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Q9JJ57 (KCIP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kv channel-interacting protein 1

Short name=KChIP1
Alternative name(s):
A-type potassium channel modulatory protein 1
Potassium channel-interacting protein 1
Gene names
Name:Kcnip1
Synonyms:Kchip1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface By similarity. Ref.1

Subunit structure

Component of heteromultimeric potassium channels. Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein Ref.1.

Tissue specificity

Expressed in brain. Found in a subpopulation of neurons widely distributed and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei. Ref.9

Sequence similarities

Belongs to the recoverin family.

Contains 4 EF-hand domains.

Sequence caution

The sequence AAN77492.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9JJ57-1)

Also known as: A; Kchip1.2; KCHIP1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9JJ57-2)

Also known as: Kchip1.1; KCHP1a;

The sequence of this isoform differs from the canonical sequence as follows:
     21-31: Missing.
Isoform 3 (identifier: Q9JJ57-3)

Also known as: Kchip1.2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
Isoform 4 (identifier: Q9JJ57-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MGAVMGTFSSLQTKQRRP → MSSCSKRCRLGFVKFAQTIFKLITGTL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Kv channel-interacting protein 1
PRO_0000073819

Regions

Domain38 – 9457EF-hand 1; degenerate
Domain97 – 13236EF-hand 2
Domain133 – 16836EF-hand 3
Domain181 – 21636EF-hand 4
Calcium binding146 – 157121 By similarity
Calcium binding194 – 205122 By similarity
Region214 – 22714Interaction with KCND2 By similarity

Natural variations

Alternative sequence1 – 3939Missing in isoform 3.
VSP_015045
Alternative sequence1 – 1818MGAVM…KQRRP → MSSCSKRCRLGFVKFAQTIF KLITGTL in isoform 4.
VSP_015046
Alternative sequence21 – 3111Missing in isoform 2.
VSP_015047

Experimental info

Sequence conflict1471I → L in AAL12488. Ref.1
Sequence conflict1851H → R in AAT68468. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) (Kchip1.2) (KCHIP1b) [UniParc].

Last modified August 16, 2005. Version 2.
Checksum: 9256B5239A13B126

FASTA22726,831
        10         20         30         40         50         60 
MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDELEM TMVCHRPEGL EQLEAQTNFT 

        70         80         90        100        110        120 
KRELQVLYRG FKNECPSGVV NEETFKQIYA QFFPHGDAST YAHYLFNAFD TTQTGSVKFE 

       130        140        150        160        170        180 
DFVTALSILL RGTVHEKLRW TFNLYDINKD GYINKEEMMD IVKAIYDMMG KYTYPVLKED 

       190        200        210        220 
TPRQHVDVFF QKMDKNKDGI VTLDEFLESC QEDDNIMRSL QLFQNVM 

« Hide

Isoform 2 (Kchip1.1) (KCHP1a) [UniParc].

Checksum: A9F32A1932B6B747
Show »

FASTA21625,258
Isoform 3 (Kchip1.2) [UniParc].

Checksum: 16D9A84482FA00AD
Show »

FASTA18822,093
Isoform 4 [UniParc].

Checksum: 1A17AA636755B0CD
Show »

FASTA23627,873

References

« Hide 'large scale' references
[1]"Differential modulation of Kv4 kinetics by KCHIP1 splice variants."
Van Hoorick D., Raes A., Keysers W., Mayeur E., Snyders D.J.
Mol. Cell. Neurosci. 24:357-366(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
Strain: BALB/c.
[2]Ohya S., Horowitz B.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: BALB/c.
Tissue: Brain.
[3]Xia K.U., Fang H.Y., Zhong X.Y., Xia J.H., Zhang Z.H.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: Swiss Webster.
[4]Fang H.Y., Xia K., Xia J.H., Zhang Z.H.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
Strain: Swiss Webster.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
Strain: C57BL/6J.
Tissue: Corpora quadrigemina and Head.
[6]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Eye.
[8]Franz O., Soloviev M., Roeper J.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-227 (ISOFORM 2).
[9]"Differential distribution of KChIPs mRNAs in adult mouse brain."
Xiong H., Kovacs I., Zhang Z.
Brain Res. Mol. Brain Res. 128:103-111(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY050525 mRNA. Translation: AAL12488.1.
AY050526 mRNA. Translation: AAL12489.1.
AB075041 mRNA. Translation: BAB78543.1.
AY171234 mRNA. Translation: AAN77492.1. Different initiation.
AY647242 mRNA. Translation: AAT68468.1.
AK081845 mRNA. Translation: BAC38347.1.
AK045948 mRNA. Translation: BAC32543.1.
AK046398 mRNA. Translation: BAC32705.1.
AL669814, AL731867 Genomic DNA. Translation: CAI25675.1.
AL669814, AL731867 Genomic DNA. Translation: CAI25676.1.
AL731867, AL669814 Genomic DNA. Translation: CAI26003.1.
AL669814 Genomic DNA. Translation: CAI25682.1.
AL731867, AL669814 Genomic DNA. Translation: CAI26004.1.
BC034241 mRNA. Translation: AAH34241.1.
AJ278534 mRNA. Translation: CAC82025.1.
CCDSCCDS24537.1. [Q9JJ57-2]
CCDS56766.1. [Q9JJ57-1]
RefSeqNP_001177814.1. NM_001190885.1. [Q9JJ57-1]
NP_001177815.1. NM_001190886.1.
NP_001277619.1. NM_001290690.1. [Q9JJ57-3]
NP_081674.2. NM_027398.3. [Q9JJ57-2]
XP_006514868.1. XM_006514805.1. [Q9JJ57-3]
UniGeneMm.252514.

3D structure databases

ProteinModelPortalQ9JJ57.
SMRQ9JJ57. Positions 49-227.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9JJ57.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000065970; ENSMUSP00000069063; ENSMUSG00000053519. [Q9JJ57-2]
ENSMUST00000101368; ENSMUSP00000098919; ENSMUSG00000053519. [Q9JJ57-3]
ENSMUST00000109340; ENSMUSP00000104964; ENSMUSG00000053519. [Q9JJ57-1]
GeneID70357.
KEGGmmu:70357.
UCSCuc007ikp.2. mouse. [Q9JJ57-1]

Organism-specific databases

CTD30820.
MGIMGI:1917607. Kcnip1.

Phylogenomic databases

eggNOGCOG5126.
GeneTreeENSGT00560000076973.
HOVERGENHBG108179.
OMAKQHVDAF.
OrthoDBEOG7GJ6F3.
PhylomeDBQ9JJ57.
TreeFamTF318560.

Gene expression databases

BgeeQ9JJ57.
CleanExMM_KCNIP1.
GenevestigatorQ9JJ57.

Family and domain databases

Gene3D1.10.238.10. 3 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERPTHR23055. PTHR23055. 1 hit.
PfamPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio331438.
PROQ9JJ57.
SOURCESearch...

Entry information

Entry nameKCIP1_MOUSE
AccessionPrimary (citable) accession number: Q9JJ57
Secondary accession number(s): Q5SSA3 expand/collapse secondary AC list , Q6DTJ1, Q8BGJ4, Q8C4K4, Q8CGL1, Q8K1U1, Q8K3M2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot