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Protein

Transcription and mRNA export factor ENY2

Gene

Eny2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processmRNA transport, Protein transport, Transcription, Transcription regulation, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription and mRNA export factor ENY2UniRule annotation
Alternative name(s):
Enhancer of yellow 2 transcription factor homologUniRule annotation
Gene namesi
Name:Eny2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1919286 Eny2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141311 – 101Transcription and mRNA export factor ENY2Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki74Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9JIX0
MaxQBiQ9JIX0
PaxDbiQ9JIX0
PeptideAtlasiQ9JIX0
PRIDEiQ9JIX0

PTM databases

iPTMnetiQ9JIX0
PhosphoSitePlusiQ9JIX0

Expressioni

Gene expression databases

BgeeiENSMUSG00000022338
CleanExiMM_ENY2
GenevisibleiQ9JIX0 MM

Interactioni

Subunit structurei

Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.UniRule annotation

Protein-protein interaction databases

BioGridi230155, 1 interactor
ComplexPortaliCPX-916 TFTC histone acetylation complex
CPX-920 SAGA complex
IntActiQ9JIX0, 2 interactors
MINTiQ9JIX0
STRINGi10090.ENSMUSP00000052905

Structurei

3D structure databases

ProteinModelPortaliQ9JIX0
SMRiQ9JIX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ENY2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4479 Eukaryota
ENOG4111PHC LUCA
GeneTreeiENSGT00390000011748
HOGENOMiHOG000007355
HOVERGENiHBG107852
InParanoidiQ9JIX0
KOiK11368
OMAiAHCKDVI
OrthoDBiEOG091G11OD
PhylomeDBiQ9JIX0
TreeFamiTF326556

Family and domain databases

Gene3Di1.10.246.140, 1 hit
HAMAPiMF_03046 ENY2_Sus1, 1 hit
InterProiView protein in InterPro
IPR018783 TF_ENY2
IPR038212 TF_EnY2_sf
PANTHERiPTHR12514 PTHR12514, 1 hit
PfamiView protein in Pfam
PF10163 EnY2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JIX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSKMNKDA QMRAAINQKL IETGERERLK ELLRAKLIEC GWKDQLKAHC
60 70 80 90 100
KEVIKEKGLE HVTVDDLVAE ITPKGRALVP DSVKKELLQR IRTFLAQHAS

L
Length:101
Mass (Da):11,529
Last modified:October 1, 2000 - v1
Checksum:iA0617024C59AABFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173297 mRNA Translation: AAF89830.1
AK032957 mRNA Translation: BAC28097.1
BC048361 mRNA Translation: AAH48361.1
CCDSiCCDS27456.1
RefSeqiNP_778174.1, NM_175009.3
UniGeneiMm.291828
Mm.490404

Genome annotation databases

EnsembliENSMUST00000060652; ENSMUSP00000052905; ENSMUSG00000022338
GeneIDi223527
KEGGimmu:223527
UCSCiuc007vpu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiENY2_MOUSE
AccessioniPrimary (citable) accession number: Q9JIX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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