Q9JJ04 (B4GT4_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 92.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Beta-1,4-galactosyltransferase 4 Short name=Beta-1,4-GalTase 4 Short name=Beta4Gal-T4 Short name=b4Gal-T4 EC=2.4.1.- Alternative name(s): UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 344 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids By similarity. |
| Catalytic activity | UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. UDP-galactose + N-acetyl-beta-D-galactosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosaminyl-(1->3)-beta-D-galactosyl-(1->4)--D-glucosyl-(1<->1)-ceramide. |
| Cofactor | Manganese By similarity. |
| Pathway | |
| Subcellular location | Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Trans cisternae of Golgi stack By similarity. |
| Sequence similarities | Belongs to the glycosyltransferase 7 family. |
| Sequence caution | The sequence BAC32433.1 differs from that shown. Reason: Frameshift at position 321. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Domain | Signal-anchor Transmembrane Transmembrane helix |
| Ligand | Manganese Metal-binding |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | N-acetyllactosamine synthase activity Inferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 344 | 344 | Beta-1,4-galactosyltransferase 4 | PRO_0000080543 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 12 | 12 | Cytoplasmic Potential | ||||||||
| Transmembrane | 13 – 38 | 26 | Helical; Signal-anchor for type II membrane protein; Potential | ||||||||
| Topological domain | 39 – 344 | 306 | Lumenal Potential | ||||||||
Sites | |||||||||||
| Metal binding | 196 | 1 | Manganese By similarity | ||||||||
| Metal binding | 289 | 1 | Manganese By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 220 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 335 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 77 ↔ 118 | By similarity | |||||||||
| Disulfide bond | 189 ↔ 208 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 238 | 1 | L → F in AAF22222. Ref.1 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The expanding beta 4-galactosyltransferase gene family: messages from the databanks." Lo N.-W., Shaper J.H., Pevsner J., Shaper N.L. Glycobiology 8:517-526(1998) [PubMed: 9597550] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Molecular cloning of mouse beta-1,4-galactosyltransferase 4." Schwientek T., Clausen H. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo. |
| [3] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Corpora quadrigemina, Hippocampus, Kidney and Thymus. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon and Mammary tumor. |
| + | Additional computationally mapped references. |
Web resources
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF142672 mRNA. Translation: AAF22222.1. AF158746 mRNA. Translation: AAF80363.1. AK041692 mRNA. Translation: BAC31035.1. AK045602 mRNA. Translation: BAC32433.1. Frameshift. AK050005 mRNA. Translation: BAC34028.1. AK052013 mRNA. Translation: BAC34832.1. AK053603 mRNA. Translation: BAC35443.1. AK085368 mRNA. Translation: BAC39433.1. BC013492 mRNA. Translation: AAH13492.1. BC031115 mRNA. Translation: AAH31115.1. |
| IPI | IPI00224047. |
| RefSeq | NP_062778.2. NM_019804.3. |
| UniGene | Mm.182377. |
3D structure databases | |
| ProteinModelPortal | Q9JJ04. |
| SMR | Q9JJ04. Positions 73-344. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9JJ04. |
Protein family/group databases | |
| CAZy | GT7. Glycosyltransferase Family 7. |
Proteomic databases | |
| PRIDE | Q9JJ04. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000023482; ENSMUSP00000023482; ENSMUSG00000022793. ENSMUST00000114712; ENSMUSP00000110360; ENSMUSG00000022793. |
| GeneID | 56375. |
| KEGG | mmu:56375. |
Organism-specific databases | |
| CTD | 8702. |
| MGI | MGI:1928387. B4galt4. |
Phylogenomic databases | |
| GeneTree | ENSGT00550000074204. |
| HOGENOM | HBG717407. |
| HOVERGEN | HBG058334. |
| InParanoid | Q9JJ04. |
| OMA | TDGLSSC. |
| OrthoDB | EOG40P474. |
Gene expression databases | |
| ArrayExpress | Q9JJ04. |
| Bgee | Q9JJ04. |
| Genevestigator | Q9JJ04. |
| GermOnline | ENSMUSG00000022793. Mus musculus. |
Family and domain databases | |
| InterPro | IPR003859. Galactosyl_T_2_met. [Graphical view] |
| KO | K07969. |
| PANTHER | PTHR19300. Galactosyl_T_2. 1 hit. |
| Pfam | PF02709. Galactosyl_T_2. 1 hit. [Graphical view] |
| PRINTS | PR02050. B14GALTRFASE. |
| ProtoNet | Search... |
Other | |
| NextBio | 312440. |
| SOURCE | Search... |
Entry information
| Entry name | B4GT4_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9JJ04 Secondary accession number(s): Q8BR54, Q9QY12 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with