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Q9JIT0

- LMBR1_MOUSE

UniProt

Q9JIT0 - LMBR1_MOUSE

Protein

Limb region 1 protein

Gene

Lmbr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Putative membrane receptor.

    GO - Biological processi

    1. embryonic digit morphogenesis Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Limb region 1 protein
    Gene namesi
    Name:Lmbr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1861746. Lmbr1.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Limb region 1 proteinPRO_0000053907Add
    BLAST

    Proteomic databases

    PaxDbiQ9JIT0.
    PRIDEiQ9JIT0.

    PTM databases

    PhosphoSiteiQ9JIT0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JIT0.
    BgeeiQ9JIT0.
    CleanExiMM_LMBR1.
    GenevestigatoriQ9JIT0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JIT0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini41 – 6222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini84 – 11027ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 15120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini173 – 18715ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 29183CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini313 – 33927ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini361 – 38323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini405 – 42622ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini448 – 49043CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei340 – 36021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei384 – 40421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei427 – 44721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili256 – 28732Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LIMR family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG246746.
    GeneTreeiENSGT00390000007809.
    HOGENOMiHOG000252995.
    HOVERGENiHBG072983.
    InParanoidiQ9JIT0.
    OMAiIREQNFH.
    OrthoDBiEOG7M0NRC.
    PhylomeDBiQ9JIT0.
    TreeFamiTF313485.

    Family and domain databases

    InterProiIPR008075. Lipcalin_1_rcpt.
    IPR006876. LMBR1-like_membr_prot.
    [Graphical view]
    PfamiPF04791. LMBR1. 1 hit.
    [Graphical view]
    PRINTSiPR01692. LIPOCALINIMR.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JIT0-1) [UniParc]FASTAAdd to Basket

    Also known as: LMBR1L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGQDEVSAR EQHFHSQVRE STICFLLFAI LYIVSYFIII RYKRKSDEQE    50
    DEDAVVNRIS LFLSTFTLAV SAGAVLLLPF SIISNEILLA FPHNYYIQWL 100
    NGSLIHGLWN LASLFSNLCL FVLMPFAFFF LESEGFAGLK KGIRARILET 150
    LVMLLLLALL ILGMVWVASA LIDSDAASME SLYDLWEFYL PYLYSCISLM 200
    GCLLLLLCTP VGLSRMFTVM GQLLVKPAIL EDLDEQIYMI TLEEEALQRR 250
    LHGLSSSVEY NVMELEQELE NVKILKTKLE RRKKASAWER NLVYPAVMVL 300
    LLIETSISVL LVACNILCLL VDETAMPKGT RGPGIGSASL STFGFVGAAL 350
    EIILIFYLMV SSVVGFYSLR FFGNFTPKKD DTTMTKIIGN CVSILVLSSA 400
    LPVMSRTLGI TRFDLLGDFG RFNWLGNFYI VLSYNLLFAI MTTLCLIRKF 450
    TSAVREELFK ALGLHKLHLS DTSRDSETTK PSANGHQKAL 490
    Length:490
    Mass (Da):55,115
    Last modified:October 1, 2000 - v1
    Checksum:i869184C2F0729C91
    GO
    Isoform 2 (identifier: Q9JIT0-2) [UniParc]FASTAAdd to Basket

    Also known as: LMBR1S

    The sequence of this isoform differs from the canonical sequence as follows:
         23-32: ICFLLFAILY → RNGRFTSYLW
         33-490: Missing.

    Show »
    Length:32
    Mass (Da):3,869
    Checksum:i4886B3DA63ED0AF2
    GO
    Isoform 3 (identifier: Q9JIT0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         107-133: Missing.

    Show »
    Length:463
    Mass (Da):52,005
    Checksum:i8A115C8C5384A0C6
    GO

    Sequence cautioni

    The sequence BAD07410.1 differs from that shown. Reason: Frameshift at position 114.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei23 – 3210ICFLLFAILY → RNGRFTSYLW in isoform 2. 1 PublicationVSP_016889
    Alternative sequencei33 – 490458Missing in isoform 2. 1 PublicationVSP_016890Add
    BLAST
    Alternative sequencei107 – 13327Missing in isoform 3. 1 PublicationVSP_016891Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190665 mRNA. Translation: AAF91092.1.
    AF190666 mRNA. Translation: AAF91093.1.
    BC016110 mRNA. Translation: AAH16110.1.
    AB114903 Genomic DNA. Translation: BAD07410.1. Frameshift.
    CCDSiCCDS19148.1. [Q9JIT0-1]
    RefSeqiNP_064691.2. NM_020295.3. [Q9JIT0-1]
    UniGeneiMm.41572.

    Genome annotation databases

    EnsembliENSMUST00000055195; ENSMUSP00000058405; ENSMUSG00000010721. [Q9JIT0-1]
    GeneIDi56873.
    KEGGimmu:56873.
    UCSCiuc008wug.1. mouse. [Q9JIT0-1]
    uc012dtv.1. mouse. [Q9JIT0-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190665 mRNA. Translation: AAF91092.1 .
    AF190666 mRNA. Translation: AAF91093.1 .
    BC016110 mRNA. Translation: AAH16110.1 .
    AB114903 Genomic DNA. Translation: BAD07410.1 . Frameshift.
    CCDSi CCDS19148.1. [Q9JIT0-1 ]
    RefSeqi NP_064691.2. NM_020295.3. [Q9JIT0-1 ]
    UniGenei Mm.41572.

    3D structure databases

    ProteinModelPortali Q9JIT0.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JIT0.

    Proteomic databases

    PaxDbi Q9JIT0.
    PRIDEi Q9JIT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055195 ; ENSMUSP00000058405 ; ENSMUSG00000010721 . [Q9JIT0-1 ]
    GeneIDi 56873.
    KEGGi mmu:56873.
    UCSCi uc008wug.1. mouse. [Q9JIT0-1 ]
    uc012dtv.1. mouse. [Q9JIT0-3 ]

    Organism-specific databases

    CTDi 64327.
    MGIi MGI:1861746. Lmbr1.

    Phylogenomic databases

    eggNOGi NOG246746.
    GeneTreei ENSGT00390000007809.
    HOGENOMi HOG000252995.
    HOVERGENi HBG072983.
    InParanoidi Q9JIT0.
    OMAi IREQNFH.
    OrthoDBi EOG7M0NRC.
    PhylomeDBi Q9JIT0.
    TreeFami TF313485.

    Miscellaneous databases

    ChiTaRSi LMBR1. mouse.
    NextBioi 313445.
    PROi Q9JIT0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JIT0.
    Bgeei Q9JIT0.
    CleanExi MM_LMBR1.
    Genevestigatori Q9JIT0.

    Family and domain databases

    InterProi IPR008075. Lipcalin_1_rcpt.
    IPR006876. LMBR1-like_membr_prot.
    [Graphical view ]
    Pfami PF04791. LMBR1. 1 hit.
    [Graphical view ]
    PRINTSi PR01692. LIPOCALINIMR.
    ProtoNeti Search...

    Publicationsi

    1. "A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of hemimelic extra-toes mutant mice."
      Clark R.M., Marker P.C., Kingsley D.M.
      Genomics 67:19-27(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: B10.D2/nSn.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Eye.
    3. "Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog (Shh)."
      Sagai T., Masuya H., Tamura M., Shimizu K., Yada Y., Wakana S., Gondo Y., Noda T., Shiroishi T.
      Mamm. Genome 15:23-34(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-141.

    Entry informationi

    Entry nameiLMBR1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JIT0
    Secondary accession number(s): Q766D0, Q91WC6, Q9JIS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3