Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9JIW9

- RALB_MOUSE

UniProt

Q9JIW9 - RALB_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ras-related protein Ral-B

Gene

Ralb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis (By similarity).By similarity

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 299GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi128 – 1314GTPBy similarity
Nucleotide bindingi158 – 1603GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB
  2. GTP binding Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cytokinesis Source: UniProtKB
  3. Ras protein signal transduction Source: InterPro
  4. regulation of exocyst assembly Source: UniProtKB
  5. regulation of exocyst localization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_207601. p38MAPK events.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Ral-B
Gene namesi
Name:Ralb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1927244. Ralb.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: During late cytokinesis localizes at the midbody.By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. midbody Source: UniProtKB
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Ras-related protein Ral-BPRO_0000082699Add
BLAST
Propeptidei204 – 2063Removed in mature formBy similarityPRO_0000281351

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei203 – 2031Cysteine methyl esterBy similarity
Lipidationi203 – 2031S-geranylgeranyl cysteineBy similarity

Post-translational modificationi

Prenylation is essential for membrane localization.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ9JIW9.
PaxDbiQ9JIW9.
PRIDEiQ9JIW9.

PTM databases

PhosphoSiteiQ9JIW9.

Expressioni

Gene expression databases

BgeeiQ9JIW9.
GenevestigatoriQ9JIW9.

Interactioni

Subunit structurei

Interacts with EXOC8. Interacts with RALBP1 via its effector domain (By similarity).By similarity

Protein-protein interaction databases

BioGridi211033. 1 interaction.
IntActiQ9JIW9. 3 interactions.
MINTiMINT-1866131.

Structurei

3D structure databases

ProteinModelPortaliQ9JIW9.
SMRiQ9JIW9. Positions 12-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 519Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00770000120468.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9JIW9.
KOiK07835.
OMAiXFVEDYE.
OrthoDBiEOG7QVM41.
PhylomeDBiQ9JIW9.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR028412. Ral.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PTHR24070:SF199. PTHR24070:SF199. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIW9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAANKGKSQG SLVLHKVIMV GSGGVGKSAL TLQFMYDEFV EDYEPTKADS
60 70 80 90 100
YRKKVVLDGE EVQIDILDTA GQEDYAAIRD NYFRSGEGFL LVFSITEHES
110 120 130 140 150
FTATAEFREQ ILRVKSEEDK IPLLVVGNKS DLEERRQVPV DEARGKAEEW
160 170 180 190 200
GVQYVETSAK TRANVDKVFF DLMREIRAKK MSENKDKNGR KSSKSKKSFK

ERCCLL
Length:206
Mass (Da):23,349
Last modified:October 1, 2000 - v1
Checksum:i6CA5994C74221232
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174296 mRNA. Translation: AAF89875.1.
AK017698 mRNA. Translation: BAB30881.1.
AK159993 mRNA. Translation: BAE35543.1.
BC006907 mRNA. Translation: AAH06907.1.
CCDSiCCDS15225.1.
RefSeqiNP_071722.1. NM_022327.5.
XP_006529845.1. XM_006529782.1.
UniGeneiMm.27832.

Genome annotation databases

EnsembliENSMUST00000004565; ENSMUSP00000004565; ENSMUSG00000004451.
GeneIDi64143.
KEGGimmu:64143.
UCSCiuc007cis.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174296 mRNA. Translation: AAF89875.1 .
AK017698 mRNA. Translation: BAB30881.1 .
AK159993 mRNA. Translation: BAE35543.1 .
BC006907 mRNA. Translation: AAH06907.1 .
CCDSi CCDS15225.1.
RefSeqi NP_071722.1. NM_022327.5.
XP_006529845.1. XM_006529782.1.
UniGenei Mm.27832.

3D structure databases

ProteinModelPortali Q9JIW9.
SMRi Q9JIW9. Positions 12-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211033. 1 interaction.
IntActi Q9JIW9. 3 interactions.
MINTi MINT-1866131.

PTM databases

PhosphoSitei Q9JIW9.

Proteomic databases

MaxQBi Q9JIW9.
PaxDbi Q9JIW9.
PRIDEi Q9JIW9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004565 ; ENSMUSP00000004565 ; ENSMUSG00000004451 .
GeneIDi 64143.
KEGGi mmu:64143.
UCSCi uc007cis.2. mouse.

Organism-specific databases

CTDi 5899.
MGIi MGI:1927244. Ralb.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00770000120468.
HOGENOMi HOG000233973.
HOVERGENi HBG009351.
InParanoidi Q9JIW9.
KOi K07835.
OMAi XFVEDYE.
OrthoDBi EOG7QVM41.
PhylomeDBi Q9JIW9.
TreeFami TF312796.

Enzyme and pathway databases

Reactomei REACT_207601. p38MAPK events.

Miscellaneous databases

ChiTaRSi Ralb. mouse.
NextBioi 319935.
PROi Q9JIW9.
SOURCEi Search...

Gene expression databases

Bgeei Q9JIW9.
Genevestigatori Q9JIW9.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR028412. Ral.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
PTHR24070:SF199. PTHR24070:SF199. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00173. RAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific expression of GTPas RalA and RalB during embryogenesis and regulation by epithelial-mesenchymal interaction."
    Zhao Z., Rivkees S.A.
    Mech. Dev. 97:201-204(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiRALB_MOUSE
AccessioniPrimary (citable) accession number: Q9JIW9
Secondary accession number(s): Q3TVS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3