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Q9JJA9 (GRASP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General receptor for phosphoinositides 1-associated scaffold protein

Short name=GRP1-associated scaffold protein
Gene names
Name:Grasp
ORF Names:MNCb-4428
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses By similarity.

Subunit structure

Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with GRM2, GRM3 and GRM5 By similarity. Interacts with PSCD3. Ref.1

Subcellular location

Cytoplasm. Cell membrane. Note: Primarily localized to the plasma membrane but also distributed diffusely throughout the cytoplasm. Ref.1

Tissue specificity

Highly expressed in brain, heart and lung, and to a lower extent in embryo, kidney and ovary. Ref.1 Ref.4

Sequence similarities

Contains 1 PDZ (DHR) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392General receptor for phosphoinositides 1-associated scaffold protein
PRO_0000087585

Regions

Domain100 – 18990PDZ
Region180 – 25778Interaction with PSCD3
Compositional bias294 – 32330Pro-rich

Amino acid modifications

Modified residue2361Phosphotyrosine By similarity

Experimental info

Sequence conflict2991P → L in BAA95086. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9JJA9 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: 52144F07D36B57FE

FASTA39242,337
        10         20         30         40         50         60 
MTLRRLRKLQ QKEEATAAPD PAGRAPDSEA ARAAPLPSGP PAAAAPPGAP GEELYAALED 

        70         80         90        100        110        120 
YHPAELYRAL AVSGGTLPRR KGSGFRWKNF TQSPEQQRKV LTLEKGDNQT FGFEIQTYGL 

       130        140        150        160        170        180 
HHREEQRVEM VTFVCRVHES SPAQLAGLTP GDTIASVNGL NVEGIRHREI VDIIKASGNV 

       190        200        210        220        230        240 
LRLETLYGTS IRKAELEARL QYLKQTLYEK WGEYRSLMVQ EQRLVHGLVV KDPSIYDTLE 

       250        260        270        280        290        300 
SVRSCLYGAG LLPGSLPFGP LLAAPGSARG GARRAKGDTD DAVYHTCFFG GAEPQALPPP 

       310        320        330        340        350        360 
PPPARALGPS SAETPASVLF PAPRSTLSRS ASVRCAGPGG GGGAPGALWT EAREQALCGA 

       370        380        390 
GLRKTKYRSF RRRLLKFIPG LNRSLEEEES QL 

« Hide

References

« Hide 'large scale' references
[1]"Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors."
Nevrivy D.J., Peterson V.J., Avram D., Ishmael J.E., Hansen S.G., Dowell P., Hruby D.E., Dawson M.I., Leid M.
J. Biol. Chem. 275:16827-16836(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PSCD3, SUBCELLULAR LOCATION.
[2]"Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[4]"Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF236099 mRNA. Translation: AAF36997.1.
AB041603 mRNA. Translation: BAA95086.1.
BC046307 mRNA. Translation: AAH46307.1.
CCDSCCDS27847.1.
RefSeqNP_062391.3. NM_019518.3.
UniGeneMm.276573.

3D structure databases

ProteinModelPortalQ9JJA9.
SMRQ9JJA9. Positions 97-191.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207817. 2 interactions.
STRING10090.ENSMUSP00000000543.

PTM databases

PhosphoSiteQ9JJA9.

Proteomic databases

PaxDbQ9JJA9.
PRIDEQ9JJA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000543; ENSMUSP00000000543; ENSMUSG00000000531.
GeneID56149.
KEGGmmu:56149.
UCSCuc007xsu.1. mouse.

Organism-specific databases

CTD160622.
MGIMGI:1860303. Grasp.

Phylogenomic databases

eggNOGNOG244814.
GeneTreeENSGT00530000063734.
HOGENOMHOG000231871.
HOVERGENHBG053061.
InParanoidQ9JJA9.
OMAEGFRHKE.
OrthoDBEOG72NRQP.
PhylomeDBQ9JJA9.
TreeFamTF316315.

Gene expression databases

BgeeQ9JJA9.
GenevestigatorQ9JJA9.

Family and domain databases

Gene3D2.30.42.10. 1 hit.
InterProIPR001478. PDZ.
[Graphical view]
PfamPF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311928.
PROQ9JJA9.
SOURCESearch...

Entry information

Entry nameGRASP_MOUSE
AccessionPrimary (citable) accession number: Q9JJA9
Secondary accession number(s): Q9JKL0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot