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Protein

Phospholipid scramblase 3

Gene

Plscr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.1 Publication

Cofactori

Ca2+By similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular response to lipopolysaccharide Source: UniProtKB
  • cholesterol homeostasis Source: MGI
  • glucose homeostasis Source: MGI

Keywordsi

Biological processApoptosis
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid scramblase 3
Short name:
PL scramblase 3
Alternative name(s):
Ca(2+)-dependent phospholipid scramblase 3
Gene namesi
Name:Plscr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917560 Plscr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 266CytoplasmicBy similarityAdd BLAST266
Transmembranei267 – 283HelicalSequence analysisAdd BLAST17
Topological domaini284 – 296ExtracellularBy similarityAdd BLAST13

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007901 – 296Phospholipid scramblase 3Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi163S-palmitoyl cysteineBy similarity1
Lipidationi164S-palmitoyl cysteineBy similarity1
Lipidationi166S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9JIZ9
PaxDbiQ9JIZ9
PRIDEiQ9JIZ9

PTM databases

iPTMnetiQ9JIZ9
PhosphoSitePlusiQ9JIZ9
SwissPalmiQ9JIZ9

Expressioni

Gene expression databases

BgeeiENSMUSG00000019461
CleanExiMM_PLSCR3
ExpressionAtlasiQ9JIZ9 baseline and differential
GenevisibleiQ9JIZ9 MM

Interactioni

Subunit structurei

Interacts with PDCD6 in a calcium-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019605

Structurei

3D structure databases

ProteinModelPortaliQ9JIZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 58Proline-rich domain (PRD)By similarityAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 15SH3-binding 1Sequence analysis9
Motifi15 – 18PPxY motifSequence analysis4
Motifi21 – 27SH3-binding 2Sequence analysis7
Motifi66 – 71SH3-binding 3Sequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 21Poly-Pro10
Compositional biasi159 – 166Cys-rich8

Domaini

The Proline-rich domain is required for phospholipid scramblase activity.By similarity

Sequence similaritiesi

Belongs to the phospholipid scramblase family.Curated

Keywords - Domaini

Repeat, SH3-binding, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0621 Eukaryota
ENOG410XSYS LUCA
GeneTreeiENSGT00390000002884
HOGENOMiHOG000237356
HOVERGENiHBG019157
InParanoidiQ9JIZ9
OMAiCGCGSDT
OrthoDBiEOG091G0CUL
PhylomeDBiQ9JIZ9
TreeFamiTF314939

Family and domain databases

InterProiView protein in InterPro
IPR005552 Scramblase
PANTHERiPTHR23248 PTHR23248, 1 hit
PfamiView protein in Pfam
PF03803 Scramblase, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JIZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGYLPPKGY APSPPPPYPV PSGYPEPVAL HPGPGQAPVP TQVPAPAPGF
60 70 80 90 100
ALFPSPGPVA PGPPAPFVPL PGVPPGLEFL VQIDQILIHQ KAERVETFLG
110 120 130 140 150
WETCNMYELR SGTGQQLGQA AEESNCCARL CCGARRPFRI RLADPGDREV
160 170 180 190 200
LRLLRPLHCG CSCCPCGLQE MEVQAPPGTT IGHVLQTWHP FLPKFSILDA
210 220 230 240 250
DRQPVLRVVG PCWTCGCGTD TNFEVKTKDE SRSVGRISKQ WGGLLREALT
260 270 280 290
DADDFGLQFP VDLDVKVKAV LLGATFLIDY MFFEKRGGAG PSAITS
Length:296
Mass (Da):31,803
Last modified:October 1, 2000 - v1
Checksum:iB7F31C29758CFB07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159850 mRNA Translation: AAF89526.1
AK011716 mRNA Translation: BAB27797.1
AK029154 mRNA Translation: BAC26329.1
AK075841 mRNA Translation: BAC35999.1
BC020143 mRNA Translation: AAH20143.1
CCDSiCCDS24916.1
RefSeqiNP_001161969.1, NM_001168497.1
NP_076053.1, NM_023564.4
XP_006534219.1, XM_006534156.2
XP_006534220.1, XM_006534157.3
UniGeneiMm.28874

Genome annotation databases

EnsembliENSMUST00000019605; ENSMUSP00000019605; ENSMUSG00000019461
ENSMUST00000108632; ENSMUSP00000104272; ENSMUSG00000019461
ENSMUST00000108633; ENSMUSP00000104273; ENSMUSG00000019461
GeneIDi70310
KEGGimmu:70310
UCSCiuc007jrz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPLS3_MOUSE
AccessioniPrimary (citable) accession number: Q9JIZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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