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Q9JJA7

- CCNL2_MOUSE

UniProt

Q9JJA7 - CCNL2_MOUSE

Protein

Cyclin-L2

Gene

Ccnl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates the expression of critical apoptotic factor, leading to cell apoptosis By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. RNA processing Source: InterPro
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-L2
    Alternative name(s):
    Cyclin Ania-6b
    Paneth cell-enhanced expression protein
    Short name:
    PCEE
    Gene namesi
    Name:Ccnl2
    Synonyms:Ania6b
    ORF Names:MNCb-5160
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1927119. Ccnl2.

    Subcellular locationi

    Nucleus speckle By similarity

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518Cyclin-L2PRO_0000080488Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei328 – 3281PhosphoserineBy similarity
    Modified residuei335 – 3351PhosphoserineBy similarity
    Modified residuei345 – 3451PhosphoserineBy similarity
    Modified residuei348 – 3481PhosphoserineBy similarity
    Modified residuei366 – 3661PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9JJA7.
    PRIDEiQ9JJA7.

    PTM databases

    PhosphoSiteiQ9JJA7.

    Expressioni

    Gene expression databases

    BgeeiQ9JJA7.
    CleanExiMM_CCNL2.
    GenevestigatoriQ9JJA7.

    Interactioni

    Subunit structurei

    Interacts with CDK11A, CDK11B, CDK12, CDK13, SFRS2, SFRS7 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II.1 Publication

    Protein-protein interaction databases

    IntActiQ9JJA7. 1 interaction.
    MINTiMINT-4129894.
    STRINGi10090.ENSMUSP00000030944.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJA7.
    SMRiQ9JJA7. Positions 50-286.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni81 – 183103Cyclin-like 1Add
    BLAST
    Regioni196 – 28085Cyclin-like 2Add
    BLAST
    Regioni382 – 42039RSAdd
    BLAST

    Domaini

    Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).By similarity

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin L subfamily.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5333.
    GeneTreeiENSGT00690000101911.
    HOVERGENiHBG056044.
    InParanoidiA2AD95.
    OMAiDQEYVNL.
    OrthoDBiEOG7K9K34.
    PhylomeDBiQ9JJA7.
    TreeFamiTF101011.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR015429. Cyclin_C/H/T/L.
    IPR017060. Cyclin_L.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10026. PTHR10026. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036580. Cyclin_L. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JJA7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAAGAAG LMAPASAACS SGSAGAAPGS QGVLIGDRLY SGVLITLENC    50
    LLPDDKLRFT PSMSSGLDVD TETGLRVVGC ELIQAAGILL RLPQVAMATG 100
    QVLFQRFFYT KSFVKHSMEH VSMACVHLAS KIEEAPRRIR DVINVFHRLR 150
    HLREKKKPVP LVLDQEYVNL KNQIIKAERR VLKELGFCVH VKHPHKIIVM 200
    YLQVLECERN QHLVQTAWNY MNDSLRTDVF VRFQPESIAC ACIYLAARTL 250
    EIPLPNRPHW FLLFGATEEE IQEICFKILQ LYTRKKVDLT HLESEVEKRK 300
    HAIEEAKARA KGLLPGTAPG LDSAAGFSPA PKLESPKEGK GGKPSPPSGK 350
    SAKRKMEGPK KAQGHSPVNG LLKGQESRSQ SRSREQSYSR SPSRSASPKR 400
    RKSDSGSTSG GSKSQSRSRS RSDSPPRQVH RGAPYKGSEV RGSRKSKDCK 450
    YLTQKPHKSR SRSSSRSRSR SRERTDNSGK YKKKSHYYRD QRRERSRSYE 500
    RTGHRYERDH PGHSRHRR 518
    Length:518
    Mass (Da):58,005
    Last modified:October 1, 2000 - v1
    Checksum:iC93AEE68682CDBA5
    GO
    Isoform 2 (identifier: Q9JJA7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         219-224: NYMNDS → VASEGK
         225-518: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:224
    Mass (Da):24,578
    Checksum:i744000F7C7D3084E
    GO
    Isoform 3 (identifier: Q9JJA7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         219-518: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:218
    Mass (Da):24,006
    Checksum:i584E197FA66E601D
    GO

    Sequence cautioni

    The sequence AAC52504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAC52504.1 differs from that shown. Reason: Erroneous termination at position 519. Translated as stop.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161S → A in BAE41413. (PubMed:16141072)Curated
    Sequence conflicti16 – 161S → A in BAE33556. (PubMed:16141072)Curated
    Sequence conflicti16 – 161S → A in EDL15040. 1 PublicationCurated
    Sequence conflicti16 – 161S → A in AAI32296. (PubMed:15489334)Curated
    Sequence conflicti131 – 1311K → R in BAC26255. (PubMed:16141072)Curated
    Sequence conflicti282 – 2821Y → F in AAH03773. (PubMed:15489334)Curated
    Sequence conflicti317 – 3171T → S in EDL15040. 1 PublicationCurated
    Sequence conflicti317 – 3171T → S in AAH03773. (PubMed:15489334)Curated
    Sequence conflicti317 – 3171T → S in AAI32296. (PubMed:15489334)Curated
    Sequence conflicti334 – 3341E → VE in AAH03773. (PubMed:15489334)Curated
    Sequence conflicti334 – 3341E → VE in AAH83055. (PubMed:15489334)Curated
    Sequence conflicti334 – 3341E → VE in AAC52504. (PubMed:8838426)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei219 – 518300Missing in isoform 3. 1 PublicationVSP_016133Add
    BLAST
    Alternative sequencei219 – 2246NYMNDS → VASEGK in isoform 2. 3 PublicationsVSP_016134
    Alternative sequencei225 – 518294Missing in isoform 2. 3 PublicationsVSP_016135Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF211859 mRNA. Translation: AAF23011.1.
    AY337018 mRNA. Translation: AAQ01205.1.
    AB041605 mRNA. Translation: BAA95088.1.
    AK007552 mRNA. Translation: BAB25103.1.
    AK029033 mRNA. Translation: BAC26255.1.
    AK048244 mRNA. Translation: BAE43334.1.
    AK156037 mRNA. Translation: BAE33556.1.
    AK169857 mRNA. Translation: BAE41413.1.
    AL670236 Genomic DNA. Translation: CAM18388.1.
    CH466594 Genomic DNA. Translation: EDL15040.1.
    BC003773 mRNA. Translation: AAH03773.2.
    BC023747 mRNA. No translation available.
    BC083055 mRNA. Translation: AAH83055.1.
    BC132295 mRNA. Translation: AAI32296.1.
    U37351 mRNA. Translation: AAC52504.1. Sequence problems.
    CCDSiCCDS19042.1. [Q9JJA7-1]
    RefSeqiNP_997561.1. NM_207678.1. [Q9JJA7-1]
    UniGeneiMm.23492.

    Genome annotation databases

    EnsembliENSMUST00000030944; ENSMUSP00000030944; ENSMUSG00000029068. [Q9JJA7-1]
    GeneIDi56036.
    KEGGimmu:56036.
    UCSCiuc008wev.1. mouse. [Q9JJA7-3]
    uc008wew.1. mouse. [Q9JJA7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF211859 mRNA. Translation: AAF23011.1 .
    AY337018 mRNA. Translation: AAQ01205.1 .
    AB041605 mRNA. Translation: BAA95088.1 .
    AK007552 mRNA. Translation: BAB25103.1 .
    AK029033 mRNA. Translation: BAC26255.1 .
    AK048244 mRNA. Translation: BAE43334.1 .
    AK156037 mRNA. Translation: BAE33556.1 .
    AK169857 mRNA. Translation: BAE41413.1 .
    AL670236 Genomic DNA. Translation: CAM18388.1 .
    CH466594 Genomic DNA. Translation: EDL15040.1 .
    BC003773 mRNA. Translation: AAH03773.2 .
    BC023747 mRNA. No translation available.
    BC083055 mRNA. Translation: AAH83055.1 .
    BC132295 mRNA. Translation: AAI32296.1 .
    U37351 mRNA. Translation: AAC52504.1 . Sequence problems.
    CCDSi CCDS19042.1. [Q9JJA7-1 ]
    RefSeqi NP_997561.1. NM_207678.1. [Q9JJA7-1 ]
    UniGenei Mm.23492.

    3D structure databases

    ProteinModelPortali Q9JJA7.
    SMRi Q9JJA7. Positions 50-286.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JJA7. 1 interaction.
    MINTi MINT-4129894.
    STRINGi 10090.ENSMUSP00000030944.

    PTM databases

    PhosphoSitei Q9JJA7.

    Proteomic databases

    PaxDbi Q9JJA7.
    PRIDEi Q9JJA7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030944 ; ENSMUSP00000030944 ; ENSMUSG00000029068 . [Q9JJA7-1 ]
    GeneIDi 56036.
    KEGGi mmu:56036.
    UCSCi uc008wev.1. mouse. [Q9JJA7-3 ]
    uc008wew.1. mouse. [Q9JJA7-1 ]

    Organism-specific databases

    CTDi 81669.
    MGIi MGI:1927119. Ccnl2.

    Phylogenomic databases

    eggNOGi COG5333.
    GeneTreei ENSGT00690000101911.
    HOVERGENi HBG056044.
    InParanoidi A2AD95.
    OMAi DQEYVNL.
    OrthoDBi EOG7K9K34.
    PhylomeDBi Q9JJA7.
    TreeFami TF101011.

    Miscellaneous databases

    ChiTaRSi CCNL2. mouse.
    NextBioi 311796.
    PROi Q9JJA7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JJA7.
    CleanExi MM_CCNL2.
    Genevestigatori Q9JJA7.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR015429. Cyclin_C/H/T/L.
    IPR017060. Cyclin_L.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10026. PTHR10026. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036580. Cyclin_L. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin."
      Berke J.D., Sgambato V., Zhu P.-P., Lavoie B., Vincent M., Krause M., Hyman S.E.
      Neuron 32:277-287(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: C57BL/6.
    2. "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells."
      Yang L., Li N., Wang C., Yu Y., Yuan L., Zhang M., Cao X.
      J. Biol. Chem. 279:11639-11648(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
    3. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
      Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Strain: C57BL/6J and NOD.
      Tissue: Head, Pancreas, Skin and Spleen.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: FVB/N.
      Tissue: Brain and Mammary gland.
    8. "Patterns of gene expression along the crypt-villus axis in mouse jejunal epithelium."
      Cheng H., Bjerknes M.
      Anat. Rec. 244:78-94(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 321-518.
      Strain: BALB/c.
      Tissue: Jejunal epithelium.
    9. "CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing."
      Chen H.H., Wong Y.H., Geneviere A.M., Fann M.J.
      Biochem. Biophys. Res. Commun. 354:735-740(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION CDK13.

    Entry informationi

    Entry nameiCCNL2_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJA7
    Secondary accession number(s): A2AD95
    , A2RSY2, Q5XK66, Q60995, Q8C136, Q8CIJ8, Q99L73, Q9QXH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3