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Q9JJ57

- KCIP1_MOUSE

UniProt

Q9JJ57 - KCIP1_MOUSE

Protein

Kv channel-interacting protein 1

Gene

Kcnip1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi146 – 157121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi194 – 205122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: Ensembl
    2. potassium channel activity Source: UniProtKB-KW
    3. potassium channel regulator activity Source: Ensembl
    4. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. positive regulation of action potential Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Calcium, Metal-binding, Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kv channel-interacting protein 1
    Short name:
    KChIP1
    Alternative name(s):
    A-type potassium channel modulatory protein 1
    Potassium channel-interacting protein 1
    Gene namesi
    Name:Kcnip1
    Synonyms:Kchip1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1917607. Kcnip1.

    Subcellular locationi

    Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. neuronal cell body Source: Ensembl
    3. plasma membrane Source: UniProtKB-SubCell
    4. potassium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Kv channel-interacting protein 1PRO_0000073819Add
    BLAST

    Proteomic databases

    PRIDEiQ9JJ57.

    Expressioni

    Tissue specificityi

    Expressed in brain. Found in a subpopulation of neurons widely distributed and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei.1 Publication

    Gene expression databases

    BgeeiQ9JJ57.
    CleanExiMM_KCNIP1.
    GenevestigatoriQ9JJ57.

    Interactioni

    Subunit structurei

    Component of heteromultimeric potassium channels. Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJ57.
    SMRiQ9JJ57. Positions 49-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 9457EF-hand 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Domaini97 – 13236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini133 – 16836EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini181 – 21636EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni214 – 22714Interaction with KCND2By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the recoverin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    GeneTreeiENSGT00560000076973.
    HOVERGENiHBG108179.
    OMAiKQHVDAF.
    OrthoDBiEOG7GJ6F3.
    PhylomeDBiQ9JJ57.
    TreeFamiTF318560.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    [Graphical view]
    PANTHERiPTHR23055. PTHR23055. 1 hit.
    PfamiPF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JJ57-1) [UniParc]FASTAAdd to Basket

    Also known as: A, Kchip1.2, KCHIP1b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDELEM TMVCHRPEGL    50
    EQLEAQTNFT KRELQVLYRG FKNECPSGVV NEETFKQIYA QFFPHGDAST 100
    YAHYLFNAFD TTQTGSVKFE DFVTALSILL RGTVHEKLRW TFNLYDINKD 150
    GYINKEEMMD IVKAIYDMMG KYTYPVLKED TPRQHVDVFF QKMDKNKDGI 200
    VTLDEFLESC QEDDNIMRSL QLFQNVM 227
    Length:227
    Mass (Da):26,831
    Last modified:August 16, 2005 - v2
    Checksum:i9256B5239A13B126
    GO
    Isoform 2 (identifier: Q9JJ57-2) [UniParc]FASTAAdd to Basket

    Also known as: Kchip1.1, KCHP1a

    The sequence of this isoform differs from the canonical sequence as follows:
         21-31: Missing.

    Show »
    Length:216
    Mass (Da):25,258
    Checksum:iA9F32A1932B6B747
    GO
    Isoform 3 (identifier: Q9JJ57-3) [UniParc]FASTAAdd to Basket

    Also known as: Kchip1.2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-39: Missing.

    Show »
    Length:188
    Mass (Da):22,093
    Checksum:i16D9A84482FA00AD
    GO
    Isoform 4 (identifier: Q9JJ57-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: MGAVMGTFSSLQTKQRRP → MSSCSKRCRLGFVKFAQTIFKLITGTL

    Show »
    Length:236
    Mass (Da):27,873
    Checksum:i1A17AA636755B0CD
    GO

    Sequence cautioni

    The sequence AAN77492.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti147 – 1471I → L in AAL12488. (PubMed:14572458)Curated
    Sequence conflicti185 – 1851H → R in AAT68468. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3939Missing in isoform 3. 1 PublicationVSP_015045Add
    BLAST
    Alternative sequencei1 – 1818MGAVM…KQRRP → MSSCSKRCRLGFVKFAQTIF KLITGTL in isoform 4. 1 PublicationVSP_015046Add
    BLAST
    Alternative sequencei21 – 3111Missing in isoform 2. 5 PublicationsVSP_015047Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050525 mRNA. Translation: AAL12488.1.
    AY050526 mRNA. Translation: AAL12489.1.
    AB075041 mRNA. Translation: BAB78543.1.
    AY171234 mRNA. Translation: AAN77492.1. Different initiation.
    AY647242 mRNA. Translation: AAT68468.1.
    AK081845 mRNA. Translation: BAC38347.1.
    AK045948 mRNA. Translation: BAC32543.1.
    AK046398 mRNA. Translation: BAC32705.1.
    AL669814, AL731867 Genomic DNA. Translation: CAI25675.1.
    AL669814, AL731867 Genomic DNA. Translation: CAI25676.1.
    AL731867, AL669814 Genomic DNA. Translation: CAI26003.1.
    AL669814 Genomic DNA. Translation: CAI25682.1.
    AL731867, AL669814 Genomic DNA. Translation: CAI26004.1.
    BC034241 mRNA. Translation: AAH34241.1.
    AJ278534 mRNA. Translation: CAC82025.1.
    CCDSiCCDS24537.1. [Q9JJ57-2]
    CCDS56766.1. [Q9JJ57-1]
    CCDS70160.1. [Q9JJ57-3]
    RefSeqiNP_001177814.1. NM_001190885.1. [Q9JJ57-1]
    NP_001177815.1. NM_001190886.1.
    NP_001277619.1. NM_001290690.1. [Q9JJ57-3]
    NP_081674.2. NM_027398.3. [Q9JJ57-2]
    XP_006514868.1. XM_006514805.1. [Q9JJ57-3]
    UniGeneiMm.252514.

    Genome annotation databases

    EnsembliENSMUST00000065970; ENSMUSP00000069063; ENSMUSG00000053519. [Q9JJ57-2]
    ENSMUST00000101368; ENSMUSP00000098919; ENSMUSG00000053519. [Q9JJ57-3]
    ENSMUST00000109340; ENSMUSP00000104964; ENSMUSG00000053519. [Q9JJ57-1]
    GeneIDi70357.
    KEGGimmu:70357.
    UCSCiuc007ikp.2. mouse. [Q9JJ57-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050525 mRNA. Translation: AAL12488.1 .
    AY050526 mRNA. Translation: AAL12489.1 .
    AB075041 mRNA. Translation: BAB78543.1 .
    AY171234 mRNA. Translation: AAN77492.1 . Different initiation.
    AY647242 mRNA. Translation: AAT68468.1 .
    AK081845 mRNA. Translation: BAC38347.1 .
    AK045948 mRNA. Translation: BAC32543.1 .
    AK046398 mRNA. Translation: BAC32705.1 .
    AL669814 , AL731867 Genomic DNA. Translation: CAI25675.1 .
    AL669814 , AL731867 Genomic DNA. Translation: CAI25676.1 .
    AL731867 , AL669814 Genomic DNA. Translation: CAI26003.1 .
    AL669814 Genomic DNA. Translation: CAI25682.1 .
    AL731867 , AL669814 Genomic DNA. Translation: CAI26004.1 .
    BC034241 mRNA. Translation: AAH34241.1 .
    AJ278534 mRNA. Translation: CAC82025.1 .
    CCDSi CCDS24537.1. [Q9JJ57-2 ]
    CCDS56766.1. [Q9JJ57-1 ]
    CCDS70160.1. [Q9JJ57-3 ]
    RefSeqi NP_001177814.1. NM_001190885.1. [Q9JJ57-1 ]
    NP_001177815.1. NM_001190886.1.
    NP_001277619.1. NM_001290690.1. [Q9JJ57-3 ]
    NP_081674.2. NM_027398.3. [Q9JJ57-2 ]
    XP_006514868.1. XM_006514805.1. [Q9JJ57-3 ]
    UniGenei Mm.252514.

    3D structure databases

    ProteinModelPortali Q9JJ57.
    SMRi Q9JJ57. Positions 49-227.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9JJ57.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000065970 ; ENSMUSP00000069063 ; ENSMUSG00000053519 . [Q9JJ57-2 ]
    ENSMUST00000101368 ; ENSMUSP00000098919 ; ENSMUSG00000053519 . [Q9JJ57-3 ]
    ENSMUST00000109340 ; ENSMUSP00000104964 ; ENSMUSG00000053519 . [Q9JJ57-1 ]
    GeneIDi 70357.
    KEGGi mmu:70357.
    UCSCi uc007ikp.2. mouse. [Q9JJ57-1 ]

    Organism-specific databases

    CTDi 30820.
    MGIi MGI:1917607. Kcnip1.

    Phylogenomic databases

    eggNOGi COG5126.
    GeneTreei ENSGT00560000076973.
    HOVERGENi HBG108179.
    OMAi KQHVDAF.
    OrthoDBi EOG7GJ6F3.
    PhylomeDBi Q9JJ57.
    TreeFami TF318560.

    Miscellaneous databases

    NextBioi 331438.
    PROi Q9JJ57.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JJ57.
    CleanExi MM_KCNIP1.
    Genevestigatori Q9JJ57.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    [Graphical view ]
    PANTHERi PTHR23055. PTHR23055. 1 hit.
    Pfami PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential modulation of Kv4 kinetics by KCHIP1 splice variants."
      Van Hoorick D., Raes A., Keysers W., Mayeur E., Snyders D.J.
      Mol. Cell. Neurosci. 24:357-366(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
      Strain: BALB/c.
    2. Ohya S., Horowitz B.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: BALB/c.
      Tissue: Brain.
    3. Xia K.U., Fang H.Y., Zhong X.Y., Xia J.H., Zhang Z.H.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: Swiss Webster.
    4. Fang H.Y., Xia K., Xia J.H., Zhang Z.H.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Strain: Swiss Webster.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Strain: C57BL/6J.
      Tissue: Corpora quadrigemina and Head.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Eye.
    8. Franz O., Soloviev M., Roeper J.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-227 (ISOFORM 2).
    9. "Differential distribution of KChIPs mRNAs in adult mouse brain."
      Xiong H., Kovacs I., Zhang Z.
      Brain Res. Mol. Brain Res. 128:103-111(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKCIP1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJ57
    Secondary accession number(s): Q5SSA3
    , Q6DTJ1, Q8BGJ4, Q8C4K4, Q8CGL1, Q8K1U1, Q8K3M2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3