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Protein

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Gene

C1galt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.1 Publication

Catalytic activityi

UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.By similarity

Cofactori

Mg2+1 Publication

Kineticsi

  1. KM=630 µM for UDP-Gal1 Publication
  1. Vmax=206 µmol/h/mg enzyme1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Glycosyltransferase, Transferase
Biological processAngiogenesis, Differentiation
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDAi2.4.1.122 5301
ReactomeiR-RNO-913709 O-linked glycosylation of mucins
SABIO-RKiQ9JJ05
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC:2.4.1.122By similarity)
Alternative name(s):
Core 1 O-glycan T-synthase
Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
Core 1 beta1,3-galactosyltransferase 1
Short name:
C1GalT1
Short name:
Core 1 beta3-Gal-T1
Gene namesi
Name:C1galt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi621105 C1galt1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 6CytoplasmicSequence analysis5
Transmembranei7 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini30 – 363LumenalSequence analysisAdd BLAST334

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002850662 – 363Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei235PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9JJ05
PRIDEiQ9JJ05

PTM databases

PhosphoSitePlusiQ9JJ05

Expressioni

Gene expression databases

BgeeiENSRNOG00000007804
ExpressionAtlasiQ9JJ05 baseline and differential
GenevisibleiQ9JJ05 RN

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with the C1GALT1C1 chaperone; required for galactosyltransferase activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010375

Structurei

3D structure databases

ProteinModelPortaliQ9JJ05
SMRiQ9JJ05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2246 Eukaryota
ENOG410YRJG LUCA
GeneTreeiENSGT00530000063264
HOGENOMiHOG000021316
HOVERGENiHBG097900
InParanoidiQ9JJ05
KOiK00731
PhylomeDBiQ9JJ05
TreeFamiTF317293

Family and domain databases

InterProiView protein in InterPro
IPR026842 C1GALT1
IPR003378 Fringe-like
PANTHERiPTHR23033:SF13 PTHR23033:SF13, 1 hit
PfamiView protein in Pfam
PF02434 Fringe, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJ05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKSWLNFL TFLCGSAIGF FLCSQLLNIL LQEQADVQPN MLHNDPHARH
60 70 80 90 100
SDDSGHNHLK GQMDFNADSS QHKDENTDVA ENLYQKVKVL CWVMTSPQNL
110 120 130 140 150
EKKAKHVKAT WAQRCNKVLF MSSEENKDFP TVGLETKEGR EQLYWKTIKA
160 170 180 190 200
FQYVHDHYLE DADWFMKADD DTYVILDNLR WLLSKYNPEQ PIYFGRRFKP
210 220 230 240 250
YVKQGYMSGG AGYVLSKEAL RRFVDAFKTE KCTHSSSIED LALGRCMEII
260 270 280 290 300
KVEAGDSRDP TGKETFHPFV PEHHLIKGYL PKTFWYWNYN YYPPVEGPGC
310 320 330 340 350
CSDIAVSFHY VDSTTMYELE YLVYHLRPYG YLYRYQPALP ENILKEINQV
360
NKKEDTKIKL GNP
Length:363
Mass (Da):42,311
Last modified:October 1, 2000 - v1
Checksum:i9482F69FCE069172
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157963 mRNA Translation: AAF81983.1
RefSeqiNP_075239.1, NM_022950.1
UniGeneiRn.37669

Genome annotation databases

EnsembliENSRNOT00000010375; ENSRNOP00000010375; ENSRNOG00000007804
GeneIDi65044
KEGGirno:65044
UCSCiRGD:621105 rat

Entry informationi

Entry nameiC1GLT_RAT
AccessioniPrimary (citable) accession number: Q9JJ05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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