Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable N-acetyltransferase CML3

Gene

Cml3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regulation of gastrulation.1 Publication

GO - Molecular functioni

  • N-acetyltransferase activity Source: UniProtKB

GO - Biological processi

  • gastrulation with mouth forming second Source: UniProtKB
  • negative regulation of cell adhesion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Developmental protein, Transferase

Keywords - Biological processi

Gastrulation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetyltransferase CML3 (EC:2.3.1.-)
Alternative name(s):
Camello-like protein 3
Gene namesi
Name:Cml3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2136449. Cml3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • Golgi apparatus Source: MGI
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Probable N-acetyltransferase CML3PRO_0000284690Add
BLAST

Proteomic databases

MaxQBiQ9JIY8.
PaxDbiQ9JIY8.
PeptideAtlasiQ9JIY8.
PRIDEiQ9JIY8.

PTM databases

iPTMnetiQ9JIY8.
PhosphoSiteiQ9JIY8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051262.
CleanExiMM_CML3.
GenevisibleiQ9JIY8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084938.

Structurei

3D structure databases

ProteinModelPortaliQ9JIY8.
SMRiQ9JIY8. Positions 104-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 220160N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the camello family.1 Publication
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3139. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00390000009559.
HOGENOMiHOG000261685.
HOVERGENiHBG060476.
InParanoidiQ9JIY8.
OMAiNECLSTD.
OrthoDBiEOG091G0LL0.
TreeFamiTF324687.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPYHIRKYQ DSDHRSVVDL FRRGMEEHIP ATFRHMLLLP RTLLLLLGVP
60 70 80 90 100
LTLFLASGSW LLVLLSILTL FLSLWFLAKY TWEKHVMNCL HTDMADITRT
110 120 130 140 150
YLSSHSSCFW VAESRGQTVG MVAARPVKDP LLQKKQLQLL HLSVSLQHRR
160 170 180 190 200
EGLGKAMVRT VLQFAQMQGF SEVVLSTSML QYAALALYQG MGFQKTGETF
210 220
YTYLSRLRKS PMINLKYSLT SREGDL
Length:226
Mass (Da):25,956
Last modified:October 1, 2000 - v1
Checksum:iD3CAD187E847B5FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111D → G in BAC32679 (PubMed:16141072).Curated
Sequence conflicti204 – 2041L → I in AAH92089 (PubMed:15489334).Curated
Sequence conflicti204 – 2041L → I in AAH14696 (PubMed:15489334).Curated
Sequence conflicti221 – 2211S → SP in AAH92089 (PubMed:15489334).Curated
Sequence conflicti221 – 2211S → SP in AAH14696 (PubMed:15489334).Curated
Sequence conflicti222 – 2221R → PW in BAC32679 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163316 mRNA. Translation: AAF80485.1.
AK046314 mRNA. Translation: BAC32679.1.
BC014696 mRNA. Translation: AAH14696.1.
BC092089 mRNA. Translation: AAH92089.1.
RefSeqiNP_001032931.1. NM_001037842.3.
NP_001188318.1. NM_001201389.1.
XP_006506864.1. XM_006506801.2.
XP_006506865.1. XM_006506802.2.
UniGeneiMm.440772.
Mm.486515.

Genome annotation databases

EnsembliENSMUST00000087656; ENSMUSP00000084938; ENSMUSG00000079495.
ENSMUST00000174143; ENSMUSP00000133846; ENSMUSG00000079495.
GeneIDi100504710.
93674.
KEGGimmu:100504710.
mmu:93674.
UCSCiuc009cqc.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163316 mRNA. Translation: AAF80485.1.
AK046314 mRNA. Translation: BAC32679.1.
BC014696 mRNA. Translation: AAH14696.1.
BC092089 mRNA. Translation: AAH92089.1.
RefSeqiNP_001032931.1. NM_001037842.3.
NP_001188318.1. NM_001201389.1.
XP_006506864.1. XM_006506801.2.
XP_006506865.1. XM_006506802.2.
UniGeneiMm.440772.
Mm.486515.

3D structure databases

ProteinModelPortaliQ9JIY8.
SMRiQ9JIY8. Positions 104-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084938.

PTM databases

iPTMnetiQ9JIY8.
PhosphoSiteiQ9JIY8.

Proteomic databases

MaxQBiQ9JIY8.
PaxDbiQ9JIY8.
PeptideAtlasiQ9JIY8.
PRIDEiQ9JIY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087656; ENSMUSP00000084938; ENSMUSG00000079495.
ENSMUST00000174143; ENSMUSP00000133846; ENSMUSG00000079495.
GeneIDi100504710.
93674.
KEGGimmu:100504710.
mmu:93674.
UCSCiuc009cqc.3. mouse.

Organism-specific databases

CTDi100504710.
93674.
MGIiMGI:2136449. Cml3.

Phylogenomic databases

eggNOGiKOG3139. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00390000009559.
HOGENOMiHOG000261685.
HOVERGENiHBG060476.
InParanoidiQ9JIY8.
OMAiNECLSTD.
OrthoDBiEOG091G0LL0.
TreeFamiTF324687.

Miscellaneous databases

ChiTaRSiNat8l. mouse.
PROiQ9JIY8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051262.
CleanExiMM_CML3.
GenevisibleiQ9JIY8. MM.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCMLO3_MOUSE
AccessioniPrimary (citable) accession number: Q9JIY8
Secondary accession number(s): Q8BQW2, Q91WM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.