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Q9JIW5

- SMAD9_MOUSE

UniProt

Q9JIW5 - SMAD9_MOUSE

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Protein

Mothers against decapentaplegic homolog 9

Gene
Smad9, Madh8, Madh9, Smad8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Zinc By similarity
Metal bindingi113 – 1131Zinc By similarity
Metal bindingi125 – 1251Zinc By similarity
Metal bindingi130 – 1301Zinc By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. BMP signaling pathway Source: MGI
  2. bone development Source: MGI
  3. cartilage development Source: MGI
  4. cellular response to organic cyclic compound Source: MGI
  5. hindbrain development Source: MGI
  6. midbrain development Source: MGI
  7. Mullerian duct regression Source: Ensembl
  8. positive regulation of cell differentiation Source: Ensembl
  9. positive regulation of transcription, DNA-templated Source: Ensembl
  10. protein phosphorylation Source: MGI
  11. response to hypoxia Source: Ensembl
  12. transcription, DNA-templated Source: UniProtKB-KW
  13. transforming growth factor beta receptor signaling pathway Source: InterPro
  14. ureteric bud development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_220505. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homolog 9
Short name:
MAD homolog 9
Short name:
Mothers against DPP homolog 9
Alternative name(s):
SMAD family member 9
Short name:
SMAD 9
Short name:
Smad9
Smad8
Gene namesi
Name:Smad9
Synonyms:Madh8, Madh9, Smad8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1859993. Smad9.

Subcellular locationi

Cytoplasm. Nucleus
Note: Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
  3. transcription factor complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Mothers against decapentaplegic homolog 9PRO_0000090876Add
BLAST

Post-translational modificationi

Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase and activin type I receptor-like kinases (ALK-2, ALK-3 and ALK-6).

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JIW5.
PaxDbiQ9JIW5.
PRIDEiQ9JIW5.

PTM databases

PhosphoSiteiQ9JIW5.

Expressioni

Gene expression databases

BgeeiQ9JIW5.
CleanExiMM_SMAD9.
GenevestigatoriQ9JIW5.

Interactioni

Subunit structurei

Interaction with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit By similarity.

Protein-protein interaction databases

BioGridi207765. 10 interactions.
IntActiQ9JIW5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9JIW5.
SMRiQ9JIW5. Positions 13-136, 233-430.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 140125MH1Add
BLAST
Domaini236 – 430195MH2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi43 – 497Poly-Lys

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.

Phylogenomic databases

eggNOGiNOG330956.
GeneTreeiENSGT00600000084186.
HOGENOMiHOG000286018.
HOVERGENiHBG053353.
InParanoidiQ9JIW5.
KOiK16791.
OMAiFQQPPCP.
OrthoDBiEOG7W1540.
PhylomeDBiQ9JIW5.
TreeFamiTF314923.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIW5-1 [UniParc]FASTAAdd to Basket

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MHPSTPISSL FSFTSPAVKR LLGWKQGDEE EKWAEKAVDS LVKKLKKKKG    50
AMDELERALS CPGQPSKCVT IPRSLDGRLQ VSHRKGLPHV IYCRVWRWPD 100
LQSHHELKPL ECCEFPFGSK QKEVCINPYH YRRVETPVLP PVLVPRHSEY 150
NPQLSLLAKF RSASLHSEPL MPHNATYPDS FQQSLCPAPP SSPGHVFPQS 200
PCPTSYPHSP GSPSESDSPY QHSDFRPVCY EEPQHWCSVA YYELNNRVGE 250
TFQASSRSVL IDGFTDPSNN RNRFCLGLLS NVNRNSTIEN TRRHIGKGVH 300
LYYVGGEVYA ECVSDSSIFV QSRNCNYQHG FHPATVCKIP SGCSLKVFNN 350
QLFAQLLAQS VHHGFEVVYE LTKMCTIRMS FVKGWGAEYH RQDVTSTPCW 400
IEIHLHGPLQ WLDKVLTQMG SPHNPISSVS 430
Length:430
Mass (Da):48,636
Last modified:May 10, 2005 - v2
Checksum:i3B15EC51D6A594E5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti214 – 2152Missing.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF175408 mRNA. Translation: AAF77079.2.
AY145520 mRNA. Translation: AAN85445.1.
CCDSiCCDS17354.1.
RefSeqiNP_062356.3. NM_019483.5.
XP_006501791.1. XM_006501728.1.
UniGeneiMm.244353.

Genome annotation databases

EnsembliENSMUST00000029371; ENSMUSP00000029371; ENSMUSG00000027796.
GeneIDi55994.
KEGGimmu:55994.
UCSCiuc008pfv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF175408 mRNA. Translation: AAF77079.2 .
AY145520 mRNA. Translation: AAN85445.1 .
CCDSi CCDS17354.1.
RefSeqi NP_062356.3. NM_019483.5.
XP_006501791.1. XM_006501728.1.
UniGenei Mm.244353.

3D structure databases

ProteinModelPortali Q9JIW5.
SMRi Q9JIW5. Positions 13-136, 233-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207765. 10 interactions.
IntActi Q9JIW5. 1 interaction.

PTM databases

PhosphoSitei Q9JIW5.

Proteomic databases

MaxQBi Q9JIW5.
PaxDbi Q9JIW5.
PRIDEi Q9JIW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029371 ; ENSMUSP00000029371 ; ENSMUSG00000027796 .
GeneIDi 55994.
KEGGi mmu:55994.
UCSCi uc008pfv.1. mouse.

Organism-specific databases

CTDi 4093.
MGIi MGI:1859993. Smad9.

Phylogenomic databases

eggNOGi NOG330956.
GeneTreei ENSGT00600000084186.
HOGENOMi HOG000286018.
HOVERGENi HBG053353.
InParanoidi Q9JIW5.
KOi K16791.
OMAi FQQPPCP.
OrthoDBi EOG7W1540.
PhylomeDBi Q9JIW5.
TreeFami TF314923.

Enzyme and pathway databases

Reactomei REACT_220505. Signaling by BMP.

Miscellaneous databases

ChiTaRSi SMAD9. mouse.
NextBioi 311730.
PROi Q9JIW5.
SOURCEi Search...

Gene expression databases

Bgeei Q9JIW5.
CleanExi MM_SMAD9.
Genevestigatori Q9JIW5.

Family and domain databases

Gene3Di 2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProi IPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view ]
PANTHERi PTHR13703. PTHR13703. 1 hit.
Pfami PF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view ]
SMARTi SM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEi PS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse Smad8 phosphorylation downstream of BMP receptors ALK-2, ALK-3, and ALK-6 induces its association with Smad4 and transcriptional activity."
    Kawai S., Faucheu C., Gallea S., Spinella-Jaegle S., Atfi A., Baron R., Roman-Roman S.
    Biochem. Biophys. Res. Commun. 271:682-687(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT 214-SER-GLU-215 DEL.
    Tissue: Embryo.
  2. Kawai S., Roman-Roman S.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 115 AND 135.
  3. "Mouse Smad8 protein mRNA alternative form (6-bp insert in linker region)."
    Kawai S., Roman-Roman S.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiSMAD9_MOUSE
AccessioniPrimary (citable) accession number: Q9JIW5
Secondary accession number(s): Q8CFF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 10, 2005
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi