Q9JJ26 (MEFV_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrin

Alternative name(s):
Marenostrin

Gene names

Name:

Mefv

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	767 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization By similarity. UniProtKB O15553
Subunit structure	Interacts with PSTPIP1 By similarity.
Subcellular location	Cytoplasm › cytoskeleton. Note: Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles By similarity.
Tissue specificity	Expressed in spleen peripheral blood granulocytes. Not expressed in lymphocytes, thymus, testis, ovary, heart, brain, lung, liver, kidney and muscle. Ref.1
Sequence similarities	Contains 1 B box-type zinc finger. Contains 1 DAPIN domain.

Ontologies

Keywords
Biological process	Inflammatory response
Cellular component	Cytoplasm Cytoskeleton Microtubule
Domain	Zinc-finger
Ligand	Actin-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inflammatory response Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	actin binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 767	767	Pyrin		PRO_0000220365
Regions
	Domain	1 – 92	92	DAPIN
	Zinc finger	439 – 481	43	B box-type
Experimental info
	Sequence conflict	543	1	E → G in AAF03766. Ref.1
	Sequence conflict	565	1	E → G in AAF03766. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9JJ26 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 828E59E4E8DF5549	FASTA	767	86,409
	10 20 30 40 50 60 MAKTLGDHLL NTLEELLPYD FEKFKFKLQN TSLEKGHSKI PRGHMQMARP VKLASLLITY 70 80 90 100 110 120 YGEEYAVRLT LQILRATNQR QLAEELRKAT GTEHLIEENR VGGSVQSSVE NKAKSVKVPD 130 140 150 160 170 180 VPEGDGTQQN NDESDTLPSS QAEVGKGPQK KSLTKRKDQR GPESLDSQTK PWTRSTAPLY 190 200 210 220 230 240 RRTQGTQSPG DKESTASAQL RRNVSSAGRL QGLYNNAPGR RESKKAEVYV YLPSGKKRPR 250 260 270 280 290 300 SLEITTYSRE GEPPNSEVLP TQEETRNGSL IRMRTATLNG RTTGALEKGT GIPEHSMVLD 310 320 330 340 350 360 EKTFRNMSSK TSLIGEERCP TSWTENGNGS PETTESSGET AGSILSDPEV PLSLCEKPAK 370 380 390 400 410 420 TPEDPASLGQ AACEGRSQDK AVCPLCHTQE GDLRGDTCVQ SSCSCSIAPG DPKASGRCSI 430 440 450 460 470 480 CFQCQGLLAR KSCEAQSPQS LPQCPRHMKQ VLLLFCEDHR EPICLICRLS LEHQGHRVRP 490 500 510 520 530 540 IEEAALEYKE QIREQLERLR EMRGYVEEHR LQGDKKTDDF LKQTEIQKQK ISCPLEKLYQ 550 560 570 580 590 600 LLEKQEQLFV TWLQELSQTI SKVRETYYTR VSLLDEMIEE LEAKQDQPEW DLMQDIGITL 610 620 630 640 650 660 HRAKMMSASE LLDTPPGVKE KLHLLYQKSK SVEKNMQCFS EMLSSEMAFS ASDVAKWEGR 670 680 690 700 710 720 QPSATQVQGL VPTVHLKCDG AHTQDCDVVF YPEREAGGSE PKDYLHPQPA QDTPELHEIH 730 740 750 760 SRNNKRKFKS FLKWKPSFSR TDWRLRTCCY RDLDQAAAHP NLIFSMI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, genomic organization, and expression analysis of the mouse and rat homologs of MEFV, the gene for familial Mediterranean fever." Chae J.J., Centola M., Aksentijevich I., Dutra A., Tran M., Wood G., Nagaraju K., Kingma D.W., Liu P.P., Kastner D.L. Mamm. Genome 11:428-435(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: 129/Sv.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF143409 mRNA. Translation: AAF03766.1. AC139347 Genomic DNA. No translation available.
IPI	IPI00121004.
RefSeq	NP_062326.2. NM_019453.2.
UniGene	Mm.143718.
3D structure databases
ProteinModelPortal	Q9JJ26.
SMR	Q9JJ26. Positions 13-84.
ModBase	Search...
PTM databases
PhosphoSite	Q9JJ26.
Proteomic databases
PRIDE	Q9JJ26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023180; ENSMUSP00000023180; ENSMUSG00000022534.
GeneID	54483.
KEGG	mmu:54483.
Organism-specific databases
CTD	4210.
MGI	MGI:1859396. Mefv.
Phylogenomic databases
eggNOG	NOG328286.
GeneTree	ENSGT00680000099707.
HOGENOM	HOG000113552.
HOVERGEN	HBG006343.
KO	K12803.
Gene expression databases
ArrayExpress	Q9JJ26.
Bgee	Q9JJ26.
CleanEx	MM_MEFV.
Genevestigator	Q9JJ26.
GermOnline	ENSMUSG00000022534. Mus musculus.
Family and domain databases
Gene3D	1.10.533.10. 1 hit.
InterPro	IPR004020. DAPIN. IPR011029. DEATH-like_dom. IPR000315. Znf_B-box. [Graphical view]
Pfam	PF02758. PYRIN. 1 hit. PF00643. zf-B_box. 1 hit. [Graphical view]
SMART	SM00336. BBOX. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50824. DAPIN. 1 hit. PS50119. ZF_BBOX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	311340.
SOURCE	Search...

Entry information

Entry name

MEFV_MOUSE

Accession

Primary (citable) accession number: Q9JJ26
Secondary accession number(s): E9QN30

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program