVHGLVV KDPSIYDTLE SVRSCLYGAG
260 270 280 290 300
LLPGSLPFGP LLAAPGSARG GARRAKGDTD DAVYHTCFFG GAEPQALPPP
310 320 330 340 350
PPPARALGPS SAETPASVLF PAPRSTLSRS ASVRCAGPGG GGGAPGALWT
360 370 380 390
EAREQALCGA GLRKTKYRSF RRRLLKFIPG LNRSLEEEES QL
Length:392
Mass (Da):42,337
Last modified:September 27, 2005 - v2
Checksum:i52144F07D36B57FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991P → L in BAA95086 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236099 mRNA. Translation: AAF36997.1.
AB041603 mRNA. Translation: BAA95086.1.
BC046307 mRNA. Translation: AAH46307.1.
CCDSiCCDS27847.1.
RefSeqiNP_062391.3. NM_019518.3.
UniGeneiMm.276573.

Genome annotation databases

EnsembliENSMUST00000000543; ENSMUSP00000000543; ENSMUSG00000000531.
GeneIDi56149.
KEGGimmu:56149.
UCSCiuc007xsu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236099 mRNA. Translation: AAF36997.1.
AB041603 mRNA. Translation: BAA95086.1.
BC046307 mRNA. Translation: AAH46307.1.
CCDSiCCDS27847.1.
RefSeqiNP_062391.3. NM_019518.3.
UniGeneiMm.276573.

3D structure databases

ProteinModelPortaliQ9JJA9.
SMRiQ9JJA9. Positions 97-191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207817. 2 interactions.
STRINGi10090.ENSMUSP00000000543.

PTM databases

PhosphoSiteiQ9JJA9.

Proteomic databases

PaxDbiQ9JJA9.
PRIDEiQ9JJA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000543; ENSMUSP00000000543; ENSMUSG00000000531.
GeneIDi56149.
KEGGimmu:56149.
UCSCiuc007xsu.1. mouse.

Organism-specific databases

CTDi160622.
MGIiMGI:1860303. Grasp.

Phylogenomic databases

eggNOGiNOG244814.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiQ9JJA9.
OMAiEGFRHKE.
OrthoDBiEOG72NRQP.
PhylomeDBiQ9JJA9.
TreeFamiTF316315.

Miscellaneous databases

NextBioi311928.
PROiQ9JJA9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JJA9.
GenevestigatoriQ9JJA9.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors."
    Nevrivy D.J., Peterson V.J., Avram D., Ishmael J.E., Hansen S.G., Dowell P., Hruby D.E., Dawson M.I., Leid M.
    J. Biol. Chem. 275:16827-16836(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PSCD3, SUBCELLULAR LOCATION.
  2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  4. "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
    Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
    J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGRASP_MOUSE
AccessioniPrimary (citable) accession number: Q9JJA9
Secondary accession number(s): Q9JKL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: March 4, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.