SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9JIZ9

- PLS3_MOUSE

UniProt

Q9JIZ9 - PLS3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phospholipid scramblase 3

Gene
Plscr3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.1 Publication

Cofactori

Calcium By similarity.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cellular response to lipopolysaccharide Source: UniProtKB
  3. cholesterol homeostasis Source: MGI
  4. glucose homeostasis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid scramblase 3
Short name:
PL scramblase 3
Alternative name(s):
Ca(2+)-dependent phospholipid scramblase 3
Gene namesi
Name:Plscr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1917560. Plscr3.

Subcellular locationi

Mitochondrion membrane; Single-pass type II membrane protein By similarity 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 266266Cytoplasmic By similarityAdd
BLAST
Transmembranei267 – 28317Helical; Reviewed predictionAdd
BLAST
Topological domaini284 – 29613Extracellular By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Phospholipid scramblase 3PRO_0000100790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi212 – 2121S-palmitoyl cysteine Inferred
Lipidationi215 – 2151S-palmitoyl cysteine Inferred
Lipidationi217 – 2171S-palmitoyl cysteine Inferred

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9JIZ9.
PRIDEiQ9JIZ9.

PTM databases

PhosphoSiteiQ9JIZ9.

Expressioni

Gene expression databases

ArrayExpressiQ9JIZ9.
BgeeiQ9JIZ9.
CleanExiMM_PLSCR3.
GenevestigatoriQ9JIZ9.

Interactioni

Subunit structurei

Interacts with PDCD6 in a calcium-dependent manner By similarity.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9JIZ9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5858Proline-rich domain (PRD) By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi7 – 159SH3-binding 1 Reviewed prediction
Motifi15 – 184WW-binding Reviewed prediction
Motifi21 – 277SH3-binding 2 Reviewed prediction
Motifi66 – 716SH3-binding 3 Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 2110Poly-Pro
Compositional biasi159 – 1668Cys-rich

Domaini

The Proline-rich domain is required for phospholipid scramblase activity By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, SH3-binding, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119855.
GeneTreeiENSGT00390000002884.
HOGENOMiHOG000237356.
HOVERGENiHBG019157.
InParanoidiQ9JIZ9.
OMAiVTPGYPE.
OrthoDBiEOG77T14X.
PhylomeDBiQ9JIZ9.
TreeFamiTF314939.

Family and domain databases

InterProiIPR005552. Scramblase.
[Graphical view]
PANTHERiPTHR23248. PTHR23248. 1 hit.
PfamiPF03803. Scramblase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIZ9-1 [UniParc]FASTAAdd to Basket

« Hide

MAGYLPPKGY APSPPPPYPV PSGYPEPVAL HPGPGQAPVP TQVPAPAPGF    50
ALFPSPGPVA PGPPAPFVPL PGVPPGLEFL VQIDQILIHQ KAERVETFLG 100
WETCNMYELR SGTGQQLGQA AEESNCCARL CCGARRPFRI RLADPGDREV 150
LRLLRPLHCG CSCCPCGLQE MEVQAPPGTT IGHVLQTWHP FLPKFSILDA 200
DRQPVLRVVG PCWTCGCGTD TNFEVKTKDE SRSVGRISKQ WGGLLREALT 250
DADDFGLQFP VDLDVKVKAV LLGATFLIDY MFFEKRGGAG PSAITS 296
Length:296
Mass (Da):31,803
Last modified:October 1, 2000 - v1
Checksum:iB7F31C29758CFB07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159850 mRNA. Translation: AAF89526.1.
AK011716 mRNA. Translation: BAB27797.1.
AK029154 mRNA. Translation: BAC26329.1.
AK075841 mRNA. Translation: BAC35999.1.
BC020143 mRNA. Translation: AAH20143.1.
CCDSiCCDS24916.1.
RefSeqiNP_001161969.1. NM_001168497.1.
NP_076053.1. NM_023564.4.
XP_006534219.1. XM_006534156.1.
XP_006534220.1. XM_006534157.1.
UniGeneiMm.28874.

Genome annotation databases

EnsembliENSMUST00000019605; ENSMUSP00000019605; ENSMUSG00000019461.
ENSMUST00000108632; ENSMUSP00000104272; ENSMUSG00000019461.
ENSMUST00000108633; ENSMUSP00000104273; ENSMUSG00000019461.
GeneIDi70310.
KEGGimmu:70310.
UCSCiuc007jrz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159850 mRNA. Translation: AAF89526.1 .
AK011716 mRNA. Translation: BAB27797.1 .
AK029154 mRNA. Translation: BAC26329.1 .
AK075841 mRNA. Translation: BAC35999.1 .
BC020143 mRNA. Translation: AAH20143.1 .
CCDSi CCDS24916.1.
RefSeqi NP_001161969.1. NM_001168497.1.
NP_076053.1. NM_023564.4.
XP_006534219.1. XM_006534156.1.
XP_006534220.1. XM_006534157.1.
UniGenei Mm.28874.

3D structure databases

ProteinModelPortali Q9JIZ9.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JIZ9.

Proteomic databases

PaxDbi Q9JIZ9.
PRIDEi Q9JIZ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019605 ; ENSMUSP00000019605 ; ENSMUSG00000019461 .
ENSMUST00000108632 ; ENSMUSP00000104272 ; ENSMUSG00000019461 .
ENSMUST00000108633 ; ENSMUSP00000104273 ; ENSMUSG00000019461 .
GeneIDi 70310.
KEGGi mmu:70310.
UCSCi uc007jrz.2. mouse.

Organism-specific databases

CTDi 57048.
MGIi MGI:1917560. Plscr3.

Phylogenomic databases

eggNOGi NOG119855.
GeneTreei ENSGT00390000002884.
HOGENOMi HOG000237356.
HOVERGENi HBG019157.
InParanoidi Q9JIZ9.
OMAi VTPGYPE.
OrthoDBi EOG77T14X.
PhylomeDBi Q9JIZ9.
TreeFami TF314939.

Miscellaneous databases

NextBioi 331360.
PROi Q9JIZ9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JIZ9.
Bgeei Q9JIZ9.
CleanExi MM_PLSCR3.
Genevestigatori Q9JIZ9.

Family and domain databases

InterProi IPR005552. Scramblase.
[Graphical view ]
PANTHERi PTHR23248. PTHR23248. 1 hit.
Pfami PF03803. Scramblase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of three new members of the phospholipid scramblase gene family."
    Wiedmer T., Zhou Q., Kwoh D.Y., Sims P.J.
    Biochim. Biophys. Acta 1467:244-253(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Skin and Stomach.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Association of protein kinase C delta and phospholipid scramblase 3 in hippocampal mitochondria correlates with neuronal vulnerability to brain ischemia."
    Kowalczyk J.E., Beresewicz M., Gajkowska B., Zablocka B.
    Neurochem. Int. 55:157-163(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PRKCD.
    Tissue: Brain.

Entry informationi

Entry nameiPLS3_MOUSE
AccessioniPrimary (citable) accession number: Q9JIZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi