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Protein

Limb region 1 protein

Gene

Lmbr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative membrane receptor.

GO - Biological processi

  • embryonic digit morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Limb region 1 protein
Gene namesi
Name:Lmbr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1861746. Lmbr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 62CytoplasmicSequence analysisAdd BLAST22
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 110ExtracellularSequence analysisAdd BLAST27
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 151CytoplasmicSequence analysisAdd BLAST20
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 187ExtracellularSequence analysisAdd BLAST15
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 291CytoplasmicSequence analysisAdd BLAST83
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 339ExtracellularSequence analysisAdd BLAST27
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 383CytoplasmicSequence analysisAdd BLAST23
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 426ExtracellularSequence analysisAdd BLAST22
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 490CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539071 – 490Limb region 1 proteinAdd BLAST490

Proteomic databases

PaxDbiQ9JIT0.
PRIDEiQ9JIT0.

PTM databases

PhosphoSitePlusiQ9JIT0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000010721.
CleanExiMM_LMBR1.
ExpressionAtlasiQ9JIT0. baseline and differential.
GenevisibleiQ9JIT0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058405.

Structurei

3D structure databases

ProteinModelPortaliQ9JIT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili256 – 287Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the LIMR family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3722. Eukaryota.
ENOG410YKEX. LUCA.
GeneTreeiENSGT00390000007809.
HOGENOMiHOG000252995.
HOVERGENiHBG072983.
InParanoidiQ9JIT0.
OMAiAYFFLES.
OrthoDBiEOG091G05XM.
PhylomeDBiQ9JIT0.
TreeFamiTF313485.

Family and domain databases

InterProiIPR008075. LIMR.
IPR006876. LMBR1-like_membr_prot.
[Graphical view]
PANTHERiPTHR12625. PTHR12625. 1 hit.
PfamiPF04791. LMBR1. 2 hits.
[Graphical view]
PRINTSiPR01692. LIPOCALINIMR.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JIT0-1) [UniParc]FASTAAdd to basket
Also known as: LMBR1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGQDEVSAR EQHFHSQVRE STICFLLFAI LYIVSYFIII RYKRKSDEQE
60 70 80 90 100
DEDAVVNRIS LFLSTFTLAV SAGAVLLLPF SIISNEILLA FPHNYYIQWL
110 120 130 140 150
NGSLIHGLWN LASLFSNLCL FVLMPFAFFF LESEGFAGLK KGIRARILET
160 170 180 190 200
LVMLLLLALL ILGMVWVASA LIDSDAASME SLYDLWEFYL PYLYSCISLM
210 220 230 240 250
GCLLLLLCTP VGLSRMFTVM GQLLVKPAIL EDLDEQIYMI TLEEEALQRR
260 270 280 290 300
LHGLSSSVEY NVMELEQELE NVKILKTKLE RRKKASAWER NLVYPAVMVL
310 320 330 340 350
LLIETSISVL LVACNILCLL VDETAMPKGT RGPGIGSASL STFGFVGAAL
360 370 380 390 400
EIILIFYLMV SSVVGFYSLR FFGNFTPKKD DTTMTKIIGN CVSILVLSSA
410 420 430 440 450
LPVMSRTLGI TRFDLLGDFG RFNWLGNFYI VLSYNLLFAI MTTLCLIRKF
460 470 480 490
TSAVREELFK ALGLHKLHLS DTSRDSETTK PSANGHQKAL
Length:490
Mass (Da):55,115
Last modified:October 1, 2000 - v1
Checksum:i869184C2F0729C91
GO
Isoform 2 (identifier: Q9JIT0-2) [UniParc]FASTAAdd to basket
Also known as: LMBR1S

The sequence of this isoform differs from the canonical sequence as follows:
     23-32: ICFLLFAILY → RNGRFTSYLW
     33-490: Missing.

Show »
Length:32
Mass (Da):3,869
Checksum:i4886B3DA63ED0AF2
GO
Isoform 3 (identifier: Q9JIT0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-133: Missing.

Show »
Length:463
Mass (Da):52,005
Checksum:i8A115C8C5384A0C6
GO

Sequence cautioni

The sequence BAD07410 differs from that shown. Reason: Frameshift at position 114.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01688923 – 32ICFLLFAILY → RNGRFTSYLW in isoform 2. 1 Publication10
Alternative sequenceiVSP_01689033 – 490Missing in isoform 2. 1 PublicationAdd BLAST458
Alternative sequenceiVSP_016891107 – 133Missing in isoform 3. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190665 mRNA. Translation: AAF91092.1.
AF190666 mRNA. Translation: AAF91093.1.
BC016110 mRNA. Translation: AAH16110.1.
AB114903 Genomic DNA. Translation: BAD07410.1. Frameshift.
CCDSiCCDS19148.1. [Q9JIT0-1]
RefSeqiNP_064691.2. NM_020295.3. [Q9JIT0-1]
UniGeneiMm.41572.

Genome annotation databases

EnsembliENSMUST00000055195; ENSMUSP00000058405; ENSMUSG00000010721. [Q9JIT0-1]
ENSMUST00000198105; ENSMUSP00000142755; ENSMUSG00000010721. [Q9JIT0-3]
GeneIDi56873.
KEGGimmu:56873.
UCSCiuc008wug.1. mouse. [Q9JIT0-1]
uc012dtv.1. mouse. [Q9JIT0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190665 mRNA. Translation: AAF91092.1.
AF190666 mRNA. Translation: AAF91093.1.
BC016110 mRNA. Translation: AAH16110.1.
AB114903 Genomic DNA. Translation: BAD07410.1. Frameshift.
CCDSiCCDS19148.1. [Q9JIT0-1]
RefSeqiNP_064691.2. NM_020295.3. [Q9JIT0-1]
UniGeneiMm.41572.

3D structure databases

ProteinModelPortaliQ9JIT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058405.

PTM databases

PhosphoSitePlusiQ9JIT0.

Proteomic databases

PaxDbiQ9JIT0.
PRIDEiQ9JIT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055195; ENSMUSP00000058405; ENSMUSG00000010721. [Q9JIT0-1]
ENSMUST00000198105; ENSMUSP00000142755; ENSMUSG00000010721. [Q9JIT0-3]
GeneIDi56873.
KEGGimmu:56873.
UCSCiuc008wug.1. mouse. [Q9JIT0-1]
uc012dtv.1. mouse. [Q9JIT0-3]

Organism-specific databases

CTDi64327.
MGIiMGI:1861746. Lmbr1.

Phylogenomic databases

eggNOGiKOG3722. Eukaryota.
ENOG410YKEX. LUCA.
GeneTreeiENSGT00390000007809.
HOGENOMiHOG000252995.
HOVERGENiHBG072983.
InParanoidiQ9JIT0.
OMAiAYFFLES.
OrthoDBiEOG091G05XM.
PhylomeDBiQ9JIT0.
TreeFamiTF313485.

Miscellaneous databases

ChiTaRSiLmbr1. mouse.
PROiQ9JIT0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010721.
CleanExiMM_LMBR1.
ExpressionAtlasiQ9JIT0. baseline and differential.
GenevisibleiQ9JIT0. MM.

Family and domain databases

InterProiIPR008075. LIMR.
IPR006876. LMBR1-like_membr_prot.
[Graphical view]
PANTHERiPTHR12625. PTHR12625. 1 hit.
PfamiPF04791. LMBR1. 2 hits.
[Graphical view]
PRINTSiPR01692. LIPOCALINIMR.
ProtoNetiSearch...

Entry informationi

Entry nameiLMBR1_MOUSE
AccessioniPrimary (citable) accession number: Q9JIT0
Secondary accession number(s): Q766D0, Q91WC6, Q9JIS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.