Q9JJ57 (KCIP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kv channel-interacting protein 1
Short name=KChIP1

Alternative name(s):
A-type potassium channel modulatory protein 1
Potassium channel-interacting protein 1

Gene names

Name:	Kcnip1
Synonyms:	Kchip1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface By similarity. Ref.1
Subunit structure	Component of heteromultimeric potassium channels. Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein Ref.1.
Tissue specificity	Expressed in brain. Found in a subpopulation of neurons widely distributed and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei. Ref.9
Sequence similarities	Belongs to the recoverin family. Contains 4 EF-hand domains.
Sequence caution	The sequence AAN77492.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	Calcium Metal-binding Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of action potential Inferred from electronic annotation. Source: Compara
Cellular_component	dendrite Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: Compara potassium channel activity Inferred from electronic annotation. Source: UniProtKB-KW potassium channel regulator activity Inferred from electronic annotation. Source: Compara voltage-gated ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9JJ57-1)

Also known as: A; Kchip1.2; KCHIP1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9JJ57-2)

Also known as: Kchip1.1; KCHP1a;

The sequence of this isoform differs from the canonical sequence as follows:
     21-31: Missing.

Isoform 3 (identifier: Q9JJ57-3)

Also known as: Kchip1.2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Isoform 4 (identifier: Q9JJ57-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MGAVMGTFSSLQTKQRRP → MSSCSKRCRLGFVKFAQTIFKLITGTL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Kv channel-interacting protein 1		PRO_0000073819
Regions
	Domain	38 – 94	57	EF-hand 1; degenerate
	Domain	97 – 132	36	EF-hand 2
	Domain	133 – 168	36	EF-hand 3
	Domain	181 – 216	36	EF-hand 4
	Calcium binding	146 – 157	12	1 By similarity
	Calcium binding	194 – 205	12	2 By similarity
	Region	214 – 227	14	Interaction with KCND2 By similarity
Natural variations
	Alternative sequence	1 – 39	39	Missing in isoform 3.		VSP_015045
	Alternative sequence	1 – 18	18	MGAVM…KQRRP → MSSCSKRCRLGFVKFAQTIF KLITGTL in isoform 4.		VSP_015046
	Alternative sequence	21 – 31	11	Missing in isoform 2.		VSP_015047
Experimental info
	Sequence conflict	147	1	I → L in AAL12488. Ref.1
	Sequence conflict	185	1	H → R in AAT68468. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) (Kchip1.2) (KCHIP1b) [UniParc]. Last modified August 16, 2005. Version 2. Checksum: 9256B5239A13B126	FASTA	227	26,831
	10 20 30 40 50 60 MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDELEM TMVCHRPEGL EQLEAQTNFT 70 80 90 100 110 120 KRELQVLYRG FKNECPSGVV NEETFKQIYA QFFPHGDAST YAHYLFNAFD TTQTGSVKFE 130 140 150 160 170 180 DFVTALSILL RGTVHEKLRW TFNLYDINKD GYINKEEMMD IVKAIYDMMG KYTYPVLKED 190 200 210 220 TPRQHVDVFF QKMDKNKDGI VTLDEFLESC QEDDNIMRSL QLFQNVM
	Isoform 2 (Kchip1.1) (KCHP1a) [UniParc]. Checksum: A9F32A1932B6B747	FASTA	216	25,258
	10 20 30 40 50 60 MGAVMGTFSS LQTKQRRPSK DKIEDELEMT MVCHRPEGLE QLEAQTNFTK RELQVLYRGF 70 80 90 100 110 120 KNECPSGVVN EETFKQIYAQ FFPHGDASTY AHYLFNAFDT TQTGSVKFED FVTALSILLR 130 140 150 160 170 180 GTVHEKLRWT FNLYDINKDG YINKEEMMDI VKAIYDMMGK YTYPVLKEDT PRQHVDVFFQ 190 200 210 KMDKNKDGIV TLDEFLESCQ EDDNIMRSLQ LFQNVM
	Isoform 3 (Kchip1.2) [UniParc]. Checksum: 16D9A84482FA00AD	FASTA	188	22,093
	10 20 30 40 50 60 MTMVCHRPEG LEQLEAQTNF TKRELQVLYR GFKNECPSGV VNEETFKQIY AQFFPHGDAS 70 80 90 100 110 120 TYAHYLFNAF DTTQTGSVKF EDFVTALSIL LRGTVHEKLR WTFNLYDINK DGYINKEEMM 130 140 150 160 170 180 DIVKAIYDMM GKYTYPVLKE DTPRQHVDVF FQKMDKNKDG IVTLDEFLES CQEDDNIMRS LQLFQNVM
	Isoform 4 [UniParc]. Checksum: 1A17AA636755B0CD	FASTA	236	27,873
	10 20 30 40 50 60 MSSCSKRCRL GFVKFAQTIF KLITGTLSKD IAWWYYQYQR DKIEDELEMT MVCHRPEGLE 70 80 90 100 110 120 QLEAQTNFTK RELQVLYRGF KNECPSGVVN EETFKQIYAQ FFPHGDASTY AHYLFNAFDT 130 140 150 160 170 180 TQTGSVKFED FVTALSILLR GTVHEKLRWT FNLYDINKDG YINKEEMMDI VKAIYDMMGK 190 200 210 220 230 YTYPVLKEDT PRQHVDVFFQ KMDKNKDGIV TLDEFLESCQ EDDNIMRSLQ LFQNVM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential modulation of Kv4 kinetics by KCHIP1 splice variants." Van Hoorick D., Raes A., Keysers W., Mayeur E., Snyders D.J. Mol. Cell. Neurosci. 24:357-366(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION. Strain: BALB/c.
[2]	Ohya S., Horowitz B. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Strain: BALB/c. Tissue: Brain.
[3]	Xia K.U., Fang H.Y., Zhong X.Y., Xia J.H., Zhang Z.H. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Strain: Swiss Webster.
[4]	Fang H.Y., Xia K., Xia J.H., Zhang Z.H. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Strain: Swiss Webster.
[5]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Strain: C57BL/6J. Tissue: Corpora quadrigemina and Head.
[6]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Eye.
[8]	Franz O., Soloviev M., Roeper J. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-227 (ISOFORM 2).
[9]	"Differential distribution of KChIPs mRNAs in adult mouse brain." Xiong H., Kovacs I., Zhang Z. Brain Res. Mol. Brain Res. 128:103-111(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY050525 mRNA. Translation: AAL12488.1. AY050526 mRNA. Translation: AAL12489.1. AB075041 mRNA. Translation: BAB78543.1. AY171234 mRNA. Translation: AAN77492.1. Different initiation. AY647242 mRNA. Translation: AAT68468.1. AK081845 mRNA. Translation: BAC38347.1. AK045948 mRNA. Translation: BAC32543.1. AK046398 mRNA. Translation: BAC32705.1. AL669814, AL731867 Genomic DNA. Translation: CAI25675.1. AL669814, AL731867 Genomic DNA. Translation: CAI25676.1. AL731867, AL669814 Genomic DNA. Translation: CAI26003.1. AL669814 Genomic DNA. Translation: CAI25682.1. AL731867, AL669814 Genomic DNA. Translation: CAI26004.1. BC034241 mRNA. Translation: AAH34241.1. AJ278534 mRNA. Translation: CAC82025.1.
IPI	IPI00402920. IPI00623643. IPI00649225. IPI00649407.
RefSeq	NP_001177814.1. NM_001190885.1. NP_001177815.1. NM_001190886.1. NP_081674.2. NM_027398.3.
UniGene	Mm.252514.
3D structure databases
ProteinModelPortal	Q9JJ57.
SMR	Q9JJ57. Positions 49-227.
ModBase	Search...
Proteomic databases
PRIDE	Q9JJ57.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000065970; ENSMUSP00000069063; ENSMUSG00000053519. ENSMUST00000101368; ENSMUSP00000098919; ENSMUSG00000053519. ENSMUST00000109340; ENSMUSP00000104964; ENSMUSG00000053519.
GeneID	70357.
KEGG	mmu:70357.
UCSC	uc007ikp.2. mouse. uc007ikq.2. mouse.
Organism-specific databases
CTD	30820.
MGI	MGI:1917607. Kcnip1.
Phylogenomic databases
eggNOG	COG5126.
GeneTree	ENSGT00560000076973.
HOVERGEN	HBG108179.
OMA	NFNKREL.
OrthoDB	EOG4N8R5P.
Gene expression databases
ArrayExpress	Q9JJ57.
Bgee	Q9JJ57.
CleanEx	MM_KCNIP1.
Genevestigator	Q9JJ57.
GermOnline	ENSMUSG00000053519. Mus musculus.
Family and domain databases
Gene3D	1.10.238.10. 3 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR001125. Recoverin. [Graphical view]
Pfam	PF13499. EF_hand_5. 1 hit. [Graphical view]
PRINTS	PR00450. RECOVERIN.
SMART	SM00054. EFh. 3 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	331438.
SOURCE	Search...

Entry information

Entry name

KCIP1_MOUSE

Accession

Primary (citable) accession number: Q9JJ57
Secondary accession number(s): Q5SSA3 , Q6DTJ1, Q8BGJ4, Q8C4K4, Q8CGL1, Q8K1U1, Q8K3M2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	August 16, 2005
Last modified:	May 1, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program