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Protein

Probable N-acetyltransferase CML3

Gene

Cml3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regulation of gastrulation.1 Publication

GO - Molecular functioni

  • H4 histone acetyltransferase activity Source: MGI
  • N-acetyltransferase activity Source: UniProtKB

GO - Biological processi

  • axis elongation Source: MGI
  • gastrulation with mouth forming second Source: UniProtKB
  • histone acetylation Source: MGI
  • negative regulation of cell adhesion Source: MGI

Keywordsi

Molecular functionAcyltransferase, Developmental protein, Transferase
Biological processGastrulation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetyltransferase CML3 (EC:2.3.1.-)
Alternative name(s):
Camello-like protein 3
Gene namesi
Name:Cml3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2136449. Cml3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846901 – 226Probable N-acetyltransferase CML3Add BLAST226

Proteomic databases

MaxQBiQ9JIY8.
PaxDbiQ9JIY8.
PeptideAtlasiQ9JIY8.
PRIDEiQ9JIY8.

PTM databases

iPTMnetiQ9JIY8.
PhosphoSitePlusiQ9JIY8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000079495.
CleanExiMM_CML3.
GenevisibleiQ9JIY8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084938.

Structurei

3D structure databases

ProteinModelPortaliQ9JIY8.
SMRiQ9JIY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 220N-acetyltransferasePROSITE-ProRule annotationAdd BLAST160

Sequence similaritiesi

Belongs to the camello family.1 Publication

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3139. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00390000009559.
HOGENOMiHOG000261685.
HOVERGENiHBG060476.
InParanoidiQ9JIY8.
KOiK20838.
OMAiELTIRRY.
OrthoDBiEOG091G0LL0.
TreeFamiTF324687.

Family and domain databases

InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
PfamiView protein in Pfam
PF00583. Acetyltransf_1. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiView protein in PROSITE
PS51186. GNAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JIY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPYHIRKYQ DSDHRSVVDL FRRGMEEHIP ATFRHMLLLP RTLLLLLGVP
60 70 80 90 100
LTLFLASGSW LLVLLSILTL FLSLWFLAKY TWEKHVMNCL HTDMADITRT
110 120 130 140 150
YLSSHSSCFW VAESRGQTVG MVAARPVKDP LLQKKQLQLL HLSVSLQHRR
160 170 180 190 200
EGLGKAMVRT VLQFAQMQGF SEVVLSTSML QYAALALYQG MGFQKTGETF
210 220
YTYLSRLRKS PMINLKYSLT SREGDL
Length:226
Mass (Da):25,956
Last modified:October 1, 2000 - v1
Checksum:iD3CAD187E847B5FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11D → G in BAC32679 (PubMed:16141072).Curated1
Sequence conflicti204L → I in AAH92089 (PubMed:15489334).Curated1
Sequence conflicti204L → I in AAH14696 (PubMed:15489334).Curated1
Sequence conflicti221S → SP in AAH92089 (PubMed:15489334).Curated1
Sequence conflicti221S → SP in AAH14696 (PubMed:15489334).Curated1
Sequence conflicti222R → PW in BAC32679 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163316 mRNA. Translation: AAF80485.1.
AK046314 mRNA. Translation: BAC32679.1.
BC014696 mRNA. Translation: AAH14696.1.
BC092089 mRNA. Translation: AAH92089.1.
RefSeqiNP_001032931.1. NM_001037842.3.
NP_001188318.1. NM_001201389.1.
XP_017177330.1. XM_017321841.1.
UniGeneiMm.440772.
Mm.486515.

Genome annotation databases

EnsembliENSMUST00000087656; ENSMUSP00000084938; ENSMUSG00000079495.
ENSMUST00000174143; ENSMUSP00000133846; ENSMUSG00000079495.
GeneIDi100504710.
93674.
KEGGimmu:100504710.
mmu:93674.
UCSCiuc009cqc.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiCMLO3_MOUSE
AccessioniPrimary (citable) accession number: Q9JIY8
Secondary accession number(s): Q8BQW2, Q91WM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families