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Protein

ATP-binding cassette sub-family B member 9

Gene

Abcb9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi535 – 542ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPeptide transport, Protein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 9
Alternative name(s):
ATP-binding cassette transporter 9
Short name:
ABC transporter 9 protein
Short name:
mABCB9
TAP-like protein
Short name:
TAPL
Gene namesi
Name:Abcb9
Synonyms:Kiaa1520
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1861729 Abcb9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei47 – 67HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei84 – 104HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei116 – 136HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei181 – 201HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei221 – 241HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei315 – 335HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei412 – 432HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000002531 – 762ATP-binding cassette sub-family B member 9Add BLAST762

Proteomic databases

PaxDbiQ9JJ59
PeptideAtlasiQ9JJ59
PRIDEiQ9JJ59

PTM databases

iPTMnetiQ9JJ59
PhosphoSitePlusiQ9JJ59

Expressioni

Tissue specificityi

Highly expressed in testis, particularly in the Sertoli cells of the seminiferous tubules, and at moderate levels in brain and spinal cord.1 Publication

Gene expression databases

BgeeiENSMUSG00000029408
ExpressionAtlasiQ9JJ59 baseline and differential
GenevisibleiQ9JJ59 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031354

Structurei

3D structure databases

ProteinModelPortaliQ9JJ59
SMRiQ9JJ59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 467ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST284
Domaini500 – 736ABC transporterPROSITE-ProRule annotationAdd BLAST237

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi380 – 385Poly-Glu6

Domaini

The N-terminal region comprising the first four transmembrane domains is required for lysosomal localization but not for homodimerization or peptide transport.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00550000074497
HOVERGENiHBG008358
InParanoidiQ9JJ59
KOiK05656
OMAiDRICVFL
OrthoDBiEOG091G0HVA
PhylomeDBiQ9JJ59
TreeFamiTF105197

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030254 ABCB9
IPR027417 P-loop_NTPase
PANTHERiPTHR24221:SF242 PTHR24221:SF242, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JJ59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLWKAVVVT LAFVSTDVGV TTAIYAFSHL DRSLLEDIRH FNIFDSVLDL
60 70 80 90 100
WAACLYRSCL LLGATIGVAK NSALGPRRLR ASWLVITLVC LFVGIYAMAK
110 120 130 140 150
LLLFSEVRRP IRDPWFWALF VWTYISLAAS FLLWGLLATV RPDAEALEPG
160 170 180 190 200
NEGFHGEGGA PAEQASGATL QKLLSYTKPD VAFLVAASFF LIVAALGETF
210 220 230 240 250
LPYYTGRAID SIVIQKSMDQ FTTAVVVVCL LAIGSSLAAG IRGGIFTLVF
260 270 280 290 300
ARLNIRLRNC LFRSLVSQET SFFDENRTGD LISRLTSDTT MVSDLVSQNI
310 320 330 340 350
NIFLRNTVKV TGVVVFMFSL SWQLSLVTFM GFPIIMMVSN IYGKYYKRLS
360 370 380 390 400
KEVQSALARA STTAEETISA MKTVRSFANE EEEAEVFLRK LQQVYKLNRK
410 420 430 440 450
EAAAYMSYVW GSGLTLLVVQ VSILYYGGHL VISGQMSSGN LIAFIIYEFV
460 470 480 490 500
LGDCMESVGS VYSGLMQGVG AAEKVFEFID RQPTMVHDGS LAPDHLEGRV
510 520 530 540 550
DFENVTFTYR TRPHTQVLQN VSFSLSPGKV TALVGPSGSG KSSCVNILEN
560 570 580 590 600
FYPLQGGRVL LDGKPIGAYD HKYLHRVISL VSQEPVLFAR SITDNISYGL
610 620 630 640 650
PTVPFEMVVE AAQKANAHGF IMELQDGYST ETGEKGAQLS GGQKQRVAMA
660 670 680 690 700
RALVRNPPVL ILDEATSALD AESEYLIQQA IHGNLQRHTV LIIAHRLSTV
710 720 730 740 750
ERAHLIVVLD KGRVVQQGTH QQLLAQGGLY AKLVQRQMLG LEHPLDYTAS
760
HKEPPSNTEH KA
Length:762
Mass (Da):83,963
Last modified:October 1, 2000 - v1
Checksum:iA03C41760974DC9F
GO
Isoform 2 (identifier: Q9JJ59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     631-636: ETGEKG → GTRRRL
     637-762: Missing.

Note: No experimental confirmation available.
Show »
Length:636
Mass (Da):70,216
Checksum:i0740982E661B370E
GO

Sequence cautioni

The sequence BAC41480 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67G → R in AAF89994 (PubMed:10748049).Curated1
Sequence conflicti513P → A in AK020749 (PubMed:16141072).Curated1
Sequence conflicti524S → N in AK020749 (PubMed:16141072).Curated1
Sequence conflicti550N → S in AAF89994 (PubMed:10748049).Curated1
Sequence conflicti605F → L in AK020749 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000032631 – 636ETGEKG → GTRRRL in isoform 2. 1 Publication6
Alternative sequenceiVSP_000033637 – 762Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045382 mRNA Translation: BAA97990.2
AF216495 mRNA Translation: AAF89994.1
AB093298 mRNA Translation: BAC41480.1 Different initiation.
AK020749 mRNA No translation available.
AK044140 mRNA Translation: BAC31796.1
BC053014 mRNA Translation: AAH53014.1
CCDSiCCDS19671.1 [Q9JJ59-1]
RefSeqiNP_063928.2, NM_019875.2 [Q9JJ59-1]
UniGeneiMm.254839

Genome annotation databases

EnsembliENSMUST00000031354; ENSMUSP00000031354; ENSMUSG00000029408 [Q9JJ59-1]
GeneIDi56325
KEGGimmu:56325
UCSCiuc008zou.1 mouse [Q9JJ59-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiABCB9_MOUSE
AccessioniPrimary (citable) accession number: Q9JJ59
Secondary accession number(s): Q8CHA1, Q9D212, Q9JIN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health