Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Gene

C1galt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.1 Publication

Catalytic activityi

UDP-alpha-D-galactose + glycoprotein N-acetyl-D-galactosamine = UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine.

Cofactori

Mg2+1 Publication

Kineticsi

  1. KM=630 µM for UDP-Gal1 Publication
  1. Vmax=206 µmol/h/mg enzyme1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosyltransferase, Transferase

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi2.4.1.122. 5301.
ReactomeiR-RNO-913709. O-linked glycosylation of mucins.
SABIO-RKQ9JJ05.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC:2.4.1.122)
Alternative name(s):
Core 1 O-glycan T-synthase
Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
Core 1 beta1,3-galactosyltransferase 1
Short name:
C1GalT1
Short name:
Core 1 beta3-Gal-T1
Gene namesi
Name:C1galt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi621105. C1galt1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 6CytoplasmicSequence analysis5
Transmembranei7 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini30 – 363LumenalSequence analysisAdd BLAST334

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002850662 – 363Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei235PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9JJ05.
PRIDEiQ9JJ05.

PTM databases

PhosphoSitePlusiQ9JJ05.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007804.
ExpressionAtlasiQ9JJ05. baseline and differential.
GenevisibleiQ9JJ05. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with the C1GALT1C1 chaperone; required for galactosyltransferase activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010375.

Structurei

3D structure databases

ProteinModelPortaliQ9JJ05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000021316.
HOVERGENiHBG097900.
InParanoidiQ9JJ05.
KOiK00731.
PhylomeDBiQ9JJ05.
TreeFamiTF317293.

Family and domain databases

InterProiIPR026842. C1GALT1.
IPR003378. Fringe-like.
[Graphical view]
PANTHERiPTHR23033:SF13. PTHR23033:SF13. 1 hit.
PfamiPF02434. Fringe. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJ05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKSWLNFL TFLCGSAIGF FLCSQLLNIL LQEQADVQPN MLHNDPHARH
60 70 80 90 100
SDDSGHNHLK GQMDFNADSS QHKDENTDVA ENLYQKVKVL CWVMTSPQNL
110 120 130 140 150
EKKAKHVKAT WAQRCNKVLF MSSEENKDFP TVGLETKEGR EQLYWKTIKA
160 170 180 190 200
FQYVHDHYLE DADWFMKADD DTYVILDNLR WLLSKYNPEQ PIYFGRRFKP
210 220 230 240 250
YVKQGYMSGG AGYVLSKEAL RRFVDAFKTE KCTHSSSIED LALGRCMEII
260 270 280 290 300
KVEAGDSRDP TGKETFHPFV PEHHLIKGYL PKTFWYWNYN YYPPVEGPGC
310 320 330 340 350
CSDIAVSFHY VDSTTMYELE YLVYHLRPYG YLYRYQPALP ENILKEINQV
360
NKKEDTKIKL GNP
Length:363
Mass (Da):42,311
Last modified:October 1, 2000 - v1
Checksum:i9482F69FCE069172
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157963 mRNA. Translation: AAF81983.1.
RefSeqiNP_075239.1. NM_022950.1.
UniGeneiRn.37669.

Genome annotation databases

EnsembliENSRNOT00000010375; ENSRNOP00000010375; ENSRNOG00000007804.
GeneIDi65044.
KEGGirno:65044.
UCSCiRGD:621105. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157963 mRNA. Translation: AAF81983.1.
RefSeqiNP_075239.1. NM_022950.1.
UniGeneiRn.37669.

3D structure databases

ProteinModelPortaliQ9JJ05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010375.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSitePlusiQ9JJ05.

Proteomic databases

PaxDbiQ9JJ05.
PRIDEiQ9JJ05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010375; ENSRNOP00000010375; ENSRNOG00000007804.
GeneIDi65044.
KEGGirno:65044.
UCSCiRGD:621105. rat.

Organism-specific databases

CTDi56913.
RGDi621105. C1galt1.

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000021316.
HOVERGENiHBG097900.
InParanoidiQ9JJ05.
KOiK00731.
PhylomeDBiQ9JJ05.
TreeFamiTF317293.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.1.122. 5301.
ReactomeiR-RNO-913709. O-linked glycosylation of mucins.
SABIO-RKQ9JJ05.

Miscellaneous databases

PROiQ9JJ05.

Gene expression databases

BgeeiENSRNOG00000007804.
ExpressionAtlasiQ9JJ05. baseline and differential.
GenevisibleiQ9JJ05. RN.

Family and domain databases

InterProiIPR026842. C1GALT1.
IPR003378. Fringe-like.
[Graphical view]
PANTHERiPTHR23033:SF13. PTHR23033:SF13. 1 hit.
PfamiPF02434. Fringe. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1GLT_RAT
AccessioniPrimary (citable) accession number: Q9JJ05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.