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Protein

Potassium channel subfamily K member 10

Gene

Kcnk10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

GO - Molecular functioni

  • potassium channel activity Source: RGD
  • voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  • memory Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-RNO-1299503. TWIK related potassium channel (TREK).

Protein family/group databases

TCDBi1.A.1.9.4. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 10
Alternative name(s):
Outward rectifying potassium channel protein TREK-2
TREK-2 K(+) channel subunit
Gene namesi
Name:Kcnk10
Synonyms:Trek2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi619732. Kcnk10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7171CytoplasmicSequence analysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Intramembranei154 – 18027Pore-forming; Name=Pore-forming 1Sequence analysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence analysisAdd
BLAST
Topological domaini203 – 23331CytoplasmicSequence analysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence analysisAdd
BLAST
Intramembranei263 – 29432Pore-forming; Name=Pore-forming 2Sequence analysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence analysisAdd
BLAST
Topological domaini320 – 538219CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Potassium channel subfamily K member 10PRO_0000101759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JIS4.
PRIDEiQ9JIS4.

PTM databases

iPTMnetiQ9JIS4.
PhosphoSiteiQ9JIS4.

Expressioni

Tissue specificityi

Expressed mainly in the cerebellum, spleen, and testis.

Gene expression databases

GenevisibleiQ9JIS4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005175.

Structurei

3D structure databases

ProteinModelPortaliQ9JIS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
InParanoidiQ9JIS4.
KOiK04920.
OMAiKQVNWDP.
OrthoDBiEOG77M8NK.
PhylomeDBiQ9JIS4.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9JIS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFPIETPRK QVNWDPKVAV PAAAPPVCQP KSATNGHHPV PRLSISSRAT
60 70 80 90 100
VVARMEGASQ GGLQTVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS
110 120 130 140 150
QKNTIALEKA EFLRDHICVS PQELETLIQH ALDADNAGVS PVGNSSNSSS
160 170 180 190 200
HWDLGSAFFF AGTVITTIGY GNIAPSTEGG KIFCILYAIF GIPLFGFLLA
210 220 230 240 250
GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI LAGCIVFVTI
260 270 280 290 300
PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV
310 320 330 340 350
WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE
360 370 380 390 400
FRETRRRLSV EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF
410 420 430 440 450
AALDTGRFKA SSQESINNRP NNLRLKGPEQ LNKHGQGASE DNIINKFGST
460 470 480 490 500
SKLTKRKNKD LKKTLPEDVQ KIYKTFRNYS LDEEKKEDET EKMCNSDNSS
510 520 530
TAMLTECIQQ QAEMENGMVP MDTKDQGLEN NSLLEDRN
Length:538
Mass (Da):59,801
Last modified:October 1, 2000 - v1
Checksum:i1FF33F0AA52B97E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196965 mRNA. Translation: AAF75132.1.
AF385401 mRNA. Translation: AAL95707.1.
RefSeqiNP_075584.1. NM_023096.2.
UniGeneiRn.53999.

Genome annotation databases

EnsembliENSRNOT00000005175; ENSRNOP00000005175; ENSRNOG00000003813.
GeneIDi65272.
KEGGirno:65272.
UCSCiRGD:619732. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196965 mRNA. Translation: AAF75132.1.
AF385401 mRNA. Translation: AAL95707.1.
RefSeqiNP_075584.1. NM_023096.2.
UniGeneiRn.53999.

3D structure databases

ProteinModelPortaliQ9JIS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005175.

Protein family/group databases

TCDBi1.A.1.9.4. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiQ9JIS4.
PhosphoSiteiQ9JIS4.

Proteomic databases

PaxDbiQ9JIS4.
PRIDEiQ9JIS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005175; ENSRNOP00000005175; ENSRNOG00000003813.
GeneIDi65272.
KEGGirno:65272.
UCSCiRGD:619732. rat.

Organism-specific databases

CTDi54207.
RGDi619732. Kcnk10.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
InParanoidiQ9JIS4.
KOiK04920.
OMAiKQVNWDP.
OrthoDBiEOG77M8NK.
PhylomeDBiQ9JIS4.
TreeFamiTF313947.

Enzyme and pathway databases

ReactomeiR-RNO-1299503. TWIK related potassium channel (TREK).

Miscellaneous databases

NextBioi614227.
PROiQ9JIS4.

Gene expression databases

GenevisibleiQ9JIS4. RN.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family."
    Bang H., Kim Y., Kim D.
    J. Biol. Chem. 275:17412-17419(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2."
    Gu W., Schlichthorl G., Hirsch J.R., Engels H., Karschin C., Karschin A., Derst C., Steinlein O.K., Daut J.
    J. Physiol. (Lond.) 539:657-668(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiKCNKA_RAT
AccessioniPrimary (citable) accession number: Q9JIS4
Secondary accession number(s): Q548D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.