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Q9JJ57

- KCIP1_MOUSE

UniProt

Q9JJ57 - KCIP1_MOUSE

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Protein
Kv channel-interacting protein 1
Gene
Kcnip1, Kchip1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface By similarity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi146 – 157121 By similarity
Add
BLAST
Calcium bindingi194 – 205122 By similarity
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. potassium channel activity Source: UniProtKB-KW
  3. potassium channel regulator activity Source: Ensembl
  4. voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of action potential Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calcium, Metal-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Kv channel-interacting protein 1
Short name:
KChIP1
Alternative name(s):
A-type potassium channel modulatory protein 1
Potassium channel-interacting protein 1
Gene namesi
Name:Kcnip1
Synonyms:Kchip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1917607. Kcnip1.

Subcellular locationi

Cell membrane; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. neuronal cell body Source: Ensembl
  3. plasma membrane Source: UniProtKB-SubCell
  4. potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Kv channel-interacting protein 1
PRO_0000073819Add
BLAST

Proteomic databases

PRIDEiQ9JJ57.

Expressioni

Tissue specificityi

Expressed in brain. Found in a subpopulation of neurons widely distributed and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei.1 Publication

Gene expression databases

BgeeiQ9JJ57.
CleanExiMM_KCNIP1.
GenevestigatoriQ9JJ57.

Interactioni

Subunit structurei

Component of heteromultimeric potassium channels. Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9JJ57.
SMRiQ9JJ57. Positions 49-227.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 9457EF-hand 1; degenerate
Add
BLAST
Domaini97 – 13236EF-hand 2
Add
BLAST
Domaini133 – 16836EF-hand 3
Add
BLAST
Domaini181 – 21636EF-hand 4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni214 – 22714Interaction with KCND2 By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the recoverin family.
Contains 4 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00560000076973.
HOVERGENiHBG108179.
OMAiKQHVDAF.
OrthoDBiEOG7GJ6F3.
PhylomeDBiQ9JJ57.
TreeFamiTF318560.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JJ57-1) [UniParc]FASTAAdd to Basket

Also known as: A, Kchip1.2, KCHIP1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDELEM TMVCHRPEGL    50
EQLEAQTNFT KRELQVLYRG FKNECPSGVV NEETFKQIYA QFFPHGDAST 100
YAHYLFNAFD TTQTGSVKFE DFVTALSILL RGTVHEKLRW TFNLYDINKD 150
GYINKEEMMD IVKAIYDMMG KYTYPVLKED TPRQHVDVFF QKMDKNKDGI 200
VTLDEFLESC QEDDNIMRSL QLFQNVM 227
Length:227
Mass (Da):26,831
Last modified:August 16, 2005 - v2
Checksum:i9256B5239A13B126
GO
Isoform 2 (identifier: Q9JJ57-2) [UniParc]FASTAAdd to Basket

Also known as: Kchip1.1, KCHP1a

The sequence of this isoform differs from the canonical sequence as follows:
     21-31: Missing.

Show »
Length:216
Mass (Da):25,258
Checksum:iA9F32A1932B6B747
GO
Isoform 3 (identifier: Q9JJ57-3) [UniParc]FASTAAdd to Basket

Also known as: Kchip1.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:188
Mass (Da):22,093
Checksum:i16D9A84482FA00AD
GO
Isoform 4 (identifier: Q9JJ57-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MGAVMGTFSSLQTKQRRP → MSSCSKRCRLGFVKFAQTIFKLITGTL

Show »
Length:236
Mass (Da):27,873
Checksum:i1A17AA636755B0CD
GO

Sequence cautioni

The sequence AAN77492.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3939Missing in isoform 3.
VSP_015045Add
BLAST
Alternative sequencei1 – 1818MGAVM…KQRRP → MSSCSKRCRLGFVKFAQTIF KLITGTL in isoform 4.
VSP_015046Add
BLAST
Alternative sequencei21 – 3111Missing in isoform 2.
VSP_015047Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471I → L in AAL12488. 1 Publication
Sequence conflicti185 – 1851H → R in AAT68468. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY050525 mRNA. Translation: AAL12488.1.
AY050526 mRNA. Translation: AAL12489.1.
AB075041 mRNA. Translation: BAB78543.1.
AY171234 mRNA. Translation: AAN77492.1. Different initiation.
AY647242 mRNA. Translation: AAT68468.1.
AK081845 mRNA. Translation: BAC38347.1.
AK045948 mRNA. Translation: BAC32543.1.
AK046398 mRNA. Translation: BAC32705.1.
AL669814, AL731867 Genomic DNA. Translation: CAI25675.1.
AL669814, AL731867 Genomic DNA. Translation: CAI25676.1.
AL731867, AL669814 Genomic DNA. Translation: CAI26003.1.
AL669814 Genomic DNA. Translation: CAI25682.1.
AL731867, AL669814 Genomic DNA. Translation: CAI26004.1.
BC034241 mRNA. Translation: AAH34241.1.
AJ278534 mRNA. Translation: CAC82025.1.
CCDSiCCDS24537.1. [Q9JJ57-2]
CCDS56766.1. [Q9JJ57-1]
CCDS70160.1. [Q9JJ57-3]
RefSeqiNP_001177814.1. NM_001190885.1. [Q9JJ57-1]
NP_001177815.1. NM_001190886.1.
NP_001277619.1. NM_001290690.1. [Q9JJ57-3]
NP_081674.2. NM_027398.3. [Q9JJ57-2]
XP_006514868.1. XM_006514805.1. [Q9JJ57-3]
UniGeneiMm.252514.

Genome annotation databases

EnsembliENSMUST00000065970; ENSMUSP00000069063; ENSMUSG00000053519. [Q9JJ57-2]
ENSMUST00000101368; ENSMUSP00000098919; ENSMUSG00000053519. [Q9JJ57-3]
ENSMUST00000109340; ENSMUSP00000104964; ENSMUSG00000053519. [Q9JJ57-1]
GeneIDi70357.
KEGGimmu:70357.
UCSCiuc007ikp.2. mouse. [Q9JJ57-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY050525 mRNA. Translation: AAL12488.1 .
AY050526 mRNA. Translation: AAL12489.1 .
AB075041 mRNA. Translation: BAB78543.1 .
AY171234 mRNA. Translation: AAN77492.1 . Different initiation.
AY647242 mRNA. Translation: AAT68468.1 .
AK081845 mRNA. Translation: BAC38347.1 .
AK045948 mRNA. Translation: BAC32543.1 .
AK046398 mRNA. Translation: BAC32705.1 .
AL669814 , AL731867 Genomic DNA. Translation: CAI25675.1 .
AL669814 , AL731867 Genomic DNA. Translation: CAI25676.1 .
AL731867 , AL669814 Genomic DNA. Translation: CAI26003.1 .
AL669814 Genomic DNA. Translation: CAI25682.1 .
AL731867 , AL669814 Genomic DNA. Translation: CAI26004.1 .
BC034241 mRNA. Translation: AAH34241.1 .
AJ278534 mRNA. Translation: CAC82025.1 .
CCDSi CCDS24537.1. [Q9JJ57-2 ]
CCDS56766.1. [Q9JJ57-1 ]
CCDS70160.1. [Q9JJ57-3 ]
RefSeqi NP_001177814.1. NM_001190885.1. [Q9JJ57-1 ]
NP_001177815.1. NM_001190886.1.
NP_001277619.1. NM_001290690.1. [Q9JJ57-3 ]
NP_081674.2. NM_027398.3. [Q9JJ57-2 ]
XP_006514868.1. XM_006514805.1. [Q9JJ57-3 ]
UniGenei Mm.252514.

3D structure databases

ProteinModelPortali Q9JJ57.
SMRi Q9JJ57. Positions 49-227.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9JJ57.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065970 ; ENSMUSP00000069063 ; ENSMUSG00000053519 . [Q9JJ57-2 ]
ENSMUST00000101368 ; ENSMUSP00000098919 ; ENSMUSG00000053519 . [Q9JJ57-3 ]
ENSMUST00000109340 ; ENSMUSP00000104964 ; ENSMUSG00000053519 . [Q9JJ57-1 ]
GeneIDi 70357.
KEGGi mmu:70357.
UCSCi uc007ikp.2. mouse. [Q9JJ57-1 ]

Organism-specific databases

CTDi 30820.
MGIi MGI:1917607. Kcnip1.

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00560000076973.
HOVERGENi HBG108179.
OMAi KQHVDAF.
OrthoDBi EOG7GJ6F3.
PhylomeDBi Q9JJ57.
TreeFami TF318560.

Miscellaneous databases

NextBioi 331438.
PROi Q9JJ57.
SOURCEi Search...

Gene expression databases

Bgeei Q9JJ57.
CleanExi MM_KCNIP1.
Genevestigatori Q9JJ57.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view ]
PANTHERi PTHR23055. PTHR23055. 1 hit.
Pfami PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential modulation of Kv4 kinetics by KCHIP1 splice variants."
    Van Hoorick D., Raes A., Keysers W., Mayeur E., Snyders D.J.
    Mol. Cell. Neurosci. 24:357-366(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
    Strain: BALB/c.
  2. Ohya S., Horowitz B.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: BALB/c.
    Tissue: Brain.
  3. Xia K.U., Fang H.Y., Zhong X.Y., Xia J.H., Zhang Z.H.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: Swiss Webster.
  4. Fang H.Y., Xia K., Xia J.H., Zhang Z.H.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Strain: Swiss Webster.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina and Head.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.
  8. Franz O., Soloviev M., Roeper J.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-227 (ISOFORM 2).
  9. "Differential distribution of KChIPs mRNAs in adult mouse brain."
    Xiong H., Kovacs I., Zhang Z.
    Brain Res. Mol. Brain Res. 128:103-111(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCIP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJ57
Secondary accession number(s): Q5SSA3
, Q6DTJ1, Q8BGJ4, Q8C4K4, Q8CGL1, Q8K1U1, Q8K3M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: September 3, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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