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Protein

Regulating synaptic membrane exocytosis protein 2

Gene

Rims2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri86 – 14257FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • ion channel binding Source: ParkinsonsUK-UCL
  • metal ion binding Source: UniProtKB-KW
  • protein domain specific binding Source: RGD
  • protein heterodimerization activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Exocytosis, Neurotransmitter transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 2
Alternative name(s):
Rab-3-interacting molecule 2
Short name:
RIM 2
Gene namesi
Name:Rims2
Synonyms:Rim2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620001. Rims2.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • intracellular Source: GOC
  • presynaptic active zone Source: InterPro
  • presynaptic membrane Source: UniProtKB-SubCell
  • protein complex Source: RGD
  • synapse Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15551555Regulating synaptic membrane exocytosis protein 2PRO_0000190203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei369 – 3691PhosphoserineBy similarity
Modified residuei611 – 6111PhosphothreonineBy similarity
Modified residuei713 – 7131PhosphoserineBy similarity
Modified residuei716 – 7161PhosphoserineBy similarity
Modified residuei1106 – 11061PhosphoserineCombined sources
Modified residuei1200 – 12001PhosphoserineCombined sources
Modified residuei1276 – 12761PhosphoserineCombined sources
Modified residuei1540 – 15401PhosphoserineCombined sources
Modified residuei1543 – 15431PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JIS1.
PRIDEiQ9JIS1.

PTM databases

iPTMnetiQ9JIS1.
PhosphoSiteiQ9JIS1.

Expressioni

Tissue specificityi

Highly expressed in hippocampus, brain cortex, cerebellum and olfactory bulb. Detected at intermediate levels in midbrain, hindbrain and spinal cord, and at low levels in testis.1 Publication

Gene expression databases

ExpressionAtlasiQ9JIS1. baseline and differential.
GenevisibleiQ9JIS1. RN.

Interactioni

Subunit structurei

Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2. Interacts with RAB3C, RAB3D and RAB26 (By similarity). Binds RAB3A and RAB3B that have been activated by GTP-binding. Interacts with BZRAP1/RIMBP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A.By similarity4 Publications

GO - Molecular functioni

  • ion channel binding Source: ParkinsonsUK-UCL
  • protein domain specific binding Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

DIPiDIP-29192N.
IntActiQ9JIS1. 1 interaction.
MINTiMINT-270417.
STRINGi10116.ENSRNOP00000045165.

Structurei

Secondary structure

1
1555
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni93 – 953Combined sources
Beta strandi105 – 1073Combined sources
Turni109 – 1113Combined sources
Beta strandi119 – 1257Combined sources
Turni126 – 1283Combined sources
Beta strandi129 – 1346Combined sources
Helixi135 – 1417Combined sources
Beta strandi730 – 7323Combined sources
Beta strandi749 – 7546Combined sources
Turni755 – 7584Combined sources
Beta strandi759 – 76911Combined sources
Beta strandi781 – 79010Combined sources
Helixi793 – 7953Combined sources
Beta strandi796 – 7983Combined sources
Beta strandi803 – 8075Combined sources
Beta strandi809 – 8168Combined sources
Helixi821 – 8266Combined sources
Beta strandi828 – 8358Combined sources
Beta strandi845 – 8539Combined sources
Helixi854 – 8563Combined sources
Beta strandi863 – 8675Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A20NMR-A83-142[»]
2BWQX-ray1.41A725-869[»]
2CJSX-ray1.78C83-142[»]
ProteinModelPortaliQ9JIS1.
SMRiQ9JIS1. Positions 83-142, 565-676, 746-872, 1387-1534.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JIS1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 154129RabBDPROSITE-ProRule annotationAdd
BLAST
Domaini590 – 67687PDZPROSITE-ProRule annotationAdd
BLAST
Domaini745 – 851107C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini1401 – 1503103C2 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1194 – 1315122Ser-richAdd
BLAST

Sequence similaritiesi

Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 RabBD (Rab-binding) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri86 – 14257FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2060. Eukaryota.
KOG3799. Eukaryota.
ENOG4111MA5. LUCA.
GeneTreeiENSGT00550000074588.
HOVERGENiHBG058147.
InParanoidiQ9JIS1.
KOiK15297.
OMAiSESSSWV.
OrthoDBiEOG7BGHJV.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR001478. PDZ.
IPR010911. Rab_BD.
IPR030631. RIM2.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12157:SF15. PTHR12157:SF15. 1 hit.
PfamiPF00168. C2. 2 hits.
PF02318. FYVE_2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF50156. SSF50156. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
PS50916. RABBD. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9JIS1-1) [UniParc]FASTAAdd to basket

Also known as: RIM2-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPLGPRGR PAPTPAASQP PPQPEMPDLS HLTEEERKII QAVMDRQKKE
60 70 80 90 100
EEKEQSVLKK LHQQFEMYKE QVKKMGEESQ QQQEQKGDAP TCGICHKTKF
110 120 130 140 150
ADGCGHNCSY CQTKFCARCG GRVSLRSNKV MWVCNLCRKQ QEILTKSGAW
160 170 180 190 200
FYNSGSNTPQ QPDQKALRGL RSEEAPQEKK AKLHEQTQFQ GPPGDSSVPA
210 220 230 240 250
VERGRAHGLT RQDSIKNGSG MKHQIASDMP SDRKRSPSVS RDQNRRYDQS
260 270 280 290 300
EEREEYSQYV PSDSTMPRSP SDYADRRSQR EPQFYEEPDH LNYRDSNRRG
310 320 330 340 350
HRHSKEYIVD DEDVESRDEY ERQRREEEYQ ARYRSDPNLA RYPVKPQPYE
360 370 380 390 400
EQMRIHAEVS RARHERRHSD VSLANAELED SRISLLRMDR PSRQRSVSER
410 420 430 440 450
RAAMENQRSY SMERTREAQG QSSYPQRTTN HSPPTPRRSP IPLDRPELRR
460 470 480 490 500
ADSLRKQHHL DPSSAVRKTK REKMETMLRN DSLSSDQSES VRPPPPRPHK
510 520 530 540 550
SKKGGKMRQV SLSSSEEELA STPEYTSCDD VEIESESVGE KGDMEYSWLE
560 570 580 590 600
HASWHSSEAS PMSLHPVTWQ PSKDGDRLIG RILLNKRLKD GSVPRDSGAM
610 620 630 640 650
LGLKVVGGKM TESGRLCAFI TKVKKGSLAD TVGHLRPGDE VLEWNGRLLQ
660 670 680 690 700
GATFEEVYNI ILESKPEPQV ELVVSRPIGD MPRIPDSTHA QLESSSSSFE
710 720 730 740 750
SQKMDRPSIS VTSPMSPGML RDVPQFLSGQ LSSQSLSRRT TPFVPRVQIK
760 770 780 790 800
LWFDKVGHQL IVTILGAKDL PSREDGRPRN PYVKIYFLPD RSDKNKRRTK
810 820 830 840 850
TVKKTLEPKW NQTFIYSPVH RREFRERMLE ITLWDQARVR EEESEFLGEI
860 870 880 890 900
LIELETALLD DEPHWYKLQT HDVSSLPLPH PSPYMPRRQL HGESPTRRLQ
910 920 930 940 950
RSKRISDSEV SDYDCEDGVG VVSDYRHDGR DLQSSTLSVP EQVMSSNHCS
960 970 980 990 1000
PSGSPHRVDV IGRTRSWSPS VPPPQRNVEQ GLRGTRATGH YNTISRMDRH
1010 1020 1030 1040 1050
RVMDDHYSSE RDSHFLTLPR SRHRQTSEHH HRDGRDCEAA DRQPYHRSRS
1060 1070 1080 1090 1100
TEQRPLLERT TTRSRSSERA DTNLMRSMPS LMTGRSAPPS PALSRSHPRT
1110 1120 1130 1140 1150
GSVQTSPSST PVTGRRGRQL PQLPPKGTLE RMITEDMDST RKRNSGAMDI
1160 1170 1180 1190 1200
EERNRQMKLN KYKQVAGSDP RLEQDYHSKY RSGWDPHRGA DTVSTKSSDS
1210 1220 1230 1240 1250
DVSDVSAVSR TSSASRFSST SYMSVQSERP RGNRKISVFT SKMQSRQMGV
1260 1270 1280 1290 1300
SGKSMAKSTS ISGDMCSLEK NDGSQSDTAV GALGTSGKKR RSSIGAKMVA
1310 1320 1330 1340 1350
IVGLSRKSRS ASQLSQTEGG GKKLRSTVQR STETGLAVEM RNWMTRQASR
1360 1370 1380 1390 1400
ESTDGSMNSY SSEGNLIFPG VRLASDSQFS DFLDGLGPAQ LVGRQTLATP
1410 1420 1430 1440 1450
AMGDIQVGMM DKKGQLEVEI IRARGLVVKP GSKTLPAPYV KVYLLDNGVC
1460 1470 1480 1490 1500
IAKKKTKVAR KTLEPLYQQL LSFEESPQGK VLQIIVWGDY GRMDHKSFMG
1510 1520 1530 1540 1550
VAQILLDELE LSNMVIGWFK LFPPSSLVDP TLAPLTRRAS QSSLESSTGP

SYSRS
Length:1,555
Mass (Da):175,913
Last modified:October 1, 2000 - v1
Checksum:iD76967BB36D9704E
GO
Isoform 2 (identifier: Q9JIS1-2) [UniParc]FASTAAdd to basket

Also known as: RIM2-2B

The sequence of this isoform differs from the canonical sequence as follows:
     544-564: MEYSWLEHASWHSSEASPMSL → SQKGKRKTSE...LNEERSHSDE
     733-748: Missing.
     1132-1318: Missing.

Show »
Length:1,399
Mass (Da):158,946
Checksum:i3F1550E3D52D237B
GO
Isoform 3 (identifier: Q9JIS1-3) [UniParc]FASTAAdd to basket

Also known as: RIM2-4C

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1013-1034: Missing.
     1132-1318: Missing.

Show »
Length:1,330
Mass (Da):151,045
Checksum:i485906E1F668FC73
GO
Isoform 4 (identifier: Q9JIS1-4) [UniParc]FASTAAdd to basket

Also known as: RIM2-5C, RIM2-2A, RIM2-3B, RIM2-4A

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1132-1318: Missing.

Show »
Length:1,352
Mass (Da):153,719
Checksum:i5E1E6F0F42DFEA9C
GO
Isoform 5 (identifier: Q9JIS1-5) [UniParc]FASTAAdd to basket

Also known as: RIM2-3A

The sequence of this isoform differs from the canonical sequence as follows:
     1132-1318: Missing.

Show »
Length:1,368
Mass (Da):155,560
Checksum:iCE08E16F0B383A11
GO
Isoform 6 (identifier: Q9JIS1-6) [UniParc]FASTAAdd to basket

Also known as: RIM2-4B

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1035-1094: Missing.
     1132-1318: Missing.

Show »
Length:1,292
Mass (Da):146,934
Checksum:iE15B2C2B25452094
GO
Isoform 7 (identifier: Q9JIS1-7) [UniParc]FASTAAdd to basket

Also known as: RIM2-beta, RIM2beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: MSAPLGPRGR...HQIASDMPSD → MQFETLRQVC...ELFGQTLNNA

Show »
Length:1,363
Mass (Da):154,503
Checksum:iC100863603514145
GO
Isoform 8 (identifier: Q9JIS1-8) [UniParc]FASTAAdd to basket

Also known as: RIM2-5B

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1132-1146: MITEDMDSTRKRNSG → S

Show »
Length:1,525
Mass (Da):172,436
Checksum:iD4930D6D2F03CF21
GO
Isoform 9 (identifier: Q9JIS1-9) [UniParc]FASTAAdd to basket

Also known as: RIM2-5A

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.

Show »
Length:1,539
Mass (Da):174,072
Checksum:i12882D2F4EE0AE8C
GO
Isoform 10 (identifier: Q9JIS1-10) [UniParc]FASTAAdd to basket

Also known as: RIM2-gamma, NIM2

The sequence of this isoform differs from the canonical sequence as follows:
     1-1270: Missing.
     1271-1317: NDGSQSDTAV...SRSASQLSQT → MGRQGLGGTG...CMNSLEEDEG

Show »
Length:285
Mass (Da):30,944
Checksum:iDBE7F39B93C4616C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 12701270Missing in isoform 10. 1 PublicationVSP_008192Add
BLAST
Alternative sequencei1 – 232232MSAPL…DMPSD → MQFETLRQVCNSVLSHFHGV FSSPPNILQNELFGQTLNNA in isoform 7. 1 PublicationVSP_008185Add
BLAST
Alternative sequencei544 – 56421MEYSW…SPMSL → SQKGKRKTSEQAVWSDSNTR SERQKKVMYSGGHSLDEDLE WSEPQTKDSGVDTCSSTTLN EERSHSDE in isoform 2. 1 PublicationVSP_008186Add
BLAST
Alternative sequencei733 – 74816Missing in isoform 2, isoform 3, isoform 4, isoform 6, isoform 8 and isoform 9. 1 PublicationVSP_008187Add
BLAST
Alternative sequencei1013 – 103422Missing in isoform 3. 1 PublicationVSP_008188Add
BLAST
Alternative sequencei1035 – 109460Missing in isoform 6. 1 PublicationVSP_008191Add
BLAST
Alternative sequencei1132 – 1318187Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_008189Add
BLAST
Alternative sequencei1132 – 114615MITED…KRNSG → S in isoform 8. 1 PublicationVSP_008190Add
BLAST
Alternative sequencei1271 – 131747NDGSQ…QLSQT → MGRQGLGGTGAAGRSMQRSQ SRSSLSASFEALAGYFPCMN SLEEDEG in isoform 10. 1 PublicationVSP_008193Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199322 mRNA. Translation: AAF81644.1.
AF199323 mRNA. Translation: AAF81645.1.
AF199324 mRNA. Translation: AAF81646.1.
AF199325 mRNA. Translation: AAF81647.1.
AF199326 mRNA. Translation: AAF81648.1.
AF199327 mRNA. Translation: AAF81649.1.
AF199328 mRNA. Translation: AAF81650.1.
AF199329 mRNA. Translation: AAF81651.1.
AF199330 mRNA. Translation: AAF81652.1.
AF199331 mRNA. Translation: AAF81653.1.
AF199332 mRNA. Translation: AAF81654.1.
AF199335 mRNA. Translation: AAF81657.1.
AF548738 mRNA. Translation: AAN59930.1.
RefSeqiNP_446397.1. NM_053945.2. [Q9JIS1-1]
NP_665888.1. NM_145881.2. [Q9JIS1-10]
UniGeneiRn.161948.

Genome annotation databases

EnsembliENSRNOT00000006393; ENSRNOP00000006393; ENSRNOG00000004201. [Q9JIS1-10]
GeneIDi116839.
KEGGirno:116839.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199322 mRNA. Translation: AAF81644.1.
AF199323 mRNA. Translation: AAF81645.1.
AF199324 mRNA. Translation: AAF81646.1.
AF199325 mRNA. Translation: AAF81647.1.
AF199326 mRNA. Translation: AAF81648.1.
AF199327 mRNA. Translation: AAF81649.1.
AF199328 mRNA. Translation: AAF81650.1.
AF199329 mRNA. Translation: AAF81651.1.
AF199330 mRNA. Translation: AAF81652.1.
AF199331 mRNA. Translation: AAF81653.1.
AF199332 mRNA. Translation: AAF81654.1.
AF199335 mRNA. Translation: AAF81657.1.
AF548738 mRNA. Translation: AAN59930.1.
RefSeqiNP_446397.1. NM_053945.2. [Q9JIS1-1]
NP_665888.1. NM_145881.2. [Q9JIS1-10]
UniGeneiRn.161948.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A20NMR-A83-142[»]
2BWQX-ray1.41A725-869[»]
2CJSX-ray1.78C83-142[»]
ProteinModelPortaliQ9JIS1.
SMRiQ9JIS1. Positions 83-142, 565-676, 746-872, 1387-1534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29192N.
IntActiQ9JIS1. 1 interaction.
MINTiMINT-270417.
STRINGi10116.ENSRNOP00000045165.

PTM databases

iPTMnetiQ9JIS1.
PhosphoSiteiQ9JIS1.

Proteomic databases

PaxDbiQ9JIS1.
PRIDEiQ9JIS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006393; ENSRNOP00000006393; ENSRNOG00000004201. [Q9JIS1-10]
GeneIDi116839.
KEGGirno:116839.

Organism-specific databases

CTDi9699.
RGDi620001. Rims2.

Phylogenomic databases

eggNOGiKOG2060. Eukaryota.
KOG3799. Eukaryota.
ENOG4111MA5. LUCA.
GeneTreeiENSGT00550000074588.
HOVERGENiHBG058147.
InParanoidiQ9JIS1.
KOiK15297.
OMAiSESSSWV.
OrthoDBiEOG7BGHJV.

Miscellaneous databases

EvolutionaryTraceiQ9JIS1.
PROiQ9JIS1.

Gene expression databases

ExpressionAtlasiQ9JIS1. baseline and differential.
GenevisibleiQ9JIS1. RN.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR001478. PDZ.
IPR010911. Rab_BD.
IPR030631. RIM2.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12157:SF15. PTHR12157:SF15. 1 hit.
PfamiPF00168. C2. 2 hits.
PF02318. FYVE_2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF50156. SSF50156. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
PS50916. RABBD. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins."
    Wang Y., Sugita S., Suedhof T.C.
    J. Biol. Chem. 275:20033-20044(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 8; 9 AND 10), TISSUE SPECIFICITY, INTERACTION WITH RAB3A; RAB3B; RIM BINDING PROTEINS 1 AND 2.
  2. "Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins."
    Wang Y., Suedhof T.C.
    Genomics 81:126-137(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), GENOMIC ORGANIZATION.
  3. "RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone."
    Schoch S., Castillo P.E., Jo T., Mukherjee K., Geppert M., Wang Y., Schmitz F., Malenka R.C., Suedhof T.C.
    Nature 415:321-326(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPFIA3 AND PPFIA4.
    Tissue: Brain.
  4. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1106; SER-1200; SER-1276; SER-1540 AND SER-1543, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch."
    Lu J., Machius M., Dulubova I., Dai H., Suedhof T.C., Tomchick D.R., Rizo J.
    PLoS Biol. 4:1159-1172(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 83-142 IN COMPLEX WITH UNC13A.
  7. "A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?"
    Dulubova I., Lou X., Lu J., Huryeva I., Alam A., Schneggenburger R., Suedhof T.C., Rizo J.
    EMBO J. 24:2839-2850(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 83-142, INTERACTION WITH UNC13A.

Entry informationi

Entry nameiRIMS2_RAT
AccessioniPrimary (citable) accession number: Q9JIS1
Secondary accession number(s): Q8CIX2
, Q9JHJ6, Q9JIR2, Q9JIR5, Q9JIR6, Q9JIR7, Q9JIR8, Q9JIR9, Q9JIS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.