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Q9JIT0 (LMBR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Limb region 1 protein
Gene names
Name:Lmbr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative membrane receptor.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the LIMR family.

Sequence caution

The sequence BAD07410.1 differs from that shown. Reason: Frameshift at position 114.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processembryonic digit morphogenesis

Inferred from mutant phenotype PubMed 11606546. Source: MGI

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9JIT0-1)

Also known as: LMBR1L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9JIT0-2)

Also known as: LMBR1S;

The sequence of this isoform differs from the canonical sequence as follows:
     23-32: ICFLLFAILY → RNGRFTSYLW
     33-490: Missing.
Isoform 3 (identifier: Q9JIT0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     107-133: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Limb region 1 protein
PRO_0000053907

Regions

Topological domain1 – 1919Extracellular Potential
Transmembrane20 – 4021Helical; Potential
Topological domain41 – 6222Cytoplasmic Potential
Transmembrane63 – 8321Helical; Potential
Topological domain84 – 11027Extracellular Potential
Transmembrane111 – 13121Helical; Potential
Topological domain132 – 15120Cytoplasmic Potential
Transmembrane152 – 17221Helical; Potential
Topological domain173 – 18715Extracellular Potential
Transmembrane188 – 20821Helical; Potential
Topological domain209 – 29183Cytoplasmic Potential
Transmembrane292 – 31221Helical; Potential
Topological domain313 – 33927Extracellular Potential
Transmembrane340 – 36021Helical; Potential
Topological domain361 – 38323Cytoplasmic Potential
Transmembrane384 – 40421Helical; Potential
Topological domain405 – 42622Extracellular Potential
Transmembrane427 – 44721Helical; Potential
Topological domain448 – 49043Cytoplasmic Potential
Coiled coil256 – 28732 Potential

Natural variations

Alternative sequence23 – 3210ICFLLFAILY → RNGRFTSYLW in isoform 2.
VSP_016889
Alternative sequence33 – 490458Missing in isoform 2.
VSP_016890
Alternative sequence107 – 13327Missing in isoform 3.
VSP_016891

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (LMBR1L) [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 869184C2F0729C91

FASTA49055,115
        10         20         30         40         50         60 
MEGQDEVSAR EQHFHSQVRE STICFLLFAI LYIVSYFIII RYKRKSDEQE DEDAVVNRIS 

        70         80         90        100        110        120 
LFLSTFTLAV SAGAVLLLPF SIISNEILLA FPHNYYIQWL NGSLIHGLWN LASLFSNLCL 

       130        140        150        160        170        180 
FVLMPFAFFF LESEGFAGLK KGIRARILET LVMLLLLALL ILGMVWVASA LIDSDAASME 

       190        200        210        220        230        240 
SLYDLWEFYL PYLYSCISLM GCLLLLLCTP VGLSRMFTVM GQLLVKPAIL EDLDEQIYMI 

       250        260        270        280        290        300 
TLEEEALQRR LHGLSSSVEY NVMELEQELE NVKILKTKLE RRKKASAWER NLVYPAVMVL 

       310        320        330        340        350        360 
LLIETSISVL LVACNILCLL VDETAMPKGT RGPGIGSASL STFGFVGAAL EIILIFYLMV 

       370        380        390        400        410        420 
SSVVGFYSLR FFGNFTPKKD DTTMTKIIGN CVSILVLSSA LPVMSRTLGI TRFDLLGDFG 

       430        440        450        460        470        480 
RFNWLGNFYI VLSYNLLFAI MTTLCLIRKF TSAVREELFK ALGLHKLHLS DTSRDSETTK 

       490 
PSANGHQKAL

« Hide

Isoform 2 (LMBR1S) [UniParc].

Checksum: 4886B3DA63ED0AF2
Show »

FASTA323,869
Isoform 3 [UniParc].

Checksum: 8A115C8C5384A0C6
Show »

FASTA46352,005

References

« Hide 'large scale' references
[1]"A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of hemimelic extra-toes mutant mice."
Clark R.M., Marker P.C., Kingsley D.M.
Genomics 67:19-27(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Strain: B10.D2/nSn.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Eye.
[3]"Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog (Shh)."
Sagai T., Masuya H., Tamura M., Shimizu K., Yada Y., Wakana S., Gondo Y., Noda T., Shiroishi T.
Mamm. Genome 15:23-34(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-141.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF190665 mRNA. Translation: AAF91092.1.
AF190666 mRNA. Translation: AAF91093.1.
BC016110 mRNA. Translation: AAH16110.1.
AB114903 Genomic DNA. Translation: BAD07410.1. Frameshift.
IPIIPI00121024.
IPI00409786.
IPI00474422.
RefSeqNP_064691.2. NM_020295.3.
UniGeneMm.41572.

3D structure databases

ProteinModelPortalQ9JIT0.
ModBaseSearch...

PTM databases

PhosphoSiteQ9JIT0.

Proteomic databases

PaxDbQ9JIT0.
PRIDEQ9JIT0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055195; ENSMUSP00000058405; ENSMUSG00000010721.
GeneID56873.
KEGGmmu:56873.
UCSCuc008wug.1. mouse.
uc012dtv.1. mouse.

Organism-specific databases

CTD64327.
MGIMGI:1861746. Lmbr1.

Phylogenomic databases

eggNOGNOG246746.
GeneTreeENSGT00390000007809.
HOGENOMHOG000252995.
HOVERGENHBG072983.
InParanoidQ9JIT0.
OMATAMPKGS.
OrthoDBEOG4TF0K6.

Gene expression databases

BgeeQ9JIT0.
CleanExMM_LMBR1.
GenevestigatorQ9JIT0.
GermOnlineENSMUSG00000010721. Mus musculus.

Family and domain databases

InterProIPR008075. Lipcalin_1_rcpt.
IPR006876. LMBR1-like_membr_prot.
[Graphical view]
PfamPF04791. LMBR1. 1 hit.
[Graphical view]
PRINTSPR01692. LIPOCALINIMR.
ProtoNetSearch...

Other

ChiTaRSLMBR1. mouse.
NextBio313445.
SOURCESearch...

Entry information

Entry nameLMBR1_MOUSE
AccessionPrimary (citable) accession number: Q9JIT0
Secondary accession number(s): Q766D0, Q91WC6, Q9JIS9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2000
Last modified: April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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