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Q9JJ00

- PLS1_MOUSE

UniProt

Q9JJ00 - PLS1_MOUSE

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Protein
Phospholipid scramblase 1
Gene
Plscr1, Tra1b, Tras1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.1 Publication
May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.1 Publication

Cofactori

Calcium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei127 – 1282Breakpoint for translocation to form MMTRA1A

GO - Molecular functioni

  1. CD4 receptor binding Source: UniProtKB
  2. DNA binding Source: UniProtKB-KW
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
  4. SH3 domain binding Source: UniProtKB
  5. calcium ion binding Source: UniProtKB
  6. epidermal growth factor receptor binding Source: UniProtKB
  7. phospholipid scramblase activity Source: UniProtKB

GO - Biological processi

  1. acute-phase response Source: UniProtKB
  2. cellular response to cytokine stimulus Source: UniProtKB
  3. cellular response to lipopolysaccharide Source: UniProtKB
  4. defense response to virus Source: UniProtKB
  5. intrinsic apoptotic signaling pathway Source: UniProtKB
  6. myeloid cell differentiation Source: MGI
  7. negative regulation of protein binding Source: MGI
  8. negative regulation of viral genome replication Source: UniProtKB
  9. phosphatidylserine biosynthetic process Source: UniProtKB
  10. phosphatidylserine exposure on apoptotic cell surface Source: MGI
  11. phospholipid scrambling Source: UniProtKB
  12. positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity Source: UniProtKB
  13. positive regulation of apoptotic process Source: MGI
  14. positive regulation of innate immune response Source: UniProtKB
  15. positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  16. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  17. regulation of Fc receptor mediated stimulatory signaling pathway Source: UniProtKB
  18. regulation of mast cell activation Source: UniProtKB
  19. response to interferon-alpha Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

Calcium, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid scramblase 1
Short name:
PL scramblase 1
Alternative name(s):
Ca(2+)-dependent phospholipid scramblase 1
Transplantability-associated protein 1
Short name:
NOR1
Short name:
TRA1
Gene namesi
Name:Plscr1
Synonyms:Tra1b, Tras1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:893575. Plscr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 297297Cytoplasmic By similarity
Add
BLAST
Transmembranei298 – 31417Helical; Reviewed prediction
Add
BLAST
Topological domaini315 – 32814Extracellular By similarity
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. extracellular matrix Source: UniProtKB
  4. integral component of plasma membrane Source: UniProtKB
  5. membrane raft Source: UniProtKB
  6. nucleolus Source: UniProtKB
  7. nucleus Source: UniProtKB
  8. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Participates in a chromosomal translocation that produces MMTRA1A which is leukemogenic to syngenic SL mice and athymic nude mice.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Phospholipid scramblase 1
PRO_0000100785Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831Phosphotyrosine; by ABL By similarity
Modified residuei170 – 1701Phosphothreonine; by PKC By similarity
Lipidationi193 – 1931S-palmitoyl cysteine By similarity
Lipidationi194 – 1941S-palmitoyl cysteine By similarity
Lipidationi197 – 1971S-palmitoyl cysteine By similarity
Lipidationi198 – 1981S-palmitoyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ9JJ00.
PaxDbiQ9JJ00.
PRIDEiQ9JJ00.

PTM databases

PhosphoSiteiQ9JJ00.

Expressioni

Tissue specificityi

Highly expressed in kidney, lung, liver and bone marrow, slightly in spleen, heart and macrophage.

Inductioni

Up-regulated by SCF/KITL and GCSF/CSF3.1 Publication

Gene expression databases

ArrayExpressiQ9JJ00.
BgeeiQ9JJ00.
CleanExiMM_PLSCR1.
GenevestigatoriQ9JJ00.

Interactioni

Protein-protein interaction databases

IntActiQ9JJ00. 1 interaction.
STRINGi10090.ENSMUSP00000108671.

Structurei

3D structure databases

ProteinModelPortaliQ9JJ00.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9393Proline-rich domain (PRD) By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi18 – 269SH3-binding 1 Reviewed prediction
Motifi22 – 254WW-binding Reviewed prediction
Motifi56 – 649SH3-binding 2 Reviewed prediction
Motifi93 – 1019SH3-binding 3 Reviewed prediction
Motifi269 – 2757Nuclear localization signal By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi96 – 1016Poly-Pro
Compositional biasi190 – 1989Cys-rich

Domaini

The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, SH3-binding, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119855.
GeneTreeiENSGT00390000002884.
HOGENOMiHOG000237356.
HOVERGENiHBG019157.
OMAiFFESTGS.
OrthoDBiEOG77T14X.
TreeFamiTF314939.

Family and domain databases

InterProiIPR005552. Scramblase.
[Graphical view]
PANTHERiPTHR23248. PTHR23248. 1 hit.
PfamiPF03803. Scramblase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JJ00-1 [UniParc]FASTAAdd to Basket

« Hide

MENHSKQTEA PHPGTYMPAG YPPPYPPAAF QGPSDHAAYP IPQAGYQGPP    50
GPYPGPQPGY PVPPGGYAGG GPSGFPVQNQ PAYNHPGGPG GTPWMPAPPP 100
PLNCPPGLEY LAQIDQLLVH QQIELLEVLT GFETNNKYEI KNSLGQRVYF 150
AVEDTDCCTR NCCGASRPFT LRILDNLGRE VMTLERPLRC SSCCFPCCLQ 200
EIEIQAPPGV PVGYVTQTWH PCLPKFTLQN EKKQDVLKVV GPCVVCSCCS 250
DIDFELKSLD EESVVGKISK QWSGFVREAF TDADNFGIQF PLDLDVKMKA 300
VMLGACFLID FMFFERTGNE EQRSGAWQ 328
Length:328
Mass (Da):35,914
Last modified:October 1, 2000 - v1
Checksum:i6CA35DF8DBF72ACF
GO

Sequence cautioni

The sequence BAA23664.1 differs from that shown. Reason: Frameshift at position 92.
The sequence BAA23663.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 274PYPP → GLCV1 Publication
Sequence conflicti130 – 1301T → A in BAB22897. 1 Publication
Sequence conflicti267 – 2671K → R in BAB22897. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159593 mRNA. Translation: AAF77076.1.
AK003628 mRNA. Translation: BAB22897.1.
D78354 mRNA. Translation: BAA23663.1. Different initiation.
D78355 mRNA. Translation: BAA23664.1. Frameshift.
CCDSiCCDS52886.1.
RefSeqiNP_035766.2. NM_011636.2.
XP_006511115.1. XM_006511052.1.
UniGeneiMm.421956.
Mm.441702.

Genome annotation databases

EnsembliENSMUST00000093801; ENSMUSP00000091318; ENSMUSG00000032369.
GeneIDi22038.
KEGGimmu:22038.
UCSCiuc009ram.2. mouse.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159593 mRNA. Translation: AAF77076.1 .
AK003628 mRNA. Translation: BAB22897.1 .
D78354 mRNA. Translation: BAA23663.1 . Different initiation.
D78355 mRNA. Translation: BAA23664.1 . Frameshift.
CCDSi CCDS52886.1.
RefSeqi NP_035766.2. NM_011636.2.
XP_006511115.1. XM_006511052.1.
UniGenei Mm.421956.
Mm.441702.

3D structure databases

ProteinModelPortali Q9JJ00.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JJ00. 1 interaction.
STRINGi 10090.ENSMUSP00000108671.

PTM databases

PhosphoSitei Q9JJ00.

Proteomic databases

MaxQBi Q9JJ00.
PaxDbi Q9JJ00.
PRIDEi Q9JJ00.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000093801 ; ENSMUSP00000091318 ; ENSMUSG00000032369 .
GeneIDi 22038.
KEGGi mmu:22038.
UCSCi uc009ram.2. mouse.

Organism-specific databases

CTDi 5359.
MGIi MGI:893575. Plscr1.

Phylogenomic databases

eggNOGi NOG119855.
GeneTreei ENSGT00390000002884.
HOGENOMi HOG000237356.
HOVERGENi HBG019157.
OMAi FFESTGS.
OrthoDBi EOG77T14X.
TreeFami TF314939.

Miscellaneous databases

NextBioi 301814.
PROi Q9JJ00.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JJ00.
Bgeei Q9JJ00.
CleanExi MM_PLSCR1.
Genevestigatori Q9JJ00.

Family and domain databases

InterProi IPR005552. Scramblase.
[Graphical view ]
PANTHERi PTHR23248. PTHR23248. 1 hit.
Pfami PF03803. Scramblase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of three new members of the phospholipid scramblase gene family."
    Wiedmer T., Zhou Q., Kwoh D.Y., Sims P.J.
    Biochim. Biophys. Acta 1467:244-253(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. "TRA1, a novel mRNA highly expressed in leukemogenic mouse monocytic sublines but not in nonleukemogenic sublines."
    Kasukabe T., Okabe-Kado J., Honma Y.
    Blood 89:2975-2985(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-328, CHROMOSOMAL TRANSLOCATION.
    Strain: BALB/c.
    Tissue: Kidney.
  4. "Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1."
    Zhou Q., Zhao J., Wiedmer T., Sims P.J.
    Blood 99:4030-4038(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiPLS1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJ00
Secondary accession number(s): O54730, O54731, Q9D1F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Knockout newborn mice display a reduced granulocyte production. Hematopoietic precursor cell from knockout mice display defective colony formation and impaired differentiation to mature granulocytes as stimulated by SCF/KITL and GCSF/CSF3.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi