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Q9JJA9

- GRASP_MOUSE

UniProt

Q9JJA9 - GRASP_MOUSE

Protein

General receptor for phosphoinositides 1-associated scaffold protein

Gene

Grasp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. intracellular protein transport Source: MGI
    2. signal transduction Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General receptor for phosphoinositides 1-associated scaffold protein
    Short name:
    GRP1-associated scaffold protein
    Gene namesi
    Name:Grasp
    ORF Names:MNCb-4428
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1860303. Grasp.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell membrane 1 Publication
    Note: Primarily localized to the plasma membrane but also distributed diffusely throughout the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nuclear envelope lumen Source: MGI
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392General receptor for phosphoinositides 1-associated scaffold proteinPRO_0000087585Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei236 – 2361PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9JJA9.
    PRIDEiQ9JJA9.

    PTM databases

    PhosphoSiteiQ9JJA9.

    Expressioni

    Tissue specificityi

    Highly expressed in brain, heart and lung, and to a lower extent in embryo, kidney and ovary.2 Publications

    Gene expression databases

    BgeeiQ9JJA9.
    GenevestigatoriQ9JJA9.

    Interactioni

    Subunit structurei

    Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with GRM2, GRM3 and GRM5 By similarity. Interacts with PSCD3.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi207817. 2 interactions.
    STRINGi10090.ENSMUSP00000000543.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJA9.
    SMRiQ9JJA9. Positions 97-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini100 – 18990PDZPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni180 – 25778Interaction with PSCD3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi294 – 32330Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG244814.
    GeneTreeiENSGT00530000063734.
    HOGENOMiHOG000231871.
    HOVERGENiHBG053061.
    InParanoidiQ9JJA9.
    OMAiEGFRHKE.
    OrthoDBiEOG72NRQP.
    PhylomeDBiQ9JJA9.
    TreeFamiTF316315.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    [Graphical view]
    PfamiPF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JJA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLRRLRKLQ QKEEATAAPD PAGRAPDSEA ARAAPLPSGP PAAAAPPGAP    50
    GEELYAALED YHPAELYRAL AVSGGTLPRR KGSGFRWKNF TQSPEQQRKV 100
    LTLEKGDNQT FGFEIQTYGL HHREEQRVEM VTFVCRVHES SPAQLAGLTP 150
    GDTIASVNGL NVEGIRHREI VDIIKASGNV LRLETLYGTS IRKAELEARL 200
    QYLKQTLYEK WGEYRSLMVQ EQRLVHGLVV KDPSIYDTLE SVRSCLYGAG 250
    LLPGSLPFGP LLAAPGSARG GARRAKGDTD DAVYHTCFFG GAEPQALPPP 300
    PPPARALGPS SAETPASVLF PAPRSTLSRS ASVRCAGPGG GGGAPGALWT 350
    EAREQALCGA GLRKTKYRSF RRRLLKFIPG LNRSLEEEES QL 392
    Length:392
    Mass (Da):42,337
    Last modified:September 27, 2005 - v2
    Checksum:i52144F07D36B57FE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti299 – 2991P → L in BAA95086. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF236099 mRNA. Translation: AAF36997.1.
    AB041603 mRNA. Translation: BAA95086.1.
    BC046307 mRNA. Translation: AAH46307.1.
    CCDSiCCDS27847.1.
    RefSeqiNP_062391.3. NM_019518.3.
    UniGeneiMm.276573.

    Genome annotation databases

    EnsembliENSMUST00000000543; ENSMUSP00000000543; ENSMUSG00000000531.
    GeneIDi56149.
    KEGGimmu:56149.
    UCSCiuc007xsu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF236099 mRNA. Translation: AAF36997.1 .
    AB041603 mRNA. Translation: BAA95086.1 .
    BC046307 mRNA. Translation: AAH46307.1 .
    CCDSi CCDS27847.1.
    RefSeqi NP_062391.3. NM_019518.3.
    UniGenei Mm.276573.

    3D structure databases

    ProteinModelPortali Q9JJA9.
    SMRi Q9JJA9. Positions 97-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207817. 2 interactions.
    STRINGi 10090.ENSMUSP00000000543.

    PTM databases

    PhosphoSitei Q9JJA9.

    Proteomic databases

    PaxDbi Q9JJA9.
    PRIDEi Q9JJA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000543 ; ENSMUSP00000000543 ; ENSMUSG00000000531 .
    GeneIDi 56149.
    KEGGi mmu:56149.
    UCSCi uc007xsu.1. mouse.

    Organism-specific databases

    CTDi 160622.
    MGIi MGI:1860303. Grasp.

    Phylogenomic databases

    eggNOGi NOG244814.
    GeneTreei ENSGT00530000063734.
    HOGENOMi HOG000231871.
    HOVERGENi HBG053061.
    InParanoidi Q9JJA9.
    OMAi EGFRHKE.
    OrthoDBi EOG72NRQP.
    PhylomeDBi Q9JJA9.
    TreeFami TF316315.

    Miscellaneous databases

    NextBioi 311928.
    PROi Q9JJA9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JJA9.
    Genevestigatori Q9JJA9.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors."
      Nevrivy D.J., Peterson V.J., Avram D., Ishmael J.E., Hansen S.G., Dowell P., Hruby D.E., Dawson M.I., Leid M.
      J. Biol. Chem. 275:16827-16836(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PSCD3, SUBCELLULAR LOCATION.
    2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
      Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.
    4. "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
      Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
      J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGRASP_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJA9
    Secondary accession number(s): Q9JKL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3