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Protein

Receptor activity-modifying protein 3

Gene

Ramp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.1 Publication

GO - Molecular functioni

  • coreceptor activity Source: RGD
  • G-protein coupled receptor binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein transporter activity Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 3
Gene namesi
Name:Ramp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi61873. Ramp3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 11795ExtracellularSequence analysisAdd
BLAST
Transmembranei118 – 13720HelicalSequence analysisAdd
BLAST
Topological domaini138 – 14710CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2109239.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 147125Receptor activity-modifying protein 3PRO_0000030178Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi39 ↔ 71By similarity
Disulfide bondi56 ↔ 103By similarity
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JJ73.
PRIDEiQ9JJ73.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008154.
GenevisibleiQ9JJ73. RN.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP3. Interacts with GPER1.By similarity

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010866.

Structurei

3D structure databases

ProteinModelPortaliQ9JJ73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXGF. Eukaryota.
ENOG4111U8C. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiQ9JJ73.
KOiK08449.
OMAiVDVWKWC.
OrthoDBiEOG091G0W6Z.
PhylomeDBiQ9JJ73.
TreeFamiTF333286.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJ73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPAQRLHL LPLLLLLCGE CAQVCGCNET GMLERLPRCG KAFAEMMQKV
60 70 80 90 100
DVWKWCNLSE FIVYYESFTN CTEMETNIVG CYWPNPLAQS FITGIHRQFF
110 120 130 140
SNCTVDRTHW EDPPDEVLIP LIAVPVLLTV AMAGLVVWRS KRTDRLL
Length:147
Mass (Da):16,781
Last modified:October 1, 2000 - v1
Checksum:iFCD518954AC5E52B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042889 mRNA. Translation: BAB03506.1.
AF181552 mRNA. Translation: AAG09436.2.
RefSeqiNP_064485.2. NM_020100.2.
UniGeneiRn.48672.

Genome annotation databases

EnsembliENSRNOT00000086468; ENSRNOP00000074204; ENSRNOG00000053766.
GeneIDi56820.
KEGGirno:56820.
UCSCiRGD:61873. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042889 mRNA. Translation: BAB03506.1.
AF181552 mRNA. Translation: AAG09436.2.
RefSeqiNP_064485.2. NM_020100.2.
UniGeneiRn.48672.

3D structure databases

ProteinModelPortaliQ9JJ73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010866.

Chemistry

ChEMBLiCHEMBL2109239.

Proteomic databases

PaxDbiQ9JJ73.
PRIDEiQ9JJ73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000086468; ENSRNOP00000074204; ENSRNOG00000053766.
GeneIDi56820.
KEGGirno:56820.
UCSCiRGD:61873. rat.

Organism-specific databases

CTDi10268.
RGDi61873. Ramp3.

Phylogenomic databases

eggNOGiENOG410IXGF. Eukaryota.
ENOG4111U8C. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiQ9JJ73.
KOiK08449.
OMAiVDVWKWC.
OrthoDBiEOG091G0W6Z.
PhylomeDBiQ9JJ73.
TreeFamiTF333286.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

PROiQ9JJ73.

Gene expression databases

BgeeiENSRNOG00000008154.
GenevisibleiQ9JJ73. RN.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAMP3_RAT
AccessioniPrimary (citable) accession number: Q9JJ73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.