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Protein

5-hydroxytryptamine receptor 3B

Gene

Htr3b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to growth factor stimulus Source: RGD
  • positive regulation of ion transmembrane transporter activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.9.2.2. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 3B
Short name:
5-HT3-B
Short name:
5-HT3B
Alternative name(s):
Serotonin receptor 3B
Gene namesi
Name:Htr3b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61820. Htr3b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 235ExtracellularSequence analysisAdd BLAST214
Transmembranei236 – 255Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini256 – 266CytoplasmicSequence analysisAdd BLAST11
Transmembranei267 – 284Helical; Name=2Sequence analysisAdd BLAST18
Topological domaini285 – 295ExtracellularSequence analysisAdd BLAST11
Transmembranei296 – 324Helical; Name=3Sequence analysisAdd BLAST29
Topological domaini325 – 410CytoplasmicSequence analysisAdd BLAST86
Transmembranei411 – 434Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini435 – 437ExtracellularSequence analysis3

GO - Cellular componenti

  • axon Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: RGD
  • postsynaptic membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2094116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031229122 – 4375-hydroxytryptamine receptor 3BAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi151 ↔ 165By similarity

Post-translational modificationi

N-glycosylation is required for membrane localization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JJ16.
PRIDEiQ9JJ16.

Expressioni

Tissue specificityi

Expressed in peripheral neurons, but not in neurons of the central nervous system.1 Publication

Inductioni

By nerve growth factor in PC12 cells.1 Publication

Interactioni

Subunit structurei

Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B; homomeric complex is functional but exhibits low conductance with modified voltage dependence and antagonist affinity.2 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009574.

Chemistry databases

BindingDBiQ9JJ16.

Structurei

3D structure databases

ProteinModelPortaliQ9JJ16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni377 – 409HA-stretchAdd BLAST33

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOGENOMiHOG000241519.
HOVERGENiHBG106638.
InParanoidiQ9JJ16.
KOiK04819.
PhylomeDBiQ9JJ16.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR008132. 5HT3_rcpt.
IPR008134. 5HT3_rcpt_B.
IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01710. 5HT3BRECEPTR.
PR01708. 5HT3RECEPTOR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLWSCLLV AVVGILGTAT PQPGNSSLHR LTRQLLQQYH KEVRPVYNWA
60 70 80 90 100
EATTVYLDLC VHAVLDVDVQ NQKLKTSMWY REVWNDEFLS WNSSLFDDIQ
110 120 130 140 150
EISLPLSAIW APDIIINEFV DVERSPDLPY VYVNSSGTIR NHKPIQVVSA
160 170 180 190 200
CSLQTYAFPF DIQNCSLTFN SILHTVEDID LGFLRNQEDI ENDKRSFLND
210 220 230 240 250
SEWQLLSVTS TYHIRQSSAG DFAQIRFNVV IRRCPLAYVV SLLIPSIFLM
260 270 280 290 300
LVDLGSFYLP PNCRARIVFK TNVLVGYTVF RVNMSDEVPR SAGCTSLIGV
310 320 330 340 350
FFTVCMALLV LSLSKSILLI KFLYEERHSE QERPLMCLRG DSDANESRLY
360 370 380 390 400
LRAPCAEDTE SPVRQEHQVP SDTLKDFWFQ LQSINNSLRT RDQVYQKEVE
410 420 430
WLAILCHFDQ LLFRIYLAVL GLYTVTLCSL WALWSRM
Length:437
Mass (Da):50,336
Last modified:October 1, 2000 - v1
Checksum:i633C2F4175FDB55A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194K → E in AAG30903 (PubMed:10854267).Curated1
Sequence conflicti217S → N in AAG30903 (PubMed:10854267).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155044 mRNA. Translation: AAF73283.1.
AF303447 mRNA. Translation: AAG30903.1.
RefSeqiNP_071525.1. NM_022189.1.
UniGeneiRn.87106.

Genome annotation databases

GeneIDi58963.
KEGGirno:58963.
UCSCiRGD:61820. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155044 mRNA. Translation: AAF73283.1.
AF303447 mRNA. Translation: AAG30903.1.
RefSeqiNP_071525.1. NM_022189.1.
UniGeneiRn.87106.

3D structure databases

ProteinModelPortaliQ9JJ16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009574.

Chemistry databases

BindingDBiQ9JJ16.
ChEMBLiCHEMBL2094116.

Protein family/group databases

TCDBi1.A.9.2.2. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Proteomic databases

PaxDbiQ9JJ16.
PRIDEiQ9JJ16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58963.
KEGGirno:58963.
UCSCiRGD:61820. rat.

Organism-specific databases

CTDi9177.
RGDi61820. Htr3b.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOGENOMiHOG000241519.
HOVERGENiHBG106638.
InParanoidiQ9JJ16.
KOiK04819.
PhylomeDBiQ9JJ16.

Miscellaneous databases

PROiQ9JJ16.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR008132. 5HT3_rcpt.
IPR008134. 5HT3_rcpt_B.
IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01710. 5HT3BRECEPTR.
PR01708. 5HT3RECEPTOR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei5HT3B_RAT
AccessioniPrimary (citable) accession number: Q9JJ16
Secondary accession number(s): Q9ERJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.