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Protein

RING finger protein 32

Gene

Rnf32

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in sperm formation.

Miscellaneous

No coding region alterations in either Hemimelic extra-toes (Hx) or Hammertoe (Hm) mutant mice was detected.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri129 – 171RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST43
Zinc fingeri295 – 358RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 32
Alternative name(s):
Limb region protein 2
Gene namesi
Name:Rnf32
Synonyms:Lmbr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1861747. Rnf32.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455341 – 368RING finger protein 32Add BLAST368

Proteomic databases

PaxDbiQ9JIT1.
PRIDEiQ9JIT1.

PTM databases

iPTMnetiQ9JIT1.
PhosphoSitePlusiQ9JIT1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029130.
CleanExiMM_RNF32.
ExpressionAtlasiQ9JIT1. baseline and differential.
GenevisibleiQ9JIT1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001247.

Structurei

3D structure databases

ProteinModelPortaliQ9JIT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 217IQPROSITE-ProRule annotationAdd BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri129 – 171RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST43
Zinc fingeri295 – 358RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00390000003759.
HOGENOMiHOG000007992.
HOVERGENiHBG082459.
InParanoidiQ9JIT1.
OMAiILCSYNT.
OrthoDBiEOG091G0AGY.
PhylomeDBiQ9JIT1.
TreeFamiTF329796.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR000048. IQ_motif_EF-hand-BS.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF00612. IQ. 1 hit.
PF13639. zf-RING_2. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 2 hits.
PROSITEiView protein in PROSITE
PS50096. IQ. 1 hit.
PS50089. ZF_RING_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9JIT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNKDRSSN KGNLAVTAVA LQDHLLHDLQ LGHLSVADPC KIKARKKEKK
60 70 80 90 100
SKSLKRDATA IIDTGLRKST EGPNMEDPEK EYVLDPTPPP LTLAQKLGLL
110 120 130 140 150
PPPPLPLSSD EWERVKQRSL LQGDSIQPCP ICKEEFELHP QVLLSCSHVF
160 170 180 190 200
HRACLQAFEK FTNKKTCPLC RKNQYQTRVI HDGARLFRVK CATRIQAYWR
210 220 230 240 250
GYIVRKWYRN LRKIIPPSDA KLRRKFFEEK FTEISHRILC SYNTNIDELF
260 270 280 290 300
SEIDVCLAVN RSILQQLDER CGQIITKEDW EKIQAQAAHH EIYECSICLT
310 320 330 340 350
PLSFHGDGRQ AAIGTSSQRP RETVLLSCAH LFHNACLLAL EEFSLGDNAP
360
FHVCPLCRSC YQKKIVEC
Length:368
Mass (Da):42,139
Last modified:October 1, 2000 - v1
Checksum:i23F8DE23EF4D02AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84L → I in BAB24557 (PubMed:16141072).Curated1
Sequence conflicti99L → I in BAB24557 (PubMed:16141072).Curated1
Sequence conflicti113E → G in BAB24242 (PubMed:16141072).Curated1
Sequence conflicti123G → R in BAB24242 (PubMed:16141072).Curated1
Sequence conflicti245N → K in BAB24557 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190664 mRNA. Translation: AAF91091.1.
AK005795 mRNA. Translation: BAB24242.1.
AK006379 mRNA. Translation: BAB24557.1.
BC089493 mRNA. Translation: AAH89493.1.
CCDSiCCDS39041.1.
RefSeqiNP_001276686.1. NM_001289757.1.
NP_067445.3. NM_021470.6.
XP_006535838.1. XM_006535775.3.
XP_006535839.1. XM_006535776.3.
XP_006535840.1. XM_006535777.3.
XP_006535841.1. XM_006535778.3.
XP_006535842.1. XM_006535779.3.
XP_006535843.1. XM_006535780.2.
XP_006535844.1. XM_006535781.3.
UniGeneiMm.487302.
Mm.87352.

Genome annotation databases

EnsembliENSMUST00000001247; ENSMUSP00000001247; ENSMUSG00000029130.
ENSMUST00000160246; ENSMUSP00000124657; ENSMUSG00000029130.
ENSMUST00000168460; ENSMUSP00000132213; ENSMUSG00000029130.
GeneIDi56874.
KEGGimmu:56874.
UCSCiuc008wuc.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiRNF32_MOUSE
AccessioniPrimary (citable) accession number: Q9JIT1
Secondary accession number(s): Q9D9X0, Q9DAJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot