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Q9JIT0

- LMBR1_MOUSE

UniProt

Q9JIT0 - LMBR1_MOUSE

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Protein

Limb region 1 protein

Gene
Lmbr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative membrane receptor.

GO - Biological processi

  1. embryonic digit morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Limb region 1 protein
Gene namesi
Name:Lmbr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1861746. Lmbr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Extracellular Reviewed predictionAdd
BLAST
Transmembranei20 – 4021Helical; Reviewed predictionAdd
BLAST
Topological domaini41 – 6222Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei63 – 8321Helical; Reviewed predictionAdd
BLAST
Topological domaini84 – 11027Extracellular Reviewed predictionAdd
BLAST
Transmembranei111 – 13121Helical; Reviewed predictionAdd
BLAST
Topological domaini132 – 15120Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei152 – 17221Helical; Reviewed predictionAdd
BLAST
Topological domaini173 – 18715Extracellular Reviewed predictionAdd
BLAST
Transmembranei188 – 20821Helical; Reviewed predictionAdd
BLAST
Topological domaini209 – 29183Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei292 – 31221Helical; Reviewed predictionAdd
BLAST
Topological domaini313 – 33927Extracellular Reviewed predictionAdd
BLAST
Transmembranei340 – 36021Helical; Reviewed predictionAdd
BLAST
Topological domaini361 – 38323Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei384 – 40421Helical; Reviewed predictionAdd
BLAST
Topological domaini405 – 42622Extracellular Reviewed predictionAdd
BLAST
Transmembranei427 – 44721Helical; Reviewed predictionAdd
BLAST
Topological domaini448 – 49043Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Limb region 1 proteinPRO_0000053907Add
BLAST

Proteomic databases

PaxDbiQ9JIT0.
PRIDEiQ9JIT0.

PTM databases

PhosphoSiteiQ9JIT0.

Expressioni

Gene expression databases

ArrayExpressiQ9JIT0.
BgeeiQ9JIT0.
CleanExiMM_LMBR1.
GenevestigatoriQ9JIT0.

Structurei

3D structure databases

ProteinModelPortaliQ9JIT0.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili256 – 28732 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the LIMR family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG246746.
GeneTreeiENSGT00390000007809.
HOGENOMiHOG000252995.
HOVERGENiHBG072983.
InParanoidiQ9JIT0.
OMAiIREQNFH.
OrthoDBiEOG7M0NRC.
PhylomeDBiQ9JIT0.
TreeFamiTF313485.

Family and domain databases

InterProiIPR008075. Lipcalin_1_rcpt.
IPR006876. LMBR1-like_membr_prot.
[Graphical view]
PfamiPF04791. LMBR1. 1 hit.
[Graphical view]
PRINTSiPR01692. LIPOCALINIMR.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JIT0-1) [UniParc]FASTAAdd to Basket

Also known as: LMBR1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEGQDEVSAR EQHFHSQVRE STICFLLFAI LYIVSYFIII RYKRKSDEQE    50
DEDAVVNRIS LFLSTFTLAV SAGAVLLLPF SIISNEILLA FPHNYYIQWL 100
NGSLIHGLWN LASLFSNLCL FVLMPFAFFF LESEGFAGLK KGIRARILET 150
LVMLLLLALL ILGMVWVASA LIDSDAASME SLYDLWEFYL PYLYSCISLM 200
GCLLLLLCTP VGLSRMFTVM GQLLVKPAIL EDLDEQIYMI TLEEEALQRR 250
LHGLSSSVEY NVMELEQELE NVKILKTKLE RRKKASAWER NLVYPAVMVL 300
LLIETSISVL LVACNILCLL VDETAMPKGT RGPGIGSASL STFGFVGAAL 350
EIILIFYLMV SSVVGFYSLR FFGNFTPKKD DTTMTKIIGN CVSILVLSSA 400
LPVMSRTLGI TRFDLLGDFG RFNWLGNFYI VLSYNLLFAI MTTLCLIRKF 450
TSAVREELFK ALGLHKLHLS DTSRDSETTK PSANGHQKAL 490
Length:490
Mass (Da):55,115
Last modified:October 1, 2000 - v1
Checksum:i869184C2F0729C91
GO
Isoform 2 (identifier: Q9JIT0-2) [UniParc]FASTAAdd to Basket

Also known as: LMBR1S

The sequence of this isoform differs from the canonical sequence as follows:
     23-32: ICFLLFAILY → RNGRFTSYLW
     33-490: Missing.

Show »
Length:32
Mass (Da):3,869
Checksum:i4886B3DA63ED0AF2
GO
Isoform 3 (identifier: Q9JIT0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-133: Missing.

Show »
Length:463
Mass (Da):52,005
Checksum:i8A115C8C5384A0C6
GO

Sequence cautioni

The sequence BAD07410.1 differs from that shown. Reason: Frameshift at position 114.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei23 – 3210ICFLLFAILY → RNGRFTSYLW in isoform 2. VSP_016889
Alternative sequencei33 – 490458Missing in isoform 2. VSP_016890Add
BLAST
Alternative sequencei107 – 13327Missing in isoform 3. VSP_016891Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF190665 mRNA. Translation: AAF91092.1.
AF190666 mRNA. Translation: AAF91093.1.
BC016110 mRNA. Translation: AAH16110.1.
AB114903 Genomic DNA. Translation: BAD07410.1. Frameshift.
CCDSiCCDS19148.1. [Q9JIT0-1]
RefSeqiNP_064691.2. NM_020295.3. [Q9JIT0-1]
UniGeneiMm.41572.

Genome annotation databases

EnsembliENSMUST00000055195; ENSMUSP00000058405; ENSMUSG00000010721. [Q9JIT0-1]
GeneIDi56873.
KEGGimmu:56873.
UCSCiuc008wug.1. mouse. [Q9JIT0-1]
uc012dtv.1. mouse. [Q9JIT0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF190665 mRNA. Translation: AAF91092.1 .
AF190666 mRNA. Translation: AAF91093.1 .
BC016110 mRNA. Translation: AAH16110.1 .
AB114903 Genomic DNA. Translation: BAD07410.1 . Frameshift.
CCDSi CCDS19148.1. [Q9JIT0-1 ]
RefSeqi NP_064691.2. NM_020295.3. [Q9JIT0-1 ]
UniGenei Mm.41572.

3D structure databases

ProteinModelPortali Q9JIT0.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JIT0.

Proteomic databases

PaxDbi Q9JIT0.
PRIDEi Q9JIT0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055195 ; ENSMUSP00000058405 ; ENSMUSG00000010721 . [Q9JIT0-1 ]
GeneIDi 56873.
KEGGi mmu:56873.
UCSCi uc008wug.1. mouse. [Q9JIT0-1 ]
uc012dtv.1. mouse. [Q9JIT0-3 ]

Organism-specific databases

CTDi 64327.
MGIi MGI:1861746. Lmbr1.

Phylogenomic databases

eggNOGi NOG246746.
GeneTreei ENSGT00390000007809.
HOGENOMi HOG000252995.
HOVERGENi HBG072983.
InParanoidi Q9JIT0.
OMAi IREQNFH.
OrthoDBi EOG7M0NRC.
PhylomeDBi Q9JIT0.
TreeFami TF313485.

Miscellaneous databases

ChiTaRSi LMBR1. mouse.
NextBioi 313445.
PROi Q9JIT0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JIT0.
Bgeei Q9JIT0.
CleanExi MM_LMBR1.
Genevestigatori Q9JIT0.

Family and domain databases

InterProi IPR008075. Lipcalin_1_rcpt.
IPR006876. LMBR1-like_membr_prot.
[Graphical view ]
Pfami PF04791. LMBR1. 1 hit.
[Graphical view ]
PRINTSi PR01692. LIPOCALINIMR.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of hemimelic extra-toes mutant mice."
    Clark R.M., Marker P.C., Kingsley D.M.
    Genomics 67:19-27(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: B10.D2/nSn.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Eye.
  3. "Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog (Shh)."
    Sagai T., Masuya H., Tamura M., Shimizu K., Yada Y., Wakana S., Gondo Y., Noda T., Shiroishi T.
    Mamm. Genome 15:23-34(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-141.

Entry informationi

Entry nameiLMBR1_MOUSE
AccessioniPrimary (citable) accession number: Q9JIT0
Secondary accession number(s): Q766D0, Q91WC6, Q9JIS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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