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Protein

Receptor activity-modifying protein 3

Gene

Ramp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.1 Publication

GO - Molecular functioni

  • adrenomedullin receptor activity Source: Ensembl
  • amylin receptor activity Source: Ensembl
  • coreceptor activity Source: RGD
  • G-protein coupled receptor binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein transporter activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-418555 G alpha (s) signalling events
R-RNO-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 3
Gene namesi
Name:Ramp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi61873 Ramp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 117ExtracellularSequence analysisAdd BLAST95
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 147CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi53

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003017823 – 147Receptor activity-modifying protein 3Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi39 ↔ 71By similarity
Disulfide bondi56 ↔ 103By similarity
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JJ73
PRIDEiQ9JJ73

Expressioni

Gene expression databases

BgeeiENSRNOG00000053766
GenevisibleiQ9JJ73 RN

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP3. Interacts with GPER1.By similarity

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010866

Structurei

3D structure databases

ProteinModelPortaliQ9JJ73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXGF Eukaryota
ENOG4111U8C LUCA
GeneTreeiENSGT00390000016200
HOGENOMiHOG000253018
HOVERGENiHBG061268
InParanoidiQ9JJ73
KOiK08449
OMAiVDVWKWC
OrthoDBiEOG091G0W6Z
PhylomeDBiQ9JJ73
TreeFamiTF333286

Family and domain databases

Gene3Di1.10.150.510, 1 hit
InterProiView protein in InterPro
IPR006985 RAMP
IPR038126 RAMP_sf
PANTHERiPTHR14076 PTHR14076, 1 hit
PfamiView protein in Pfam
PF04901 RAMP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJ73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPAQRLHL LPLLLLLCGE CAQVCGCNET GMLERLPRCG KAFAEMMQKV
60 70 80 90 100
DVWKWCNLSE FIVYYESFTN CTEMETNIVG CYWPNPLAQS FITGIHRQFF
110 120 130 140
SNCTVDRTHW EDPPDEVLIP LIAVPVLLTV AMAGLVVWRS KRTDRLL
Length:147
Mass (Da):16,781
Last modified:October 1, 2000 - v1
Checksum:iFCD518954AC5E52B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042889 mRNA Translation: BAB03506.1
AF181552 mRNA Translation: AAG09436.2
RefSeqiNP_064485.2, NM_020100.2
UniGeneiRn.48672

Genome annotation databases

EnsembliENSRNOT00000086468; ENSRNOP00000074204; ENSRNOG00000053766
GeneIDi56820
KEGGirno:56820
UCSCiRGD:61873 rat

Similar proteinsi

Entry informationi

Entry nameiRAMP3_RAT
AccessioniPrimary (citable) accession number: Q9JJ73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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