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Q9JIW9

- RALB_MOUSE

UniProt

Q9JIW9 - RALB_MOUSE

Protein

Ras-related protein Ral-B

Gene

Ralb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis By similarity.By similarity

    Enzyme regulationi

    Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 299GTPBy similarity
    Nucleotide bindingi68 – 725GTPBy similarity
    Nucleotide bindingi128 – 1314GTPBy similarity
    Nucleotide bindingi158 – 1603GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB
    2. GTP binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cytokinesis Source: UniProtKB
    3. Ras protein signal transduction Source: InterPro
    4. regulation of exocyst assembly Source: UniProtKB
    5. regulation of exocyst localization Source: UniProtKB

    Keywords - Biological processi

    Apoptosis, Cell cycle, Cell division

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_207601. p38MAPK events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Ral-B
    Gene namesi
    Name:Ralb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1927244. Ralb.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: During late cytokinesis localizes at the midbody.By similarity

    GO - Cellular componenti

    1. midbody Source: UniProtKB
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Ras-related protein Ral-BPRO_0000082699Add
    BLAST
    Propeptidei204 – 2063Removed in mature formBy similarityPRO_0000281351

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei203 – 2031Cysteine methyl esterBy similarity
    Lipidationi203 – 2031S-geranylgeranyl cysteineBy similarity

    Post-translational modificationi

    Prenylation is essential for membrane localization.By similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiQ9JIW9.
    PaxDbiQ9JIW9.
    PRIDEiQ9JIW9.

    PTM databases

    PhosphoSiteiQ9JIW9.

    Expressioni

    Gene expression databases

    BgeeiQ9JIW9.
    GenevestigatoriQ9JIW9.

    Interactioni

    Subunit structurei

    Interacts with EXOC8. Interacts with RALBP1 via its effector domain By similarity.By similarity

    Protein-protein interaction databases

    BioGridi211033. 1 interaction.
    IntActiQ9JIW9. 3 interactions.
    MINTiMINT-1866131.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JIW9.
    SMRiQ9JIW9. Positions 12-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 519Effector region

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Ras family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00750000117261.
    HOGENOMiHOG000233973.
    HOVERGENiHBG009351.
    InParanoidiQ9JIW9.
    KOiK07835.
    OMAiXFVEDYE.
    OrthoDBiEOG7QVM41.
    PhylomeDBiQ9JIW9.
    TreeFamiTF312796.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR028412. Ral.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PTHR24070:SF199. PTHR24070:SF199. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00173. RAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JIW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAANKGKSQG SLVLHKVIMV GSGGVGKSAL TLQFMYDEFV EDYEPTKADS    50
    YRKKVVLDGE EVQIDILDTA GQEDYAAIRD NYFRSGEGFL LVFSITEHES 100
    FTATAEFREQ ILRVKSEEDK IPLLVVGNKS DLEERRQVPV DEARGKAEEW 150
    GVQYVETSAK TRANVDKVFF DLMREIRAKK MSENKDKNGR KSSKSKKSFK 200
    ERCCLL 206
    Length:206
    Mass (Da):23,349
    Last modified:October 1, 2000 - v1
    Checksum:i6CA5994C74221232
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174296 mRNA. Translation: AAF89875.1.
    AK017698 mRNA. Translation: BAB30881.1.
    AK159993 mRNA. Translation: BAE35543.1.
    BC006907 mRNA. Translation: AAH06907.1.
    CCDSiCCDS15225.1.
    RefSeqiNP_071722.1. NM_022327.5.
    XP_006529845.1. XM_006529782.1.
    UniGeneiMm.27832.

    Genome annotation databases

    EnsembliENSMUST00000004565; ENSMUSP00000004565; ENSMUSG00000004451.
    GeneIDi64143.
    KEGGimmu:64143.
    UCSCiuc007cis.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174296 mRNA. Translation: AAF89875.1 .
    AK017698 mRNA. Translation: BAB30881.1 .
    AK159993 mRNA. Translation: BAE35543.1 .
    BC006907 mRNA. Translation: AAH06907.1 .
    CCDSi CCDS15225.1.
    RefSeqi NP_071722.1. NM_022327.5.
    XP_006529845.1. XM_006529782.1.
    UniGenei Mm.27832.

    3D structure databases

    ProteinModelPortali Q9JIW9.
    SMRi Q9JIW9. Positions 12-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211033. 1 interaction.
    IntActi Q9JIW9. 3 interactions.
    MINTi MINT-1866131.

    PTM databases

    PhosphoSitei Q9JIW9.

    Proteomic databases

    MaxQBi Q9JIW9.
    PaxDbi Q9JIW9.
    PRIDEi Q9JIW9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004565 ; ENSMUSP00000004565 ; ENSMUSG00000004451 .
    GeneIDi 64143.
    KEGGi mmu:64143.
    UCSCi uc007cis.2. mouse.

    Organism-specific databases

    CTDi 5899.
    MGIi MGI:1927244. Ralb.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00750000117261.
    HOGENOMi HOG000233973.
    HOVERGENi HBG009351.
    InParanoidi Q9JIW9.
    KOi K07835.
    OMAi XFVEDYE.
    OrthoDBi EOG7QVM41.
    PhylomeDBi Q9JIW9.
    TreeFami TF312796.

    Enzyme and pathway databases

    Reactomei REACT_207601. p38MAPK events.

    Miscellaneous databases

    NextBioi 319935.
    PROi Q9JIW9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JIW9.
    Genevestigatori Q9JIW9.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR028412. Ral.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    PTHR24070:SF199. PTHR24070:SF199. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00173. RAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tissue-specific expression of GTPas RalA and RalB during embryogenesis and regulation by epithelial-mesenchymal interaction."
      Zhao Z., Rivkees S.A.
      Mech. Dev. 97:201-204(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiRALB_MOUSE
    AccessioniPrimary (citable) accession number: Q9JIW9
    Secondary accession number(s): Q3TVS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3