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Q9JIZ9

- PLS3_MOUSE

UniProt

Q9JIZ9 - PLS3_MOUSE

Protein

Phospholipid scramblase 3

Gene

Plscr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.1 Publication

    Cofactori

    Calcium.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cellular response to lipopolysaccharide Source: UniProtKB
    3. cholesterol homeostasis Source: MGI
    4. glucose homeostasis Source: MGI

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipid scramblase 3
    Short name:
    PL scramblase 3
    Alternative name(s):
    Ca(2+)-dependent phospholipid scramblase 3
    Gene namesi
    Name:Plscr3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1917560. Plscr3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Phospholipid scramblase 3PRO_0000100790Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi212 – 2121S-palmitoyl cysteineCurated
    Lipidationi215 – 2151S-palmitoyl cysteineCurated
    Lipidationi217 – 2171S-palmitoyl cysteineCurated

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ9JIZ9.
    PRIDEiQ9JIZ9.

    PTM databases

    PhosphoSiteiQ9JIZ9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JIZ9.
    BgeeiQ9JIZ9.
    CleanExiMM_PLSCR3.
    GenevestigatoriQ9JIZ9.

    Interactioni

    Subunit structurei

    Interacts with PDCD6 in a calcium-dependent manner.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JIZ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 266266CytoplasmicBy similarityAdd
    BLAST
    Topological domaini284 – 29613ExtracellularBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei267 – 28317HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5858Proline-rich domain (PRD)By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi7 – 159SH3-binding 1Sequence Analysis
    Motifi15 – 184WW-bindingSequence Analysis
    Motifi21 – 277SH3-binding 2Sequence Analysis
    Motifi66 – 716SH3-binding 3Sequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi12 – 2110Poly-Pro
    Compositional biasi159 – 1668Cys-rich

    Domaini

    The Proline-rich domain is required for phospholipid scramblase activity.By similarity

    Sequence similaritiesi

    Belongs to the phospholipid scramblase family.Curated

    Keywords - Domaini

    Repeat, SH3-binding, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG119855.
    GeneTreeiENSGT00390000002884.
    HOGENOMiHOG000237356.
    HOVERGENiHBG019157.
    InParanoidiQ9JIZ9.
    OMAiVTPGYPE.
    OrthoDBiEOG77T14X.
    PhylomeDBiQ9JIZ9.
    TreeFamiTF314939.

    Family and domain databases

    InterProiIPR005552. Scramblase.
    [Graphical view]
    PANTHERiPTHR23248. PTHR23248. 1 hit.
    PfamiPF03803. Scramblase. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JIZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGYLPPKGY APSPPPPYPV PSGYPEPVAL HPGPGQAPVP TQVPAPAPGF    50
    ALFPSPGPVA PGPPAPFVPL PGVPPGLEFL VQIDQILIHQ KAERVETFLG 100
    WETCNMYELR SGTGQQLGQA AEESNCCARL CCGARRPFRI RLADPGDREV 150
    LRLLRPLHCG CSCCPCGLQE MEVQAPPGTT IGHVLQTWHP FLPKFSILDA 200
    DRQPVLRVVG PCWTCGCGTD TNFEVKTKDE SRSVGRISKQ WGGLLREALT 250
    DADDFGLQFP VDLDVKVKAV LLGATFLIDY MFFEKRGGAG PSAITS 296
    Length:296
    Mass (Da):31,803
    Last modified:October 1, 2000 - v1
    Checksum:iB7F31C29758CFB07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159850 mRNA. Translation: AAF89526.1.
    AK011716 mRNA. Translation: BAB27797.1.
    AK029154 mRNA. Translation: BAC26329.1.
    AK075841 mRNA. Translation: BAC35999.1.
    BC020143 mRNA. Translation: AAH20143.1.
    CCDSiCCDS24916.1.
    RefSeqiNP_001161969.1. NM_001168497.1.
    NP_076053.1. NM_023564.4.
    XP_006534219.1. XM_006534156.1.
    XP_006534220.1. XM_006534157.1.
    UniGeneiMm.28874.

    Genome annotation databases

    EnsembliENSMUST00000019605; ENSMUSP00000019605; ENSMUSG00000019461.
    ENSMUST00000108632; ENSMUSP00000104272; ENSMUSG00000019461.
    ENSMUST00000108633; ENSMUSP00000104273; ENSMUSG00000019461.
    GeneIDi70310.
    KEGGimmu:70310.
    UCSCiuc007jrz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159850 mRNA. Translation: AAF89526.1 .
    AK011716 mRNA. Translation: BAB27797.1 .
    AK029154 mRNA. Translation: BAC26329.1 .
    AK075841 mRNA. Translation: BAC35999.1 .
    BC020143 mRNA. Translation: AAH20143.1 .
    CCDSi CCDS24916.1.
    RefSeqi NP_001161969.1. NM_001168497.1.
    NP_076053.1. NM_023564.4.
    XP_006534219.1. XM_006534156.1.
    XP_006534220.1. XM_006534157.1.
    UniGenei Mm.28874.

    3D structure databases

    ProteinModelPortali Q9JIZ9.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JIZ9.

    Proteomic databases

    PaxDbi Q9JIZ9.
    PRIDEi Q9JIZ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019605 ; ENSMUSP00000019605 ; ENSMUSG00000019461 .
    ENSMUST00000108632 ; ENSMUSP00000104272 ; ENSMUSG00000019461 .
    ENSMUST00000108633 ; ENSMUSP00000104273 ; ENSMUSG00000019461 .
    GeneIDi 70310.
    KEGGi mmu:70310.
    UCSCi uc007jrz.2. mouse.

    Organism-specific databases

    CTDi 57048.
    MGIi MGI:1917560. Plscr3.

    Phylogenomic databases

    eggNOGi NOG119855.
    GeneTreei ENSGT00390000002884.
    HOGENOMi HOG000237356.
    HOVERGENi HBG019157.
    InParanoidi Q9JIZ9.
    OMAi VTPGYPE.
    OrthoDBi EOG77T14X.
    PhylomeDBi Q9JIZ9.
    TreeFami TF314939.

    Miscellaneous databases

    NextBioi 331360.
    PROi Q9JIZ9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JIZ9.
    Bgeei Q9JIZ9.
    CleanExi MM_PLSCR3.
    Genevestigatori Q9JIZ9.

    Family and domain databases

    InterProi IPR005552. Scramblase.
    [Graphical view ]
    PANTHERi PTHR23248. PTHR23248. 1 hit.
    Pfami PF03803. Scramblase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of three new members of the phospholipid scramblase gene family."
      Wiedmer T., Zhou Q., Kwoh D.Y., Sims P.J.
      Biochim. Biophys. Acta 1467:244-253(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Skin and Stomach.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Association of protein kinase C delta and phospholipid scramblase 3 in hippocampal mitochondria correlates with neuronal vulnerability to brain ischemia."
      Kowalczyk J.E., Beresewicz M., Gajkowska B., Zablocka B.
      Neurochem. Int. 55:157-163(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PRKCD.
      Tissue: Brain.

    Entry informationi

    Entry nameiPLS3_MOUSE
    AccessioniPrimary (citable) accession number: Q9JIZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3